Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Open accessAbstract
Growing evidence suggests that oxytocin plays an important role in the regulation of energy balance and that central oxytocin administration induces weight loss in diet-induced obese (DIO) animals. To gain a better understanding of how oxytocin mediates these effects, we examined feeding and neuronal responses to oxytocin in animals rendered obese following exposure to either a high-fat (HFD) or low-fat diet (LFD). Our findings demonstrate that peripheral administration of oxytocin dose-dependently reduces food intake and body weight to a similar extent in rats maintained on either diet. Moreover, the effect of oxytocin to induce weight loss remained intact in leptin receptor-deficient Koletsky (fa(k)/fa(k)) rats relative to their lean littermates. To determine whether systemically administered oxytocin activates hindbrain areas that regulate meal size, we measured neuronal c-Fos induction in the nucleus of the solitary tract (NTS) and area postrema (AP). We observed a robust neuronal response to oxytocin in these hindbrain areas that was unexpectedly increased in rats rendered obese on a HFD relative to lean, LFD-fed controls. Finally, we report that repeated daily peripheral administration of oxytocin in DIO animals elicited a sustained reduction of food intake and body weight while preventing the reduction of energy expenditure characteristic of weight-reduced animals. These findings extend recent evidence suggesting that oxytocin circumvents leptin resistance and induces weight-loss in DIO animals through a mechanism involving activation of neurons in the NTS and AP, key hindbrain areas for processing satiety-related inputs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodent studies, oxytocin affects energy expenditure.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [7]
In rodent studies, oxytocin acts as a strong inhibitor of food intake.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [7]
In rodent studies, oxytocin affects glucose homeostasis.
“evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [7]
Peripheral administration of high oxytocin doses can mimic the feeding-inhibitory effect, supposedly by triggering hypothalamic oxytocin release in a feed-forward fashion.
“This effect could be mimicked by the peripheral administration of high oxytocin doses that supposedly trigger hypothalamic oxytocin release in a feed-forward fashion (7,12).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [7]
In another study of diet induced obesity in rats, systemic oxytocin reduced caloric intake and body weight without changing REE, indicating that oxytocin blocked the effect of weight loss to reduce energy expenditure.
“In another study of diet induced obesity in rats, systemic oxytocin reduced caloric intake and body weight without changing REE, indicating that oxytocin blocked the effect of weight loss to reduce energy expenditure(33).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [33]
Oxytocin enhances insulin sensitivity and glucose tolerance in a rodent model of diet-induced obesity independent of its effects on body weight.
“Although this conclusion is in need of corroboration in experiments focusing on glucose homeostasis, it is in line with findings that oxytocin enhances insulin sensitivity and glucose tolerance in a rodent model of diet-induced obesity independent of its effects on body weight (7,50).”
From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [7]
Similar anti-obesity effects of OXT occur in rat models.
“similar anti-obesity effects of OXT were reported to occur in rat models [16], [17].”
From Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models (2013) · cites this paper as [16]
Peripheral OXT delivery can exert anti-obesity effects.
