Cited by 119Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol

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Microglia: A Central Player in Depression

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Deng, Si-long, Chen, Jian-guo, Wang, Fang·2020·Current Medical Science

DOI 10.1007/s11596-020-2193-1

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Summary: Microglia are the major immune cells in the central nervous system and play a key role in the normal function of the brain. Microglia exhibit functional diversity, and they control the inflammation in central nervous system through releasing inflammatory cytokine, clearing apoptotic cells via phagocytosis, regulating synaptic plasticity and the formation of neural network by synapse pruning. Recent studies have strongly indicated that the microglial dysfunction is associated with a variety of neuropsychiatric diseases such as depression, which have been termed as “microgliopathy”. The emergency of advanced technologies and tools has enabled us to comprehensively understand the role of microglia in physiology and pathology, and growing studies have targetted microglia to explore the treatment of neuropsychiatric diseases. Here, we describe the key progress of microglia research, and review the recent developments in the understanding of the role of microglia in physiology and etiology of depression.

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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622
Microglial interactions with synapses are modulated by visual experience
Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
The microglial sensome revealed by direct RNA sequencing
Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511
Microglia in physiology and disease
Wolf, S. A., Boddeke, H. W. G. M., & Kettenmann, H. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034406 · Cited by 1,426
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
Masuda, T., Sankowski, R., Staszewski, O., Böttcher, C., Amann, L., Sagar, Scheiwe, C., Nessler, S., Kunz, P., van Loo, G., et al. (2019) · Nature · doi:10.1038/s41586-019-0924-x · Cited by 1,310
Characterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
Zhan, Y., Paolicelli, R. C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F., Vyssotski, A. L., Bifone, A., Gozzi, A., Ragozzino, D., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3641 · Cited by 1,236
An environment-dependent transcriptional network specifies human microglia identity
Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220
Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180
Microglia: new roles for the synaptic stripper
Kettenmann, H., Kirchhoff, F., & Verkhratsky, A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.023 · Cited by 1,173
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153
The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.
van Furth, R., Cohn, Z. A., Jg, H., Humphrey, J., Spector, W. G., & Langevoort, H. L. (1972) · PubMed Central · Cited by 1,133
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S., & Colonna, M. (2012) · Nature Immunology · doi:10.1038/ni.2360 · Cited by 1,011
The Role of Microglia in the Healthy Brain: Figure 1.
Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944
Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939
Layer V cortical neurons require microglial support for survival during postnatal development
Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M., & Yamashita, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3358 · Cited by 781
Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766
Microglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757
Turnover of resident microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., & Gordon, S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90500-2 · Cited by 709
Microglia Modulate Wiring of the Embryonic Forebrain
Squarzoni, P., Oller, G., Hoeffel, G., Pont‐Lezica, L., Rostaing, P., Low, D., Bessis, A., Ginhoux, F., & Garel, S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.042 · Cited by 697
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
Vainchtein, I. D., Chin, G., Cho, F. S., Kelley, K. W., Miller, J. G., Chien, E. C., Liddelow, S. A., Nguyen, P. T., Nakao-Inoue, H., Dorman, L. C., et al. (2018) · Science · doi:10.1126/science.aal3589 · Cited by 657
Sex-specific features of microglia from adult mice
Villa, A., Gelosa, P., Castiglioni, L., Cimino, M., Rizzi, N., Pepe, G., Lolli, F., Marcello, E., Sironi, L., Vegeto, E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.048 · Cited by 651
