Cited by 213Bone Metabolism and DiseasesBone health and osteoporosis researchOsteomyelitis and Bone Disorders Research

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RANKL/OPG; Critical role in bone physiology

Martin, T. John, Sims, Natalie A.·2015·Reviews in Endocrine and Metabolic Disorders

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Abstract

After it was proposed that the osteoblast lineage controlled the formation of osteoclasts, cell culture methods were developed that established this to be the case. Evidence was obtained that cytokines and hormones that promote osteoclast formation act first on osteoblast lineage cells to promote the production of a membrane-bound regulator of osteoclastogenesis. This proved to be receptor activator of NF-kB ligand (RANKL) a member of the tumor necrosis factor ligand family that acts upon its receptor RANK in the hematopoietic lineage, with interaction restricted by a decoy soluble receptor osteoprotegerin (OPG), also a product of the osteoblast lineage. The physiological roles of these factors were established through genetic and pharmacological studies, have led to a new physiology of bone, with complete revision of older ideas over the last 15 years, ultimately leading to the development of new pharmaceutical agents for bone disease.

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis
Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483
Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,345
Self-citation
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778

Show all 88 references

Research works printed but not linked: 1

Parfitt AM. Skeletal heterogeneity and the purposes of bone remodelling: Implications for the understanding of osteoporosis. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. San Diego, CA: Academic; 1996. p. 315–39.

