Acetaldehyde-Induced Oxidative Modifications and Morphological Changes in Isolated Human Erythrocytes: An in Vitro Study
Abstract
Acetaldehyde is a toxic, mutagenic and carcinogenic metabolite of alcohol which can bind to proteins, DNA and several other cellular macromolecules. Chronic alcohol consumption increases intracellular acetaldehyde levels which enhances the generation of reactive oxygen and nitrogen species (ROS and RNS). In this study, we have examined the effect of acetaldehyde on human erythrocytes under in vitro conditions. Treatment of human erythrocytes with different concentrations of acetaldehyde (0.05-2 mM) for 24 h at 37 °C increased intracellular generation of ROS and RNS. It also increased oxidation of proteins and lipids but decreased glutathione, total sulphhydryl and free amino group content. Methemoglobin level was increased accompanied by a decrease in methemoglobin reductase activity. Acetaldehyde impaired the antioxidant defence system and lowered the total antioxidant capacity of the cell. It decreased the activity of metabolic and membrane-bound enzymes and altered erythrocyte morphology. Our results show that acetaldehyde enhances the generation of ROS and RNS that results in oxidative modification of cellular components. This will lower the oxygen transporting ability of blood and shorten erythrocyte lifespan (red cell senescence).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GSH levels can be used as a biomarker for the oxidative status of the cell.
“As GSH levels can be used as a biomarker for the oxidative status of the cell [176,181,182,183]”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [181]
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,298 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · see citing works
[30] Microsomal lipid peroxidation
Buege, J. A., & Aust, S. D. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)52032-6 · Cited by 13,437 · see citing works
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382 · see citing works
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Sedlak, J., & Lindsay, R. H. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90092-4 · Cited by 8,092 · see citing works
Improved method for the determination of blood glutathione.
Beutler, E., Duron, O., & KELLY, B. M. (1963) · PubMed · Cited by 6,932 · see citing works
Prieto, P., Pineda, M., & Aguilar, M. R. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4019 · Cited by 6,232 · see citing works
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
[12] Assays of glutathione peroxidase
Flohé, L., & Günzler, W. A. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05015-1 · Cited by 4,954 · see citing works
A Rapid, Simple Spectrophotometric Method for Simultaneous Detection of Nitrate and Nitrite
Miranda, K. M., Espey, M. G., & Wink, D. A. (2001) · Nitric Oxide · doi:10.1006/niox.2000.0319 · Cited by 3,858 · see citing works
Carlberg, I., & Mannervik, B. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13062-4 · Cited by 3,009 · see citing works
Antioxidant Activity of Various Tea Extracts in Relation to Their Antimutagenicity
Yen, G., & Chen, H.-Y. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00049a007 · Cited by 2,634 · see citing works
A MICROCOLORIMETRIC METHOD FOR THE DETERMINATION OF INORGANIC PHOSPHORUS
Taussky, H. H., Shorr, E., & Kurzmann, G. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66180-0 · Cited by 2,587 · see citing works
Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions
Sheetz, M. P., & Singer, S. J. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4457 · Cited by 1,389 · see citing works
A review of human carcinogens–Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish
Secretan, B., Straif, K., Baan, R., Grosse, Y., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70326-2 · Cited by 1,114 · see citing works
Estimation of antiradical properties of antioxidants using DPPH assay: A critical review and results
Mishra, K., Ojha, H., & Chaudhury, N. K. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.127 · Cited by 1,097 · see citing works
Peroxynitrite, a Stealthy Biological Oxidant
Radí, R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.472936 · Cited by 891 · see citing works
Boffetta, P., & Hashibe, M. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70577-0 · Cited by 877 · see citing works
An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines
Snyder, S. L., & Sobocinski, P. Z. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90431-5 · Cited by 756 · see citing works
Studies on sodium-potassium-activated adenosine triphosphatase
BONTING, S. L., Simon, K. A., & Hawkins, N. M. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90170-9 · Cited by 687 · see citing works
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595 · cited 1× · see citing works
“Erythrocytes are continuously exposed to endogenous and exogenous ROS that induce oxidative stress, damage the cell and impair its function (Mohanty et al. 2014).”
