In vivo dissolution of levothyroxine soft gel capsules
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An in vitro study revealed that the dissolution time of soft gel capsules was approximately 20 minutes regardless of pH, which explains the discrepancy in AUCs in the trial.
“An in vitro study revealed that the dissolution time of soft gel capsules was ∼20 minutes regardless of pH (228), which explains the discrepancy in AUCs in the trial.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [228]
Cites
Pabla, D., Akhlaghi, F., & Zia, H. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.10.008 · Cited by 124 · see citing works
Vita, R., & Benvenga, S. (2014) · Endocrine Practice · doi:10.4158/ep13316.cr · Cited by 60 · see citing works
Thyroxine treatment: absorption, malabsorption, and novel therapeutic approaches
Centanni, M. (2013) · Endocrine · doi:10.1007/s12020-012-9814-9 · Cited by 56 · see citing works
Thyroid hormone and cardiovascular system: from basic concepts to clinical application
Iervasi, G., & Nicolini, G. (2013) · Internal and Emergency Medicine · doi:10.1007/s11739-013-0911-4 · Cited by 45 · see citing works
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Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164 · see citing works
Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
Doki, K., Darwich, A. S., Patel, N. K., & Rostami‐Hodjegan, A. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.07.035 · Cited by 56 · see citing works
Levothyroxine therapy in gastric malabsorptive disorders
Virili, C., Brusca, N., Capriello, S., & Centanni, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.621616 · Cited by 52 · see citing works
Novel thyroxine formulations: a further step toward precision medicine
Virili, C., Trimboli, P., & Centanni, M. (2019) · Endocrine · doi:10.1007/s12020-019-02049-x · Cited by 41 · see citing works
Castellana, M., Castellana, C., Giovanella, L., & Trimboli, P. (2020) · Endocrine · doi:10.1007/s12020-019-02185-4 · Cited by 41 · see citing works
Centanni, M., Duntas, L., Feldt-Rasmussen, U., Koehrle, J., Peeters, R. P., Razvi, S., Trimboli, P., & Virili, C. (2025) · European Thyroid Journal · doi:10.1530/etj-25-0123 · Cited by 38 · see citing works
“LS does not need speci fi c pathways in the gastric lumen to achieve the liberation of LT4, while SG preparation simply requires that the shell melts, which takes a few minutes (122).”
Medications and Food Interfering with the Bioavailability of Levothyroxine: A Systematic Review
Liu, H., Lu, M., Hu, J., Fu, G., Feng, Q., Sun, S., & Chen, C. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s414460 · Cited by 29 · see citing works
Different formulations of levothyroxine for treating hypothyroidism: a real-life study
Trimboli, P., Scappaticcio, L., De Bellis, A., Maiorino, M. I., Knappe, L., Esposito, K., Bellastella, G., & Giovanella, L. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4524759 · Cited by 27 · see citing works
Levothyroxine sodium pentahydrate tablets – formulation considerations
Kaur, N., & Suryanarayanan, R. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.08.006 · Cited by 19 · see citing works
Daily requirement of softgel thyroxine is independent from gastric juice pH
Virili, C., Capriello, S., Stramazzo, I., Brusca, N., Santaguida, M. G., Gargano, L., Bagaglini, M. F., Bruno, G., Severi, C., & Centanni, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1002583 · Cited by 8 · see citing works
Cappelli, C., Pirola, I., & Castellano, M. (2020) · Case Reports in Endocrinology · doi:10.1155/2020/8858887 · Cited by 5 · see citing works
Analysis of dose-TSH response effect of levothyroxine soft-gel formulation
Trimboli, P., Piticchio, T., Dadda, Z., Stramazzo, I., Gamarra, E., Ruinelli, L., & Virili, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1340204 · Cited by 2 · see citing works
Thyrogastric syndrome: a modern view of the problem
Troshina, E. A., Botasheva, M. H., Mazurina, N. V., Leites, Y. G., & Galeev, A. S. (2025) · Clinical and experimental thyroidology · doi:10.14341/ket12827 · Cited by 1 · see citing works
- Authors
- Fiorini, G., Ribichini, D., Pasquali, R., & Vaira, D.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Vaira, Dino
- Venue
- Internal and Emergency Medicine
- Published
- 2016-08-25
- Volume
- 11
- Issue
- 8
- Pages
- 1151-1152
- ISSN
- 1828-0447 (ISSN-L)
- 1970-9366
- OpenAlex
- W2507920006
- Cited by
- 14
- References
- 4
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Internal and Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Keywords
- levothyroxine, soft gel capsules, in vivo dissolution, drug release, oral drug delivery
- MeSH terms
- Administration, Oral, Capsules, Humans, Thyroxine, Gastric Absorption
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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