The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
Open accessAbstract
Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives transporter proteins a unique gatekeeper function in controlling drug access to metabolizing enzymes and excretory pathways. This review seeks to discuss the influence intestinal and hepatic drug transporters have on pharmacokinetic parameters, including bioavailability, exposure, clearance, volume of distribution, and half-life, for orally dosed drugs. This review also describes in detail the Biopharmaceutics Drug Disposition Classification System (BDDCS) and explains how many of the effects drug transporters exert on oral drug pharmacokinetic parameters can be predicted by this classification scheme.
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Cites
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Wu, C.-Y., & Benet, L. Z. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-9004-4 · Cited by 1,401
Self-citationKast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916
Challenges and opportunities with modelling and simulation in drug discovery and drug development
Lavé, T., Parrott, N., Grimm, H. P., Fleury, A., & Reddy, M. (2007) · Xenobiotica · doi:10.1080/00498250701534885 · Cited by 115
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The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340
Self-citationXu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)
Varma, M. V., Steyn, S. J., Allerton, C., & El-Kattan, A. F. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1749-4 · Cited by 334
DrugCentral 2021 supports drug discovery and repositioning
Avram, S., Bologa, C. G., Holmes, J., Bocci, G., Wilson, T. B., Nguyen, D.-T., Curpan, R., Halip, L., Bora, A., Yang, J. J., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa997 · Cited by 189
Organic anion transporters and their implications in pharmacotherapy
Emami Riedmaier, A., Nies, A. T., Schaeffeler, E., & Schwab, M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004614 · Cited by 128
Khurana, R. K., Bansal, A. K., Beg, S., Burrow, A. J., Katare, O. P., Singh, K. K., & Singh, B. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.044 · Cited by 91
Minocha, M., Khurana, V., Qin, B., Pal, D., & Mitra, A. K. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.05.028 · Cited by 82
Yoshikado, T., Toshimoto, K., Nakada, T., Ikejiri, K., Kusuhara, H., Maeda, K., & Sugiyama, Y. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.074823 · Cited by 54
Shimizu, T., Kijima, A., Masuo, Y., Ishimoto, T., Sugiura, T., Takahashi, S., Nakamichi, N., & Kato, Y. (2015) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00109 · Cited by 8
Metadata
- Authors
- Shugarts, S., & Benet, L. Z.
- Venue
- Pharmaceutical Research
- Published
- 2009-06-30
- Volume
- 26
- Issue
- 9
- Pages
- 2039-2054
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2096523918
- Cited by
- 438
- References
- 4
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
