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The influence of GDF11 on brain fate and function

Schafer, Marissa J., LeBrasseur, Nathan K.·2019·GeroScience
DOI 10.1007/s11357-019-00054-6
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  • RNA-seq of hippocampal tissues from middle-aged mice treated with TAC for 3 weeks induced a significant increase in expression of genes positively associated with adult hippocampus neurogenesis and brain function, including Eomes, Dlk1, Gdnf, Dcx, Sox1/2, Gdf11, and Fos.

    “Remarkably, TAC treatment induced a significant increase in the expression of genes positively associated with adult hippocampus neurogenesis and brain function,30–35 including Eomes, a driver of immune cell development & neurogenesis, Dlk1, a mediator of adult hippocampal neurogenesis and cognition, Gdnf, a neurotrophic factor, Dcx, a marker for new-born neurons, Sox1/2, critical determinants of”

    From TERT activation targets DNA methylation and multiple aging hallmarks (2024) · cites this paper as [35]

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Research works printed but not linked: 58

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Metadata

Authors
Schafer, M. J., & LeBrasseur, N. K.
Venue
GeroScience
Publisher
Springer Science and Business Media LLC
Published
2019-02
Volume
41
Issue
1
Pages
1-11
ISSN
  • 2509-2715
  • 2509-2723
DOI
10.1007/s11357-019-00054-6
Cited by
39
References
6
Language
en
Licence
www.springer.com/tdm (tdm)
Funders
Alzheimer's Disease Research Center, Mayo Clinic

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