BackgroundTamura, T., & Stadtman, T. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1006 · Cited by 538 · see citing works
Equations for the spectrophotometric analysis of hemoglobin mixtures
Benesch, R. E., Benesch, R., & Yung, S. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90309-6 · Cited by 445 · see citing works
ENZYME PATTERNS IN HUMAN TISSUES. I. METHODS FOR THE DETERMINATION OF GLYCOLYTIC ENZYMES.
Shonk, C. E., & Boxer, G. E. (1964) · PubMed · Cited by 431 · see citing works
Mammalian catalase: a venerable enzyme with new mysteries
Kirkman, H. N., & Gaetani, G. F. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.003 · Cited by 411 · see citing works
Bratosin, D., Estaquier, J., Petit, F., Arnoult, D., Quatannens, B., Tissier, J. P., Slomianny, C., Sartiaux, C., Alonso, C., Huart, J.-J., et al. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400946 · Cited by 393 · see citing works
Methemoglobin—It's not just blue: A concise review
Umbreit, J. N. (2006) · American Journal of Hematology · doi:10.1002/ajh.20738 · Cited by 380 · see citing works
A Critical Evaluation of the Effect of Sorbitol on the Ferric–Xylenol Orange Hydroperoxide Assay
Gay, C. A., & Gebicki, J. M. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4696 · Cited by 376 · see citing works
Acetaldehyde adducts in alcoholic liver disease
Setshedi, M., Wands, J. R., & de la Monte, S. M. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.3.12288 · Cited by 365 · see citing works
Mechanism of alcohol-induced oxidative stress and neuronal injury
Haorah, J., Ramirez, S. H., Floreani, N. A., Gorantla, S., Morsey, B., & Persidsky, Y. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.030 · Cited by 349 · see citing works
Byrnes, J. R., & Wolberg, A. S. (2017) · Blood · doi:10.1182/blood-2017-03-745349 · Cited by 346 · see citing works
Homann, N. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1739 · Cited by 318 · see citing works
Methods to Monitor ROS Production by Fluorescence Microscopy and Fluorometry
Wojtala, A., Bonora, M., Malińska, D., Pinton, P., Duszyński, J., & Wieckowski, M. R. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00013-3 · Cited by 289 · see citing works
A sensitive and simple method for determination of ferrocyanide
Avron, M., & Shavit, N. (1963) · Analytical Biochemistry · doi:10.1016/0003-2697(63)90149-0 · Cited by 272 · see citing works
Alcoholic disease: Liver and beyond
Rocco, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14652 · Cited by 260 · see citing works
Erythrocytes as a biological model for screening of xenobiotics toxicity
Farag, M. R., & Alagawany, M. M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.11.007 · Cited by 240 · see citing works
The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)
Eriksson, C. J. P. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02369.x · Cited by 235 · see citing works
The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)
Eriksson, C. J. P. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105051-00005 · Cited by 205 · see citing works
Gay, C. A., & Gebicki, J. M. (2003) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00606-1 · Cited by 199 · see citing works
Ethanol-induced oxidative stress: basic knowledge
Comporti, M., Signorini, C., Leoncini, S., Gardi, C., Ciccoli, L., Giardini, A., Vecchio, D., & Arezzini, B. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0159-9 · Cited by 188 · see citing works
Schallreuter, K. U., Elwary, S. M., Gibbons, N. C. J., Rokos, H., & Wood, J. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.082 · Cited by 182 · see citing works
Cazzola, R., Rondanelli, M., Russo-Volpe, S., Ferrari, E., & Cestaro, B. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300509-jlr200 · Cited by 161 · see citing works
