Anti-inflammatory Effects of Flavonoids in Neurodegenerative Disorders

Polyphenols: Food sources and bioavailability

Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Chemistry and biochemistry of dietary polyphenols

Tsao, R. (2010) · Nutrients · doi:10.3390/nu2121231 · Cited by 2,415 · see citing works

How neuroinflammation contributes to neurodegeneration

Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967 · see citing works

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation

Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980 · see citing works

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 933 · see citing works

Dietary flavonols: chemistry, food content, and metabolism

Aherne, S. A., & O’Brien, N. M. (2002) · Nutrition · doi:10.1016/s0899-9007(01)00695-5 · Cited by 849 · see citing works

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

Chhor, V., Charpentier, T. L., Lebon, S., Oré, M. V., Lara‐Celador, I., Josserand, J., Degos, V., Jacotot, E. D., Hagberg, H., Sävman, K., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.02.005 · Cited by 647 · see citing works

Flavones and flavone synthases

Martens, S., & Mithöfer, A. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.07.013 · Cited by 616 · see citing works

Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities

Prior, R. L., & Wu, X. (2006) · Free Radical Research · doi:10.1080/10715760600758522 · Cited by 585 · see citing works

Blueberry supplementation improves memory in older adults

Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9029332 · Cited by 577 · see citing works

The neuroprotective potential of flavonoids: a multiplicity of effects

Vauzour, D., Vafeiadou, K., Rodriguez‐Mateos, A., Rendeiro, C., & Spencer, J. P. E. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0091-4 · Cited by 561 · see citing works

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

Yin, F., Sancheti, H., Patil, I., & Cadenas, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.200 · Cited by 538 · see citing works

Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation

Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.02.004 · Cited by 481 · see citing works

Inhibition of Pro-inflammatory Markers in Primary Bone Marrow-Derived Mouse Macrophages by Naturally Occurring Flavonoids: Analysis of the Structure-Activity Relationship

Comalada, M., Ballester, I., Bailón, E., Sierra, S., Xaus, J., Gálvez, J., Medina, F. S. D., & Zarzuelo, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.016 · Cited by 440 · see citing works

PHYTOESTROGENS

Dixon, R. A. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141729 · Cited by 433 · see citing works

Intestinal absorption of luteolin and luteolin 7‐O‐β‐glucoside in rats and humans

Shimoi, K., Okada, H., Furugori, M., Goda, T., Takase, S., Suzuki, M., Hara, Y., Yamamoto, H., & Kinae, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01304-0 · Cited by 418 · see citing works

Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

Javed, H., Khan, M. M., Ahmad, A., Vaibhav, K., Ahmad, M. E., Khan, A., Ashafaq, M., Islam, F., Siddiqui, M. S., Safhi, M. M., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.046 · Cited by 367 · see citing works

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.016 · Cited by 315 · see citing works

Neuroinflammation in Neurodegenerative Disorders-a Review

Schain, M., & Kreisl, W. C. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0733-2 · Cited by 301 · see citing works

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

Rehman, S. U., Shah, S. A., Ali, T., Chung, J. I., & Kim, M. O. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9604-5 · Cited by 285 · see citing works

Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases

Solanki, I., Parihar, P., Mansuri, M. L., & Parihar, M. S. (2015) · Advances in Nutrition · doi:10.3945/an.114.007500 · Cited by 267 · see citing works

Role of neuroinflammation in neurodegeneration: new insights

McManus, R. M., & Heneka, M. T. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0241-2 · Cited by 247 · see citing works

Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation

Xu, P., Wang, S.-W., Yu, X., Su, Y., Wang, T., Zhou, W., Zhang, H., Wang, Y., & Liu, R. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.002 · Cited by 245 · see citing works

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

Suganthy, N., Devi, K. P., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.011 · Cited by 236 · see citing works

Kaempferol acts through mitogen‐activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

Park, S. E., Sapkota, K., Kim, S. H., Kim, H., & Kim, S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01389.x · Cited by 235 · see citing works

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury

Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez‐Mateos, A., Williams, R. J., & Spencer, J. P. E. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.01.016 · Cited by 224 · see citing works

