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Cited by 45Garlic and Onion StudiesBlood Pressure and Hypertension StudiesBotanical Studies and Applications

The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats

Asdaq, Syed Mohammed Basheeruddin, Inamdar, Mohammed Naseeruddin·2011·Journal of Natural Medicines
DOI 10.1007/s11418-010-0467-9
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Abstract

The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administered garlic (125, 250 and 500 mg/kg, 3 weeks in separate groups) and HCTZ (10 mg/kg, 6th week) once daily in their respective groups. At the end of 6 weeks, myocardial damage was induced by subcutaneous administration of isoproterenol (175 mg/kg) for 2 consecutive days. The results showed that garlic and HCTZ increase the lactate dehydrogenase, creatinine phosphokinase, superoxide dismutase and catalase activities in heart homogenate when used concurrently or separately. Further, restoration of normal values in fluid/food intake, body weight, systolic blood pressure, cholesterol, triglycerides, glucose and histopathological scores were observed in all treated groups. Furthermore, histological disturbances and hypertension were significantly ameliorated in treated animals. Moreover, moderate dose of garlic was more effective than low dose, while a high dose of garlic was least effective in correcting electrocardiographic changes. Thus it is concluded that garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against fructose- and isoproterenol-induced toxicities.

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Crossref · 10.1007/s11418-010-0467-9

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  • Combination therapy of 250 mg/kg of garlic with hydrochlorothiazide shows synergistic antihypertensive and cardioprotective activities against toxicity caused by fructose and isoproterenol.

    “Asdaq and Inamdar. [126] indicated that the combination therapy of 250 mg/kg of garlic with hydrochlorothiazide shows synergistic antihypertensive and cardioprotective activities against toxicity caused by fructose and isoproterenol.”

    From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [126]

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Authors
Asdaq, S. M. B., & Inamdar, M. N.
Affiliations
Al-Ameen College of Pharmacy (IN)
Corresponding author
Asdaq, Syed Mohammed Basheeruddin
ORCID
Asdaq, Syed Mohammed Basheeruddin
Venue
Journal of Natural Medicines
Publisher
Springer Science and Business Media LLC
Published
2010-09-07
Volume
65
Issue
1
Pages
81-88
ISSN
  • 1340-3443 (ISSN-L)
  • 1861-0293
DOI
10.1007/s11418-010-0467-9
OpenAlex
W2057776478
Cited by
45
References
37
Citations by year
2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 7 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 4
FWCI
5.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Natural Medicines (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
Keywords
garlic, hydrochlorothiazide, hypertension, cardioprotection, myocardial injury, isoproterenol-induced cardiotoxicity, fructose-induced hypertension, combination therapy, antioxidant enzymes, superoxide dismutase, catalase, lactate dehydrogenase, creatine kinase, electrocardiographic changes, synergistic effect, dose-dependent effects
MeSH terms
Animals, Antihypertensive Agents, Blood Pressure, Electrocardiography, Female, Garlic, Heart, Hydrochlorothiazide, Isoproterenol, Myocardium, Plant Extracts, Rats, Wistar, Rats

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