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Sheela, S., Kheder, W., & Samsudin, A. B. R. (2024) · Biomaterial Investigations in Dentistry · doi:10.2340/biid.v11.40843 · Cited by 1
Coxiella burnetii infects osteoclasts and alters their differentiation and function in a type IV secretion system-dependent manner
Lai, C., Siddique, M. N. A. A., Asghar, F., Su, X., Schulze‐Luehrmann, J., Jia, Y., Escarrega, E. A., Bachmann, E., Bözec, A., Lang, R., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1724684 · Cited by 2
Design and Synthesis of 9α-Hydroxyandrost-4-ene-3,17-dione Derivatives as Novel Potent Antiosteoporosis Agents
Zhang, J.-Z., Hu, Y.-X., Yu, A.-Q., Ning, R., Jiang, M., & Qiu, W.-W. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00008 · Cited by 1
Precision biomaterial therapeutic strategies for osteolytic diseases
Xue, H., Wang, Y., Kong, K., Ng, S., Li, Y., Fan, W., Wang, Z., Xue, Q., Jin, M., & Li, H. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb00511j · Cited by 1
Bone Markers Throughout Sexual Development: Epidemiological Significance and Population-Based Findings
Lucas, R., Martins, A., Monjardino, T., Caetano‐Lopes, J., & Fonseca, J. E. (2017) · Biomarkers in disease · doi:10.1007/978-94-007-7693-7_26 · Cited by 1
A simple and robust reporter gene assay for measuring the bioactivity of anti-RANKL therapeutic antibodies
Yu, C., Wang, L., Ni, Y., & Wang, J. (2019) · RSC Advances · doi:10.1039/c9ra07328k · Cited by 1
[Progress in the regulation of bone remodeling at the cellular level].
Hu, Y., Wang, L., Jiang, L., Xu, H., & Zhu, S. (2017) · PubMed Central · doi:10.7507/1001-5515.201606011 · Cited by 1
Inhibition of osteoclastogenesis and inflammation by phosvitin and phosvitin hydrolysate via NF-κB and MAPK pathways in RAW 264.7 cells
Ren, J., Chakrabarti, S., & Wu, J. (2021) · Journal of Food Bioactives · doi:10.31665/jfb.2020.13261 · Cited by 1
Management of Peripheral Arterial Calcification
Moawad, M. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-81515-8_11 · Cited by 1
Bone Markers Throughout Sexual Development: Epidemiological Significance and Population-Based Findings
Lucas, R., Martins, A., Monjardino, T., Caetano‐Lopes, J., & Fonseca, J. E. (2016) · Biomarkers in disease · doi:10.1007/978-94-007-7745-3_26-1 · Cited by 1
Hypercalcemia: Other Causes than Primary Hyperparathyroidism
Rizzoli, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64344-1 · Cited by 1
[Effect of MT01/PEN complexes on the expression of osteoprotegerin and receptor activator of nuclear factor κB ligand in human osteoblast-like cell line MG63].
Ye, C., Yi, Z., Shen, Y., Hou, X., Lou, Y., & Xinhua, S. (2016) · PubMed Central · doi:10.7518/hxkq.2016.01.007
Detection of sonic hedgehog in patients undergoing orthognathic surgery
Kunisada, Y., Shimo, T., Masui, M., Yoshioka, N., Ibaragi, S., Matsumoto, K., Okui, T., Kurio, N., Domae, S., Kishimoto, K., et al. (2016) · International Journal of Surgery Open · doi:10.1016/j.ijso.2016.09.002
Avaliação dos níveis séricos e salivares de RANKL, OPG, IL-1?, IL-6 e TNF-? e sua relação com o índice da cortical mandibular em pacientes com cirrose hepática
Tenório, J. R. (2019) · doi:10.11606/t.23.2019.tde-08072020-132813
Osteoclast biology
Arnett, T. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00005-8
Total flavonoids of Chinese herb Rhizoma Drynariae alleviates bone loss in caged laying hensPreprint
Huang, J., Yu, Z., Tong, X., Zhang, L., Hu, Y., & Zhou, Z. (2019) · doi:10.21203/rs.2.18412/v1
Total flavonoids of Chinese herb Rhizoma Drynariae alleviates bone loss in caged laying hensPreprint
Huang, J., Yu, Z., Tong, X., Zhang, L., Hu, Y., & Zhou, Z. (2020) · doi:10.21203/rs.2.18412/v2
Faculty Opinions recommendation of SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nakajima, T., & Fujita, H. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733671993.793548965
Novel Small Molecule Inhibitor of Osteoclast Differentiation
Martin, M. L., Holliday, L. S., & Ostrov, D. A. (2022) · UF Journal of Undergraduate Research · doi:10.32473/ufjur.24.130745
Einfluss von Zoledronat und Denosumab auf humane Zellen der osteoblastären Linie aus dem Kieferknochen anhand osteogener Marker
Lautenbacher, F. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9917
Parabiosis reinvigorates age-related bone quality through Wnt/β-catenin signalingPreprint
Feng, R., Yu, T., Duan, X., Wu, G., Huang, Y., & Hu, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2961382/v1
Natural Dietary Antioxidants and Bone Health
Misra, S., Shyam, S., & Shin, T. S. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839166112-00348
miRNAs Associated with Bone Metastases in Breast Cancer
蔡, 艳. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.1361402
References
(2023) · Wiley eBooks · doi:10.1002/9781394236329.refs
Bone Remodeling – Clinical Evaluation
Nuti, R. (2023) · Endocrinology · doi:10.1007/978-3-030-19632-5_6-1 · Cited by 1
Inflammation and macrophage development
Izquierdo, E., Ardura, J. A., Gortázar, A. R., Alonso, V., Barker‐Tejeda, T. C., Pérez‐Gordo, M., & Escribese, M. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-821754-2.00006-0
Hypercalcemia: Other causes than primary hyperparathyroidism
Rizzoli, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00063-7
The role of bone in energy metabolism
Luo, X., Guo, Q., & Xiong, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0261
Fragilità ossea nel diabete: meccanismi fisiopatologici e strategie terapeutiche
Viola, V., Faraj, M., Cannata, F., & Napoli, N. (2025) · L Endocrinologo · doi:10.1007/s40619-025-01595-z
Nanovibrational stimulation of osteogenesis engages non-canonical Wnt signalling and NF-κB regulator BCL3 as a mechanotransducerPreprint
Jaffery, H., Dhawan, U., Williams, J. A., Huesa, C., Carmody, R. J., Windmill, J. F. C., Reid, S. D., Childs, P. G., Salmerón‐Sánchez, M., & Dalby, M. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.666351
Bone Fragility in Diabetes: Insights into Mechanisms and Therapeutic Strategies
Faraj, M., & Napoli, N. (2025) · Springer eBooks · doi:10.1007/978-3-032-01700-0_4
Emerging viroporins, RBP dynamics, and skeletal remodeling: Targeting liquid-liquid phase separation for dual antiviral and bone-protective therapies
Huai, Y., Wang, X., Yan, J. F., Li, S., Zhao, H., & Liao, B. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101445

Authors: Martin, T. J., & Sims, N. A.
Affiliations: The University of Melbourne (AU)
Corresponding author: Martin, T. John
ORCID: Martin, T. John
Sims, Natalie A.
Venue: Reviews in Endocrine and Metabolic Disorders
Publisher: Springer Science and Business Media LLC
Published: 2015-01-04
Volume: 16
Issue: 2
Pages: 131-139
ISSN: 1389-9155 (ISSN-L)
1573-2606
DOI: 10.1007/s11154-014-9308-6
OpenAlex: W1999943656
Cited by: 213
References: 88
Citations by year: 2026: 15 · 2025: 14 · 2024: 18 · 2023: 19 · 2022: 12 · 2021: 23 · 2020: 29 · 2019: 25 · 2018: 21 · 2017: 26 · 2016: 9 · 2015: 2
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Reviews in Endocrine and Metabolic Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Keywords: RANKL, osteoprotegerin, RANK, osteoclastogenesis, osteoblast lineage, bone physiology, bone remodeling
MeSH terms: Animals, Bone and Bones, Humans, Mutation, Osteoblasts, Signal Transduction, Paracrine Communication, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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RANKL/OPG; Critical role in bone physiology

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