Organic anion transporters and their implications in pharmacotherapy

Molecular identification of a renal urate–anion exchanger that regulates blood urate levels

Enomoto, A., Kimura, H. J., Chairoungdua, A., Shigeta, Y., Jutabha, P., Ho, S., Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., et al. (2002) · Nature · doi:10.1038/nature742 · Cited by 1,535 · see citing works

PDZ Domains: Structural Modules for Protein Complex Assembly

Hung, A. Y., & Sheng, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100065200 · Cited by 699 · see citing works

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farrall, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000504 · Cited by 659 · see citing works

Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter

Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., & Endou, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18526 · Cited by 623 · see citing works

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

Zanger, U. M., Turpeinen, M., Klein, K., & Schwab, M. G. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2291-6 · Cited by 593 · see citing works

Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

Hilgendorf, C., Ahlin, G., Seithel‐Keuth, A., Artursson, P., Ungell, A.-L. B., & Karlsson, J. E. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.014902 · Cited by 583 · see citing works

The SLC22 drug transporter family

Koepsell, H., & Endou, H. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1089-9 · Cited by 521 · see citing works

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Nishizato, Y. (2003) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(03)00060-2 · Cited by 511 · see citing works

Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney

Ho, S., Sekine, T., Fukushima, J., Kanai, Y., Kobayashi, Y., Goya, T., & Endou, H. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1277 · Cited by 508 · see citing works

Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney

Motohashi, H., Sakurai, Y., Saito, H., Masuda, S., Urakami, Y., Goto, M., Fukatsu, A., Ogawa, O., & Inui, K. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134866 · Cited by 507 · see citing works

Mechanisms mediating renal secretion of organic anions and cations

Pritchard, J. B., & Miller, D. S. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.4.765 · Cited by 495 · see citing works

Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

Kusuhara, H., Sekine, T., Utsunomiya‐Tate, N., Tsuda, M., Kojima, R., Ho, S., Sugiyama, Y., Kanai, Y., & Endou, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13675 · Cited by 488 · see citing works

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

Döring, A., Gieger, C., Mehta, D., Gohlke, H., Prokisch, H., Coassin, S., Fischer, G., Henke, K., Klopp, N., Kronenberg, F., et al. (2008) · Nature Genetics · doi:10.1038/ng.107 · Cited by 444 · see citing works

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

Shugarts, S. B., & Benet, L. Z. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9924-0 · Cited by 439 · see citing works

Expression Cloning and Characterization of ROAT1

Sweet, D. H., Wolff, N. A., & Pritchard, J. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30088 · Cited by 426 · see citing works

Genomic strategies to identify mammalian regulatory sequences

Pennacchio, L., & Rubin, E. (2001) · Nature reviews genetics · doi:10.1038/35052548 · Cited by 417 · see citing works

Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta

Ho, S., Sekine, T., Kusuhara, H., Yu, E., Kim, J. Y., Kim, D. K., Sugiyama, Y., Kanai, Y., & Endou, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4507 · Cited by 407 · see citing works

Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport

Wright, S. H., & Dantzler, W. H. (2004) · Physiological Reviews · doi:10.1152/physrev.00040.2003 · Cited by 404 · see citing works

Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydrazide Chemistry

Chen, R., Jiang, X., Sun, D., Han, G., Wang, F., Ye, M., Wang, L., & Zou, H. (2009) · Journal of Proteome Research · doi:10.1021/pr8008012 · Cited by 400 · see citing works

Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia

Matsuo, H., Chiba, T., Nagamori, S., Nakayama, A., Domoto, H., Phetdee, K., Wiriyasermkul, P., Kikuchi, Y., Oda, T., Nishiyama, J., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.11.001 · Cited by 389 · see citing works

Tissue-specific mRNA Expression Profiles of Human ATP-binding Cassette and Solute Carrier Transporter Superfamilies

Nishimura, M., & Naito, S. (2005) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.20.452 · Cited by 388 · see citing works

Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion

Ichida, K., Hosoyamada, M., Hisatome, I., Enomoto, A., Hikita, M., Endou, H., & Hosoya, T. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000105320.04395.d0 · Cited by 384 · see citing works

Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy

Nies, A. T., Koepsell, H., Damme, K., & Schwab, M. G. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-14541-4_3 · Cited by 373 · see citing works

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

Hosoyamada, M., Sekine, T., Kanai, Y., & Endou, H. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.276.1.f122 · Cited by 359 · see citing works

Cytotoxicity of Antiviral Nucleotides Adefovir and Cidofovir Is Induced by the Expression of Human Renal Organic Anion Transporter 1

Ho, E. S., Lin, D. C., Mendel, D. B., & Cihlář, T. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v113383 · Cited by 356 · see citing works

Molecular Physiology of Urate Transport

Hediger, M. A., Johnson, R. J., Miyazaki, H., & Endou, H. (2005) · Physiology · doi:10.1152/physiol.00039.2004 · Cited by 351 · see citing works

The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1

Cihlář, T., Lin, D. C., Pritchard, J. B., Fuller, M. D., Mendel, D. B., & Sweet, D. H. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.3.570 · Cited by 345 · see citing works

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

Sekine, T., Ho, S., Tsuda, M., Apiwattanakul, N., Nakajima, N., Kanai, Y., & Endou, H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00585-7 · Cited by 334 · see citing works

Genetic susceptibility to adverse drug reactions

Pirmohamed, M., & Park, B. K. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01717-x · Cited by 328 · see citing works

The multispecific organic anion transporter (OAT) family

Sekine, T., H, S., & Endou, H. (2000) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240000297 · Cited by 324 · see citing works

ORGANIC CATION TRANSPORTERS IN INTESTINE, KIDNEY, LIVER, AND BRAIN

Koepsell, H. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.243 · Cited by 310 · see citing works

The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts

Li, S., Sanna, S., Maschio, A., Busonero, F., Usala, G., Mulas, A., Lai, S., Dei, M., Orrù, M., Albai, G., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030194 · Cited by 305 · see citing works

Structure of renal organic anion and cation transporters

Burckhardt, G., & Wolff, N. A. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.6.f853 · Cited by 298 · see citing works

Transport of organic anions across the basolateral membrane of proximal tubule cells

Burckhardt, B. C., & Burckhardt, G. (2003) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/s10254-002-0003-8 · Cited by 295 · see citing works

Impaired Organic Anion Transport in Kidney and Choroid Plexus of Organic Anion Transporter 3 (Oat3 (Slc22a8)) Knockout Mice

Sweet, D. H., Miller, D. S., Pritchard, J. B., Fujiwara, Y., Beier, D. R., & Nigám, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203803200 · Cited by 287 · see citing works

Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Antiviral Transport

Takeda, M., Khamdang, S., Narikawa, S., Kimura, H. J., Kobayashi, Y., Yamamoto, T., Ho, S., Sekine, T., & Endou, H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.918 · Cited by 276 · see citing works

Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles

Rizwan, A., & Burckhardt, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9181-4 · Cited by 276 · see citing works

Human Renal Organic Anion Transporter 4 Operates as an Asymmetric Urate Transporter

Hagos, Y., Stein, D., Ugele, B., Burckhardt, G., & Bahn, A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006040415 · Cited by 273 · see citing works

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition

Bleasby, K., Castle, J. C., Roberts, C. J., Cheng, C., Bailey, W. J., Sina, J. F., Kulkarni, A., Hafey, M., Evers, R., Johnson, J. M., et al. (2006) · Xenobiotica · doi:10.1080/00498250600861751 · Cited by 269 · see citing works

Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters

Takeda, M., Khamdang, S., Narikawa, S., Kimura, H. J., Hosoyamada, M., Ho, S., Sekine, T., & Endou, H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034330 · Cited by 268 · see citing works

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

VanWert, A. L., Gionfriddo, M. R., & Sweet, D. H. (2010) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.693 · Cited by 252 · see citing works

Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

López-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G., Beier, D. R., & Nigám, S. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6471 · Cited by 251 · see citing works

CLINICAL AND PHARMACOKINETIC EVIDENCE OF A LIFE-THREATENING INTERACTION BETWEEN METHOTREXATE AND KETOPROFEN

Thyss, A., Kubar, J., Milano, G. A., Namer, M., & Schneider, M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90786-5 · Cited by 250 · see citing works

Molecular physiology of renal organic anion transporters

Sekine, T., Miyazaki, H., & Endou, H. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00439.2004 · Cited by 245 · see citing works

Homozygous SLC2A9 Mutations Cause Severe Renal Hypouricemia

Dinour, D., Gray, N. K., Campbell, S. E., Shu, X., Sawyer, L., Richardson, W. A., Rechavi, G., Amariglio, N., Ganon, L., Sela, B.-A., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009040406 · Cited by 240 · see citing works

