Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet
Abstract
Aronia melanocrpa fruit juice (AMFJ) used in our experiment was very rich in phenolic substances (709.3 mg gallic acid equivalents/100 ml juice). Anthocyanins (106.8 mg cyanidin-3-glucoside equivalents/100 ml juice) were the main flavonoid group. The aim of this study was to assess the influence of AMFJ on plasma lipids and lipoprotein profile, and histopathology of liver and aorta in rats with dietary-induced hyperlipidemia. AMFJ was administered by gavage for 30 days at doses of 5, 10 and 20 ml/kg body weight to rats fed a standard diet (SD) or a 4% cholesterol-containing diet (4% ChD). The 4% ChD caused a significant elevation of plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). AMFJ did not significantly influence plasma lipids in rats fed the SD and significantly hindered the elevation of plasma TC, LDL-C and TG in rats fed the 4% ChD. High-density lipoprotein cholesterol (HDL-C) levels were not significantly influenced either by the 4% ChD or by AMFJ. Neither the cholesterol feeding, nor AMFJ treatment induced any histopathological changes in rat liver and aorta. In conclusion, AMFJ showed an antihyperlipidemic effect in rats with hyperlipidemia and could be valuable in reducing this factor of cardiovascular risk.
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Berry anthocyanins affect lipid metabolism in cellular and animal models of dyslipidemia.
“Berry anthocyanins have also been shown to affect lipid metabolism in cellular and animal models of dyslipidemia.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [70]
Administration of chokeberry juice for 30 days in rats fed a standard or 4% cholesterol-containing diet showed anti-hyperlipidemic effects of chokeberry juice in the cholesterol-fed group.
“Administration of chokeberry juice for 30 days in rats fed a standard or 4% cholesterol-containing diet, showed the anti-hyperlipidemic effects of chokeberry juice in the cholesterol-fed group.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [70]
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- Authors
- VALCHEVA-KUZMANOVA, S., KUZMANOV, K., MIHOVA, V., KRASNALIEV, I., BORISOVA, P., & BELCHEVA, A.
- Affiliations
- Medical University of Varna (BG)
- Corresponding author
- VALCHEVA-KUZMANOVA, S.
- Venue
- Plant Foods for Human Nutrition
- Published
- 2006-11-29
- Volume
- 62
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0033-5134 (ISSN-L)
- 0921-9668
- 1573-9104
- OpenAlex
- W1966529143
- Cited by
- 119
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 7
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Plant Foods for Human Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
- Keywords
- Aronia melanocarpa, chokeberry juice, hypolipidemic effect, hyperlipidemia, high-cholesterol diet, plasma lipids, LDL cholesterol, triglycerides, HDL cholesterol, phenolic compounds, anthocyanins, cardiovascular risk, liver histopathology
- MeSH terms
- Administration, Oral, Animals, Anthocyanins, Hypolipidemic Agents, Aorta, Cholesterol, Dietary, Disease Models, Animal, Dose-Response Relationship, Drug, Hyperlipidemias, Lipids, Lipoproteins, Liver, Male, Phytotherapy, Phenols, Plant Extracts, Random Allocation, Rats, Wistar, Photinia, Rats
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