Inflammation is genetically implicated in Parkinson’s disease

Dzamko, N., Geczy, C. L., & Halliday, G. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.028 · Cited by 222 · see citing works

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression

Rezai-Zadeh, K. P., Ehrhart, J. C., Bai, Y., Sanberg, P. R., Bickford, P. C., Tan, J. R., & Shytle, R. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-41 · Cited by 217 · see citing works

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke

Raza, S. S., Khan, M. M., Ahmad, A., Ashafaq, M., Islam, F., Popa‐Wagner, A., Safhi, M. M., & Islam, F. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.041 · Cited by 213 · see citing works

Dietary Flavonoids as Potential Neuroprotectants

Youdim, K. A., Spencer, J. P. E., Schroeter, H., & Rice-Evans, C. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.052 · Cited by 210 · see citing works

Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

Macready, A. L., Kennedy, O. B., Ellis, J. A., Williams, C. M., Spencer, J. P. E., & Butler, L. T. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0135-4 · Cited by 198 · see citing works

Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties

Lee, Y., Choi, D., Yun, Y., Han, S., Oh, K., & Hong, J. T. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.011 · Cited by 195 · see citing works

Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke

Yu, L., Chen, C., Wang, L.-F., Kuang, X., Liu, K., Zhang, H., & Du, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055839 · Cited by 190 · see citing works

Nutrition and neurodegeneration: epidemiological evidence and challenges for future research

Guyonnet, S., Secher, M., & Vellas, B. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12058 · Cited by 187 · see citing works

(−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

Lee, Y. K., Yuk, D. Y., Lee, J. W., Lee, S. Y., Ha, T. Y., Oh, K. W., Yun, Y. P., & Hong, J. T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.012 · Cited by 181 · see citing works

Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1

Sun, G. Y., Chen, Z., Jasmer, K. J., Chuang, D. Y., Gu, Z., Hannink, M., & Simonyi, Á. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141509 · Cited by 177 · see citing works

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., Moehle, C., Fuchshofer, R., & Langmann, T. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-3 · Cited by 175 · see citing works

Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System

Bournival, J., Plouffe, M., Renaud, J., Provencher, C., & Martinoli, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/921941 · Cited by 150 · see citing works

Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines

Cho, N., Choi, J. H., Yang, H., Jeong, E. J., Lee, K. Y., Kim, Y. C., & Sung, S. H. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.03.052 · Cited by 146 · see citing works

Neuronal injury in chronic CNS inflammation

Zindler, E., & Zipp, F. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.11.001 · Cited by 144 · see citing works

Quercetin Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells by Suppressing the NF-Κb Pathway and Activating the Nrf2-dependent HO-1 Pathway

Kang, C.-H., Choi, Y. H., Moon, S.-K., Kim, W.-J., & Kim, G.-Y. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.09.009 · Cited by 138 · see citing works

Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

Pandareesh, M. D., Mythri, R. B., & Bharath, M. M. S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.003 · Cited by 137 · see citing works

Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway

Kim, H., Kang, C., Jayasooriya, R. G. P. T., Dilshara, M. G., Lee, S., Choi, Y. H., Seo, Y. T., & Kim, G. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.022 · Cited by 136 · see citing works

Estrogen Action in Neuroprotection and Brain Inflammation

Pozzi, S., Benedusi, V., Maggi, A. C., & Vegeto, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.035 · Cited by 136 · see citing works

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

Mehta, V., Parashar, A., & Malairaman, U. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.01.006 · Cited by 136 · see citing works

Microglia in Alzheimer’s disease: A multifaceted relationship

ElAli, A., & Rivest, S. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.021 · Cited by 134 · see citing works

Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia–reperfusion injury through suppression of apoptosis and inflammation

Zhang, S., Qi, Y., Xu, Y., Han, X., Peng, J., Liu, K., & Sun, C. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.08.008 · Cited by 129 · see citing works

Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression

Wu, L.-H., Lin, C., Lin, H., Liu, Y.-S., Wu, C. Y.-J., Tsai, C., Chang, P.-C., Yeh, W., & Lu, D. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9042-9 · Cited by 128 · see citing works

Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia

Wei, J. C., Huang, H., Chen, W. J., Huang, C., Peng, C., & Lin, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.048 · Cited by 128 · see citing works

Neuroprotective Role of Natural Polyphenols

Spagnuolo, C., Napolitano, M., Tedesco, I., Moccia, S., Milito, A., & Russo, G. L. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160204122449 · Cited by 127 · see citing works

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

Yuan, Y., Zha, H., Rangarajan, P., Ling, E., & Wu, C. (2014) · BMC Neuroscience · doi:10.1186/s12868-014-0125-3 · Cited by 124 · see citing works

Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex

Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Jo, M. G., Badshah, H., & Kim, M. O. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.005 · Cited by 124 · see citing works

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways

Guo, C., Yang, L., Wan, C., Xia, Y., Zhang, C., Chen, M., Wang, Z., Li, Z.-R., Li, X., Geng, Y., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.007 · Cited by 123 · see citing works

Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells

Candiracci, M., Piatti, E., Dominguez-Barragán, M., García-Antrás, D., Rodríguez-Morgado, B., Ruano, D., Gutiérrez, J. F., Parrado, J., & Castaño, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302468h · Cited by 122 · see citing works

Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males

Alharbi, M. H., Lamport, D. J., Dodd, G. F., Saunders, C., Harkness, L., Butler, L. T., & Spencer, J. P. E. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1016-9 · Cited by 118 · see citing works

Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice

Javed, H., Vaibhav, K., Ahmed, M. E., Khan, A., Tabassum, R., Islam, F., Safhi, M. M., & Islam, F. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.10.044 · Cited by 118 · see citing works

Toll-like receptors are key players in neurodegeneration

Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117 · see citing works

Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities

Cho, N., Lee, K. Y., Huh, J., Choi, J. H., Yang, H., Jeong, E. J., Kim, H. P., & Sung, S. H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.007 · Cited by 115 · see citing works

Loading into Nanoparticles Improves Quercetin's Efficacy in Preventing Neuroinflammation Induced by Oxysterols

Testa, G., Gamba, P., Badıllı, U., Gargiulo, S., Maina, M., Guina, T., Calfapietra, S., Biasi, F., Cavalli, R., Poli, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096795 · Cited by 110 · see citing works

Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

Wang, S., Wang, H., Guo, H. W., Kang, L., Gao, X., & Hu, L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.005 · Cited by 107 · see citing works

(−)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells

Li, J., Li, Y., Wang, X., Liu, J., Wang, Y., Zhou, Y., & Ho, W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-161 · Cited by 106 · see citing works

Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise

Rani, N., Bharti, S., Krishnamurthy, B., et al. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160530150936 · Cited by 104 · see citing works

Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation

Herges, K., Millward, J. M., Hentschel, N., Infante‐Duarte, C., Aktaş, O., & Zipp, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025456 · Cited by 100 · see citing works

Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation

Wu, K., Hsieh, M., Wu, C., Wood, W. G., & Chen, Y.-F. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/163106 · Cited by 96 · see citing works

Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB

Mohamed, R. H., Karam, R. A., & Amer, M. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.001 · Cited by 93 · see citing works

The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults

Lamport, D. J., Pal, D., Macready, A. L., Bouças, S. B., Fletcher, J. M., Williams, C. M., Spencer, J. P. E., & Butler, L. T. (2016) · British Journal Of Nutrition · doi:10.1017/s000711451600430x · Cited by 93 · see citing works

Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice

Sawmiller, D. R., Habib, A., Li, S., Darlington, D., Hou, H., Tian, J., Shytle, R. D., de Smith, A. J., Giunta, B. N., Mori, T., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.018 · Cited by 90 · see citing works

Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions

Ginwala, R., McTish, E., Raman, C., Singh, N. P., Nagarkatti, M., Nagarkatti, P. S., Sagar, D., Jain, P., & Khan, Z. K. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9617-x · Cited by 89 · see citing works