Multiple organic anion transporters contribute to net renal excretion of uric acid

Eraly, S. A., Vallon, V., Rieg, T., Gangoiti, J. A., Wikoff, W. R., Siuzdak, G., Barshop, B. A., & Nigam, S. K. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00207.2007 · Cited by 235 · see citing works

Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3, in Rat Kidney

Kojima, R., Sekine, T., Kawachi, M., Ho, S., Suzuki, Y., & Endou, H. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134848 · Cited by 232 · see citing works

Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice

Eraly, S. A., Vallon, V., Vaughn, D. A., Gangoiti, J. A., Richter, K., Nagle, M. A., Monte, J. C. M., Rieg, T., Truong, D. M., Long, J. M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508050200 · Cited by 230 · see citing works

Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13)

Bahn, A., Hagos, Y., Reuter, S., Balen, D., Brzica, H., Krick, W., Burckhardt, B. C., Sabolić, I., & Burckhardt, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800737200 · Cited by 227 · see citing works

Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules

Ekaratanawong, S., Anzai, N., Jutabha, P., Miyazaki, H., Noshiro, R., Takeda, M., Kanai, Y., Sophasan, S., & Endou, H. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.297 · Cited by 221 · see citing works

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+gradient

Sweet, D. H., Chan, L. M. S., Walden, R., Yang, X.-P., Miller, D. S., & Pritchard, J. B. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00405.2002 · Cited by 220 · see citing works

Molecular cloning and characterization of a novel liver-specific transport protein

Simonson, G. D., Vincent, A. C., Roberg, K. J., Huang, Y., & Iwanij, V. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.4.1065 · Cited by 214 · see citing works

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

Sun, W. Y., Wu, R., van Poelje, P. D., & Erion, M. D. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4774 · Cited by 212 · see citing works

PYRIDOXINE AND SERUM CONCENTRATION OF PHENYTOIN AND PHENOBARBITONE

Hansson, O., & Sillanpää, M. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91385-4 · Cited by 202 · see citing works

Interactions of Human Organic Anion Transporters with Diuretics

Hasannejad, H., Takeda, M., Taki, K., Shin, H. J., Babu, E., Jutabha, P., Khamdang, S., Aleboyeh, M., Onozato, M. L., Tojo, A., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.059139 · Cited by 200 · see citing works

In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy

Burckhardt, G., & Burckhardt, B. C. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-14541-4_2 · Cited by 199 · see citing works

The Multivalent PDZ Domain-containing Protein PDZK1 Regulates Transport Activity of Renal Urate-Anion Exchanger URAT1 via Its C Terminus

Anzai, N., Miyazaki, H., Noshiro, R., Khamdang, S., Chairoungdua, A., Shin, H. J., Enomoto, A., Sakamoto, S., Hirata, T., Tomita, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406724200 · Cited by 193 · see citing works

Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs

Khamdang, S., Takeda, M., Noshiro, R., Narikawa, S., Enomoto, A., Anzai, N., Piyachaturawat, P., & Endou, H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.037580 · Cited by 189 · see citing works

PDZK1: I. A major scaffolder in brush borders of proximal tubular cells11See Editorial by Moe, p. 1916.

Gisler, S. M., Pribanić, S., Bacic, D., Forrer, P., Gantenbein, A., Sabourin, L. A., Tsuji, A., Zhao, Z.-S., Manser, E. J., Biber, J., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00266.x · Cited by 188 · see citing works

Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors

Enomoto, A., Takeda, M., Shimoda, M., Narikawa, S., Kobayashi, Y., Kobayashi, Y., Yamamoto, T., Sekine, T., Ho, S., Niwa, T., et al. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.797 · Cited by 187 · see citing works

Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition

Ljubojević, M., Herak-Kramberger, C. M., Hagos, Y., Bahn, A., Endou, H., Burckhardt, G., & Sabolić, I. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00029.2004 · Cited by 186 · see citing works

Gender-Specific and Developmental Influences on the Expression of Rat Organic Anion Transporters

Buist, S. C. N., Cherrington, N. J., Choudhuri, S., Hartley, D. P., & Klaassen, C. D. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.145 · Cited by 186 · see citing works

Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Transport of Prostaglandins

Kimura, H. J., Takeda, M., Narikawa, S., Enomoto, A., Ichida, K., & Endou, H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.293 · Cited by 182 · see citing works

Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease

Enomoto, A., & Endou, H. (2005) · Clinical and Experimental Nephrology · doi:10.1007/s10157-005-0368-5 · Cited by 181 · see citing works

Renal Transport of Adefovir, Cidofovir, and Tenofovir by SLC22A Family Members (hOAT1, hOAT3, and hOCT2)

Uwai, Y., Ida, H., Tsuji, Y., Katsura, T., & Inui, K. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9196-x · Cited by 179 · see citing works

Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein

Chu, X., Bleasby, K., Yabut, J. A., Cai, X., Chan, G. H., Hafey, M. J., Xu, S. S., Bergman, A. J., Braun, M. P., Dean, D. C., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.116517 · Cited by 179 · see citing works

Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])

Kobayashi, Y., Ohshiro, N., Sakai, R., Ohbayashi, M., Kohyama, N., & Yamamoto, T. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357055966 · Cited by 176 · see citing works

Characterization and identification of steroid sulfate transporters of human placenta

Ugele, B., St–Pierre, M. V., Pihusch, M., Bahn, A., & Hantschmann, P. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2002 · Cited by 174 · see citing works

Rat Organic Anion Transporter 3 (rOAT3) Is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells

Mori, S., Takanaga, H., Ohtsuki, S., Deguchi, T., Kang, Y., Hosoya, K., & Terasaki, T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000050062.57184.75 · Cited by 172 · see citing works

A Species Difference in the Transport Activities of H2 Receptor Antagonists by Rat and Human Renal Organic Anion and Cation Transporters

Tahara, H., Kusuhara, H., Endou, H., Koepsell, H., Imaoka, T., Fuse, E., & Sugiyama, Y. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.088104 · Cited by 171 · see citing works

Molecular pharmacology of renal organic anion transporters

van Aubel, R. A. M. H., Masereeuw, R., & Rüssel, F. G. M. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.2.f216 · Cited by 170 · see citing works

Human Organic Anion Transporter 3 (hOAT3) can Operate as an Exchanger and Mediate Secretory Urate Flux

Bakhiya, A., Bahn, A., Burckhardt, G., & Wolff, N. A. (2003) · Cellular Physiology and Biochemistry · doi:10.1159/000074539 · Cited by 169 · see citing works

Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)

Race, J. E., Grassl, S. M., Williams, W. J., & Holtzman, E. J. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9978 · Cited by 168 · see citing works

Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C

Lu, R., Chan, B. S., & Schuster, V. L. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.276.2.f295 · Cited by 168 · see citing works

Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices

Nozaki, Y., Kusuhara, H., Kondo, T., Iwaki, M., Shiroyanagi, Y., Nakayama, H., Horita, S., Nakazawa, H., Okano, T., & Sugiyama, Y. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121491 · Cited by 158 · see citing works

Function and Localization of Urate Transporter 1 in Mouse Kidney

Hosoyamada, M., Ichida, K., Enomoto, A., Hosoya, T., & Endou, H. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000107560.80107.19 · Cited by 158 · see citing works

The organic anion transporter family: from physiology to ontogeny and the clinic

Sweet, D. H., Bush, K. T., & Nigám, S. K. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.2.f197 · Cited by 155 · see citing works

Human Vascular Smooth Muscle Cells Express a Urate Transporter

Price, K. L., Sautin, Y. Y., Long, D. A., Zhang, L., Miyazaki, H., Mu, W., Endou, H., & Johnson, R. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030264 · Cited by 154 · see citing works

Role of human organic anion transporter 4 in the transport of ochratoxin A

Babu, E., Takeda, M., Narikawa, S., Kobayashi, Y., Enomoto, A., Tojo, A., Ho, S., Sekine, T., Sakthisekaran, D., & Endou, H. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00187-8 · Cited by 149 · see citing works

Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1

Mulato, A. S., Ho, E. S., & Cihlář, T. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38862-7 · Cited by 144 · see citing works

Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor

Yamada, A., Maeda, K., Kamiyama, E., Sugiyama, D., Kondo, T., Shiroyanagi, Y., Nakazawa, H., Okano, T., Adachi, M., Schuetz, J. D., et al. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.017459 · Cited by 143 · see citing works

Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates

Ullrich, K. J. (1997) · The Journal of Membrane Biology · doi:10.1007/s002329900247 · Cited by 142 · see citing works

