Cited by 233RNA modifications and cancerRNA regulation and diseaseCancer-related gene regulation

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RNA m6A modification and its function in diseases

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Tong, Jiyu, Flavell, Richard A., Li, Hua-Bing·2018·Frontiers of Medicine

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Abstract

N 6 -methyladenosine (m 6 A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m 6 A modification could be installed by m 6 A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m 6 A “erasers” (FTO and ALKBH5). The function of m 6 A is executed by m 6 A “readers” that bind to m 6 A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m 6 A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m 6 A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m 6 A are still largely unknown. Moreover, investigations of the m 6 A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m 6 A research and highlight the functional relevance and importance of m 6 A modification in in vitro cell lines, in physiological contexts, and in cancers.

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Authors: Tong, J., Flavell, R. A., & Li, H.-B.
Affiliations: Shanghai Jiao Tong University (CN)
Howard Hughes Medical Institute (US)
Corresponding author: Flavell, Richard A.
ORCID: Tong, Jiyu
Flavell, Richard A.
Venue: Frontiers of Medicine
Publisher: Springer Science and Business Media LLC
Published: 2018-08
Volume: 12
Issue: 4
Pages: 481-489
ISSN: 1673-7342 (ISSN-L)
2095-0217
2095-0225
DOI: 10.1007/s11684-018-0654-8
OpenAlex: W2885250628
Cited by: 233
References: 72
Citations by year: 2026: 7 · 2025: 16 · 2024: 28 · 2023: 41 · 2022: 42 · 2021: 37 · 2020: 45 · 2019: 16 · 2018: 1
FWCI: 2.48
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
Locations: Frontiers of Medicine (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Natural Science Foundation of China (91753141)
Shanghai Jiao Tong University
School of Medicine, Shanghai Jiao Tong University
Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: N6-methyladenosine, m6A RNA methylation, post-transcriptional RNA modification, m6A writers, m6A erasers, m6A reader, FTO, ALKBH5, YTH domain proteins, IGF2BP, HNRNPA2B1, eIF3, cancer, human disease, RNA metabolism
MeSH terms: Adenosine, Cell Differentiation, Humans, Neoplasms, RNA, RNA Processing, Post-Transcriptional

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