Emerging risk of environmental factors: insight mechanisms of Alzheimer’s diseases.
Abstract
Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. Latest observations have hypothesized that exposure of environmental factors may increase the prospective risk of Alzheimer's diseases (AD). However, the role of environmental factors as a possible dangerous issue has extended importance concerned in AD pathology, although actual etiology of the disorder is still not yet clear. Thus, the aim of this review is to highlight the possible correlation between environmental factors and AD, based on the present literature view. Environmental risk factors might play an important role in decelerating or accelerating AD progression. Among well-known environmental risk factors, prolonged exposure to several heavy metals, for example, aluminum, arsenic, cadmium, lead, and mercury; particulate air, and some pesticides as well as metal-containing nanoparticles have been participated to cause AD. These heavy metals have the capacity to enhance amyloid β (Aβ) peptide along with tau phosphorylation, initiating amyloid/senile plaques, as well as neurofibrillary tangle formation; therefore, neuronal cell death has been observed. Furthermore, particulate air, pesticides, and heavy metal exposure have been recommended to lead AD susceptibility and phenotypic diversity though epigenetic mechanisms. Therefore, this review deliberates recent findings detailing the mechani…
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Many individuals are likely to develop LOAD due to a combination of genetic and environmental factors.
“Studies also suggest that genetic factors may only contribute between 50 and 70% of the risk for LOAD, meaning many individuals are likely to develop LOAD due to a combination of genetic and environmental factors (Kawahara et al., 2017; Sarkar et al., 2019; Rahman et al., 2020; Kim et al., 2021).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Rahman et al., 2020
Genetic factors may contribute only between 50 and 70% of the risk for LOAD.
“Studies also suggest that genetic factors may only contribute between 50 and 70% of the risk for LOAD, meaning many individuals are likely to develop LOAD due to a combination of genetic and environmental factors (Kawahara et al., 2017; Sarkar et al., 2019; Rahman et al., 2020; Kim et al., 2021).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Rahman et al., 2020
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- Authors
- Rahman, M. A., Rahman, M. S., Uddin, M. J., Mamum-Or-Rashid, A. N. M., Pang, M.-G., & Rhim, H.
- Affiliations
- Islamic University (BD)
- Chung-Ang University (KR)
- Ewha Womans University (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Rahman, Md Ataur
- Rhim, Hyewhon
- Venue
- Environmental Science and Pollution Research
- Published
- 2020-03-23
- Volume
- 27
- Issue
- 36
- Pages
- 44659-44672
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W3012828832
- Cited by
- 115
- References
- 9
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 27 · 2023: 15 · 2022: 19 · 2021: 11 · 2020: 8
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- Alzheimer's disease, environmental risk factors, heavy metal exposure, aluminum, arsenic, cadmium, lead, mercury, particulate matter pollution, pesticide exposure, metal-containing nanoparticles, amyloid-beta, tau phosphorylation, neurofibrillary tangles, amyloid plaques, neuronal cell death, epigenetic mechanisms, neurodegeneration
- MeSH terms
- Alzheimer Disease, Humans, Phosphorylation, Prospective Studies, Amyloid beta-Peptides, Epigenesis, Genetic
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