RAT AND MOUSE DIFFERENCES IN GENDER-PREDOMINANT EXPRESSION OF ORGANIC ANION TRANSPORTER (OAT1–3; SLC22A6–8) mRNA LEVELS

Buist, S. C. N., & Klaassen, C. D. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.6.620 · Cited by 142 · see citing works

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney

Uwai, Y., Okuda, M., Takami, K., Hashimoto, Y., & Inui, K. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01328-3 · Cited by 142 · see citing works

Functional Involvement of Rat Organic Anion Transporter 3 (rOat3;Slc22a8) in the Renal Uptake of Organic Anions

Hasegawa, M., Kusuhara, H., Sugiyama, D., Ito, K., Ueda, S., Endou, H., & Sugiyama, Y. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.746 · Cited by 141 · see citing works

Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population

Graessler, J., Graessler, A., Unger, S., Kopprasch, S., Tausche, A., Kuhlisch, E., & Schroeder, H. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21499 · Cited by 140 · see citing works

Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis

Ahn, S.-Y., & Nigám, S. K. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056564 · Cited by 138 · see citing works

Novel liver‐specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate†

Shin, H. J., Anzai, N., Enomoto, A., He, X., Kim, D. K., Endou, H., & Kanai, Y. (2007) · Hepatology · doi:10.1002/hep.21596 · Cited by 138 · see citing works

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics

Vallon, V., Rieg, T., Ahn, S.-Y., Wu, W., Eraly, S. A., & Nigám, S. K. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00528.2007 · Cited by 133 · see citing works

Physiology, structure, and regulation of the cloned organic anion transporters

Srimaroeng, C., Perry, J. L., & Pritchard, J. B. (2008) · Xenobiotica · doi:10.1080/00498250801927435 · Cited by 132 · see citing works

Role of Glycosylation in the Organic Anion Transporter OAT1

Tanaka, K., Xu, W., Zhou, F., & You, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400197200 · Cited by 128 · see citing works

Rat Multispecific Organic Anion Transporter 1 (rOAT1) Transports Zidovudine, Acyclovir, and Other Antiviral Nucleoside Analogs

Wada, S., Tsuda, M., Sekine, T., Ho, S., Kimura, M., Kanai, Y., & Endou, H. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39144-x · Cited by 128 · see citing works

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

Tin, A., Woodward, O. M., Kao, W. H. L., Liu, C., Lu, X., Nalls, M. A., Shriner, D., Semmo, M., Akylbekova, E. L., Wyatt, S. B., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr307 · Cited by 127 · see citing works

Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP

Cropp, C. D., Komori, T., Shima, J. E., Urban, T. J., Yee, S. W., More, S. S., & Giacomini, K. M. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043117 · Cited by 126 · see citing works

BindingDB Entry 50040211: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1.

BindingDB (2013) · PubMed · doi:10.7270/q2h41sjq · Cited by 126 · see citing works

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney

Youngblood, G. L., & Sweet, D. H. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00012.2004 · Cited by 124 · see citing works

Interaction of human organic anion transporters with various cephalosporin antibiotics

Takeda, M., Babu, E., Narikawa, S., & Endou, H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01306-7 · Cited by 121 · see citing works

Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1

Ueo, H., Motohashi, H., Katsura, T., & Inui, K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.06.024 · Cited by 120 · see citing works

The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4

Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P. J., Ma, J., & You, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.007583 · Cited by 119 · see citing works

Functional Consequences of Single Nucleotide Polymorphisms in the Human Organic Anion Transporter hOAT1 (SLC22A6)

Bleasby, K., Hall, L. A., Perry, J. L., Mohrenweiser, H. W., & Pritchard, J. B. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084301 · Cited by 119 · see citing works

A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese

Iwai, N., Mino, Y., Hosoyamada, M., Tago, N., Kokubo, Y., & Endou, H. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00839.x · Cited by 118 · see citing works

Contribution of Organic Anion Transporter 3 (Slc22a8) to the Elimination of p-Aminohippuric Acid and Benzylpenicillin across the Blood-Brain Barrier

Kikuchi, R., Kusuhara, H., Sugiyama, D., & Sugiyama, Y. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049197 · Cited by 115 · see citing works

Interaction and Transport of Thiazide Diuretics, Loop Diuretics, and Acetazolamide via Rat Renal Organic Anion Transporter rOAT1

Uwai, Y., Saito, H., Hashimoto, Y., & Inui, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38896-2 · Cited by 114 · see citing works

Pharmacokinetics and Pharmacodynamics of Oral Methotrexate and Mercaptopurine in Children With Lower Risk Acute Lymphoblastic Leukemia: A Joint Children’s Cancer Group and Pediatric Oncology Branch Study

Balis, F. M., Holcenberg, J. S., Poplack, D. G., Ge, J., Sather, H. N., Murphy, R. F., Ames, M. M., Waskerwitz, M. J., Tubergen, D. G., Zimm, S., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3569 · Cited by 112 · see citing works

Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters

Takeda, M., Narikawa, S., Hosoyamada, M., Ho, S., Sekine, T., & Endou, H. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00962-1 · Cited by 111 · see citing works

Modulation of Renal Apical Organic Anion Transporter 4 Function by Two PDZ Domain–Containing Proteins

Miyazaki, H., Anzai, N., Ekaratanawong, S., Sakata, T., Shin, H. J., Jutabha, P., Hirata, T., He, X., Nonoguchi, H., Tomita, K., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005030306 · Cited by 111 · see citing works

Organic anion and cation transporters occur in pairs of similar and similarly expressed genes

Eraly, S. A., Hamilton, B. A., & Nigám, S. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02853-x · Cited by 110 · see citing works

Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones

Ljubojević, M., Balen, D., Breljak, D., Kušan, M., Anzai, N., Bahn, A., Burckhardt, G., & Sabolić, I. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00207.2006 · Cited by 110 · see citing works

Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites

Alebouyeh, M. R., Takeda, M., Onozato, M. L., Tojo, A., Noshiro, R., Hasannejad, H., Inatomi, J., Narikawa, S., Huang, X.-L., Khamdang, S., et al. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.430 · Cited by 109 · see citing works

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α

Maher, J. M., Slitt, A. L., Callaghan, T. N., Cheng, X., Cheung, C., Gonzalez, F. J., & Klaassen, C. D. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.016 · Cited by 106 · see citing works

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

VanWert, A. L., Srimaroeng, C., & Sweet, D. H. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.042853 · Cited by 104 · see citing works

Organic Anion Transporter OAT1 Undergoes Constitutive and Protein Kinase C-regulated Trafficking through a Dynamin- and Clathrin-dependent Pathway

Zhang, Q., Hong, M., Duan, P., Pan, Z., Ma, J., & You, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800298200 · Cited by 103 · see citing works

The human organic anion transporter 3 (OAT3;SLC22A8): genetic variation and functional genomics

Erdman, A. R., Mangravite, L. M., Urban, T. J., Lagpacan, L. L., Castro, R. A., de la Cruz, M., Chan, W., Huang, C. C., Johns, S. J., Kawamoto, M., et al. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00272.2005 · Cited by 103 · see citing works

Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter

Iwanaga, T., Sato, M., Maeda, T., Ogihara, T., & Tamai, I. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112755 · Cited by 103 · see citing works

Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat

Hasegawa, M., Kusuhara, H., Endou, H., & Sugiyama, Y. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046847 · Cited by 102 · see citing works

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)

Fujita, T., Brown, C., Carlson, E. J., Taylor, T. R., de la Cruz, M., Johns, S. J., Stryke, D., Kawamoto, M., Fujita, K., Castro, R. A., et al. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01213011-200504000-00003 · Cited by 102 · see citing works

XENOBIOTIC AND ENDOBIOTIC TRANSPORTER MRNA EXPRESSION IN THE BLOOD-TESTIS BARRIER

Augustine, L. M., Markelewicz, R. J., Boekelheide, K., & Cherrington, N. J. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.001024 · Cited by 102 · see citing works

Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa

Monte, J. C. M., Nagle, M. A., Eraly, S. A., & Nigám, S. K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.112 · Cited by 100 · see citing works

Human Organic Anion Transporters Mediate the Transport of Tetracycline

Babu, E., Takeda, M., Narikawa, S., Kobayashi, Y., Yamamoto, T., Ho, S., Sekine, T., Sakthisekaran, D., & Endou, H. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.88.69 · Cited by 100 · see citing works

Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms

van der Harst, P., Bakker, S. J. L., de Boer, R. A., Wolffenbuttel, B. H. R., Johnson, T., Caulfield, M. J., & Navis, G. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp489 · Cited by 99 · see citing works

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

Cheng, X., Buckley, D. B., & Klaassen, C. D. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.014 · Cited by 98 · see citing works

Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation

Kikuchi, R., Kusuhara, H., Hattori, N., Shiota, K., Kim, I., Gonzalez, F. J., & Sugiyama, Y. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025494 · Cited by 95 · see citing works

Methotrexate-Loxoprofen Interaction: Involvement of Human Organic Anion Transporters hOAT1 and hOAT3

Uwai, Y., Taniguchi, R., Motohashi, H., Saito, H., Okuda, M., & Inui, K. (2004) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.19.369 · Cited by 94 · see citing works

Functional Characterization of Rat Organic Anion Transporter 2 in LLC-PK1 Cells

Morita, N., Kusuhara, H., Sekine, T., Endou, H., & Sugiyama, Y. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29490-8 · Cited by 93 · see citing works

Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)] Rapid Communication

Xu, G., Bhatnagar, V., Wen, G., Hamilton, B. A., Eraly, S. A., & Nigám, S. K. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00612.x · Cited by 93 · see citing works

Regulation of mOAT-mediated Organic Anion Transport by Okadaic Acid and Protein Kinase C in LLC-PK1 Cells

You, G., Kuze, K., Kohanski, R. A., Amsler, K., & Henderson, S. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10278 · Cited by 92 · see citing works

Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites

Bahn, A., Ljubojević, M., Lorenz, H., Schultz, C., Ghebremedhin, E., Ugele, B., Sabolić, I., Burckhardt, G., & Hagos, Y. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00619.2004 · Cited by 92 · see citing works

Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers

Sato, M., Iwanaga, T., Mamada, H., Ogihara, T., Yabuuchi, H., Maeda, T., & Tamai, I. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9401-6 · Cited by 91 · see citing works

Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G

VanWert, A. L., Bailey, R. M., & Sweet, D. H. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00319.2007 · Cited by 91 · see citing works

Molecular Insights into the Structure–Function Relationship of Organic Anion Transporters OATs

Zhou, F., & You, G. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9144-9 · Cited by 90 · see citing works

Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors

Takeda, M., Noshiro, R., Onozato, M. L., Tojo, A., Hasannejad, H., Huang, X.-L., Narikawa, S., & Endou, H. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.017 · Cited by 89 · see citing works

Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family

Jacobsson, J. A., Haitina, T., Lindblom, J., & Fredriksson, R. (2007) · Genomics · doi:10.1016/j.ygeno.2007.03.017 · Cited by 89 · see citing works

Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs

Kaler, G. V., Truong, D. M., Khandelwal, A., Nagle, M. A., Eraly, S. A., Swaan, P. W., & Nigám, S. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703467200 · Cited by 89 · see citing works

Isolation, Characterization and Differential Gene Expression of Multispecific Organic Anion Transporter 2 in Mice

Kobayashi, Y., Ohshiro, N., Shibusawa, A., Sasaki, T., Tokuyama, S., Sekine, T., Endou, H., & Yamamoto, T. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.7 · Cited by 89 · see citing works

Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics

Khamdang, S., Takeda, M., Babu, E., Noshiro, R., Onozato, M. L., Tojo, A., Enomoto, A., Huang, X.-L., Narikawa, S., Anzai, N., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01381-5 · Cited by 88 · see citing works

Protein Kinase C Activation Downregulates Human Organic Anion Transporter 1-Mediated Transport through Carrier Internalization

Wolff, N. A., Thies, K. M., Kuhnke, N. G., Reid, G., Friedrich, B., Lang, F. J. W., & Burckhardt, G. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000079040.55124.25 · Cited by 86 · see citing works

Human renal organic anion transporters: Characteristics and contributions to drug and drug metabolite excretion

Robertson, E. E., & Rankin, G. O. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.005 · Cited by 84 · see citing works

The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α and Suppressed by Bile Acids

Popowski, K., Eloranta, J. J., Saborowski, M., Fried, M., Meier, P. J., & Kullak-Ublick, G. A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.010223 · Cited by 84 · see citing works

The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia

Komoda, F., Sekine, T., Inatomi, J., Enomoto, A., Endou, H., Ota, T., Matsuyama, T., Ogata, T., Ikeda, M., Awazu, M., et al. (2004) · Pediatric Nephrology · doi:10.1007/s00467-004-1424-1 · Cited by 83 · see citing works

Organic Anion Transporter 3 Contributes to the Regulation of Blood Pressure

Vallon, V., Eraly, S. A., Wikoff, W. R., Rieg, T., Kaler, G. V., Truong, D. M., Ahn, S.-Y., Mahapatra, N. R., Mahata, S. K., Gangoiti, J. A., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008020180 · Cited by 83 · see citing works

Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal Tubules

Anzai, N., Jutabha, P., Enomoto, A., Yokoyama, H., Nonoguchi, H., Hirata, T., Shiraya, K., He, X., Ho, S., Takeda, M., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.088583 · Cited by 82 · see citing works

Getting the right drug into the right patient

Marshall, A. (1997) · Nature Biotechnology · doi:10.1038/nbt1197-1249 · Cited by 81 · see citing works

The Contribution of Organic Anion Transporters OAT1 and OAT3 to the Renal Uptake of Rosuvastatin

Windass, A. S., Lowes, S., Wang, Y., & Brown, C. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125831 · Cited by 81 · see citing works

Kidney‐specific expression of a novel mouse organic cation transporter‐like protein

Mori, K., Ogawa, Y., Ebihara, K., Aoki, T., Tamura, N., Sugawara, A., Kuwahara, T., Ozaki, S., Mukoyama, M., Tashiro, K., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01325-2 · Cited by 80 · see citing works

The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules

Dantzler, W. H., & Wright, S. H. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.08.015 · Cited by 80 · see citing works

The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?

Eraly, S. A., Bush, K. T., Sampogna, R. V., Bhatnagar, V., & Nigám, S. K. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.479 · Cited by 80 · see citing works

Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates

VanWert, A. L., & Sweet, D. H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9407-0 · Cited by 79 · see citing works

PHYSIOLOGIC SECRETION OF GROWTH HORMONE AND PROLACTIN IN MALE AND FEMALE RATS

Terry, L. C., SAUNDERS, A., AUDET, J., Willoughby, J. O., Brazeau, P., & Martin, J. B. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb03335.x · Cited by 79 · see citing works

Mouse Reduced in Osteosclerosis Transporter Functions as an Organic Anion Transporter 3 and Is Localized at Abluminal Membrane of Blood-Brain Barrier

Ohtsuki, S., Kikkawa, T., Mori, S., Hori, S., Takanaga, H., Otagiri, M., & Terasaki, T. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.063370 · Cited by 78 · see citing works

A Novel Putative Transporter Maps to the Osteosclerosis (oc) Mutation and Is Not Expressed in theocMutant Mouse

Brady, K. P., Dushkin, H., Förnzler, D., Koike, T., Magner, F., Her, H., Gullans, S. R., Segre, G. V., Green, R. M., & Beier, D. R. (1999) · Genomics · doi:10.1006/geno.1998.5722 · Cited by 78 · see citing works

Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney

Tahara, H., Shono, M., Kusuhara, H., Kinoshita, H., Fuse, E., Takadate, A., Otagiri, M., & Sugiyama, Y. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-2503-0 · Cited by 77 · see citing works

Mutational analysis of idiopathic renal hypouricemia in Korea

Cheong, H. I., Kang, J. H., Lee, J. H., Ha, I. S., Kim, S., Komoda, F., Sekine, T., Igarashi, T., & Choi, Y. (2005) · Pediatric Nephrology · doi:10.1007/s00467-005-1863-3 · Cited by 77 · see citing works

Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins

Kato, Y., Yoshida, K., Watanabe, C., Sai, Y., & Tsuji, A. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000045244.83999.43 · Cited by 77 · see citing works

Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier

Nozaki, Y., Kusuhara, H., Endou, H., & Sugiyama, Y. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.061812 · Cited by 76 · see citing works

The molecular biology of renal organic anion and organic cation transporters

Sweet, D. H., & Pritchard, J. B. (1999) · Cell Biochemistry and Biophysics · doi:10.1007/bf02738157 · Cited by 75 · see citing works

Heterologous Expression and Functional Characterization of a Mouse Renal Organic Anion Transporter in Mammalian Cells

Kuze, K., Graves, P., Leahy, A., Wilson, P. D., Stuhlmann, H., & You, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1519 · Cited by 74 · see citing works

Transcriptional Regulation of Human and Mouse Organic Anion Transporter 1 by Hepatocyte Nuclear Factor 1 α/β

Saji, T., Kikuchi, R., Kusuhara, H., Kim, I., Gonzalez, F. J., & Sugiyama, Y. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.128249 · Cited by 73 · see citing works

Orotic Acid Excretion and Arginine Metabolism

Brosnan, M. E., & Brosnan, J. T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1656s · Cited by 72 · see citing works