Keller, A., Mohamed, A., Dröse, S., Brandt, U., Fleming, I., & Brandes, R. P. (2004) · Free Radical Research · doi:10.1080/10715760400022145 · Cited by 157 · see citing works
Iron-deficiency anaemia enhances red blood cell oxidative stress
Nagababu, E., Gulyani, S., Earley, C. J., Cutler, R. G., Mattson, M. P., & Rifkind, J. M. (2008) · Free Radical Research · doi:10.1080/10715760802459879 · Cited by 155 · see citing works
Peters, A. L., & Noorden, C. J. F. V. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953828 · Cited by 151 · see citing works
Yan, T., & Zhao, Y. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101381 · Cited by 137 · see citing works
Reaction of acetaldehyde with human erythrocyte membrane proteins
Gaines, K. C., Salhany, J. M., Tuma, D. J., & Sorrell, M. F. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80065-3 · Cited by 133 · see citing works
Seeman, J. I., Dixon, M., & Haussmann, H.-J. (2002) · Chemical Research in Toxicology · doi:10.1021/tx020069f · Cited by 132 · see citing works
Harwood, D. G., Kalechstein, A. D., Barker, W., Strauman, S., George‐Hyslop, P. S., Iglesias, C., Loewenstein, D., & Duara, R. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2372 · Cited by 112 · see citing works
Thioredoxin reductase inhibitors: a patent review
Zhang, B., Zhang, J., Peng, S., Liu, R., Li, X., Hou, Y., Han, X., & Fang, J. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1272576 · Cited by 96 · see citing works
Effect of ischemia and reperfusion on enzymes of carbohydrate metabolism in rat kidney
Khundmiri, S. J., Asghar, M., Khan, F., Salim, S., & Yusufi, A. N. K. (2004) · Journal of Nephrology · doi:10.1093/joneph/17.3.377 · Cited by 96 · see citing works
Local Acetaldehyde—An Essential Role in Alcohol-Related Upper Gastrointestinal Tract Carcinogenesis
Nieminen, M. T., & Salaspuro, M. P. (2018) · Cancers · doi:10.3390/cancers10010011 · Cited by 95 · see citing works
Human Erythrocyte Recycling of Ascorbic Acid
May, J. M., Qu, Z., & Cobb, C. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312548200 · Cited by 92 · see citing works
A novel fluorescent method for determination of peroxynitrite using folic acid as a probe
Huang, J., LI, D., DIAO, J., HOU, J., YUAN, J., & Zou, G.-Y. (2007) · Talanta · doi:10.1016/j.talanta.2007.01.033 · Cited by 79 · see citing works
Human Blood Acetaldehyde Levels: With Improved Methods, a Clearer Picture Emerges
Lindros, K. O. (1983) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1983.tb05414.x · Cited by 78 · see citing works
Studies on Methemoglobin Reductase
Fumio, K. U. M. A., Ishizawa, S., Hirayama, K., & Nakajima, H. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45737-2 · Cited by 67 · see citing works
Rizvi, S. I., & Pandey, K. B. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70330-3 · Cited by 59 · see citing works
Barodka, V. M., Nagababu, E., Mohanty, J. G., Nyhan, D. P., Berkowitz, D. E., Rifkind, J. M., & Strouse, J. J. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.10.004 · Cited by 57 · see citing works
Santos, H. D. L., Lopes, M. L., Maggio, B., & Ciancaglini, P. (2005) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.12.013 · Cited by 56 · see citing works
Qasim, N., & Mahmood, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141975 · Cited by 55 · see citing works
Self-citationRedox Reactions and Electron Transfer Across the Red Cell Membrane
Kennett, E. C., & Kuchel, P. W. (2003) · IUBMB Life · doi:10.1080/15216540310001592843 · Cited by 55 · see citing works
Novitskiy, G., Traore, K., Wang, L., Trush, M. A., & Mezey, E. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00171.x · Cited by 53 · see citing works
Çekiç, S. D., Kara, N., Tütem, E., Başkan, K. S., & Apak, R. (2012) · Analytical Letters · doi:10.1080/00032719.2011.653901 · Cited by 49 · see citing works
Human blood acetaldehyde (update 1992).