β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat
Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638
Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System
Bruttger, J., Karram, K., Wörtge, S., Regen, T., Marini, F., Hoppmann, N., Klein, M., Blank, T., Yona, S., Wolf, Y., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.012 · Cited by 634
Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia
Greter, M., Lelios, I., Pelczar, P., Hoeffel, G., Price, J., Leboeuf, M., Kündig, T. M., Frei, K., Ginhoux, F., Merad, M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.11.001 · Cited by 630
CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624
Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo
Peri, F., & Nüsslein-Volhard, C. (2008) · Cell · doi:10.1016/j.cell.2008.04.037 · Cited by 617
A new fate mapping system reveals context-dependent random or clonal expansion of microglia
Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4547 · Cited by 597
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
Steiner, J., Walter, M., Gos, T., Guillemin, G. J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-94 · Cited by 568
Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood
Hagemeyer, N., Hanft, K.-M., Akriditou, M.-A., Unger, N., Park, E. S., Stanley, E. R., Staszewski, O., Dimou, L., & Prinz, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1747-1 · Cited by 558
A novel microglial subset plays a key role in myelinogenesis in developing brain
Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar‐Badel, A., de Boer‐Bergsma, J. J., Martin, N. A., Karram, K., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696056 · Cited by 535
Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions
Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 518
Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus
Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L.-J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-14.2014 · Cited by 509
Generation and assembly of human brain region-specific three-dimensional cultures
Sloan, S. A., Andersen, J., Pașca, A. M., Birey, F., & Pașca, S. P. (2018) · Nature Protocols · doi:10.1038/s41596-018-0032-7 · Cited by 490
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1
Madry, C., Kyrargyri, V., Arancibia-Cárcamo, I. L., Jolivet, R., Kohsaka, S., Bryan, R. M., & Attwell, D. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.002 · Cited by 464
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460
Microglia: actively surveying and shaping neuronal circuit structure and function
Wake, H., Moorhouse, A. J., Miyamoto, A., & Nabekura, J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.007 · Cited by 448
Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.
Hume, D. A., Perry, V. H., & Gordon, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.1.253 · Cited by 447
Origin of microglia: current concepts and past controversies
Ginhoux, F., & Prinz, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020537 · Cited by 446
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry
NBB-Psy, Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0290-2 · Cited by 436
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 435
Local cues establish and maintain region-specific phenotypes of basal ganglia microglia
De Biase, L. M., Schuebel, K. E., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H.-Y., Liu, Q.-R., Shen, H., Xi, Z.-X., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.020 · Cited by 432
Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines
Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., Greenwood, B. N., & Fleshner, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.090 · Cited by 424
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling
Liu, Y., Ying, Y., Li, Y., Eyo, U. B., Chen, T., Zheng, J., Umpierre, A. D., Zhu, J., Bosco, D. B., Dong, H., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0511-3 · Cited by 401
Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387
Microglia: Architects of the Developing Nervous System
Frost, J. L., & Schafer, D. P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.02.006 · Cited by 385
Immune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374
A Starring Role for Microglia in Brain Sex Differences
Lenz, K. M., & McCarthy, M. M. (2015) · The Neuroscientist · doi:10.1177/1073858414536468 · Cited by 342
The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation
Nie, X., Kitaoka, S., Tanaka, K., Segi‐Nishida, E., Imoto, Y., Ogawa, A., Nakano, F., Tomohiro, A., Nakayama, K., Taniguchi, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.035 · Cited by 330
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation
Zhang, Y., Liu, L., Liu, Y.-Z., Shen, X.-L., Wu, T.-Y., Zhang, T., Wang, W., Wang, Y.-X., & Jiang, C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv006 · Cited by 328
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex
Stowell, R. D., Sipe, G. O., Dawes, R. P., Batchelor, H. N., Lordy, K. A., Whitelaw, B. S., Stoessel, M. B., Bidlack, J. M., Brown, E., Sur, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0514-0 · Cited by 321
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 316
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
Otero, K., Turnbull, I. R., Poliani, P. L., Vermi, W., Cerutti, E., Aoshi, T., Tassi, I., Takai, T., Stanley, S. L., Miller, M., et al. (2009) · Nature Immunology · doi:10.1038/ni.1744 · Cited by 315
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia
Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.014 · Cited by 283
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice
Wohleb, E. S., Fenn, A. M., Pacenta, A. M., Powell, N. D., Sheridan, J. F., & Godbout, J. P. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.003 · Cited by 275
Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
Kopec, A. M., Smith, C. J. W., Ayre, N. R., Sweat, S. C., & Bilbo, S. D. (2018) · Nature Communications · doi:10.1038/s41467-018-06118-z · Cited by 272
Opposite Molecular Signatures of Depression in Men and Women
Seney, M. L., Huo, Z., Cahill, K., French, L., Puralewski, R., Zhang, J., Logan, R. W., Tseng, G., Lewis, D. A., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.017 · Cited by 272
Synapse elimination and learning rules co-regulated by MHC class I H2-Db
Lee, H., Brott, B. K., Kirkby, L. A., Adelson, J. D., Cheng, S., Feller, M. B., Datwani, A., & Shatz, C. J. (2014) · Nature · doi:10.1038/nature13154 · Cited by 228
Effects of Antidepressant Drugs on the Behavioral and Physiological Responses to Lipopolysaccharide (LPS) in Rodents
Yirmiya, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00226-8 · Cited by 227
A distinct population of microglia supports adult neurogenesis in the subventricular zone
Ribeiro Xavier, A. L., Kress, B. T., Goldman, S. A., Lacerda de Menezes, J. R., & Nedergaard, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1217-15.2015 · Cited by 225
CSF‐1 Controls Cerebellar Microglia and Is Required for Motor Function and Social Interaction
Kana, V., Desland, F. A., Casanova-Acebes, M., Ayata, P., Badimon, A., Nabel, E., Yamamuro, K., Sneeboer, M., Tan, I.-L., Flanigan, M. E., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182037 · Cited by 220
Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia
Mazaheri, F., Breus, O., Durdu, S., Haas, P., Wittbrodt, J., Gilmour, D. T., & Peri, F. (2014) · Nature Communications · doi:10.1038/ncomms5046 · Cited by 211
Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat
McKim, D. B., Niraula, A., Tarr, A. J., Wohleb, E. S., Sheridan, J. F., & Godbout, J. P. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2394-15.2016 · Cited by 204
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
Li, T., Chiou, B., Gilman, C. K., Luo, R., Koshi, T., Yu, D., Oak, H. C., Giera, S., Johnson‐Venkatesh, E., Muthukumar, A. K., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104136 · Cited by 188
PPAR ? agonists stimulate oligodendrocyte differentiation in tissue culture
Saluja, I., Granneman, J. G., & Skoff, R. P. (2001) · Glia · doi:10.1002/1098-1136(200103)33:3 · Cited by 186
CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination
Zhang, Y., Du, L., Bai, Y., Han, B., He, C., Gong, L., Huang, R., Shen, L., Chao, J., Liu, P., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0285-0 · Cited by 184
Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation
Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179
The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1β responses to stress
Blandino, P., Barnum, C. J., & Terrence Deak, B. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.11.021 · Cited by 175
Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome
Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9408-7 · Cited by 172
Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture
Yin, Z., Han, Z., Hu, T., Zhang, S., Ge, X., Huang, S., Wang, L., Yu, J., Li, W., Wang, Y., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.004 · Cited by 171
Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”