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Khamdang, S., Takeda, M., Shimoda, M., Noshiro, R., Narikawa, S., Huang, X.-L., Enomoto, A., Piyachaturawat, P., & Endou, H. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.197 · Cited by 71 · see citing works

OAT2 catalyses efflux of glutamate and uptake of orotic acid

Fork, C., Bauer, T., Gölz, S., Geerts, A., Weiland, J., Turco, D. D., Schömig, E., & Gründemann, D. (2011) · Biochemical Journal · doi:10.1042/bj20101904 · Cited by 69 · see citing works

Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation

Kikuchi, R., Kusuhara, H., Hattori, N., Kim, I., Shiota, K., Gonzalez, F. J., & Sugiyama, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.039701 · Cited by 68 · see citing works

Endocrine Regulation of Rat Organic Anion Transporters

Buist, S. C. N., Cherrington, N. J., & Klaassen, C. D. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.5.559 · Cited by 68 · see citing works

Hepatocyte nuclear factor-4α regulates the human organic anion transporter 1 gene in the kidney

Ogasawara, K., Terada, T., Asaka, J., Katsura, T., & Inui, K. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00017.2007 · Cited by 65 · see citing works

Raltegravir Is a Substrate for SLC22A6: a Putative Mechanism for the Interaction between Raltegravir and Tenofovir

Moss, D. M., Kwan, W. S., Liptrott, N. J., Smith, D., Siccardi, M., Khoo, S., Back, D. J., & Owen, A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00623-10 · Cited by 62 · see citing works

Renal handling of Organic Anions and Cations : Excretion of Uric Acid

Da, S. (2000) · Medical Entomology and Zoology · Cited by 62 · see citing works

Regulation by protein kinase C of organic anion transport driven by rat organic anion transporter 3 (rOAT3)

Takeda, M., Sekine, T., & Endou, H. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00694-9 · Cited by 61 · see citing works

Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters

Vormfelde, S. V., Schirmer, M., Hagos, Y., Toliat, M. R., Engelhardt, S., Meineke, I., Burckhardt, G., Nürnberg, P., & Brockmöller, J. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02655.x · Cited by 61 · see citing works

Cephalosporin-Probenecid Drug Interactions

Brown, G. R. (1993) · Clinical Pharmacokinetics · doi:10.2165/00003088-199324040-00003 · Cited by 60 · see citing works

Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue ofPept2−/−mice

Frey, I. M., Rubio‐Aliaga, I., Siewert, A., Sailer, D., Drobyshev, A., Beckers, J., de Angelis, M. H., Aubert, J., Bar‐Hen, A., Fiehn, O., et al. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00193.2006 · Cited by 60 · see citing works

The Interaction and Transport of β-Lactam Antibiotics with the Cloned Rat Renal Organic Anion Transporter 1

Jariyawat, S., Sekine, T., Takeda, M., Apiwattanakul, N., Kanai, Y., Sophasan, S., & Endou, H. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34949-3 · Cited by 60 · see citing works

The Renal-Specific Transporter Mediates Facilitative Transport of Organic Anions at the Brush Border Membrane of Mouse Renal Tubules

Imaoka, T., Kusuhara, H., Adachi‐Akahane, S., Hasegawa, M., Morita, N., Endou, H., & Sugiyama, Y. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000135049.20420.e5 · Cited by 58 · see citing works

Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule

Zhang, X., Groves, C. E., Bahn, A., Barendt, W. M., Prado, M. D., Rödiger, M., Chatsudthipong, V., Burckhardt, G., & Wright, S. H. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00156.2004 · Cited by 56 · see citing works

Sex Differences in the mRNA, Protein, and Functional Expression of Organic Anion Transporter (Oat) 1, Oat3, and Organic Cation Transporter (Oct) 2 in Rabbit Renal Proximal Tubules

Groves, C. E., Suhre, W. B., Cherrington, N. J., & Wright, S. H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.094979 · Cited by 56 · see citing works

Genomic Structure and in Vivo Expression of the Human Organic Anion Transporter 1 (hOAT1) Gene

Bahn, A., Prawitt, D., Buttler, D., Reid, G., Enklaar, T., Wolff, N. A., Ebbinghaus, C., Hillemann, A., Schulten, H.-J., Gunawan, B., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3230 · Cited by 55 · see citing works

Mutations in Human Urate Transporter 1 Gene in Presecretory Reabsorption Defect Type of Familial Renal Hypouricemia

Wakida, N., Tuyển, Đ. G., Adachi, M., Miyoshi, T., Nonoguchi, H., Oka, T., Ueda, O., Tazawa, M., Kurihara, S., Yoneta, Y., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1111 · Cited by 54 · see citing works

The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker

Defoor, E., Kryger, M.-B., & Martinussen, J. (2007) · Microbiology · doi:10.1099/mic.0.2007/005959-0 · Cited by 53 · see citing works

Functional genomics of membrane transporters in human populationsPreprint

Urban, T. J., Sebro, R., Hurowitz, E. H., Leabman, M. K., Badagnani, I., Lagpacan, L. L., RISCH, N. J., & Giacomini, K. M. (2005) · Genome Research · doi:10.1101/gr.4356206 · Cited by 53 · see citing works

Prostaglandin E2 Inhibits Its Own Renal Transport by Downregulation of Organic Anion Transporters rOAT1 and rOAT3

Sauvant, C., Holzinger, H., & Gekle, M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005070727 · Cited by 52 · see citing works

Activation of Protein Kinase Cζ Increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated Transport

Barros, S. A., Srimaroeng, C., Perry, J. L., Walden, R., Dembla-Rajpal, N., Sweet, D. H., & Pritchard, J. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808078200 · Cited by 50 · see citing works

Interaction of the Metal Chelator 2,3-Dimercapto-1-propanesulfonate with the Rabbit Multispecific Organic Anion Transporter 1 (rbOAT1)

Bahn, A., Knabe, M., Hagos, Y., Rödiger, M., GODEHARDT, S., Graber-Neufeld, D. S., Evans, K. K., Burckhardt, G., & Wright, S. H. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.1128 · Cited by 50 · see citing works

Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells

Asif, A. R., Steffgen, J., Metten, M., Grunewald, R. W., Muller, G. A., Bahn, A., Burckhardt, G., & Hagos, Y. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1373-3 · Cited by 49 · see citing works

Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)

Motohashi, H., Uwai, Y., Hiramoto, K., Okuda, M., & Inui, K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.09.032 · Cited by 46 · see citing works

Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)

Bhatnagar, V., Xu, G., Hamilton, B. A., Truong, D. M., Eraly, S. A., Wu, W., & Nigám, S. K. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0398-1 · Cited by 45 · see citing works

In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver.

Tsuji, A., Terasaki, T., Tamai, I., & Takeda, K. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12462-2 · Cited by 45 · see citing works

RENAL TRANSPORT OF ORGANIC COMPOUNDS MEDIATED BY MOUSE ORGANIC ANION TRANSPORTER 3 (MOAT3): FURTHER SUBSTRATE SPECIFICITY OF MOAT3

Kobayashi, Y., Ohshiro, N., Tsuchiya, A., Kohyama, N., Ohbayashi, M., & Yamamoto, T. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.5.479 · Cited by 44 · see citing works

Structure–affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites

Sugawara, M., Mochizuki, T., Takekuma, Y., & Miyazaki, K. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.06.006 · Cited by 43 · see citing works

Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis

Chen, J., Terada, T., Ogasawara, K., Katsura, T., & Inui, K. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00139.2008 · Cited by 43 · see citing works

Novel aspects of renal organic anion transporters

Eraly, S. A., Blantz, R. C., Bhatnagar, V., & Nigám, S. K. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200309000-00011 · Cited by 40 · see citing works

Comparison of the Interaction of Human Organic Anion Transporter hOAT4 with PDZ Proteins between Kidney Cells and Placental Cells

Zhou, F., Xu, W., Tanaka, K., & You, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9359-4 · Cited by 38 · see citing works

Torasemide Transport by Organic Anion Transporters Contributes to Hyperuricemia

Hagos, Y., Bahn, A., Vormfelde, S. V., Diaeresis]ller, J. D. B., & Burckhardt, G. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010106 · Cited by 38 · see citing works

Renal Organic Anion Transporter-Mediated Drug-Drug Interaction between Gemcabene and Quinapril

Yuan, H., Feng, B., Yu, Y., Chupka, J., Zheng, J. Y., Heath, T. G., & Bond, B. R. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149476 · Cited by 37 · see citing works

Short-Term Regulation of Basolateral Organic Anion Uptake in Proximal Tubular Opossum Kidney Cells

