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Cited by 206Vitamin D Research StudiesAdipokines, Inflammation, and Metabolic DiseasesMagnesium in Health and Disease

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects

Bellia, Alfonso, Garcovich, Caterina, D’Adamo, Monica, Lombardo, Mauro, Tesauro, Manfredi, Donadel, Giulia, Gentileschi, Paolo, Lauro, Davide, Federici, Massimo, Lauro, Renato, Sbraccia, Paolo·2013·Internal and Emergency Medicine
DOI 10.1007/s11739-011-0559-x
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Abstract

Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m(2) were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass.

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Crossref · 10.1007/s11739-011-0559-x

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Metadata

Authors
Bellia, A., Garcovich, C., D’Adamo, M., Lombardo, M., Tesauro, M., Donadel, G., Gentileschi, P., Lauro, D., Federici, M., Lauro, R., & Sbraccia, P.
Affiliations
University of Rome Tor Vergata (IT)
Corresponding author
Sbraccia, Paolo
ORCID
Venue
Internal and Emergency Medicine
Publisher
Springer Science and Business Media LLC
Published
2011-03-25
Volume
8
Issue
1
Pages
33-40
ISSN
  • 1828-0447 (ISSN-L)
  • 1970-9366
DOI
10.1007/s11739-011-0559-x
OpenAlex
W2162663427
Cited by
206
References
33
Citations by year
2026: 1 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 9 · 2013: 22 · 2012: 13
FWCI
9.87
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Internal and Emergency Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
25-hydroxyvitamin D, vitamin D deficiency, obesity, systemic inflammation, insulin resistance, C-reactive protein, interleukin-6, TNF-α, bariatric surgery candidates, adipokines, leptin, adiponectin
MeSH terms
Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Insulin Resistance, Male, Obesity, Tumor Necrosis Factor-alpha, Vitamin D, Cohort Studies, Interleukin-6, Body Mass Index, Multivariate Analysis

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