Eriksson, C. J. P., & Fukunaga, T. (1993) · PubMed · Cited by 48 · see citing works
Linderborg, K., Salaspuro, M. P., & Vakevainen, S. M. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.05.024 · Cited by 43 · see citing works
Yan, T., Zhao, Y., & Zhang, X. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4512309 · Cited by 41 · see citing works
Wang, Y., Yang, L., Cheng, W., Liu, M., Chen, X., Zhang, K., Chen, H., & Liao, Z. (2009) · Legal Medicine · doi:10.1016/j.legalmed.2009.01.097 · Cited by 40 · see citing works
Self-digestion of human erythrocyte membranes. Role of adenosine triphosphate and glutathione
BROVELLI, A., Suhail, M., Pallavicini, G., Sinigaglia, F., & Balduini, C. L. (1977) · Biochemical Journal · doi:10.1042/bj1640469 · Cited by 37 · see citing works
Characterization of the Increased Binding of Acetaldehyde to Red Blood Cells in Alcoholics
Hernández-Muñoz, R. E., Baraona, E., Blacksberg, I., & Lieber, C. S. (1989) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1989.tb00399.x · Cited by 36 · see citing works
Acetaldehyde is an oxidative stressor for gastric epithelial cells
Tamura, M., Ito, H., Matsui, H., & Hyodo, I. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-12 · Cited by 36 · see citing works
Acetylcholinesterase provides new insights into red blood cell ageing in vivo and in vitro.
Leal, J. K. F., Adjobo-Hermans, M. J. W., Brock, R. E., & Bosman, G. J. C. G. M. (2017) · Europe PMC (PubMed Central) · doi:10.2450/2017.0370-16 · Cited by 35 · see citing works
Maurya, P. K., Kumar, P., & Chandra, P. (2015) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2015.1136648 · Cited by 31 · see citing works
Erythrocyte and plasma protein modification in alcoholism: A possible role of acetaldehyde
Tyulina, O. V., Prokopieva, V. D., Болдырев, А. А., & Johnson, P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.03.003 · Cited by 30 · see citing works
Braun, K. P., Pavlovich, J. G., Jones, D. R., & Peterson, C. M. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03726.x · Cited by 30 · see citing works
The plasma membrane redox system: a candidate source of aging-related oxidative stress
de Grey, A. D. N. J. (2005) · AGE · doi:10.1007/s11357-005-1630-1 · Cited by 29 · see citing works
Ansari, F. A., & Mahmood, R. (2016) · Cell Biology International · doi:10.1002/cbin.10628 · Cited by 29 · see citing works
Self-citationGlucose‐6‐phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells
Peters, A. L., van Bruggen, R., de Korte, D., Noorden, C. J. F. V., & Vlaar, A. P. J. (2015) · Transfusion · doi:10.1111/trf.13378 · Cited by 26 · see citing works
Erythrocyte plasma membrane redox system may determine maximum life span
Rizvi, S. I., Kumar, D., Chakravarty, S., & Singh, P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2010.12.014 · Cited by 26 · see citing works
Reaction of Acetaldehyde with Proteins: Formation of Stable Fluorescent Adducts
Hoffmann, T., Meyer, R. J., Sorrell, M. F., & Tuma, D. J. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00728.x · Cited by 26 · see citing works
Vajreswari, A., RUPALATHA, M., & Rao, P. S. (2002) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.48.365 · Cited by 22 · see citing works
Clinical implications of acetaldehyde adducts with hemoglobin.
Cm, P., & Lb, N. (1985) · PubMed · Cited by 21 · see citing works
Unt, E., Kairane, Č., Vaher, I., & Zilmer, M. (2008) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Maheshwari, N., Khan, F. H., & Mahmood, R. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1327714 · Cited by 15 · see citing works
Self-citationSolomon, L. R. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90101-5 · Cited by 14 · see citing works
Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus.