Sauvant, C., Holzinger, H., & Gekle, M. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000099376.87890.71 · Cited by 36 · see citing works

The Role of Glycine Residues in the Function of Human Organic Anion Transporter 4

Zhou, F., Tanaka, K., Pan, Z., Ma, J., & You, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1141 · Cited by 36 · see citing works

Establishment and Analysis ofSLC22A12(URAT1) Knockout Mouse

Hosoyamada, M., Takiue, Y., Morisaki, H., Cheng, J., Ikawa, M., Okabe, M., Morisaki, T., Ichida, K., Hosoya, T., & Shibasaki, T. (2010) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257771003738634 · Cited by 35 · see citing works

Short-Term Regulation of Basolateral Organic Anion Uptake in Proximal Tubular OK cells

Sauvant, C., Holzinger, H., & Gekle, M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000024437.62046.af · Cited by 35 · see citing works

Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine

Gekle, M., Mildenberger, S., Sauvant, C., Bednarczyk, D., Wright, S. H., & Dantzler, W. H. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.2.f251 · Cited by 35 · see citing works

Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters

Nishiwaki, T., Daigo, Y., Tamari, M., Fujii, Y., & Nakamura, Y. (1998) · Cytogenetic and Genome Research · doi:10.1159/000015197 · Cited by 34 · see citing works

In Vitro and In Vivo Assessment of Renal Drug Transporters in the Disposition of Mesna and Dimesna

Cutler, M. J., Urquhart, B. L., Velenosi, T. J., zu Schwabedissen, H. E. M., Dresser, G. K., Leake, B. F., Tirona, R. G., Kim, R. B., & Freeman, D. J. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011400414 · Cited by 33 · see citing works

Cloning of the pig renal organic anion transporter 1 (pOAT1)

Hagos, Y. (2002) · Biochimie · doi:10.1016/s0300-9084(02)00022-6 · Cited by 33 · see citing works

Molecular Cloning and Functional Characterization of a Polyspecific Organic Anion Transporter from Caenorhabditis elegans

George, R. L., Wu, X., Huang, W. Y., Fei, Y.-J., Leibach, F. H., & Ganapathy, V. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35144-4 · Cited by 32 · see citing works

Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects

König, J., Müller, F., & Fromm, M. F. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007518 · Cited by 576 · see citing works

What do drug transporters really do?

Nigám, S. K. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4461 · Cited by 531 · see citing works

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

Nigám, S. K., Bush, K. T., Martovetsky, G., Ahn, S.-Y., Liu, H. C., Richard, E., Bhatnagar, V., & Wu, W. (2014) · Physiological Reviews · doi:10.1152/physrev.00025.2013 · Cited by 505 · see citing works

Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models

Ng, C. A., & Hungerbühler, K. (2014) · Environmental Science & Technology · doi:10.1021/es404008g · Cited by 393 · see citing works

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Bhowmik, A., Khan, R., & Ghosh, M. K. (2015) · BioMed Research International · doi:10.1155/2015/320941 · Cited by 293 · see citing works

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease

Nigám, S. K. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052713 · Cited by 263 · see citing works

Solute carrier transporters: the metabolic gatekeepers of immune cells

Song, W., Li, D., Tao, L., Luo, Q., & Chen, L. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.006 · Cited by 256 · see citing works

Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women

Franconi, F., & Campesi, I. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12362 · Cited by 250 · see citing works

Bioconcentration of perfluorinated alkyl acids: How important is specific binding?

Ng, C. A., & Hungerbühler, K. (2013) · Environmental Science & Technology · doi:10.1021/es400981a · Cited by 241 · see citing works

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

Sanchez‐Covarrubias, L., Slosky, L. M., Thompson, B. J., Davis, T. P., & Ronaldson, P. T. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990463 · Cited by 232 · see citing works

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

Wu, W., Bush, K. T., & Nigám, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-04949-2 · Cited by 219 · see citing works

Intracrine androgen biosynthesis, metabolism and action revisited

Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works

Glucuronidation: driving factors and their impact on glucuronide disposition

Yang, G., Ge, S., Singh, R., Basu, S., Shatzer, K., Zen, M., Liu, J., Tu, Y., Zhang, C., Wei, J., et al. (2017) · Drug Metabolism Reviews · doi:10.1080/03602532.2017.1293682 · Cited by 216 · see citing works

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Kell, D. B., & Oliver, S. G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00231 · Cited by 155 · see citing works

Clinical Aspects of Transporter‐Mediated Drug–Drug Interactions

Gessner, A., König, J., & Fromm, M. F. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1360 · Cited by 136 · see citing works

Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism

Peterson, B., Weyers, M., Steenekamp, J. H., Steyn, D., Gouws, C., & Hamman, J. H. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11010033 · Cited by 114 · see citing works

A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state

Fremder, M., Kim, S. W., Khamaysi, A., Shimshilashvili, L., Eini-Rider, H., Park, I. S., Hadad, U., Cheon, J. H., & Ohana, E. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109521 · Cited by 111 · see citing works

Rethinking succinate: an unexpected hormone-like metabolite in energy homeostasis

Fernández‐Veledo, S., Ceperuelo‐Mallafré, V., & Vendrell, J. J. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.06.003 · Cited by 106 · see citing works

Eicosanoids in Metabolic Syndrome

Hardwick, J. P., Eckman, K., Lee, Y., Abdelmegeed, M. A., Esterle, A. R., Chilian, W. M., Chiang, J. Y. L., & Song, B. (2013) · Advances in pharmacology · doi:10.1016/b978-0-12-404717-4.00005-6 · Cited by 91 · see citing works

Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs

Zhu, C., Nigam, K. B., Date, R. C., Bush, K. T., Springer, S. A., Saier, M. H., Wu, W., & Nigám, S. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140569 · Cited by 84 · see citing works

Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination

Zhang, J., Wang, H., Fan, Y., Yu, Z., & You, G. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107647 · Cited by 78 · see citing works

Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

Tsuruya, Y., Kato, K., Sano, Y., Imamura, Y., Maeda, K., Kumagai, Y., Sugiyama, Y., & Kusuhara, H. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.071472 · Cited by 77 · see citing works

Organic Anion Transporter 2: An Enigmatic Human Solute Carrier

Shen, H., Lai, Y., & Rodrigues, A. D. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.072264 · Cited by 77 · see citing works

Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach

Liu, H. C., Goldenberg, A., Chen, Y., Lun, C., Wu, W., Bush, K. T., Balac, N., Rodriguez, P. F., Abagyan, R. A., & Nigám, S. K. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.232660 · Cited by 74 · see citing works

Steroids and the Blood–Brain Barrier

WITT, K. A., & Sandoval, K. E. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.018 · Cited by 73 · see citing works

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics

Mooij, M. G., Nies, A. T., Knibbe, C. A. J., Schaeffeler, E., Tibboel, D., Schwab, M. G., & de Wildt, S. N. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0328-5 · Cited by 72 · see citing works

Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance

Miners, J. O., Polasek, T. M., Hulin, J.-A., Rowland, A., & Meech, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108459 · Cited by 68 · see citing works

P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate

Jia, Y., Liu, Z., Wang, C., Meng, Q., Huo, X., Liu, Q., Sun, H., Sun, P., Yang, X., Ma, X., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.06.030 · Cited by 67 · see citing works

Across the pulmonary epithelial barrier: Integration of physicochemical properties and human cell models to study pulmonary drug formulations

Haghi, M., Ong, H. X., Traini, D., & Young, P. M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.003 · Cited by 65 · see citing works

Renal organic anion transporters in drug–drug interactions and diseases

Huo, X., & Liu, K. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.11.001 · Cited by 64 · see citing works

Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan

Qin, X.-D., Qian, Z. M., Vaughn, M. G., Huang, J., Ward, P., Zeng, X., Zhou, Y., Zhu, Y., Yuan, P., Li, M., et al. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.02.050 · Cited by 57 · see citing works

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning

Nigam, A. K., Li, J. G., Lall, K., Shi, D., Bush, K. T., Bhatnagar, V., Abagyan, R. A., & Nigám, S. K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010729 · Cited by 56 · see citing works

Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis

Khamaysi, A., Anbtawee-Jomaa, S., Fremder, M., Eini-Rider, H., Shimshilashvili, L., Aharon, S., Aizenshtein, E., Shlomi, T., Noguchi, A. C., Springer, D., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018030277 · Cited by 51 · see citing works

Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1

Parker, J. L., Kato, T., Kuteyi, G., Sitsel, O., & Newstead, S. L. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01039-y · Cited by 50 · see citing works

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network

Liu, H. C., Jamshidi, N., Chen, Y., Eraly, S. A., Cho, S. Y., Bhatnagar, V., Wu, W., Bush, K. T., Abagyan, R. A., Palsson, B. Ø., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.745216 · Cited by 50 · see citing works

Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms

Hagenbuch, B., Stieger, B., & Locher, K. P. (2024) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100023 · Cited by 50 · see citing works

Efflux proteins at the blood–brain barrier: review and bioinformatics analysis

Saidijam, M., Dermani, F. K., Sohrabi, S., & Patching, S. G. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1328148 · Cited by 45 · see citing works

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3

Granados, J. C., Richelle, A., Gutierrez, J. M., Zhang, P., Zhang, X., Bhatnagar, V., Lewis, N. E., & Nigám, S. K. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100575 · Cited by 43 · see citing works

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research

Fisel, P., Renner, O., Nies, A. T., Schwab, M. G., & Schaeffeler, E. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.876990 · Cited by 43 · see citing works

The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance

Caetano-Pinto, P., Jansen, J., Assaraf, Y. G., & Masereeuw, R. (2017) · Drug Resistance Updates · doi:10.1016/j.drup.2017.01.002 · Cited by 40 · see citing works

Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

Fu, Y., Breljak, D., Ōnishi, A., Batz, F., Patel, R., Huang, W., Song, P., Freeman, B., Mayoux, E., Koepsell, H., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00503.2017 · Cited by 40 · see citing works

Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a Science Park in Taiwan

Lin, T.-W., Chen, M., Lin, C., Chen, M., Tsai, M., Chan, D., Hung, K., & Chen, P. (2020) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2020.113607 · Cited by 40 · see citing works

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors

Riedmaier, A. E., Burk, O., van Eijck, B. A. C., Schaeffeler, E., Klein, K., Fehr, S., Biskup, S., Müller, S., Winter, S., Zanger, U. M., et al. (2015) · The Pharmacogenomics Journal · doi:10.1038/tpj.2015.55 · Cited by 40 · see citing works

Effect of Gemfibrozil, Rifampicin, or Probenecid on the Pharmacokinetics of the SGLT2 Inhibitor Empagliflozin in Healthy Volunteers

Macha, S., Koenen, R., Sennewald, R., Schöne, K., Hummel, N., Riedmaier, S., Woerle, H. J., Salsali, A., & Broedl, U. C. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.01.003 · Cited by 39 · see citing works

Succinate in innate immunity: linking metabolic reprogramming to immune modulation

Atallah, R., Gindlhuber, J., & Heinemann, Á. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1661948 · Cited by 41 · see citing works

Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: understanding and improving key determinants of pharmacological properties

Kinzel, O., Steeneck, C., Schlüter, T., Schulz, A., Gege, C., Hahn, U., Hambruch, E., Hornberger, M., Spalwisz, A., Frick, K., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.070 · Cited by 35 · see citing works

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism

Hull, J., Moraes, M. U., Brookes, E., Love, S., & Conway, M. E. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.10.014 · Cited by 29 · see citing works

Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria

Ranganath, L. R., Milan, A. M., Hughes, A. T., Khedr, M., Davison, A. S., Shweihdi, E., Norman, B. P., Hughes, J. H., Bygott, H., Luangrath, E., et al. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12181 · Cited by 29 · see citing works

The Importance of Tubular Function in Chronic Kidney Disease

Risso, M., Sallustio, S., Sueiro, V., Bertoni, V., González-Torres, H. J., & Musso, C. G. (2019) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s216673 · Cited by 29 · see citing works

Quantitative determination of five metabolites of aspirin by UHPLC–MS/MS coupled with enzymatic reaction and its application to evaluate the effects of aspirin dosage on the metabolic profile

Li, J., Guo, J., Shang, E., Zhu, Z., Liu, Y., Zhao, B., Zhao, J., Tang, Z., & Duan, J. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.12.038 · Cited by 29 · see citing works

Kidney Drug Transporters in Pharmacotherapy

Łapczuk-Romańska, J., Droździk, M., Oswald, S., & Droździk, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032856 · Cited by 29 · see citing works

Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism

Li, X., Zeng, Z.-X., Cheng, Z., Wang, Y.-L., Yuan, L.-J., Zhai, Z.-Y., & Gong, W. J. (2023) · Amino Acids · doi:10.1007/s00726-023-03334-w · Cited by 28 · see citing works

Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study

Zheng, X., Pan, Y., Qu, Y., Ji, S., Wang, J., Li, Z., Zhao, F., Wu, B., Xie, L., Li, Y., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c11095 · Cited by 29 · see citing works

Transporter effects on cell permeability in drug delivery

Mandal, A., Agrahari, V., Khurana, V., Pal, D., & Mitra, A. K. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1214565 · Cited by 25 · see citing works

Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

Nigam, A. K., Ojha, A. A., Li, J. G., Shi, D., Bhatnagar, V., Nigam, K. B., Abagyan, R. A., & Nigám, S. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101720 · Cited by 23 · see citing works

The transporter-mediated cellular uptake of pharmaceutical drugs is based on their metabolite-likeness and not on their bulk biophysical properties: Towards a systems pharmacology

Kell, D. B. (2015) · Perspectives in Science · doi:10.1016/j.pisc.2015.06.004 · Cited by 21 · see citing works

Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors

Wu, W., Bush, K. T., Liu, H. C., Zhu, C., Abagyan, R. A., & Nigám, S. K. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065250 · Cited by 21 · see citing works

Gender Differences in Pharmacokinetics: A Perspective on Contrast Agents

Courchesne, M., Manrique, G., Bernier, L., Moussa, L., Cresson, J., Gutzeit, A., Froehlich, J. M., Koh, D., Chartrand‐Lefebvre, C., & Matoori, S. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00116 · Cited by 20 · see citing works

The interactions of lenalidomide with human uptake and efflux transporters and UDP-glucuronosyltransferase 1A1: lack of potential for drug–drug interactions

Tong, Z., Yerramilli, U., Surapaneni, S., & Kumar, G. N. (2014) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-014-2415-y · Cited by 18 · see citing works

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy

Wang, Y., Moussian, B., Schaeffeler, E., Schwab, M. G., & Nies, A. T. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.06.002 · Cited by 18 · see citing works

Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins

Kong, F., Pang, X., Zhong, K., Guo, Z., Li, X., Zhong, D., & Chen, X. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.074492 · Cited by 17 · see citing works

Associations between serum perfluoroalkyl acid (PFAA) concentrations and health related biomarkers in firefighters

Nilsson, S., Smurthwaite, K. S., Aylward, L. L., Kay, M. P., Toms, L.-M. L., King, L., Marrington, S., Kirk, M., Mueller, J. F., & Bräunig, J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114370 · Cited by 17 · see citing works

Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation

Momper, J. D., Yang, J. Y., Gockenbach, M., Vaida, F., & Nigám, S. K. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10350818 · Cited by 17 · see citing works

Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin

Li, S., Xu, B., Fan, S., Kang, B., Deng, L., Chen, D., Yang, B., Tang, F., He, Z., Xue, Y., et al. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2118714 · Cited by 16 · see citing works

Identification of histamine receptor subtypes in skeletal myogenesis

Chen, Y., Stegaev, V., Kouri, V., Sillat, T., Chazot, P. L., Stark, H., Wen, J., & Konttinen, Y. T. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3073 · Cited by 15 · see citing works

Sunitinib Possible Sex-Divergent Therapeutic Outcomes

Segarra, I., Modamio, P., Fernández, C., & Mariño, E. L. (2016) · Clinical Drug Investigation · doi:10.1007/s40261-016-0428-5 · Cited by 15 · see citing works

Organic anion transporters 1 (OAT1) and OAT3 meditated the protective effect of rhein on methotrexate-induced nephrotoxicity

Liu, Z., Jia, Y., Wang, C., Meng, Q., Huo, X., Sun, H., Sun, P., Yang, X., Ma, X., Peng, J., et al. (2017) · RSC Advances · doi:10.1039/c7ra02968c · Cited by 14 · see citing works

Association between exposure to perfluoroalkyl substances and uric acid in Chinese adults

Yang, Z., Men, K., Guo, J., Liu, R., Liu, H., Wei, J., Zhang, J., Liu, L., Lin, X., Zhang, M., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137164 · Cited by 15 · see citing works

Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma

Ekizoğlu, S., Seven, D., Ulutin, T., Guliyev, J., & Buyru, N. (2018) · BMC Cancer · doi:10.1186/s12885-018-4381-y · Cited by 14 · see citing works

Complex roles for sulfation in the toxicities of polychlorinated biphenyls

Duffel, M. W., & Lehmler, H. (2024) · Critical Reviews in Toxicology · doi:10.1080/10408444.2024.2311270 · Cited by 13 · see citing works

