Thyroxine treatment: absorption, malabsorption, and novel therapeutic approaches

The Evidence for a Narrower Thyrotropin Reference Range Is Compelling

Wartofsky, L., & Dickey, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0455 · Cited by 424 · see citing works

Hypothyroidism as a Risk Factor for Cardiovascular Disease

Biondi, B., & Klein, I. L. (2004) · Endocrine · doi:10.1385/endo:24:1:001 · Cited by 411 · see citing works

Thyroxine in Goiter, <i>Helicobacter pylori</i> Infection, and Chronic Gastritis

Centanni, M., Gargano, L., Canettieri, G., Viceconti, N., Franchi, A., Fave, G. D., & Annibale, B. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa043903 · Cited by 329 · see citing works

Drugs that suppress TSH or cause central hypothyroidism

Haugen, B. R. (2009) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1016/j.beem.2009.08.003 · Cited by 252 · see citing works

Neonatal Effects of Maternal Hypothyroxinemia During Early Pregnancy

Kooistra, L., Crawford, S. G., van Baar, A. L., Brouwers, E. P. M., & Pop, V. J. M. (2006) · PEDIATRICS · doi:10.1542/peds.2005-0227 · Cited by 239 · see citing works

Timing of levothyroxine administration affects serum thyrotropin concentration

Bach-Huynh, T.-G., Nayak, B., Loh, J., Soldin, S., & Jonklaas, J. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2009-0860 · Cited by 198 · see citing works

Altered intestinal absorption of L-thyroxine caused by coffee

Benvenga, S., Bartolone, L., Pappalardo, M. A., Russo, A., Lapa, D., Giorgianni, G., Saraceno, G., & Trimarchi, F. (2008) · Thyroid · doi:10.1089/thy.2007.0222 · Cited by 191 · see citing works

A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry

Pabla, D., Akhlaghi, F., & Zia, H. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.10.008 · Cited by 124 · see citing works

Atypical celiac disease as cause of increased need for thyroxine: a systematic study

Virili, C., Bassotti, G., Santaguida, M. G., Iuorio, R., Del Duca, S. C., Mercuri, V., Picarelli, A., Gargiulo, P., Gargano, L., & Centanni, M. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-1851 · Cited by 114 · see citing works

A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations

Vita, R., Saraceno, G., Trimarchi, F., & Benvenga, S. (2013) · Endocrine · doi:10.1007/s12020-012-9772-2 · Cited by 91 · see citing works

Sex and Age Differences in Levothyroxine Dosage Requirement

Jonklaas, J. (2010) · Endocrine Practice · doi:10.4158/ep09257.or · Cited by 72 · see citing works

Gastrointestinal malabsorption of thyroxine

Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164 · see citing works

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Cellini, M., Santaguida, M. G., Virili, C., Capriello, S., Brusca, N., Gargano, L., & Centanni, M. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00092 · Cited by 120 · see citing works

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report

Centanni, M., Benvenga, S., & Sachmechi, I. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0706-y · Cited by 113 · see citing works

“With a little help from my friends”—the role of microbiota in thyroid hormone metabolism and enterohepatic recycling

Virili, C., & Centanni, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.053 · Cited by 105 · see citing works

Levothyroxine interactions with food and dietary supplements – a systematic review

Wiesner, A., Gajewska, D., & Paśko, P. (2021) · Pharmaceuticals · doi:10.3390/ph14030206 · Cited by 85 · see citing works

Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine

Cellini, M., Santaguida, M. G., Gatto, I., Virili, C., Del Duca, S. C., Brusca, N., Capriello, S., Gargano, L., & Centanni, M. (2014) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2014-1217 · Cited by 72 · see citing works

Thyroxine softgel capsule in patients with gastric-related T4 malabsorption

Santaguida, M. G., Virili, C., Duca, S. C. D., Cellini, M., Gatto, I., Brusca, N., De Vito, C., Gargano, L., & Centanni, M. (2015) · Endocrine · doi:10.1007/s12020-014-0476-7 · Cited by 68 · see citing works

Comorbidities, Concomitant Medications, and Diet as Factors Affecting Levothyroxine Therapy: Results of the CONTROL Surveillance Project

McMillan, M., Rotenberg, K. S., Vora, K., Sterman, A. B., Thevathasan, L., Ryan, M. F., Mehra, M., & Sandulli, W. (2016) · Drugs in R&amp;D · doi:10.1007/s40268-015-0116-6 · Cited by 64 · see citing works

Levothyroxine therapy: changes of TSH levels by switching patients from tablet to liquid formulation. a systematic review and meta-analysis

Virili, C., Giovanella, L., Fallahi, P., Antonelli, A., Santaguida, M. G., Centanni, M., & Trimboli, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00010 · Cited by 61 · see citing works

Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance

Asik, M., Gunes, F., Binnetoglu, E., Eroglu, M., Bozkurt, N., Sen, H., Akbal, E., Bakar, C., Beyazit, Y., & Ukinc, K. (2014) · Endocrine · doi:10.1007/s12020-013-0065-1 · Cited by 58 · see citing works

Inadequate levothyroxine replacement for primary hypothyroidism is associated with poor health-related quality of life-a Brazilian multicentre study

Vigário, P. D. S., Vaisman, F., Coeli, C. M., Ward, L., Graf, H., Carvalho, G., Júnior, R. M., & Vaisman, M. (2013) · Endocrine · doi:10.1007/s12020-013-9886-1 · Cited by 54 · see citing works

The economic impact of levothyroxine dose adjustments: the CONTROL HE study

Ernst, F. R., Barr, P., Elmor, R., Sandulli, W., Thevathasan, L., Sterman, A. B., Goldenberg, J., & Vora, K. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-016-0462-3 · Cited by 53 · see citing works

Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study

Fallahi, P., Ferrari, S. M., & Antonelli, A. (2016) · Endocrine · doi:10.1007/s12020-015-0836-y · Cited by 53 · see citing works

Novel thyroxine formulations: a further step toward precision medicine

Virili, C., Trimboli, P., & Centanni, M. (2019) · Endocrine · doi:10.1007/s12020-019-02049-x · Cited by 41 · see citing works

Individually-tailored thyroxine requirement in the same patients before and after thyroidectomy: a longitudinal study

Del Duca, S. C., Santaguida, M. G., Brusca, N., Gatto, I., Cellini, M., Gargano, L., Verga Falzacappa, C., Frattaroli, F. M., Virili, C., & Centanni, M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0314 · Cited by 31 · see citing works

Timing of breakfast does not influence therapeutic efficacy of liquid levothyroxine formulation

Morelli, S., Reboldi, G., Moretti, S., Menicali, E., Avenia, N., & Puxeddu, E. (2016) · Endocrine · doi:10.1007/s12020-015-0788-2 · Cited by 30 · see citing works

Comparative study between the effects of replacement therapy with liquid and tablet formulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients

Lombardi, C. P., Bocale, R., Barini, A., Barini, A., D’Amore, A., Boscherini, M., & Bellantone, R. (2017) · Endocrine · doi:10.1007/s12020-016-1003-9 · Cited by 23 · see citing works

Thyroxine treatment with softgel capsule formulation: usefulness in hypothyroid patients without malabsorption

Trimboli, P., Virili, C., Centanni, M., & Giovanella, L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00118 · Cited by 21 · see citing works

Ulcerative colitis as a novel cause of increased need for levothyroxine

Virili, C., Stramazzo, I., Santaguida, M. G., Bruno, G., Brusca, N., Capriello, S., Cellini, M., Severi, C., Gargano, L., & Centanni, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00233 · Cited by 20 · see citing works

In vivo dissolution of levothyroxine soft gel capsules

Fiorini, G., Ribichini, D., Pasquali, R., & Vaira, D. (2016) · Internal and Emergency Medicine · doi:10.1007/s11739-016-1526-3 · Cited by 14 · see citing works

Levothyroxine pseudo-malabsorption: testing and treatment in the outpatient setting

Rdzak, G. M., Whitman, L. M., & Inzucchi, S. E. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818771433 · Cited by 14 · see citing works

Therapeutic efficacy and patient compliance of levothyroxine liquid and softgel formulations taken with meals: a systematic review.

Oteri, V., Volpe, S., Lopes, M., Sceusa, G., Tumminia, A., Belfiore, A., Frasca, F., & Gullo, D. (2024) · Endocrine · doi:10.1007/s12020-024-04016-7 · Cited by 9 · see citing works

The efficacy of levothyroxine in the treatment of subclinical hypothyroidism

Xueyan, Z. (2013) · Guoji yiyao weisheng daobao · doi:10.3760/cma.j.issn.1007-1245.2013.13.040

Diagnosis and Treatment of Subclinical Hypothyroidism

Li, C. (2006) · The Journal of Medical Theory and Practice

Levothyroxine Does Not Lower Hypothyroidism Symptoms in Older Adults with Mild Subclinical Hypothyroidism

Korevaar, T. I. M. (2017) · Clinical Thyroidology · doi:10.1089/ct.2017;29.224-228

Is the treatment of subclinical hypothyroidism beneficial?

Feldt‐Rasmussen, U. (2009) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet1049 · Cited by 14 · see citing works

Levothyroxine for Subclinical Hypothyroidism Does Not Improve Thyroid-Related Symptoms in Patients 80 Years of Age or Older

Angell, T. E. (2019) · Clinical Thyroidology · doi:10.1089/ct.2019;31.509-511