The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects
Abstract
Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m(2) were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass.
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“several studies have suggested that vitamin D deficiency is associated with lower muscle strength, greater body instability, falls and disability in geriatric population (153).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [153]
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Cites
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Decreased bioavailability of vitamin D in obesity
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Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis
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Social isolation stress, obesity, and breast cancer risk in mice
Sumis, A. M. (2014) · DigitalGeorgetown (Georgetown University Library)
Huang, X., Yang, Y., Jiang, Y., Zhou, Z., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.24054372
Huang, X., Yang, Y., Jiang, Y., Zhou, Z., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.24054378
Huang, X., Yang, Y., Jiang, Y., Zhou, Z., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.24054375
Barker, T., Rogers, V. E., & Henriksen, V. T. (2026) · Journal of Interferon & Cytokine Research · doi:10.1177/10799907261465487
Metadata
- Authors
- Bellia, A., Garcovich, C., D’Adamo, M., Lombardo, M., Tesauro, M., Donadel, G., Gentileschi, P., Lauro, D., Federici, M., Lauro, R., & Sbraccia, P.
- Affiliations
- University of Rome Tor Vergata (IT)
- Corresponding author
- Sbraccia, Paolo
- ORCID
- Venue
- Internal and Emergency Medicine
- Published
- 2011-03-25
- Volume
- 8
- Issue
- 1
- Pages
- 33-40
- ISSN
- 1828-0447 (ISSN-L)
- 1970-9366
- OpenAlex
- W2162663427
- Cited by
- 206
- References
- 33
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 9 · 2013: 22 · 2012: 13
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Internal and Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- 25-hydroxyvitamin D, vitamin D deficiency, obesity, systemic inflammation, insulin resistance, C-reactive protein, interleukin-6, TNF-α, bariatric surgery candidates, adipokines, leptin, adiponectin
- MeSH terms
- Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Insulin Resistance, Male, Obesity, Tumor Necrosis Factor-alpha, Vitamin D, Cohort Studies, Interleukin-6, Body Mass Index, Multivariate Analysis
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