How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer

Stock, C. M. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_41 · Cited by 13 · see citing works

Renal Transporter Alterations in Patients with Chronic Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination

Frost, K. L., Jilek, J. L., Sinari, S. A., Klein, R. R., Billheimer, D. D., Wright, S. H., & Cherrington, N. J. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001038 · Cited by 13 · see citing works

Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model

Gou, X., Ran, F., Yang, J., Ma, Y., & Wu, X. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112307 · Cited by 12 · see citing works

Cytosolic sulfotransferases in endocrine disruption

Duffel, M. W. (2024) · Essays in Biochemistry · doi:10.1042/ebc20230101 · Cited by 12 · see citing works

Nephroprotector activity of hydro alcoholic extract of Tinospora cordifolia roots on cisplatin induced nephrotoxicity in rats

Spandana, U., Ali, S. L., Nirmala, T., Shanthi, M., Sipay, B., & Uppuluri, K. B. (2013) · Drug Invention Today · doi:10.1016/j.dit.2013.09.001 · Cited by 12 · see citing works

Allgemeine Pharmakologie und Toxikologie

(2013) · Elsevier eBooks · doi:10.1016/b978-3-437-42523-3.00001-4 · Cited by 11 · see citing works

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

Janaszkiewicz, A., Tóth, Á., Faucher, Q., Arnion, H., Védrenne, N., Guellec, C. B., Marquet, P., & Meo, F. D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114342 · Cited by 10 · see citing works

Identification of gene co-expression clusters in liver tissues from multiple porcine populations with high and low backfat androstenone phenotype

Sahadevan, S., Tholen, E., Große‐Brinkhaus, C., Schellander, K., Tesfaye, D., Hofmann‐Apitius, M., Çınar, M. U., Gunawan, A., Hoelker, M., & Neuhoff, C. (2015) · BMC Genetics · doi:10.1186/s12863-014-0158-8 · Cited by 9 · see citing works

D‐Malate decreases renal content of α‐ketoglutarate, a driving force of organic anion transporters OAT1 and OAT3, resulting in inhibited tubular secretion of phenolsulfonphthalein, in rats

Uwai, Y., Kawasaki, T., & Nabekura, T. (2017) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2089 · Cited by 8 · see citing works

C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice

Kume, M., Ahmad, A., Shiers, S. I., Burton, M. D., DeFea, K., Vágner, J., Dussor, G. O., Boitano, S. A., & Price, T. J. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.11.006 · Cited by 8 · see citing works

Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation

Nies, A. T., König, J., Leuthold, P., Damme, K., Winter, S., Haag, M., Masuda, S., Kruck, S., Daniel, H., Spanier, B., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106941 · Cited by 8 · see citing works

Sunitinib-paracetamol sex-divergent pharmacokinetics and tissue distribution drug-drug interaction in mice

Liew, M. H., Ng, S., Chew, C. C., Koo, T. W., Chee, Y. L., Chee, E. L.-C., Modamio, P., Fernández, C., Mariño, E. L., & Segarra, I. (2017) · Investigational New Drugs · doi:10.1007/s10637-016-0415-y · Cited by 8 · see citing works

Glaucomics: A Call for Systems Diagnostics for 21 st Century Ophthalmology and Personalized Visual Health

Güngör, K., Hotez, P. J., Özdemir, V., & Aynacıoğlu, Ş. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2014.0040 · Cited by 8 · see citing works

Transporters involved in renal excretion ofN-carbamoylglutamate, an orphan drug to treat inbornn-acetylglutamate synthase deficiency

Schwob, E., Hagos, Y., Burckhardt, G., & Burckhardt, B. C. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00482.2014 · Cited by 6 · see citing works

Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers

Hamada, Y., Ikemura, K., Iwamoto, T., & Okuda, M. (2018) · Pharmacology · doi:10.1159/000485920 · Cited by 6 · see citing works

Structures and membrane interactions of human OAT1 in complex with clinical used drugs

Wu, X., Luo, Y., Feng, S., Ma, H., Ke, B., Wang, K., Su, Z., & Yang, D. (2025) · Science Advances · doi:10.1126/sciadv.ads5405 · Cited by 5 · see citing works

A comprehensive analysis of adverse drug reactions in 2020–2023: case studies

Zhai, J., Yan, H., Zhang, J., Yan, H., Ma, J., & Zhang, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1628347 · Cited by 5 · see citing works

Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors

Kerhoas, M., Vée, M. L., Carteret, J., Jouan, E., Tastet, V., Bruyère, A., Laurence Therese, H. U. C., & Fardel, O. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142122 · Cited by 5 · see citing works

Biflavonoids from Juniperus oblonga inhibit organic anion transporter 3

Qiao, Y., Liu, X., Li, X., Wang, X., Li, C., Khutsishvili, M., Alizade, V. М., Atha, D. E., Zhang, Y., & Borris, R. P. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.039 · Cited by 5 · see citing works

Organic Anion Transporters

Bush, K. T., Nagle, M. A., Truong, D. M., Bhatnagar, V., Kaler, G. V., Eraly, S. A., Wu, W., & Nigám, S. K. (2014) · doi:10.1002/9781118705308.ch3 · Cited by 5 · see citing works

Solubility, Permeability, and Their Interplay

Beig, A., Marković, M., & Dahan, A. (2018) · Methods and principles in medicinal chemistry · doi:10.1002/9783527801756.ch8 · Cited by 5 · see citing works

Hypertensive Nephropathy Changes the Expression of Drug-Metabolizing Enzymes and Transporters in Spontaneously Hypertensive Rat Liver and Kidney

Pan, Y., Yang, Z. Z., Wei, M., Gan, Y., Liu, M., & Zou, W. (2024) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-024-00923-2 · Cited by 4 · see citing works

Role of solute carrier transporters in the biodistribution and toxicity of chemotherapeutic drugs

Boeckman, M., Drabison, T., Germakovski, A., Warmuth, A., Ahmed, B., Chowdhury, A. T., Hu, S., Sprowl, J. A., Sparreboom, A., & Huang, K. M. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100117 · Cited by 4 · see citing works

The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans

Nies, A. T., Weiß, S., Schaeffeler, E., Hannemann, A., Völker, U., Wallaschofski, H., & Schwab, M. G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00532 · Cited by 4 · see citing works

The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3

Schulz, K., Hagos, Y., Burckhardt, G., Schley, G., Burzlaff, N. I., Willam, C., & Burckhardt, B. C. (2015) · The Nephron journals/Nephron journals · doi:10.1159/000442531 · Cited by 4 · see citing works

Elevated Maternal Testosterone Levels Alter PFOA Elimination and Tissue Distribution in Pregnant Rats

Yadav, P., Mishra, J. S., & Kumar, S. (2023) · Journal of Environmental Science and Public Health · doi:10.26502/jesph.96120193 · Cited by 3 · see citing works

Sulfotransferases

Duffel, M. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00005-x · Cited by 3 · see citing works

Factors influencing the bioactivity of natural matrices: The case of osmolarity-dependent modulation of cell viability by different dilutions of camel urines

Pastrana, C. I., Sgobba, M. N., González, F. J. N., Bermejo, J. V. D., Pierri, C. L., Lentini, G., Musio, B., Osman, T. K., Gallo, V., Duarte, I. F., et al. (2024) · Research in Veterinary Science · doi:10.1016/j.rvsc.2024.105419 · Cited by 3 · see citing works

Estimation of Proximal Tubular Function by Stimulation of Organic Anion and Cation Transporters

Madero, M., Yepez, A. K. F., Reséndiz‐Albor, A. A., Rivera‐Chávez, J., Seegmiller, J. C., & Rodríguez‐Iturbe, B. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000686 · Cited by 3 · see citing works

Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2

He, X., Garza, D., Nigám, S. K., & Chang, G. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152969 · Cited by 3 · see citing works

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

VanWert, A. L., Gionfriddo, M. R., & Sweet, D. H. (2010) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.693 · Cited by 252 · see citing works

Novel aspects of renal organic anion transporters

Eraly, S. A., Blantz, R. C., Bhatnagar, V., & Nigám, S. K. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200309000-00011 · Cited by 40 · see citing works

Physiology, structure, and regulation of the cloned organic anion transporters

Srimaroeng, C., Perry, J. L., & Pritchard, J. B. (2008) · Xenobiotica · doi:10.1080/00498250801927435 · Cited by 132 · see citing works

Organic Anion Transporters

Tsuji, A., & Tamai, I. (2002) · Pharmaceutical biotechnology · doi:10.1007/0-306-46812-3_16 · Cited by 18 · see citing works

Therapeutic implications of renal anionic drug transporters

Masereeuw, R., & Rüssel, F. G. M. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.007 · Cited by 89 · see citing works