The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.
Role of oxytocin signaling in the regulation of body weight
Open accessAbstract
Obesity and its associated metabolic disorders are growing health concerns in the US and worldwide. In the US alone, more than two-thirds of the adult population is classified as either overweight or obese [1], highlighting the need to develop new, effective treatments for these conditions. Whereas the hormone oxytocin is well known for its peripheral effects on uterine contraction during parturition and milk ejection during lactation, release of oxytocin from somatodendrites and axonal terminals within the central nervous system (CNS) is implicated in both the formation of prosocial behaviors and in the control of energy balance. Recent findings demonstrate that chronic administration of oxytocin reduces food intake and body weight in diet-induced obese (DIO) and genetically obese rodents with impaired or defective leptin signaling. Importantly, chronic systemic administration of oxytocin out to 6 weeks recapitulates the effects of central administration on body weight loss in DIO rodents at doses that do not result in the development of tolerance. Furthermore, these effects are coupled with induction of Fos (a marker of neuronal activation) in hindbrain areas (e.g. dorsal vagal complex (DVC)) linked to the control of meal size and forebrain areas (e.g. hypothalamus, amygdala) linked to the regulation of food intake and body weight. This review assesses the potential central and peripheral targets by which oxytocin may inhibit body weight gain, its regulation by anorexigenic and orexigenic signals, and its potential use as a therapy that can circumvent leptin resistance and reverse the behavioral and metabolic abnormalities associated with DIO and genetically obese models.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The reliability of peripheral ADH and OT levels as biomarkers of AN is weakened by the global hypothalamic-pituitary dysfunction, the impact of fluid and sodium restriction and purging behaviours observed in AN and the putative role of the two hormones in the regulation of the gut brain axis and energy homeostasis (Blevins and Ho, 2013).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as Blevins and Ho, 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Prevalence of obesity in the United States, 2009-2010.
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2012) · PubMed · Cited by 2,057
Prevalence of obesity in the United States.
Ogden, C., Carroll, M., & Flegal, K. (2014) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2014.6228 · Cited by 1,588
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Hypothalamic CART is a new anorectic peptide regulated by leptin
Kristensen, P. L., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., et al. (1998) · Nature · doi:10.1038/29993 · Cited by 1,282
De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141
Research works printed but not linked: 1
- Rothe E, Rinaman L. Central oxytocin (OT) activates hindbrain glucagon-like peptide-1 (GLP-1) neurons in rats. Appetite. 2001;37:160.
Cited by
Sorted by citations
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M., Brunstrom, J. M., de Graaf, K., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J., Preissl, H., et al. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s002966511600286x · Cited by 465
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M. V. K., Brunstrom, J. M., de Graaf, K. C., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J. R. W., Preissl, H. T., et al. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-146390 · Cited by 255
Serotonin, food intake, and obesity
van Galen, K. A., ter Horst, K. W., & Serlie, M. J. M. (2021) · Obesity Reviews · doi:10.1111/obr.13210 · Cited by 220
Peters, S., Slattery, D. A., Uschold‐Schmidt, N., Reber, S. O., & Neumann, I. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.021 · Cited by 189
Metadata
- Authors
- Blevins, J. E., & Ho, J. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Blevins, James E.
- ORCID
- Blevins, James E.
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2013-09-25
- Volume
- 14
- Issue
- 4
- Pages
- 311-329
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- PMC
- PMC4213929
- OpenAlex
- W2068155003
- Cited by
- 108
- References
- 235
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 12 · 2014: 10
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX001213)
- Office of Research and Development
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oxytocin, body weight regulation, obesity, diet-induced obesity, leptin resistance, energy balance, dietary intake, dorsal vagal complex, hypothalamus, amygdala, Fos expression, oxytocin therapy
- MeSH terms
- Adult, Animals, Appetite Depressants, Appetite Regulation, Body Weight, Energy Metabolism, Humans, Oxytocin, Signal Transduction, Weight Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