Genistein Antagonizes Inflammatory Damage Induced by β-amyloid Peptide in Microglia through TLR4 and NF-Κb

Zhou, X., Yuan, L., Zhao, X., Hou, C., Ma, W., Yu, H., & Xiao, R. (2014) · Nutrition · doi:10.1016/j.nut.2013.06.006 · Cited by 89 · see citing works

The interplay between inflammation and neurodegeneration in CNS disease

Esiri, M. M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.013 · Cited by 87 · see citing works

Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microglia

Jantaratnotai, N., Utaisincharoen, P., Sanvarinda, P., Thampithak, A., & Sanvarinda, Y. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.07.013 · Cited by 85 · see citing works

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

Carvalho, F. B., Gutierres, J. M., Bueno, A., Agostinho, P. M., Zago, A. M., Vieira, J. M., Frühauf, P., Cechella, J. L., Nogueira, C. W., Oliveira, S. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9900-8 · Cited by 76 · see citing works

Therapeutic Attenuation of Neuroinflammation and Apoptosis by Black Tea Theaflavin in Chronic MPTP/Probenecid Model of Parkinson’s Disease

Anandhan, A., Essa, M. M., & Manivasagam, T. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9332-9 · Cited by 73 · see citing works

Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice

Burton, M. D., Rytych, J. L., Amin, R., & Johnson, R. W. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1708 · Cited by 69 · cited 1× · see citing works

Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Carvalho, F. B., Gutierres, J. M., Bohnert, C., Zago, A. M., Abdalla, F. H., Vieira, J. M., Palma, H. E., Oliveira, S. M., Spanevello, R. M., Duarte, M. M. M. F., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.006 · Cited by 68 · see citing works

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J. F., Ramos, A. B., Devier, D. J., Garrison, V., Kovner, B., Reza, T., Koop, D. R., Rooney, W. D., Foundas, A. L., & BOURDETTE, D. N. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.08.006 · Cited by 68 · see citing works

Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE–NF-κB Inflammatory Signaling Pathway

Hao, G., Dong, Y., Huo, R., Wen, K., Zhang, Y., & Liang, G. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1863-7 · Cited by 62 · see citing works

Rutin attenuates neuroinflammation in spinal cord injury rats

Jiang, W., Li, M., He, F., Zhenyu, B., He, Q., Xuepeng, W., & Liulong, Z. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.02.041 · Cited by 62 · see citing works

Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the nuclear transcription factor-κB, mitogen-activated protein kinase and protein kinase B pathways in lipopolysaccharide-stimulated cocultured BV2 cells

ZHU, L., Bi, W., Lu, D., Zhang, C., SHU, X., & Lu, D. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1564 · Cited by 57 · see citing works

Oral administration of the flavanol (−)‐epicatechin bolsters endogenous protection against focal ischemia through the N rf2 cytoprotective pathway

Leonardo, C. C., Agrawal, M., Singh, N., Moore, J. R., Biswal, S. S., & Doré, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12362 · Cited by 56 · see citing works

C-Jun N-Terminal Kinase (JNK) Regulation of iNOS Expression in Glial Cells: Predominant Role of JNK1 Isoform

Pawate, S., & Bhat, N. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.903 · Cited by 56 · see citing works

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

Yang, X., Li, Y., Zhang, H., Zhao, Y., Ding, Z., Yu, J., Liu, C., Liu, J., Jiang, W., Feng, Q., et al. (2015) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632015617065 · Cited by 54 · see citing works

Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223

Shi, L., Tang, P., Zhang, W., et al. (2016) · Gene · doi:10.1016/j.gene.2016.07.037 · Cited by 53 · see citing works

Effect of flavonoids rich extract ofCapparis spinosaon inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease

Mohebali, N., Fazeli, S. A. S., Ghafouri, H., et al. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1238026 · Cited by 52 · see citing works

Hesperidin Alleviates Lipopolysaccharide-Induced Neuroinflammation in Mice by Promoting the miRNA-132 Pathway

Li, M., Shao, H., Zhang, X., & Qin, B. (2016) · Inflammation · doi:10.1007/s10753-016-0402-7 · Cited by 50 · see citing works