Wohleb, E. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00544 · Cited by 170
Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice
Corona, A. W., Norden, D. M., Skendelas, J. P., Huang, Y., O’Connor, J. C., Lawson, M. A., Dantzer, R., Kelley, K. W., & Godbout, J. P. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.008 · Cited by 156
Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus
Liu, L., Li, J., Su, W., Wang, B., & Jiang, C. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.012 · Cited by 155
Ontogeny and Functions of Central Nervous System Macrophages
Katsumoto, A., Lu, H., Miranda, A. S., & Ransohoff, R. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400716 · Cited by 149
Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation
Hagemeyer, N., Kierdorf, K., Frenzel, K., Xue, J., Ringelhan, M., Abdullah, Z., Godin, I., Wieghofer, P., Jordão, M. J. C., Ulas, T., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201693801 · Cited by 144
Phenotypic clustering: a novel method for microglial morphology analysis
Verdonk, F., Roux, P., Flamant, P., Fiette, L., Bozza, F. A., Simard, S., Lemaire, M., Plaud, B., Shorte, S. L., Sharshar, T., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0614-7 · Cited by 142
Translocator protein (18 kDa TSPO) binding, a marker of microglia, is reduced in major depression during cognitive-behavioral therapy
Li, H., Sagar, A. P., & Kéri, S. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.011 · Cited by 134
Macrophage-Derived Tumor Necrosis Factor α, an Early Developmental Signal for Motoneuron Death
Sedel, F., Béchade, C., Vyas, S., & Triller, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4464-03.2004 · Cited by 128
Regulation of brain microglia by female gonadal steroids
Habib, P., & Beyer, C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.02.018 · Cited by 118
Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats
Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117
Brain region-specific gene expression profiles in freshly isolated rat microglia
Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W. G. M., Huitinga, I., Lucassen, P. J., & van Dam, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00084 · Cited by 114
Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula
Guan, Y., Huang, G., Xu, M.-D., Gao, F., Lin, S., Huang, J., Wang, J., Li, Y., Wu, C.-H., Yao, S., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.032 · Cited by 113
The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat
Weber, M. D., McKim, D. B., Niraula, A., Witcher, K. G., Yin, W., Sobol, C. G., Wang, Y., Sawicki, C. M., Sheridan, J. F., & Godbout, J. P. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.10.009 · Cited by 112
(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation
Zhao, Y., Wang, Q., Jia, M., Fu, S., Pan, J., Chu, C., Liu, X., Liu, X., & Liu, Z. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.006 · Cited by 109
Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia
Puñal, V. M., Paisley, C. E., Brecha, F. S., Lee, M. A., Perelli, R. M., Wang, J., O’Koren, E. G., Ackley, C. R., Saban, D. R., Reese, B. E., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000492 · Cited by 107
Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress
Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.030 · Cited by 100
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine
Verdonk, F., Petit, A.-C., Abdel-Ahad, P., Vinckier, F., Jouvion, G., de Maricourt, P., De Medeiros, G. F., Danckaert, A., Van Steenwinckel, J., Blatzer, M., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.033 · Cited by 99
Differential microglial activation between acute stress and lipopolysaccharide treatment
Sugama, S., Takenouchi, T., Fujita, M., Conti, B., & Hashimoto, M. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.11.007 · Cited by 98
Deciphering Resting Microglial Morphology and Process Motility from a Synaptic Prospect
Hristovska, I., & Pascual, O. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00073 · Cited by 92
Microglia heterogeneity along a spatio–temporal axis: More questions than answers
Silvin, A., & Ginhoux, F. (2018) · Glia · doi:10.1002/glia.23458 · Cited by 90
Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation
Gong, Y. L., Tong, L., Yang, R., Hu, W., Xu, X., Wang, W., Wang, P., Lu, X., Gao, M., Wu, Y. H., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.023 · Cited by 87
Generation of microglial cells from mouse embryonic stem cells
Beutner, C., Roy, K., Linnartz, B., Napoli, I., & Neumann, H. (2010) · Nature Protocols · doi:10.1038/nprot.2010.90 · Cited by 85