Reshamwala, S. M. S., & Patil, N. D. (2005) · PubMed · Cited by 11 · see citing works
Buthet, L. R., Maciel, M. E., Quintans, L. N., de Castro, C. R., Costantini, M. H., Fanelli, S. L., Castro, J. A., & Castro, G. D. (2013) · Journal of Toxicology · doi:10.1155/2013/161496 · Cited by 8 · see citing works
Pastorino, R., Iuliano, L., Vecchioni, A., Arzani, D., Milić, M., Annunziata, F., Zerbinati, C., Capoluongo, E., Bonassi, S., McKay, J., et al. (2017) · Drug Testing and Analysis · doi:10.1002/dta.2251 · Cited by 7 · see citing works
Waris, S., Habib, S., Tantry, I. Q., Khan, R. H., Mahmood, R., & Ali, A. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.03.013 · Cited by 6 · see citing works
Self-citationCharacterization of Membrane and Cytosolic Proteins of Erythrocytes
Álvarez‐Llamas, G., de la Cuesta, F., Barderas, M. G., Zubiri, I., Posada-Ayala, M., & Vivanco, F. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-405-0_6 · Cited by 5 · see citing works
Naproxen-induced methemoglobinemia in an alcohol-dependent patient
Lee, W. S., Lee, J. Y., Sung, W. Y., & Seo, S. W. (2014) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2014.04.027 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism
Pham, V. N., Bruemmer, K. J., Toh, J. D. W., Ge, E. J., Tenney, L., Ward, C. C., Dingler, F. A., Millington, C. L., García-Prieto, C. A., Pulos-Holmes, M. C., et al. (2023) · Science · doi:10.1126/science.abp9201 · Cited by 88 · see citing works
Sui, Y., Ansari, M. F., Fang, B., Zhang, S., & Zhou, C. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113557 · Cited by 59 · see citing works
Study on the release characteristics of volatile organic compounds from different aged asphalt
Zhang, X., Tang, B., Cao, X., Li, J., & Zhu, H. (2023) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2023.138774 · Cited by 50 · see citing works
Chung, J., Akter, S., Han, S., Shin, Y., Choi, T., Kang, I., & Kim, S. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010129 · Cited by 49 · see citing works
Sicińska, P., Malinowska, K., & Bukowska, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124480 · Cited by 37 · see citing works
Guo, M., Gu, L., Hui, H., Li, X., & Jin, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.830532 · Cited by 23 · see citing works
Pyun, C., Seo, T.-S., Kim, D. J., Kim, T.-W., & Bae, J.-S. (2020) · BioMed Research International · doi:10.1155/2020/9720387 · Cited by 17 · see citing works
Chen, J., Zhang, Q., Wang, R., Yang, Y., Wang, Y., Liu, X., Zhang, X., Qiao, X., Zhong, G., Wei, J., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116230 · Cited by 15 · see citing works
Yano, S., Wang, J., Kabayama, S., & Hara, T. (2021) · Antioxidants · doi:10.3390/antiox10050801 · Cited by 14 · see citing works
Sinha, R. K. (2022) · Plasmonics · doi:10.1007/s11468-022-01763-z · Cited by 13 · see citing works
Foucault, A., Ravalet, N., Besombes, J., Picou, F., Gallay, N., Babin, L., Bourgeais, J., Hamard, S., Domenech, J., Loyer, P., et al. (2021) · Cancers · doi:10.3390/cancers13225699 · Cited by 13 · see citing works
Li, Q., He, R., Feng, F., Jiang, C., Song, S., Peng, H., & Tang, X. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135863 · Cited by 12 · see citing works
Bisphenol A and Bisphenol S Oxidative Effects in Sheep Red Blood Cells: An In Vitro Study
Baralla, E., Demontis, M. P., Varoni, M. V., & Pasciu, V. (2021) · BioMed Research International · doi:10.1155/2021/6621264 · Cited by 10 · see citing works
Coral Hydrate, a Novel Antioxidant, Improves Alcohol Intoxication in Mice
Wu, H., Chao, T., Ou, H., & Tsai, L. (2022) · Antioxidants · doi:10.3390/antiox11071290 · Cited by 10 · see citing works
The ALDH2, IGSF9, and PRDM16 Proteins as Predictive Biomarkers for Prognosis in Breast Cancer
Han, Y., Fu, Y., Shi, Q., Liu, H., Sun, H. Q., Niu, C., & Fu, L. (2022) · Clinical Breast Cancer · doi:10.1016/j.clbc.2022.12.009 · Cited by 9 · see citing works
