Deep learning for diagnosis of head and neck cancers through radiographic data: a systematic review and meta-analysis
Abstract
Purpose This study aims to review deep learning applications for detecting head and neck cancer (HNC) using magnetic resonance imaging (MRI) and radiographic data. Methods Through January 2023, a PubMed, Scopus, Embase, Google Scholar, IEEE, and arXiv search were carried out. The inclusion criteria were implementing head and neck medical images (computed tomography (CT), positron emission tomography (PET), MRI, Planar scans, and panoramic X-ray) of human subjects with segmentation, object detection, and classification deep learning models for head and neck cancers. The risk of bias was rated with the quality assessment of diagnostic accuracy studies (QUADAS-2) tool. For the meta-analysis diagnostic odds ratio (DOR) was calculated. Deeks' funnel plot was used to assess publication bias. MIDAS and Metandi packages were used to analyze diagnostic test accuracy in STATA. Results From 1967 studies, 32 were found eligible after the search and screening procedures. According to the QUADAS-2 tool, 7 included studies had a low risk of bias for all domains. According to the results of all included studies, the accuracy varied from 82.6 to 100%. Additionally, specificity ranged from 66.6 to 90.1%, sensitivity from 74 to 99.68%. Fourteen studies that provided sufficient data were included for meta-analysis. The pooled sensitivity was 90% (95% CI 0.820.94), and the pooled specificity was 92% (CI 95% 0.87-0.96). The DORs were 103 (27-251). Publication bias was not detected based on the p-value of 0.75 in the meta-analysis. Conclusion With a head and neck screening deep learning model, detectable screening processes can be enhanced with high specificity and sensitivity.
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Emerging evidence suggests that AI-enabled applications can improve operational efficiency, clinical decision-making, patient triage, scheduling, and treatment planning when supported by appropriate governance, infrastructure, and workforce competencies.
“Similarly, emerging evidence suggests that AI-enabled applications can improve operational efficiency, clinical decision-making, patient triage, scheduling, and treatment planning when supported by appropriate governance, infrastructure, and workforce competencies”
From A Scoping Review of Implemented Innovations in Cancer Care: Implications for Pan-Canadian Scaling (2026) · cites this paper as [47]
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- Authors
- Rokhshad, R., Salehi, S. N., Yavari, A., Shobeiri, P., Esmaeili, M., Manila, N., Motamedian, S. R., & Mohammad-Rahimi, H.
- Affiliations
- Islamic Azad University, Tehran (IR)
- Isfahan University of Medical Sciences (IR)
- University of Tehran (IR)
- Louisiana State University (US)
- Shahid Beheshti University (IR)
- Corresponding author
- Motamedian, Saeed Reza
- ORCID
- Venue
- Oral Radiology
- Published
- 2023-10-19
- Volume
- 40
- Issue
- 1
- Pages
- 1-20
- ISSN
- 0911-6028 (ISSN-L)
- 1613-9674
- OpenAlex
- W4387765606
- Cited by
- 23
- References
- 59
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 3 · 2023: 2
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Oral Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- head and neck cancer, deep learning, computer-aided diagnosis, magnetic resonance imaging, computed tomography, positron emission tomography, panoramic radiography, diagnostic accuracy, sensitivity and specificity, cancer screening
- MeSH terms
- Deep Learning, Head and Neck Neoplasms, Humans, Magnetic Resonance Imaging, Sensitivity and Specificity, Positron-Emission Tomography
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