Effects of hydrogen-rich water on depressive-like behavior in mice
Zhang, Y., Su, W.-J., Chen, Y., Wu, T.-Y., Gong, H., Shen, X.-L., Wang, Y.-X., Sun, X.-J., & Jiang, C.-L. (2016) · Scientific Reports · doi:10.1038/srep23742 · Cited by 79
Nonsteroidal Anti-Inflammatory Drugs and Severe Psychiatric Side Effects
Browning, C. H. (1996) · The International Journal of Psychiatry in Medicine · doi:10.2190/1b32-79ea-b6h5-395v · Cited by 75
Glia Open Access Database ( GOAD ): A comprehensive gene expression encyclopedia of glia cells in health and disease
Holtman, I. R., Noback, M. A., Bijlsma, M., Duong, K. N., van der Geest, M. A., Ketelaars, P. T., Brouwer, N., Vainchtein, I. D., Eggen, B. J. L., & Boddeke, H. W. G. M. (2015) · Glia · doi:10.1002/glia.22810 · Cited by 57
Neuronal extracellular microRNAs miR‐124 and miR‐9 mediate cell–cell communication between neurons and microglia
Veremeyko, T., Kuznetsova, I. S., Dukhinova, M., W. Y. Yung, A., Kopeikina, E., Barteneva, N. S., & Ponomarev, E. D. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24344 · Cited by 52
Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1
Haage, V. C., Elmadany, N., Roll, L., Faissner, A., Gutmann, D. H., Semtner, M., & Kettenmann, H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.047 · Cited by 48
PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy
Benetatos, J., Bennett, R. E., Evans, H. T., Ellis, S. A., Hyman, B. T., Bodea, L., & Götz, J. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02151-9 · Cited by 43
TLR2 controls random motility, while TLR7 regulates chemotaxis of microglial cells via distinct pathways
Ifuku, M., Buonfiglioli, A., Jordan, P., Lehnardt, S., & Kettenmann, H. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.003 · Cited by 35
Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids
Djurisic, M. R., Brott, B. K., Saw, N. L., Shamloo, M., & Shatz, C. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0034-4 · Cited by 35
Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress
Ye, T., Wang, D., Cai, Z., Tong, L., Chen, Z., Lu, J., Lu, X., Huang, C., & Yuan, X. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108132 · Cited by 28
Suicide attempt in ulcerative colitis patient after 4months of infliximab therapy — A case report
Eshuis, E. J., Magnin, K. M. M. Y., Stokkers, P. C. F., Bemelman, W. A., & Bartelsman, J. F. W. M. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.04.001 · Cited by 26
Infliximab-induced Depression and Suicidal Behavior in Adolescent with Crohn’s Disease: Case Report and Review of Literature
Shayowitz, M., Bressler, M. Y., Ricardo, A. P., & Grudnikoff, E. (2019) · Pediatric Quality and Safety · doi:10.1097/pq9.0000000000000229 · Cited by 22
Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome
Gao, M., Hu, P., Cai, Z., Wu, Y. H., Wang, D., Hu, W., Xu, X., Zhang, Y.-R., Lu, X., Chen, D., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.04.005 · Cited by 18
Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease
Bijlsma, M., Vainchtein, I. D., Duong, K. N., Holtman, I. R., Eggen, B. J. L., Ketelaars, P. T., van der Geest, M. A., Brouwer, N., Boddeke, H. W. G. M., & Noback, M. A. (2015) · Data Archiving and Networked Services (DANS) · Cited by 1

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See all 119

Authors: Deng, S.-L., Chen, J.-G., & Wang, F.
Affiliations: Huazhong University of Science and Technology (CN)
Corresponding author: Wang, Fang
ORCID: Deng, Si-long
Wang, Fang
Venue: Current Medical Science
Publisher: Springer Science and Business Media LLC
Published: 2020-06
Volume: 40
Issue: 3
Pages: 391-400
ISSN: 2096-5230 (ISSN-L)
2523-899X
DOI: 10.1007/s11596-020-2193-1
OpenAlex: W3042758594
Cited by: 119
References: 127
Citations by year: 2026: 11 · 2025: 19 · 2024: 18 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 2
FWCI: 1.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor, 46 d)
Locations: Current Medical Science (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81721005)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: microglia, depression, neuroinflammation, inflammatory cytokines, phagocytosis, synaptic pruning, synaptic plasticity, neuropsychiatric disorders, microglial dysfunction, etiology of depression, depression treatment
MeSH terms: Animals, Brain, Depression, Humans, Inflammation, Neuronal Plasticity, Microglia

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Microglia: A Central Player in Depression

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