Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia
Abstract
This report presents a complex analysis of changes proceeding in the gut, blood and internal organs of rats with induced oxidative stress, glucose intolerance and hyperlipidemia after dietary supplementation with an extract from black chokeberry (Aronia melanocarpa) fruit, that is a condensed source of polyphenols (714 mg/g), especially anthocyanin glycosides (56.6%). The disturbances mimicking those observed in metabolic syndrome were induced by a high-fructose diet and simultaneous single injection of streptozotocin (20 mg/kg). Dietary supplementation with the chokeberry fruit extract (0.2%) decreased activity of maltase and sucrase as well as increased activity of lactase in the mucosa of the small intestine. Its ingestion led also to the improvement of antioxidant status, especially, the concentration of a lipid peroxidation indicator (TBARS) in organ tissues (liver, kidney and lung) was normalized; some cholesterol-lowering and distinct hypoglycemic actions were also observed. The mechanism of glucose reduction is likely to be multifactorial, and we suggest the factors related with the decreased activity of mucosal disaccharidases important for further investigation. In conclusion, chokeberry fruit derivatives may act as a promising supplementary therapeutic option in the prevention and treatment of disorders occurring in metabolic syndrome, as well as their complications.
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In a rat model of prediabetes and hyperlipidemia, dietary supplementation with chokeberry fruit extract for 4 weeks decreased activities of intestinal mucosal disaccharidases (maltase and sucrose).
“In a rat model of prediabetes and hyperlipidemia, Jurgoski et al.65 further demonstrated decreased activities of inńtestinal mucosal disaccharidases (maltase and sucrose) following dietary supplementation with chokeberry fruit extract for 4 weeks.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [65]
Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.
“Several lines of evidence indicate a role for berry anthocyanins in significantly decreasing oxidative damage and inflammation in cellular and animal models of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [65]
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Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
- Authors
- Jurgoński, A., Juśkiewicz, J., & Zduńczyk, Z.
- Affiliations
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- Corresponding author
- Jurgoński, Adam
- Venue
- Plant Foods for Human Nutrition
- Published
- 2008-08-23
- Volume
- 63
- Issue
- 4
- Pages
- 176-182
- ISSN
- 0033-5134 (ISSN-L)
- 0921-9668
- 1573-9104
- OpenAlex
- W2043265389
- Cited by
- 132
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 17 · 2016: 10 · 2015: 10 · 2014: 6 · 2013: 15 · 2012: 7
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Plant Foods for Human Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- Aronia melanocarpa, fruit extract, prediabetes, hyperlipidemia, metabolic syndrome, oxidative stress, impaired glucose tolerance, anthocyanin glycosides, polyphenols, high-fructose diet, streptozotocin, disaccharidase activity, lactase, maltase, sucrase, lipid peroxidation, antioxidant status, cholesterol lowering, hypoglycemic effect, dietary supplementation
- MeSH terms
- alpha-Glucosidases, Animals, Anthocyanins, Hypolipidemic Agents, beta-Galactosidase, Diabetes Mellitus, Experimental, Disaccharidases, Disease Models, Animal, Flavonoids, Fruit, Hyperlipidemias, Hypoglycemic Agents, Intestine, Small, Male, Phytotherapy, Phenols, Plant Extracts, Prediabetic State, Random Allocation, Sucrase, Lipid Peroxidation, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Photinia, Rats, Polyphenols
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