“our studies and others showed that peripheral OXT delivery can work to exert anti-obesity effects [15], [16]”
From Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models (2013) · cites this paper as [16]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works
New methods for calculating metabolic rate with special reference to protein metabolism
Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,610 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012 · see citing works
Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029 · see citing works
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830 · see citing works
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus
Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.10.5570 · Cited by 769 · see citing works
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
van Heek, M., Compton, D. S., France, C. F., Tedesco, R. P., Fawzi, A. B., Graziano, M. P., Sybertz, E. J., Strader, C. D., & Davis, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119171 · Cited by 752 · see citing works
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575 · see citing works
Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons
Enriori, P. J., Evans, A. E., Sinnayah, P., Jobst, E. E., Tonelli-Lemos, L., Billes, S. K., Glavas, M. M., Grayson, B. E., Perello, M., Nillni, E. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.004 · Cited by 552 · see citing works
Melanocortin receptors in leptin effects
Seeley, R. J., Yagaloff, K. A., Fisher, S. L., Burn, P., Thiele, T. E., van Dijk, G., Baskin, D. G., & Schwartz, M. W. (1997) · Nature · doi:10.1038/37016 · Cited by 522 · see citing works
Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421 · see citing works
Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2391 · Cited by 407 · see citing works
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
L., J., Jr. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.101 · Cited by 400 · see citing works
Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 375 · see citing works
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
Self-citationInfluence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works
Butler, A. A., & Kozak, L. P. (2010) · Diabetes · doi:10.2337/db09-1471 · Cited by 263 · see citing works
Leptin action in the forebrain regulates the hindbrain response to satiety signals
Morton, G. J., Blevins, J. E., Williams, D. L., Niswender, K. D., Gelling, R. W., Rhodes, C. J., Baskin, D. G., & Schwartz, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22081 · Cited by 253 · see citing works
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239 · see citing works
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works
Jansen, A. S. P., Wessendorf, M. W., & Loewy, A. D. (1995) · Brain Research · doi:10.1016/0006-8993(95)00276-v · Cited by 229 · see citing works
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., & Cai, D. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.036 · Cited by 208 · see citing works
Body Weight Set-Points: Determination and Adjustment
Keesey, R. E., & Hirvonen, M. D. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1875s · Cited by 206 · see citing works
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
Yosten, G. L. C., & Samson, W. K. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00804.2009 · Cited by 177 · see citing works
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
Kaiyala, K. J., Morton, G. J., Leroux, B. G., Ogimoto, K., Wisse, B. E., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1582 · Cited by 163 · see citing works
Kaiyala, K. J., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db10-0909 · Cited by 156 · see citing works
Olson, B. R., Freilino, M. L., Hoffman, G. E., Stricker, E. M., Sved, A. F., & Verbalis, J. G. (1993) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1993.1011 · Cited by 155 · see citing works
PostnatalSim1Deficiency Causes Hyperphagic Obesity and ReducedMc4randOxytocinExpression
Tolson, K. P., Gemelli, T., Gautron, L., Elmquist, J. K., Zinn, A. R., & Kublaoui, B. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5444-09.2010 · Cited by 137 · see citing works
Multiple brain sites sensitive to feeding stimulation by opioid agonists: A cannula-mapping study
Stanley, B. G., Lanthier, D., & LEIBOWITZ, S. F. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90391-7 · Cited by 136 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., Pizzolato, G., & Dreifuss, J. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90317-x · Cited by 136 · see citing works
