abiliti® Closed-Loop Gastric Electrical Stimulation System for Treatment of Obesity: Clinical Results with a 27-Month Follow-Up
Open accessAbstract
BACKGROUND: The aim of the study was to evaluate the safety and effectiveness of a novel closed-loop gastric electric stimulation device (abiliti system) featuring a transgastric sensor to detect food intake and an accelerometer to record physical activity to induce and maintain lifestyle changes to treat obesity. METHODS: In a prospective, multi-center study, 34 obese subjects (BMI of 42.1 ± 5.3 kg/m(2)) who passed an eligibility evaluation were implanted with the abiliti system. Safety evaluation included an endoscopic exam to assess the intragastric electrode healing. Efficacy evaluation at 1 year of therapy included weight loss, improvements in eating, and exercise behavior and quality of life. RESULTS: The transgastric implant controlled by endoscopy was stable for all participants. At 12 months (12 M) the mean excess weight loss (EWL) was 28.7% (95%CI, 34.5 to 22.5%), and mean reduction in BMI was 4.8 ± 3.2 kg/m(2). At 27 months (27 M), the EWL was 27.5% (95% CI, 21.3% to 33.7%). Eating behavior, evaluated by the "Three Factor Eating Questionnaire", showed a significant increase in the cognition factor and decrease in the disinhibition and hunger factors at 12 M in comparison to baseline (p < 0.001). Participants significantly increased their weekly physical activity (p < 0.001). Quality of life was improved in 55.2% of the patients. CONCLUSIONS: Gastric electrical stimulation with abiliti system in obese participants is well tolerated and leads to significant 12 M weight loss, which was stable to 27 M. We suggest that weight loss is achieved due to the assessed alteration of eating behavior in particular the reduction in disinhibition and hunger, and the measured increase in physical activity.
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Three cohort studies reported on the abiliti® device at 1-year follow-up, with excess weight loss ranging from 28.7% to 49.3%.
“Three cohort studies reported on the abiliti® device and 1-year follow-up [141–143]. EWL ranged from 28.7 to 49.3%.”
From Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP (2020) · cites this paper as [142]
Few self-limiting adverse events and 2% severe adverse events were reported for the abiliti® device.
“Few self-limiting adverse events were reported and 2% severe adverse events.”
From Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP (2020) · cites this paper as [142]
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- Authors
- Horbach, T., Thalheimer, A., Seyfried, F., Eschenbacher, F., Schuhmann, P., & Meyer, G.
- Affiliations
- Schön Klinik Nürnberg Fürth (DE)
- Schön Klinik Bad Aibling (DE)
- Universitätsklinikum Würzburg (DE)
- Corresponding author
- Horbach, T.
- Venue
- Obesity Surgery
- Published
- 2015-03-15
- Volume
- 25
- Issue
- 10
- Pages
- 1779-1787
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- PMC
- PMC4559577
- OpenAlex
- W1979189196
- Cited by
- 51
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 1
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Obesity Surgery (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- MeSH terms
- Adult, Electrodes, Implanted, Electric Stimulation Therapy, Feeding Behavior, Female, Follow-Up Studies, Humans, Hunger, Life Style, Male, Middle Aged, Obesity, Morbid, Quality of Life, Surveys and Questionnaires, Stomach, Weight Loss, Exercise, Treatment Outcome, Prostheses and Implants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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