Cited by 213Bone Metabolism and DiseasesBone health and osteoporosis researchOsteomyelitis and Bone Disorders Research

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RANKL/OPG; Critical role in bone physiology

Martin, T. John, Sims, Natalie A.·2015·Reviews in Endocrine and Metabolic Disorders

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Abstract

After it was proposed that the osteoblast lineage controlled the formation of osteoclasts, cell culture methods were developed that established this to be the case. Evidence was obtained that cytokines and hormones that promote osteoclast formation act first on osteoblast lineage cells to promote the production of a membrane-bound regulator of osteoclastogenesis. This proved to be receptor activator of NF-kB ligand (RANKL) a member of the tumor necrosis factor ligand family that acts upon its receptor RANK in the hematopoietic lineage, with interaction restricted by a decoy soluble receptor osteoprotegerin (OPG), also a product of the osteoblast lineage. The physiological roles of these factors were established through genetic and pharmacological studies, have led to a new physiology of bone, with complete revision of older ideas over the last 15 years, ultimately leading to the development of new pharmaceutical agents for bone disease.

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Authors: Martin, T. J., & Sims, N. A.
Affiliations: The University of Melbourne (AU)
Corresponding author: Martin, T. John
ORCID: Martin, T. John
Sims, Natalie A.
Venue: Reviews in Endocrine and Metabolic Disorders
Publisher: Springer Science and Business Media LLC
Published: 2015-01-04
Volume: 16
Issue: 2
Pages: 131-139
ISSN: 1389-9155 (ISSN-L)
1573-2606
DOI: 10.1007/s11154-014-9308-6
OpenAlex: W1999943656
Cited by: 213
References: 88
Citations by year: 2026: 15 · 2025: 14 · 2024: 18 · 2023: 19 · 2022: 12 · 2021: 23 · 2020: 29 · 2019: 25 · 2018: 21 · 2017: 26 · 2016: 9 · 2015: 2
FWCI: 1.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Reviews in Endocrine and Metabolic Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
Keywords: RANKL, osteoprotegerin, RANK, osteoclastogenesis, osteoblast lineage, bone physiology, bone remodeling
MeSH terms: Animals, Bone and Bones, Humans, Mutation, Osteoblasts, Signal Transduction, Paracrine Communication, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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RANKL/OPG; Critical role in bone physiology

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