Impact of Weight Regain on the Evolution of Non-alcoholic Fatty Liver Disease After Roux-en-Y Gastric Bypass: a 3-Year Follow-up
Abstract
Background The influence of post-surgical weight regain on the course of non-alcoholic fatty liver disease (NAFLD) is unclear. Objective To evaluate the influence of weight regain on the NAFLD assessed by means of a non-invasive score after Roux-en-gastric bypass (RYGB) over a 3-year period. Methods This is a prospective observational cohort study which evaluated individuals who underwent RYGB. Comparisons were made between the periods immediately before surgery and 12, 24, and 36 months following surgery. Liver disease was estimated by means of the NAFLD fibrosis score. Individuals were classified into three categories according to weight regain status: (1) no weight regain, (2) expected weight regain (regain less or equal than 20% of the maximal weight lost), (3) obesity recidivism (regain above 20% of the maximal weight lost). Results Of 90 patients analyzed after 3 years of surgery, 35.6% presented obesity recidivism and 28.8% of the expected regain; 35.6% presented no regain. There was no difference in baseline fibrosis score between groups; at 3 years, the score observed in the relapse group was significantly higher than that observed in the other two groups (p = 0.015). The percent variation of the fibrosis score was significantly higher in the recidivism group (+ 11.8 ± 77.2%) than in the expected regain (- 45.6 ± 64.5%) and no regain (- 37.8 ± 63.2%) groups (p = 0.013). Conclusion Long-term significant post-RYGB weight regain is associated with a significantly attenuated improvement of NAFLD evaluated by means of liver fibrosis score.
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RYGB improves fibrosis score by 0.9 points.
“RYGB and VSG improved fibrosis scores by 0.9 and 0.65 points, respectively [121,122].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [121]
VSG improves fibrosis score by 0.65 points.
“RYGB and VSG improved fibrosis scores by 0.9 and 0.65 points, respectively [121,122].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [121]
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- Authors
- Jimenez, L. S., Mendonça Chaim, F. H., Mendonça Chaim, F. D., Utrini, M. P., Gestic, M. A., Chaim, E. A., & Cazzo, E.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Corresponding author
- Cazzo, Everton
- Venue
- Obesity Surgery
- Published
- 2018-05-03
- Volume
- 28
- Issue
- 10
- Pages
- 3131-3135
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2801237214
- Cited by
- 43
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 9
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- non-alcoholic fatty liver disease, Roux-en-Y gastric bypass
- MeSH terms
- Follow-Up Studies, Humans, Prospective Studies, Gastric Bypass, Weight Gain, Non-alcoholic Fatty Liver Disease
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