The DOI matches its Crossref record; 126 of the 127 references it cites were found in a registry or an index.
Microglia: A Central Player in Depression
Open accessAbstract
Summary: Microglia are the major immune cells in the central nervous system and play a key role in the normal function of the brain. Microglia exhibit functional diversity, and they control the inflammation in central nervous system through releasing inflammatory cytokine, clearing apoptotic cells via phagocytosis, regulating synaptic plasticity and the formation of neural network by synapse pruning. Recent studies have strongly indicated that the microglial dysfunction is associated with a variety of neuropsychiatric diseases such as depression, which have been termed as “microgliopathy”. The emergency of advanced technologies and tools has enabled us to comprehensively understand the role of microglia in physiology and pathology, and growing studies have targetted microglia to explore the treatment of neuropsychiatric diseases. Here, we describe the key progress of microglia research, and review the recent developments in the understanding of the role of microglia in physiology and etiology of depression.
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“Therefore, the occurrence and development of depression may be associated with neuroglial cells.269”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [269]
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Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
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Kukuia, K. K. E., Takyi, F. Y., Dugbartey, G. J., Amoateng, P., Kudzi, W., Amponsah, S. K., Koomson, A. E., Appiah, F., Adi‐Dako, O., Ameyaw, E. O., et al. (2023) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17508.1
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Bhardwaj, S., Kaur, R., Kumari, P., Sharma, S. K., Pasricha, C., Jamwal, N., Singh, R., Arora, P., Kaur, P., & Sahu, S. K. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/20248601039
Kukuia, K. K. E., Takyi, F. Y., Dugbartey, G. J., Amoateng, P., Kudzi, W., Amponsah, S. K., Koomson, A. E., Appiah, F., Adi‐Dako, O., Ameyaw, E. O., et al. (2024) · Molecular Psychology Brain Behavior and Society · doi:10.12688/molpsychol.17508.2
Wang, H., He, Y., Sun, Z., Ren, S., Liu, M., Wang, G., & Yang, J. (2022) · Figshare · doi:10.6084/m9.figshare.20012331
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Shao, Y., Wu, B., Zhang, X., Zhang, Q., Zhang, B., Xu, K., Jiang, L., Roberts, N., & Jia, Z. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03174-5
Liu, X., & Guo, Z. (2026) · Depression and Anxiety · doi:10.1155/da/8792696
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Melin, E. O., Landin‐Olsson, M., & Hillman, M. (2026) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2026.100457
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Jia, Y., Zhao, S., Miao, F., Yang, Z., Zhao, S., Wu, Q., Wang, Y., & Xia, X. (2026) · Inflammation and Regeneration · doi:10.1186/s41232-026-00444-2
Metadata
- Authors
- Deng, S.-L., Chen, J.-G., & Wang, F.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Wang, Fang
- Venue
- Current Medical Science
- Published
- 2020-06
- Volume
- 40
- Issue
- 3
- Pages
- 391-400
- ISSN
- 2096-5230 (ISSN-L)
- 2523-899X
- OpenAlex
- W3042758594
- Cited by
- 119
- References
- 127
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 18 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Medical Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81721005)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- microglia, depression, neuroinflammation, inflammatory cytokines, phagocytosis, synaptic pruning, synaptic plasticity, neuropsychiatric disorders, microglial dysfunction, etiology of depression, depression treatment
- MeSH terms
- Animals, Brain, Depression, Humans, Inflammation, Neuronal Plasticity, Microglia
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