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Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer
Open accessAbstract
PurposeProstate-specific membrane antigen (PSMA) is a recognized target for imaging prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry results with [18F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate cancer.ProceduresBiodistribution was evaluated using sequential positron-emission tomography (PET) scans in nine patients with prostate cancer. Time-activity curves from the most avid tumor foci were determined. The radiation dose to selected organs was estimated using OLINDA/EXM.ResultsNo major radiotracer-specific adverse events were observed. Physiologic accumulation was observed in known sites of PSMA expression. Accumulation in putative sites of prostate cancer was observed (SUVmax up to >100, and tumor-to-blood ratios up to >50). The effective radiation dose from [18F]DCFPyL was 0.0139 mGy/MBq or 5 mGy (0.5 rem) from an injected dose of 370 MBq (10 mCi).Conclusions[18F]DCFPyL is safe with biodistribution as expected, and its accumulation is high in presumed primary and metastatic foci. The radiation dose from [18F]DCFPyL is similar to that from other PET radiotracers.
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Cited by
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Rowe, S. P., Macura, K. J., Mena, E., Blackford, A. L., Nadal, R., Antonarakis, E. S., Eisenberger, M., Carducci, M., Fan, H., Dannals, R. F., et al. (2016) · Molecular Imaging and Biology · doi:10.1007/s11307-016-0957-6 · Cited by 258
Self-citationWerner, R. A., Bundschuh, R. A., Bundschuh, L., Javadi, M. S., Leal, J. P., Higuchi, T., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.217588 · Cited by 55
Self-citationJansen, B. H. E., Jansen, R. W., Wondergem, M., Srbljin, S., de Klerk, J. M. H., Lissenberg-Witte, B. I., Vis, A. N., van Moorselaar, R. J. A., Boellaard, R., Hoekstra, O. S., et al. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.222513 · Cited by 12
Metadata
- Authors
- Szabo, Z., Mena, E., Rowe, S. P., Plyku, D., Nidal, R., Eisenberger, M. A., Antonarakis, E. S., Fan, H., Dannals, R. F., Chen, Y., Mease, R. C., Vranesic, M., Bhatnagar, A., Sgouros, G., Cho, S. Y., & Pomper, M. G.
- Venue
- Molecular Imaging and Biology
- Published
- 2015-04-21
- Volume
- 17
- Issue
- 4
- Pages
- 565-574
- ISSN
- 1536-1632 (ISSN-L)
- 1860-2002
- OpenAlex
- W1994463565
- Cited by
- 443
- References
- 0
- FWCI
- 42.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Szabo, Z., Mena, E., Rowe, S. P., Plyku, D., Nidal, R., Eisenberger, M. A., Antonarakis, E. S., Fan, H., Dannals, R. F., Chen, Y., Mease, R. C., Vranesic, M., Bhatnagar, A., Sgouros, G., Cho, S. Y., & Pomper, M. G. (2015). Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer. Molecular Imaging and Biology. https://doi.org/10.1007/s11307-015-0850-8
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