The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain
Open accessAbstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has caused a global pandemic in only 3 months. In addition to major respiratory distress, characteristic neurological manifestations are also described, indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain. Based on previous studies of neuroinvasive human respiratory coronaviruses, it is proposed that after physical contact with the nasal mucosa, laryngopharynx, trachea, lower respiratory tract, alveoli epithelium, or gastrointestinal mucosa, SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release, tissue damage, and high neurosusceptibility to COVID-19, especially in the hypoxic conditions caused by lung injury. In some immune-compromised individuals, the virus may invade the brain through multiple routes, such as the vasculature and peripheral nerves. Therefore, in addition to drug treatments, such as pharmaceuticals and traditional Chinese medicine, non-pharmaceutical precautions, including facemasks and hand hygiene, are critically important.
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Cited by
Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection
Butowt, R., & von Bartheld, C. S. (2021) · The Neuroscientist · doi:10.1177/1073858420956905 · Cited by 345
Alquisiras-Burgos, I., Peralta-Arrieta, I., Alonso-Palomares, L. A., Zacapala-Gómez, A. E., Salmerón-Bárcenas, E. G., & Aguilera, P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02134-7 · Cited by 115
Metadata
- Authors
- Li, Z., Liu, T., Yang, N., Han, D., Mi, X., Li, Y., Liu, K., Vuylsteke, A., Xiang, H., & Guo, X.
- Venue
- Frontiers of Medicine
- Published
- 2020-05-04
- Volume
- 14
- Issue
- 5
- Pages
- 533-541
- ISSN
- 1673-7342 (ISSN-L)
- 2095-0217
- 2095-0225
- OpenAlex
- W3023859835
- Cited by
- 269
- References
- 63
- FWCI
- 22.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Z., Liu, T., Yang, N., Han, D., Mi, X., Li, Y., Liu, K., Vuylsteke, A., Xiang, H., & Guo, X. (2020). Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain. Frontiers of Medicine. https://doi.org/10.1007/s11684-020-0786-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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