Cited by 119Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol

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Microglia: A Central Player in Depression

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Deng, Si-long, Chen, Jian-guo, Wang, Fang·2020·Current Medical Science

DOI 10.1007/s11596-020-2193-1

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Summary: Microglia are the major immune cells in the central nervous system and play a key role in the normal function of the brain. Microglia exhibit functional diversity, and they control the inflammation in central nervous system through releasing inflammatory cytokine, clearing apoptotic cells via phagocytosis, regulating synaptic plasticity and the formation of neural network by synapse pruning. Recent studies have strongly indicated that the microglial dysfunction is associated with a variety of neuropsychiatric diseases such as depression, which have been termed as “microgliopathy”. The emergency of advanced technologies and tools has enabled us to comprehensively understand the role of microglia in physiology and pathology, and growing studies have targetted microglia to explore the treatment of neuropsychiatric diseases. Here, we describe the key progress of microglia research, and review the recent developments in the understanding of the role of microglia in physiology and etiology of depression.

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Authors: Deng, S.-L., Chen, J.-G., & Wang, F.
Affiliations: Huazhong University of Science and Technology (CN)
Corresponding author: Wang, Fang
ORCID: Deng, Si-long
Wang, Fang
Venue: Current Medical Science
Publisher: Springer Science and Business Media LLC
Published: 2020-06
Volume: 40
Issue: 3
Pages: 391-400
ISSN: 2096-5230 (ISSN-L)
2523-899X
DOI: 10.1007/s11596-020-2193-1
OpenAlex: W3042758594
Cited by: 119
References: 127
Citations by year: 2026: 11 · 2025: 19 · 2024: 18 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 2
FWCI: 1.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor, 46 d)
Locations: Current Medical Science (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81721005)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: microglia, depression, neuroinflammation, inflammatory cytokines, phagocytosis, synaptic pruning, synaptic plasticity, neuropsychiatric disorders, microglial dysfunction, etiology of depression, depression treatment
MeSH terms: Animals, Brain, Depression, Humans, Inflammation, Neuronal Plasticity, Microglia

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Microglia: A Central Player in Depression

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