The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
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Many existing models assume a linear relation between biomarkers of aging and the likelihood of aging outcomes throughout the lifespan, while recent studies have discovered multiple examples of non-linearity.
“For example, many existing models assume a linear relation between biomarkers of aging and the likelihood of aging outcomes throughout the lifespan, while recent studies have discovered multiple examples of non-linearity5,12,49.”
From Validation of biomarkers of aging (2024) · cites this paper as [49]
The ‘Challenges in defining healthspan’ section describes health as changing dynamically over life, but it does not discuss linear assumptions in biomarker-based models or report studies finding nonlinear relationships with aging outcomes. Searches for the claimed linear relation and for nonlinear biomarker–outcome models found no passage addressing either point; page numbers were unavailable in our copy. (LLM, conf=0.76)
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Rapamycin extends murine lifespan but has limited effects on aging
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67674 · Cited by 374
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Research works printed but not linked: 21
- An JY, Quarles EK, Mekvanich S, Kang A, Liu A, Santos D, Miller RA, Rabinovitch PS, Cox TC, Kaeberlein M (2017) Rapamycin treatment attenuates age-associated periodontitis in mice. Geroscience 39:457–463. https://doi.org/10.1007/s11357-017-9994-6 · DOI
- Bansal A, Zhu LJ, Yen K, Tissenbaum HA (2015) Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A 112:E277–E286. https://doi.org/10.1073/pnas.1412192112 · DOI · Paper page
- Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M (2016) Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife 5:e16351. https://doi.org/10.7554/eLife.16351 · DOI · Paper page
- Burch JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC (2014) Advances in geroscience: impact on healthspan and chronic disease. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S1–S3. https://doi.org/10.1093/gerona/glu041 · DOI
- Ewald CY, Castillo-Quan JI, Blackwell TK (2018) Untangling longevity, Dauer, and healthspan in Caenorhabditis elegans insulin/IGF-1-signalling. Gerontology 64:96–104. https://doi.org/10.1159/000480504 · DOI
- Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D, Olshansky SJ (2013) Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff 32:1698–1705. https://doi.org/10.1377/hlthaff.2013.0052 · DOI · Paper page
- Hahm JH, Kim S, DiLoreto R, Shi C, Lee SJ, Murphy CT, Nam HG (2015) C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun 6:8919. https://doi.org/10.1038/ncomms9919 · DOI
- Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M (2013) Preserving youth: does rapamycin deliver? Sci Transl Med 5:211fs240. https://doi.org/10.1126/scitranslmed.3007316 · DOI
- Johnson SC, Sangesland M, Kaeberlein M, Rabinovitch PS (2015) Modulating mTOR in aging and health. Interdiscip Top Gerontol 40:107–127. https://doi.org/10.1159/000364974 · DOI
- Kane AE, Gregson E, Theou O, Rockwood K, Howlett SE (2017) The association between frailty, the metabolic syndrome, and mortality over the lifespan. Geroscience 39:221–229. https://doi.org/10.1007/s11357-017-9967-9 · DOI
- Kim S, Myers L, Wyckoff J, Cherry KE, Jazwinski SM (2017) The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. Geroscience 39:83–92. https://doi.org/10.1007/s11357-017-9960-3 · DOI
- Leiser SF, Begun A, Kaeberlein M (2011) HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging Cell 10:318–326. https://doi.org/10.1111/j.1474-9726.2011.00672.x · DOI
- Mitnitski AB, Rutenberg AD, Farrell S, Rockwood K (2017) Aging, frailty and complex networks. Biogerontology 18:433–446. https://doi.org/10.1007/s10522-017-9684-x · DOI · Paper page
- Nikolich-Zugich J et al (2016) Preparing for an aging world: engaging biogerontologists, geriatricians, and the society. J Gerontol A Biol Sci Med Sci 71:435–444. https://doi.org/10.1093/gerona/glv164 · DOI
- Pijnenburg MA, Leget C (2007) Who wants to live forever? Three arguments against extending the human lifespan. J Med Ethics 33:585–587. https://doi.org/10.1136/jme.2006.017822 · DOI
- Richardson A (2013) Rapamycin, anti-aging, and avoiding the fate of Tithonus. J Clin Invest 123:3204–3206 · DOI
- Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN (2016) Measures of healthspan as indices of aging in mice-a recommendation. J Gerontol A Biol Sci Med Sci 71:427–430. https://doi.org/10.1093/gerona/glv080 · DOI · Paper page
- Sierra F, Kohanski R (2017) Geroscience and the trans-NIH Geroscience interest group. GSIG Geroscience 39:1–5. https://doi.org/10.1007/s11357-016-9954-6 · DOI · Paper page
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- Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M (2012) Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan 1:9. https://doi.org/10.1186/2046-2395-1-9 · DOI
- Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience 39:117–127. https://doi.org/10.1007/s11357-017-9972-z · DOI · Paper page
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Validation of biomarkers of aging
Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02784-9 · Cited by 361
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278
Identification of 12 genetic loci associated with human healthspan
Zenin, A., Tsepilov, Y., Sharapov, S., Getmantsev, E., Menshikov, L. I., Fedichev, P. O., & Aulchenko, Y. (2019) · Communications Biology · doi:10.1038/s42003-019-0290-0 · Cited by 170
Targeting aging mechanisms: pharmacological perspectives
Moskalev, A., Guvatova, Z., Lopes, I. D. A., Beckett, C. W., Kennedy, B. K., De Magalhaes, J. P., & Makarov, A. A. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.007 · Cited by 164
Glossmann, H. H., & Lutz, O. M. D. (2019) · Gerontology · doi:10.1159/000502257 · Cited by 149
Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension
Musci, R., Hamilton, K., & Linden, M. (2019) · Sports · doi:10.3390/sports7070170 · Cited by 73
Khokhar, E. S., Borikar, S., Eudy, E., Stearns, T., Young, K., & Trowbridge, J. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.014 · Cited by 26
Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone
Liu, T., Gatto, N. M., Chen, Z., Qiu, H., Lee, G., Duerksen-Hughes, P., Fraser, G., & Wang, C. (2020) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbaa037 · Cited by 26
A Regulatory Pathway for Medicines That Target Aging
Fleming, G. A., Zhao, J. H., Seoh, T. C., & Barzilai, N. (2019) · Public Policy & Aging Report · doi:10.1093/ppar/prz018 · Cited by 7
Metadata
- Authors
- Kaeberlein, M.
- Venue
- GeroScience
- Published
- 2018-08
- Volume
- 40
- Issue
- 4
- Pages
- 361-364
- ISSN
- 2509-2715
- 2509-2723
- Cited by
- 176
- References
- 1
- Language
- en
- Funders
- National Institute on Aging (P30AG013280)
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