The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
Open accessAbstract
Chronic inflammation and infection are major causes of cancer. There are continued improvements to our understanding of the molecular connections between inflammation and cancer. Key mediators of inflammation-induced cancer include nuclear factor kappa B, reactive oxygen and nitrogen species, inflammatory cytokines, prostaglandins and specific microRNAs. The collective activity of these mediators is largely responsible for either a pro-tumorigenic or anti-tumorigenic inflammatory response through changes in cell proliferation, cell death, cellular senescence, DNA mutation rates, DNA methylation and angiogenesis. As our understanding grows, inflammatory mediators will provide opportunities to develop novel diagnostic and therapeutic strategies. In this review, we provide a general overview of the connection between inflammation, microRNAs and cancer and highlight how our improved understanding of these connections may provide novel preventive, diagnostic and therapeutic strategies to reduce the health burden of cancer.
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Cites
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Cited by
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
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Metadata
- Authors
- Schetter, A. J., Heegaard, N. H. H., & Harris, C. C.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-02
- Volume
- 31
- Issue
- 1
- Pages
- 37-49
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2104478726
- Cited by
- 657
- References
- 184
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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