Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
Open accessAbstract
The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic. In this study, we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia (FOP) patients who underwent lung surgery and served as controls. We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In contrast to the FOP patients, Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients. This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic.
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- Authors
- Duan, Y.-Q., Xia, M.-H., Ren, L., Zhang, Y.-F., Ao, Q.-L., Xu, S.-P., Kuang, D., Liu, Q., Yan, B., Zhou, Y.-W., Chu, Q., Liu, L., Yang, X.-P., & Wang, G.-P.
- Affiliations
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Liu, Liang
- Yang, Xiang-Ping
- Wang, Guo-ping
- Venue
- Current Medical Science
- Published
- 2020-08
- Volume
- 40
- Issue
- 4
- Pages
- 618-624
- ISSN
- 2096-5230 (ISSN-L)
- 2523-899X
- PMC
- PMC7412778
- OpenAlex
- W3048326226
- Cited by
- 59
- References
- 20
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 13 · 2022: 16 · 2021: 21 · 2020: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Medical Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- COVID-19 pandemic, SARS-CoV-2, T follicular helper cells, germinal center, humoral immunity, humoral immune deficiency, lung tissue, hilar lymph nodes, macrophages, T cell deficiency, B cell deficiency, IgM, IgG, fatal COVID-19, immune dysregulation
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, Aged, 80 and over, China, Female, T-Lymphocytes, Helper-Inducer, Humans, Lymphopenia, Macrophages, Male, Middle Aged, Pneumonia, Viral, Case-Control Studies, Fatal Outcome, Coronavirus Infections, Germinal Center, Adaptive Immunity, Pandemics
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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