Carson, D. S., Hunt, G. E., Guastella, A. J., Barber, L., Cornish, J. L., Arnold, J. C., Boucher, A. A., & McGregor, I. S. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00247.x · Cited by 126 · see citing works
Kublaoui, B. M., Holder, J. L., Gemelli, T., & Zinn, A. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0483 · Cited by 121 · see citing works
Central administration of peptides alters thermoregulation in the rabbit
Lipton, J. M., & Glyn, J. R. (1980) · Peptides · doi:10.1016/0196-9781(80)90029-7 · Cited by 111 · see citing works
Rinaman, L., & Rothe, E. E. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00008.2002 · Cited by 95 · see citing works
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
Holder, J. L., Zhang, L., Kublaoui, B. M., Dileone, R., Öz, O. K., Bair, C.-H., Lee, Y.-H., & Zinn, A. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2003 · Cited by 95 · see citing works
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
KASAHARA, Y., TAKAYANAGI, Y., KAWADA, T., ITOI, K., & NISHIMORI, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70498 · Cited by 89 · see citing works
Zittel, T. T., GIORGIO, R. D., Sternini, C., & Raybould, H. E. (1994) · Brain Research · doi:10.1016/0006-8993(94)91272-6 · Cited by 83 · see citing works
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
Blevins, J. E., Morton, G. J., Williams, D. L., Caldwell, D. W., Bastian, L. S., Wisse, B. E., Schwartz, M. W., & Baskin, D. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90544.2008 · Cited by 73 · see citing works
A New Oxytocin-Saporin Cytotoxin for Lesioning Oxytocin-Receptive Neurons in the Rat Hindbrain
Baskin, D. G., Kim, F., Gelling, R. W., Russell, B. J., Schwartz, M. W., Morton, G. J., Simhan, H. N., Moralejo, D. H., & Blevins, J. E. (2010) · Endocrinology · doi:10.1210/en.2010-0295 · Cited by 72 · see citing works
Oxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61 · see citing works
Mitra, A., Gosnell, B. A., Schiöth, H. B., Grace, M. K., Klockars, A., Olszewski, P. K., & Levine, A. S. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.005 · Cited by 61 · see citing works
Role of α-MSH in the regulation of consummatory behavior: immunohistochemical evidence
Olszewski, P. K., Wirth, M. M., Shaw, T. J., Grace, M. K., Billington, C. J., Giraudo, S. Q., & Levine, A. S. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.2.r673 · Cited by 55 · see citing works
Histochemical identification of a PVN-hindbrain feeding pathway
Kirchgessner, A. L., Sclafani, A. J., & Nilaver, G. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90154-0 · Cited by 51 · see citing works
Studies of the SIM1 gene in relation to human obesity and obesity-related traits
Hung, C.-C. C., Luan, J., Sims, M., Keogh, J. M., Hall, C., Wareham, N. J., O’Rahilly, S., & Farooqi, I. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803443 · Cited by 51 · see citing works
Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
Amico, J. A., Vollmer, R. R., Karam, J. R., Lee, P. R., Li, X., Koenig, J. I., & McCarthy, M. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.006 · Cited by 46 · see citing works
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Mantella, R. C., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2002 · Cited by 44 · see citing works
Mason, G., Caldwell, J. D., Stanley, D. A., Hatley, O. L., Prange, A. J., & Pedersen, C. A. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90008-x · Cited by 24 · see citing works
Flow-Through Respirometry: The Equations
Lighton, J. R. B. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195310610.003.0009 · Cited by 11 · see citing works
Rinaman (1998) · doi:10.1002/(sici)1096-9861(19980914)399:1
Flagged first, then by citations
Cited by
Sorted by citations
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works
Intranasal Treatment of Central Nervous System Dysfunction in Humans
Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310 · see citing works
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226 · see citing works
Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models
Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J., & Cai, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061477 · Cited by 224 · see citing works
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220 · see citing works
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
The effects of oxytocin on eating behaviour and metabolism in humans
Lawson, E. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.115 · Cited by 196 · see citing works
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 187 · see citing works
