Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years
Abstract
Background and Aim: Although nonalcoholic fatty liver disease (NAFLD) is very common among morbidly obese patients, the effect of weight loss after bariatric surgery on inflammation and fibrosis related to NAFLD is still a matter of debate. The aim of this study was to evaluate the impact of Roux‐en‐Y gastric bypass (RYGB) surgery on NAFLD with a follow up of 2 years. Methods: Eighteen consecutive NAFLD patients with body mass index >40 kg/m 2 undergoing gastroplasty with RYGB were enrolled, and wedge liver biopsy was obtained at the operation. After 2 years, these patients underwent percutaneous liver biopsy. Results: At baseline, 67% of patients had nonalcoholic steatohepatitis (NASH) and 33% had steatosis, according to the NASH Clinical Research Network Scoring System (NAS) for biopsy. Cirrhosis was present in 5.5% of the patients with NASH. After a mean excess weight loss of 60%, steatosis disappeared in 84% and fibrosis disappeared in 75% of the patients. Hepatocellular ballooning disappeared in 50%. A slight lobular inflammatory infiltrate remained in 81%, apparently unrelated to fatty degeneration. As liver biochemical variables had been found within normal limits in 92.3% of patients at initial biopsy, no difference was found 2 years later. Lipid profile and blood sugar plasma concentration were closer to normal in all patients after 2 years (P < 0.05). Conclusions: Aspects of NAFLD including steatohepatitis improved significantly with massive weight loss at 2 years after RYGB surgery. No patient in this series had progression of hepatic fibrosis.
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RYGB achieves steatosis remission in 89-95% of patients, especially in those with moderate-to-severe baseline steatosis (grades 2 and 3).
“RYGB achieved steatosis remission in 89–95% of patients, especially in those with moderate-to-severe baseline steatosis (grades 2 and 3) [114,115,116,117].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [116]
38% of RYGB patients achieve full MASH remission.
“RYGB also reduced MASH severity by 75–88.9%, with 38% of patients achieving full remission [114,116], while VSG achieved 100% resolution [118].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [116]
RYGB reduces MASH severity by 75-88.9%.
“RYGB also reduced MASH severity by 75–88.9%, with 38% of patients achieving full remission [114,116], while VSG achieved 100% resolution [118].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [116]
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- Authors
- Furuya, C. K., De Oliveira, C. P. M. S., De Mello, E. S., Faintuch, J., Raskovski, A., Matsuda, M., Vezozzo, D. C. P., Halpern, A., Garrido, A. B., Alves, V. A. F., & Carrilho, F. J.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2007-03-20
- Volume
- 22
- Issue
- 4
- Pages
- 510-514
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W2067021370
- Cited by
- 193
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 18 · 2014: 10 · 2013: 10 · 2012: 11
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- non-alcoholic fatty liver disease, Roux-en-Y gastric bypass, bariatric surgery, morbid obesity, weight loss, nonalcoholic steatohepatitis, hepatic steatosis, liver fibrosis, liver biopsy, hepatocyte ballooning, liver cirrhosis, lipid profile, blood glucose
- MeSH terms
- Adult, Biopsy, Fatty Liver, Female, Follow-Up Studies, gamma-Glutamyltransferase, Humans, Lipids, Liver, Liver Cirrhosis, Male, Middle Aged, Obesity, Morbid, Comorbidity, Body Mass Index, Bariatric Surgery
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