Cited by 133Advanced Glycation End Products researchPhytochemicals and Antioxidant ActivitiesFlavonoids in Medical Research

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Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase

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Kim, Ji Min, Lee, Eun Kyeong, Kim, Dae Hyun, Yu, Byung Pal, Chung, Hae Young·2010·AGE

DOI 10.1007/s11357-009-9124-1PMC PMC2861750

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Abstract

Advanced glycation endproducts (AGE) are oxidative products formed from the reaction between carbohydrates and a free amino group of proteins that are provoked by reactive species (RS). It is also known that AGE enhance the generation of RS and that the binding of AGE to a specific AGE receptor (RAGE) induces the activation of the redox-sensitive, pro-inflammatory transcription factor, nuclear factor-kappa B (NF-kB). In this current study, we investigated the anti-oxidative effects of short-term kaempferol supplementation on the age-related formation of AGE and the binding activity of RAGE in aged rat kidney. We further investigated the suppressive action of kaempferol against AGE's ability to stimulate activation of pro-inflammatory NF-kB and its molecular mechanisms. For this study, we utilized young (6 months old), old (24 months old), and kaempferol-fed (2 and 4 mg/kg/day for 10 days) old rats. In addition, for the molecular work, the rat endothelial cell line, YPEN-1 was used. The results show that AGE and RAGE were increased during aging and that these increases were blunted by kaempferol. In addition, dietary kaempferol reduced age-related increases in NF-kappaB activity and NF-kB-dependant pro-inflammatory gene activity. The most significant new finding from this study is that kaempferol supplementation prevented age-related NF-kappaB activation by suppressing AGE-induced nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). Taken together, our results demonstrated that dietary kaempferol exerts its anti-oxidative and anti-inflammatory actions by modulating the age-related NF-kappaB signaling cascade and its pro-inflammatory genes by suppressing AGE-induced NADPH oxidase activation. Based on these data, dietary kaempferol is proposed as a possible anti-AGE agent that may have the potential for use in anti-inflammation therapies.

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Authors: Kim, J. M., Lee, E. K., Kim, D. H., Yu, B. P., & Chung, H. Y.
Affiliations: Pusan National University (KR)
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Chung, Hae Young
ORCID: Kim, Ji Min
Lee, Eun Kyeong
Chung, Hae Young
Venue: AGE
Publisher: Springer Science and Business Media LLC
Published: 2010-01-13
Volume: 32
Issue: 2
Pages: 197-208
ISSN: 0161-9152 (ISSN-L)
1574-4647
DOI: 10.1007/s11357-009-9124-1
PMC: PMC2861750
OpenAlex: W1989395374
Cited by: 133
References: 50
Citations by year: 2026: 15 · 2025: 12 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 11 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 3 · 2013: 2 · 2012: 6
FWCI: 4.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: AGE (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation
National Research Foundation of Korea
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Keywords: kaempferol, advanced glycation end products, NF-κB activation, NADPH oxidase, AGE receptor, aging, oxidative stress, inflammation, dietary supplementation, kidney, endothelial cells
MeSH terms: Animals, Antioxidants, Kidney, Male, Rats, Inbred F344, Transfection, Blotting, Western, NF-kappa B, Glycation End Products, Advanced, Reactive Oxygen Species, NADPH Oxidases, Kaempferols, Rats

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Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase

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