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R. D., Lara-Lince, F., Meek, T. H., Shi, X., Damian, V. M., Hồng, N. T., Matsen, M. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14556 · Cited by 169 · see citing works
Iwasaki, Y., Maejima, Y., Suyama, S., Yoshida, M., Arai, T., Katsurada, K., Kumari, P., Nakabayashi, H., Kakei, M., & Yada, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00344.2014 · Cited by 148 · see citing works
Welch, M. G., Margolis, K. G., Li, Z., & Gershon, M. D. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00176.2014 · Cited by 152 · see citing works
Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Qian, W., Zhu, T., Tang, B., Yu, S., Hu, H., Sun, W., Pan, R., Wang, J., Wang, D., Yang, L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2206 · Cited by 149 · see citing works
Li, C., Navarrete, J. S., Liang-Guallpa, J., Lü, C., Funderburk, S. C., Chang, R. B., Liberles, S. D., Olson, D. P., & Krashes, M. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.016 · Cited by 145 · see citing works
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Oxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men
Thienel, M., Fritsche, A., Heinrichs, M., Peter, A., Ewers, M., Lehnert, H., Jan Born, A., & Hallschmid, M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.149 · Cited by 139 · see citing works
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Appetite Regulation: Hormones, Peptides, and Neurotransmitters and Their Role in Obesity
Miller, G. D. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617716376 · Cited by 126 · see citing works
The long-term psychiatric and medical prognosis of perinatal mental illness
Meltzer-Brody, S. E., & Stuebe, A. M. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.08.009 · Cited by 121 · see citing works
Oxytocin action in the ventral tegmental area affects sucrose intake
Mullis, K., Kay, K., & Williams, D. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.026 · Cited by 122 · see citing works
Psychopharmacological advances in eating disorders
Himmerich, H., & Treasure, J. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1383895 · Cited by 119 · see citing works
Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes
Altirriba, J., Poher, A.-L., Caillon, A., Arsenijevic, D., Veyrat‐Durebex, C., Lyautey, J., Dulloo, A. G., & Rohner‐Jeanrenaud, F. (2014) · Endocrinology · doi:10.1210/en.2014-1466 · Cited by 111 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
Self-citationOxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice
Plante, É., Ménaouar, A., Danalache, B. A., Yip, D., Broderick, T. L., Chiasson, J., Jankowski, M., & Gutkowska, J. (2015) · Endocrinology · doi:10.1210/en.2014-1718 · Cited by 107 · see citing works
Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden‐Hanson, T., Nelson, J. T., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00220.2015 · Cited by 107 · see citing works
Glutamate Mediates the Function of Melanocortin Receptor 4 on Sim1 Neurons in Body Weight Regulation
Xu, Y., Wu, Z., Sun, H., Zhu, Y., Kim, E. R., Lowell, B. B., Arenkiel, B. R., Xu, Y., & Tong, Q. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.003 · Cited by 105 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2014 · Cited by 102 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12805 · Cited by 97 · see citing works
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Central and peripheral control of food intake
Abdalla, M. M. I. (2017) · Endocrine Regulations · doi:10.1515/enr-2017-0006 · Cited by 92 · see citing works
Mitchell, J. M., Arcuni, P. A., Weinstein, D., & Woolley, J. D. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000213 · Cited by 82 · see citing works
Hsu, E. A., Miller, J. L., Perez, F. A., & Roth, C. L. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02080 · Cited by 86 · see citing works
Perelló, M., & Raingo, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059625 · Cited by 84 · see citing works
Role of oxytocin in energy metabolism
Chaves, V. E., Tilelli, C. Q., Brito, N. A., & Brito, M. N. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.010 · Cited by 90 · see citing works
Satiety: a gut–brain–relationship
Barakat, G. M., Ramadan, W., Assi, G., & Khoury, N. B. E. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00904-9 · Cited by 82 · see citing works
Peripheral oxytocin administration reduces ethanol consumption in rats
MacFadyen, K., Loveless, R., DeLucca, B., Wardley, K., Deogan, S., Thomas, C., & Peris, J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.10.014 · Cited by 76 · see citing works