Phloretin ameliorates 2-chlorohexadecanal-mediated brain microvascular endothelial cell dysfunction in vitro

Üllen, A., Fauler, G., Bernhart, E. M., Nusshold, C., Reicher, H., Leis, H., Malle, E., & Sattler, W. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.575 · Cited by 48 · see citing works

Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression

Meireles, M., Marques, C., Norberto, S., Santos, P. F., Fernandes, I., Mateus, N. F. D. C. B., Faria, A., & Calhau, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.010 · Cited by 47 · see citing works

Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ1–42 in BV-2 cells

Zhang, Z., Wu, Z., Zhu, X., Hui, X.-C., Pan, J., & Xu, Y. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.01.005 · Cited by 40 · see citing works

Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B

Chen, X., Shi, X., Zhang, X., Lei, H., Long, S., Su, H., Pei, Z., & Huang, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/432623 · Cited by 37 · see citing works

Molecular biomarkers of neurodegeneration

Höglund, K., & Salter, H. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.850033 · Cited by 33 · see citing works

A tetramethoxychalcone from Chloranthus henryi suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia

Luo, X.-L., Liu, S., Wang, L., Zhang, Q.-Y., Xu, P., Pan, L., & Hu, J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.013 · Cited by 28 · see citing works

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

Lutz, J. A., Kulshrestha, M., Rogers, D. T., & Littleton, J. M. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.06.012 · Cited by 27 · see citing works

Luteolin reduces primary hippocampal neurons death induced by neuroinflammation

Zhu, L.-H., Bi, W., Qi, R., Wang, H., Wang, Z.-G., Zeng, Q., Zhao, Y., & Lu, D. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000023 · Cited by 26 · see citing works

The Plant‐Derived Chalcone 2,2′,5′‐Trihydroxychalcone Provides Neuroprotection against Toll‐Like Receptor 4 Triggered Inflammation in Microglia

Jiwrajka, M., Phillips, A., Butler, M., Rossi, M., & Pocock, J. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6301712 · Cited by 17 · see citing works

The Dietary Flavonoid Rhamnetin Inhibits Both Inflammation and Excitotoxicity During Ethanol Withdrawal in Rat Organotypic Hippocampal Slice Cultures

Lutz, J. A., Carter, M., Fields, L., Barron, S., & Littleton, J. M. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12896 · Cited by 13 · see citing works

Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-alpha, iNOS and NF-kappa B

Mohamed, R. H. (2011) · Cited by 10 · see citing works

Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia

Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433 · see citing works

Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline

Rajaram, S., Jones, J., & Lee, G. J. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz081 · Cited by 235 · see citing works

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145 · see citing works

Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptom: a randomized controlled study

Park, M., Choi, J., & Lee, H.-J. (2020) · Nutrients · doi:10.3390/nu12061815 · Cited by 139 · see citing works

Senescent Microglia: The Key to the Ageing Brain?

Greenwood, E. K., & Brown, D. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094402 · Cited by 84 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection

Elsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., & Gallorini, M. (2022) · Molecules · doi:10.3390/molecules27030738 · Cited by 67 · see citing works

It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis

Gruessner, B. M., Cornet-Vernet, L., Desrosiers, M. R., Lutgen, P., Towler, M. J., & Weathers, P. J. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09645-9 · Cited by 31 · see citing works

Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine “matalafi”

Molimau-Samasoni, S., Woolner, V. H., Foliga, S. T., Robichon, K., Patel, V., Andreassend, S. K., Sheridan, J. P., Te Kawa, T., Gresham, D., Miller, D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100880118 · Cited by 20 · see citing works

Alzheimer’s Disease Research Using Human Microglia

Lue, L., Beach, T. G., & Walker, D. G. (2019) · Cells · doi:10.3390/cells8080838 · Cited by 26 · see citing works

Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019

Shir, D., & Day, G. S. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001033 · Cited by 13 · see citing works

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112 · see citing works

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.52405 · Cited by 34 · see citing works

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Vande Walle, L., Jordao, M. J. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04376-5 · Cited by 227 · see citing works