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Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice
Abstract
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.
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“Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [135]
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Cites
Official Methods of Analysis of
Helrick, K. (1980) · Analytical Chemistry · doi:10.1021/ac50052a726 · Cited by 59,351
(2023) · Oxford University Press eBooks · doi:10.1093/9780197610145.002.001 · Cited by 28,136
Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L., & Pariza, M. W. (1992) · Journal of Food Composition and Analysis · doi:10.1016/0889-1575(92)90037-k · Cited by 1,197
Self-citationEffect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Self-citationConjugated linoleic acid and atherosclerosis in rabbits
Lee, K. N., Kritchevsky, D., & Parizaa, M. W. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90034-5 · Cited by 998
Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1881 · Cited by 929
Self-citationA stable, radioactive substrate emulsion for assay of lipoprotein lipase
Nilsson‐Ehle, P., & Schotz, M. C. (1976) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41752-3 · Cited by 841
Ha, Y. L., STORKSON, J. M., & Pariza, M. W. (1990) · PubMed · Cited by 669
Self-citationHouseknecht, K. L., Heuvel, J. P. V., Moya-Camarena, S. Y., Portocarrero, C. P., Peck, L. W., Nickel, K. P., & Belury, M. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8303 · Cited by 643
Frost, S. C., & Lane, M. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89409-1 · Cited by 513
Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse
West, D. B., DeLany, J. P., Camet, P. M., Blohm, F., Truett, A. A., & Scimeca, J. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.3.r667 · Cited by 468
The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs
Dugan, M. E. R., Aalhus, J. L., Schaefer, A. L., & Kramer, J. K. G. (1997) · Canadian Journal of Animal Science · doi:10.4141/a97-084 · Cited by 347
Conjugated Linoleic Acid Decreases Hepatic Stearoyl-CoA Desaturase mRNA Expression
Lee, K. N., Pariza, M. W., & Ntambi, J. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8994 · Cited by 305
Self-citationSehat, N., Yurawecz, M. P., Roach, J. A. G., Mossoba, M. M., Kramer, J. K. G., & Ku, Y. (1998) · Lipids · doi:10.1007/s11745-998-0198-6 · Cited by 248
Metabolites of conjugated isomers of linoleic acid (CLA) in the rat
Sébédio, J. L., Juanéda, P., Dobson, G., Ramilison, I., Martin, J. C., Chardigny, J., & Christie, W. W. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00015-5 · Cited by 183
A simple method for preparation of methyltrans‐10,cis‐12 octadecadienoate
Scholfield, C. R., & Koritala, S. V. (1970) · Journal of the American Oil Chemists Society · doi:10.1007/bf02609501 · Cited by 13
Research works printed but not linked: 7
- Doyle E., 1998, Scientific Forum Explores CLA Knowledge, INFORM, 9, 69
- Sisk M., 1998, Effect of Conjugated Linoleic Acid on Fat Pad Weights and Cellularity in Sprague‐Dawley and Zucker Rats, FASEB J., 12, A536
- Cook M.E., 1998, Feeding Conjugated Linoleic Acid Improves Feed Efficiency and Reduces Whole Body Fat in Pigs, FASEB J., 12, A836
- Thiel R.L., 1998, Midwest Animal Science Meetings 1998 Abstracts, 61
- Dunshea F.R., 1998, Dietary Conjugated Linoleic Acid Decreases Back Fat in Finisher Gilts, J. Animal Sci., 76
- Snedecor G.W., 1989, Statistical Methods, 238
- Pariza M.W., 1998, Synthesis and Biological Activity of Conjugated Eicosadienoic Acid, Abstracts of the 89th American Oil Chemists' Society Annual Meeting, 21
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The biologically active isomers of conjugated linoleic acid
Pariza, M. W., Park, Y., & Cook, M. E. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00008-x · Cited by 1,098
Self-citationD IETARY C ONJUGATED L INOLEIC A CID IN H EALTH : Physiological Effects and Mechanisms of Action
Belury, M. A. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.021302.121842 · Cited by 815
Hasler, C. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3772 · Cited by 736
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663
Regulation and nutritional manipulation of milk fat: low-fat milk syndrome
Bauman, D. E., & Griinari, J. M. (2001) · Livestock Production Science · doi:10.1016/s0301-6226(01)00195-6 · Cited by 642
Metadata
- Authors
- Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Pariza, Michael W.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1999-03
- Volume
- 34
- Issue
- 3
- Pages
- 235-241
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2057643905
- Cited by
- 815
- References
- 16
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
- FWCI
- 49.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
- MeSH terms
- Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice
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