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74 · see citing works
Spetter, M. S., Feld, G. B., Thienel, M., Preissl, H. T., Hege, M. A., & Hallschmid, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20963-4 · Cited by 70 · see citing works
Oxytocin in survivors of childhood-onset craniopharyngioma
Daubenbüchel, A. M. M., Hoffmann, A., Eveslage, M., Özyurt, J., Lohle, K., Reichel, J. F., Thiel, C. M., Martens, H., Geenen, V. G., & Muller, H. L. (2016) · Endocrine · doi:10.1007/s12020-016-1084-5 · Cited by 69 · see citing works
Roberts, Z. S., Wolden‐Hanson, T., Matsen, M. E., Ryu, V., Vaughan, C. H., Graham, J. L., Havel, P. J., Chukri, D. W., Schwartz, M. W., Morton, G. J., et al. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00169.2017 · Cited by 68 · see citing works
Oxytocin Improves β-Cell Responsivity and Glucose Tolerance in Healthy Men
Klement, J., Ott, V., Rapp, K., Brede, S., Piccinini, F., Cobelli, C., Lehnert, H., & Hallschmid, M. (2016) · Diabetes · doi:10.2337/db16-0569 · Cited by 68 · see citing works
Haines, M. S., Marengi, D. A., Pulumo, R., Yu, E. W.-Y., Eddy, K. T., Klibanski, A., Miller, K. K., & Lawson, E. A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3963 · Cited by 68 · see citing works
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67 · see citing works
Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat Gain
Béranger, G. E., Pisani, D. F., Castel, J., Djedaini, M., Battaglia, S., Amiaud, J., Boukhechba, F., Ailhaud, G. P., Michiels, J., Heymann, D., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1688 · Cited by 67 · see citing works
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 68 · see citing works
The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication
Maejima, Y., Yokota, S., Nishimori, K., & Shimomura, K. (2018) · Neuroendocrinology · doi:10.1159/000489263 · Cited by 65 · see citing works
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Altirriba, J., Poher, A.-L., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00119 · Cited by 63 · see citing works
Oxytocin enhances cognitive control of food craving in women
Striepens, N., Schröter, F., Stoffel‐Wagner, B., Maier, W., Hurlemann, R., & Scheele, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23308 · Cited by 63 · see citing works
PVN pathways controlling energy homeostasis
Hill, J. W. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105581 · Cited by 62 · see citing works
Ong, Z. Y., Alhadeff, A. L., & Grill, H. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00534.2014 · Cited by 62 · see citing works
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Liu, Y., Conboy, M. J., Mehdipour, M., Liu, Y., Tran, T. P., Blotnick, A. M., Rajan, P., Santos, T. C., & Conboy, I. M. (2017) · Nature Communications · doi:10.1038/s41467-017-00698-y · Cited by 60 · see citing works
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61 · see citing works
A systematic review and quantitative meta‐analysis of the effects of oxytocin on feeding
Leslie, M. R., Silva, P., Paloyelis, Y., Blevins, J. E., & Treasure, J. L. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12584 · Cited by 60 · see citing works
Kaiyala, K. J., Ogimoto, K., Nelson, J. T., Schwartz, M. W., & Morton, G. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119391 · Cited by 59 · see citing works
Oxytocin and cardioprotection in diabetes and obesity
Jankowski, M., Broderick, T. L., & Gutkowska, J. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-016-0110-1 · Cited by 59 · see citing works
Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors
Song, Z., Levin, B. E., Stevens, W., & Sladek, C. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2013 · Cited by 58 · see citing works
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 58 · see citing works
Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue
Balážová, L., Kršková, K., Segarra, A. B., Špolcová, A., Suski, M., Olszanecki, R., & Zórad, Š. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0417 · Cited by 57 · see citing works
Actions of Pituitary Hormones Beyond Traditional Targets
Zaidi, M., New, M., Blair, H., Zallone, A., Baliram, R., Davies, T., Cardozo, C., Iqbal, J., Sun, L., Rosen, C., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0680 · Cited by 49 · see citing works
Oxytocin regulates body composition
Sun, L., Lizneva, D., Ji, Y., Colaianni, G., Hadelia, E., Gumerova, A. A., Ievleva, K., Kuo, T., Korkmaz, F., Ryu, V., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913611116 · Cited by 56 · see citing works
Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms
Liu, C. M., Spaulding, M. O., Rea, J. J., Noble, E. E., & Kanoski, S. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910859 · Cited by 53 · see citing works
Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives
Giel, K. E., Zipfel, S., & Hallschmid, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171128143158 · Cited by 53 · see citing works
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Wallace Fitzsimons, S. E., Chruścicka, B., Druelle, C., Stamou, P., Nally, K., Dinan, T. G., Cryan, J. F., & Schellekens, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.022 · Cited by 49 · see citing works
Kania, A., Guguła, A., Grabowiecka, A., de Ávila, C., Błasiak, T., Rajfur, Z., Lewandowski, M. H., Hess, G., Timofeeva, E., Gundlach, A. L., et al. (2017) · The Journal of Physiology · doi:10.1113/jp273787 · Cited by 49 · see citing works
An overview of energy and metabolic regulation
Wen, S., Wang, C., Gong, M., & Zhou, L. (2018) · Science China Life Sciences · doi:10.1007/s11427-018-9371-4 · Cited by 48 · see citing works
Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response
Dong, X., Long, C., Lai, M., Casella, A., O’Lear, L., Kublaoui, B. M., & Roizen, J. D. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00136 · Cited by 46 · see citing works
Oxytocin: Potential to mitigate cardiovascular risk
Reiss, A. B., Glass, D. S., Lam, E., Glass, A. D., Leon, J. D., & Kasselman, L. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.05.001 · Cited by 44 · see citing works
Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster
Williams, M. J., Goergen, P., Rajendran, J., Zheleznyakova, G. Y., Hägglund, M. G., Perland, E., Bagchi, S., Kalogeropoulou, A., Khan, Z., Fredriksson, R., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004499 · Cited by 45 · see citing works
Matarazzo, V. A., Schaller, F., Nédélec, E., Bénani, A., Pénicaud, L., Muscatelli, F., Moyse, E., & Bauer, Š. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1669-12.2012 · Cited by 45 · see citing works
Yuan, J., Zhang, R., Wu, R., Gu, Y., & Lu, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110903 · Cited by 45 · see citing works
Sex Differences and Estrous Influences on Oxytocin Control of Food Intake
Liu, C. M., Davis, E. A., Suarez, A. N., Wood, R. I., Noble, E. E., & Kanoski, S. E. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.020 · Cited by 44 · see citing works
Bush, N. R., Allison, A. L., Miller, A. L., Deardorff, J., Adler, N. E., & Boyce, W. T. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2332 · Cited by 42 · see citing works
Nakata, M., Gantulga, D., Santoso, P., Zhang, B., Masuda, C., Mori, M., Okada, T., & Yada, T. (2016) · Endocrinology · doi:10.1210/en.2015-2082 · Cited by 42 · see citing works
den Hartigh, L. J., Wang, S., Goodspeed, L., Wietecha, T., Houston, B. A., Omer, M., Ogimoto, K., Subramanian, S., Gowda, G. A. N., O’Brien, K. D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172912 · Cited by 40 · see citing works
A new horizon: oxytocin as a novel therapeutic option for obesity and diabetes
Cai, D., & Purkayastha, S. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.05.006 · Cited by 38 · see citing works
Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation
Jeong, J. K., Dow, S. A., & Young, C. N. (2021) · Metabolites · doi:10.3390/metabo11080494 · Cited by 38 · see citing works
Freeman, S. M., Ngo, J., Singh, B., Masnaghetti, M., Bales, K. L., & Blevins, J. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.037 · Cited by 37 · see citing works
Cook, N., Miller, J. E., & Hart, J. (2016) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2015-0445 · Cited by 36 · see citing works
Akour, A. A., Kasabri, V. N., Bulatova, N., AlMuhaissen, S. A., Naffa, R. G., Fahmawi, H. A., Momani, M. S., Zayed, A. A., & Bustanji, Y. K. (2017) · The Review of Diabetic Studies · doi:10.1900/rds.2017.14.364 · Cited by 35 · see citing works
Maestrini, S., Mele, C., Mai, S., Vietti, R., Blasio, A. M. D., Castello, L. M., Surico, D., Aimaretti, G., Scacchi, M., & Marzullo, P. (2018) · Obesity Facts · doi:10.1159/000492001 · Cited by 35 · see citing works
Bojanowska, E., & Ciosek, J. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151109103147 · Cited by 34 · see citing works
Oxytocin administration suppresses hypothalamic activation in response to visual food cues
van der Klaauw, A. A., Ziauddeen, H., Keogh, J. M., Henning, E., Dachi, S. V., Fletcher, P. C., & Farooqi, I. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-04600-0 · Cited by 34 · see citing works
