The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
RNA m6A modification and its function in diseases
Open accessAbstract
N 6 -methyladenosine (m 6 A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m 6 A modification could be installed by m 6 A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m 6 A “erasers” (FTO and ALKBH5). The function of m 6 A is executed by m 6 A “readers” that bind to m 6 A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m 6 A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m 6 A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m 6 A are still largely unknown. Moreover, investigations of the m 6 A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m 6 A research and highlight the functional relevance and importance of m 6 A modification in in vitro cell lines, in physiological contexts, and in cancers.
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“The increases in m6A are also consistent with the observed increase in the m6A writer, METTL3, and decrease in m6A eraser, ALKBH5 (Tong et al., 2018).”
From β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease (2024) · cites this paper as Tong et al., 2018
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Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Ping, X.-L., Sun, B.-F., Wang, L., Xiao, W., Yang, X., Wang, W.-J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.-S., et al. (2014) · Cell Research · doi:10.1038/cr.2014.3 · Cited by 2,375
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054
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Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Libera, J., Wang, Z., Kilci, A., Jenkins, M., Ortiz, A. R., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1372297 · Cited by 15
Metadata
- Authors
- Tong, J., Flavell, R. A., & Li, H.-B.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Flavell, Richard A.
- Venue
- Frontiers of Medicine
- Published
- 2018-08
- Volume
- 12
- Issue
- 4
- Pages
- 481-489
- ISSN
- 1673-7342 (ISSN-L)
- 2095-0217
- 2095-0225
- OpenAlex
- W2885250628
- Cited by
- 233
- References
- 72
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 28 · 2023: 41 · 2022: 42 · 2021: 37 · 2020: 45 · 2019: 16 · 2018: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Frontiers of Medicine (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Natural Science Foundation of China (91753141)
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- N6-methyladenosine, m6A RNA methylation, post-transcriptional RNA modification, m6A writers, m6A erasers, m6A reader, FTO, ALKBH5, YTH domain proteins, IGF2BP, HNRNPA2B1, eIF3, cancer, human disease, RNA metabolism
- MeSH terms
- Adenosine, Cell Differentiation, Humans, Neoplasms, RNA, RNA Processing, Post-Transcriptional
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