Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample
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Two functionally related genes, FOXP2 and CNTNAP2, influence language abilities in families with rare syndromic and common nonsyndromic forms of impaired language, respectively. We investigated whether these genes are associated with component phenotypes of dyslexia and measures of sequential motor ability. Quantitative transmission disequilibrium testing (QTDT) and linear association modeling were used to evaluate associations with measures of phonological memory (nonword repetition, NWR), expressive language (sentence repetition), reading (real word reading efficiency, RWRE; word attack, WATT), and timed sequential motor activities (rapid alternating place of articulation, RAPA; finger succession in the dominant hand, FS-D) in 188 family trios with a child with dyslexia. Consistent with a prior study of language impairment, QTDT in dyslexia showed evidence of CNTNAP2 single nucleotide polymorphism (SNP) association with NWR. For FOXP2, we provide the first evidence for SNP association with component phenotypes of dyslexia, specifically NWR and RWRE but not WATT. In addition, FOXP2 SNP associations with both RAPA and FS-D were observed. Our results confirm the role of CNTNAP2 in NWR in a dyslexia sample and motivate new questions about the effects of FOXP2 in neurodevelopmental disorders.
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The same allele that increases risk for language delay in ASD increases risk for specific language impairment and modifies language ability in the general population.
“Several groups have demonstrated that this is indeed the case with respect to CNTNAP2 [60, 61, 63], as the same allele that increases risk for language delay in ASD, increases risk for specific language impairment (SLI) and modifies language ability in the general population.”
From Genetics of autism spectrum disorders (2011) · cites this paper as [63]
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- Authors
- Peter, B., Raskind, W. H., Matsushita, M., Lisowski, M., Vu, T., Berninger, V. W., Wijsman, E. M., & Brkanac, Z.
- Affiliations
- University of Washington (US)
- Corresponding author
- Peter, Beate
- Venue
- Journal of Neurodevelopmental Disorders
- Published
- 2010-11-09
- Volume
- 3
- Issue
- 1
- Pages
- 39-49
- ISSN
- 1866-1947 (ISSN-L)
- 1866-1955
- PMC
- PMC3163991
- OpenAlex
- W1989563742
- Cited by
- 117
- References
- 63
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 19 · 2012: 9
- FWCI
- 19.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (T32DC000033)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD049342, R01HD054562)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- CNTNAP2, FOXP2, dyslexia, non-word repetition, phonological memory, motor abilities, word attack, language impairment, single nucleotide polymorphisms, family trios, transmission disequilibrium test, neurodevelopmental disorders
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