The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
MicroRNA-21 is Overexpressed in Pancreatic Cancer and a Potential Predictor of Survival
Open accessAbstract
BackgroundMicroRNAs are small (18–22 nucleotides) noncoding RNAs involved in posttranscriptional modification of many target genes. One of these, microRNA-21 (miR-21), has been shown to play a role in multiple hematologic and solid organ malignancies. We sought to determine the expression pattern of miR-21 in pancreatic cancers and its impact on clinicopathologic characteristics.MethodsEighty resected pancreatic cancer specimens were microdissected and tissue microarrays (TMA) created in duplicate. TMAs were also created for benign pancreas (N = 12) and chronic pancreatitis (N = 45). In situ hybridization (ISH) was undertaken utilizing locked nucleic acid probes for miR-21. RNA U6 and scrambled RNA served as positive and negative control, respectively. ISH was scored as 0 (absent), 1+ (faint/focal expression), or 2+ (strong expression). Kaplan–Meier survival curves were constructed and compared by log-rank analysis.ResultsMiR-21 expression was demonstrated in 63 (79%) pancreatic cancers (1+ in 49, 2+ in 14) compared to one of 12 (8%, p < 0.0001) benign pancreas and 12/45 (27%, p < 0.0001) chronic pancreatitis. None of the benign tissues demonstrated strong miR-21 expression. Although miR-21 expression did not correlate with tumor size, differentiation, nodal status, or T stage, strong miR-21 expression was predictive of poorer outcome compared to absent or faint/focal miR-21 expression in patients with node-negative disease (median 27.7 months vs. 15.2, p = 0.037). Nodal status was also predictive of survival (p = 0.029).ConclusionsMicroRNA-21 is significantly overexpressed in pancreatic cancers as detected by in situ hybridization. Its strong expression predicts limited survival in patients with node-negative disease and may be an important biologic marker for outcome.
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Self-citationMicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
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Self-citationExpression profiling identifies microRNA signature in pancreatic cancer
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Self-citationMicroRNA: Biogenesis, Function and Role in Cancer
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Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
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Metadata
- Authors
- Dillhoff, M., Liu, J., Frankel, W., Croce, C., & Bloomston, M.
- Venue
- Journal of Gastrointestinal Surgery
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 12
- Issue
- 12
- Pages
- 2171-2176
- ISSN
- 1091-255X (ISSN-L)
- OpenAlex
- W2035987476
- Cited by
- 408
- References
- 16
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- green
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