ALDH2 gene rs671 G > a polymorphism and the risk of colorectal cancer: A hospital‐based study
Zhang, Z., Chen, Y., Zhuo, Q., Deng, C., Yang, Y., Luo, W., Lai, S., & Rao, H. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24789 · Cited by 9 · see citing works
Zhang, J., Wang, H., Chen, H., Liu, Y., Wang, A., Hou, H., & Hu, Q. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27508-x · Cited by 8 · see citing works
Liao, L., & Pinhu, L. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14483 · Cited by 7 · see citing works
Da, F., Meng, Y.-T., Chen, Y., Yuan, Z.-W., Liu, Y., & Dai, Z.-H. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102913 · Cited by 4 · see citing works
Zhai, Z., Yamauchi, T., Sandoval, K., Villarreal, K., Kwong, M. W. C., Swanson, E. J., Tan, A. C., & Fujita, M. (2025) · Cells · doi:10.3390/cells14120913 · Cited by 4 · see citing works
Le, Y. T.-H., Youn, J., Cho, H., Jeon, K., Lim, J., & Jeon, K. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119578 · Cited by 4 · see citing works
Robsha, O., Girma, S., Teshome, T., & Kanko, T. K. (2025) · PLoS ONE · doi:10.1371/journal.pone.0336409 · Cited by 3 · see citing works
Li, S., Nawroth, P. P., & Krøll, J. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03130-2 · Cited by 3 · see citing works
Tao, D., Wang, Y., Liu, J., Chen, R., Qi, M., & Xu, S. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111730 · Cited by 3 · see citing works
Protective Effect of Probiotic in Alcohol-Induced Liver Disorders
Bedi, O., Chaudhary, S., & Singh, T. G. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_8 · Cited by 3 · see citing works
Mechanisms of Acetaldehyde-Induced Organ Injury via Impairment of Vascular Endothelial Cells
Xie, M.-Z., Dong, J.-Q., Guo, C., Ge, S., Sun, R.-X., & Lin, F. (2025) · Vascular Health and Risk Management · doi:10.2147/vhrm.s560614 · Cited by 2 · see citing works
Melese, D. M., Mekonen, W., Aragaw, A., Asefa, A., & Belete, A. M. (2022) · Journal of Blood Medicine · doi:10.2147/jbm.s373280 · Cited by 2 · see citing works
Yang, Y., Liang, Q., Chen, Y., Cao, Y., Zhuo, Q., Liu, B., & Wang, S. (2023) · Journal of International Medical Research · doi:10.1177/03000605231206257 · Cited by 2 · see citing works
Antil, S., Varatharajan, G. R., Ndayishimiye, J. C., Nyirabuhoro, P., Saldaev, D. A., Kumar, S., Toteja, R., Makhija, S., Terza, A. L., & Mazei, Y. (2026) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2026.107412 · Cited by 2 · see citing works
A-Fe 2O 3 Nanoparticles Release During Cooking Using Cast Iron Wok in a Commercial RestaurantPreprint
Le, Y. T.-H., Youn, J., Cho, H., & Jeon, K. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3986947
Zhang, Q., Shi, F., Song, B.-J., Bao, Y., & Cao, Y. (2024) · Pan African Medical Journal · doi:10.11604/pamj.2024.49.37.44226
Impact des pesticides sur le microenvironnement médullaire des hémopathies myéloïdes
Foucault, A. (2021) · theses.fr (ABES) · doi:10.70675/51b4285ez9d41z40faz9d68zb018c0bd6733
- Authors
- Waris, S., Patel, A., Ali, A., & Mahmood, R.
- Affiliations
- Aligarh Muslim University (IN)
- King Khalid University (SA)
- Corresponding author
- Mahmood, Riaz
- Venue
- Environmental Science and Pollution Research
- Published
- 2020-03-02
- Volume
- 27
- Issue
- 14
- Pages
- 16268-16281
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W3010490567
- Cited by
- 33
- References
- 93
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 4
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- acetaldehyde, human erythrocytes, oxidative stress, reactive oxygen species, reactive nitrogen species, protein oxidation, lipid peroxidation, glutathione depletion, methemoglobin, methemoglobin reductase, antioxidant capacity, erythrocyte morphology, alcohol consumption
- MeSH terms
- Acetaldehyde, Erythrocytes, Glutathione, Humans, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review