Vu, J. P., Luong, L., Parsons, W. F., Oh, S., Sanford, D., Gabalski, A. H., Lighton, J. R. B., Pisegna, J. R., & Germano, P. M. (2017) · Journal of Nutrition · doi:10.3945/jn.117.257873 · Cited by 34 · see citing works
NTS and VTA oxytocin reduces food motivation and food seeking
Wald, H. S., Chandra, A., Kalluri, A. L., Ong, Z. Y., Hayes, M. R., & Grill, H. J. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00201.2020 · Cited by 34 · see citing works
Oxytocin: A citation network analysis of 10 000 papers
Leng, G., & Leng, R. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13014 · Cited by 33 · see citing works
Yuan, G., Qian, W., Pan, R., Jia, J., Jiang, D., Yang, Q., Wang, S., Liu, Y., Yu, S., Hu, H., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0078 · Cited by 33 · see citing works
Endogenous Oxytocin Levels in Relation to Food Intake, Menstrual Phase, and Age in Females
Aulinas, A., Pulumo, R., Asanza, E., Mancuso, C. J., Slattery, M. J., Tolley, C., Plessow, F., Thomas, J. J., Eddy, K. T., Miller, K. K., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02036 · Cited by 32 · see citing works
Iwasa, T., Matsuzaki, T., Mayila, Y., Yanagihara, R., Yamamoto, Y., Kawakita, T., Kuwahara, A., & Irahara, M. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.002 · Cited by 32 · see citing works
Snider, B. M., Geiser, A., Yu, X.-P., Beebe, E., Willency, J. A., Qing, K., Guo, L., Lu, J., Wang, X., Yang, Q., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00004 · Cited by 32 · see citing works
Oxytocin reduces adipose tissue inflammation in obese mice
Szeto, A., Cecati, M., Ahmed, R., McCabe, P. M., & Mendez, A. J. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01364-x · Cited by 31 · see citing works
Slamková, M., Zórad, Š., & Kršková, K. (2016) · Endocrine Regulations · doi:10.1515/enr-2016-0025 · Cited by 30 · see citing works
Dong, T. S., Vu, J. P., Oh, S., Sanford, D., Pisegna, J. R., & Germano, P. M. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05950-7 · Cited by 30 · see citing works
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30 · see citing works
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 30 · see citing works
Dunigan, A. I., & Roseberry, A. G. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100011 · Cited by 28 · see citing works
Control of bone and fat mass by oxytocin
Amri, E., & Pisani, D. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0045 · Cited by 27 · see citing works
Weingarten, M. F. J., Scholz, M. R., Wohland, T., Horn, K., Stümvoll, M., Kovacs, P. L., & Tönjes, A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00643 · Cited by 28 · see citing works
- Authors
- Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E.
- Affiliations
- University of Washington (US)
- United States Department of Veterans Affairs (US)
- Creighton University (US)
- Office of Research and Development Medical Research Service, Veterans Affairs Puget Sound Health Care System, Department of Veterans Affairs Medical Center, Seattle, Washington;
- Corresponding author
- Morton, Gregory J.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-01-01
- Volume
- 302
- Issue
- 1
- Pages
- E134-E144
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- PMC
- PMC3328087
- OpenAlex
- W2154655754
- Cited by
- 213
- References
- 66
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 16 · 2023: 3 · 2022: 13 · 2021: 24 · 2020: 17 · 2019: 18 · 2018: 20 · 2017: 22 · 2016: 19 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 7
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- National Institutes of Health (1u24dk076126-01)
- Nutrition Obesity Research Center, University of North Carolina
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-083042, DK-068304, U24-DK076126, P30-DK 17047, R01DK089056, DK089056, DK052989, R01DK052989, R01DK090320, P30DK035816, P30DK017047, R01DK083042)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oxytocin, diet-induced obesity, dietary intake, weight loss, energy balance, leptin resistance, leptin receptor deficiency, high-fat diet, nucleus tractus solitarius, area postrema, c-Fos neuronal activation, satiety, energy expenditure, hindbrain
- MeSH terms
- Animals, Appetite Depressants, Combined Modality Therapy, Crosses, Genetic, Dietary Fats, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Male, Nerve Tissue Proteins, Neurons, Obesity, Oxytocin, Rats, Mutant Strains, Recombinant Proteins, Weight Loss, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Solitary Nucleus, Leptin, Area Postrema, Rats, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
