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Cited by 1,163Fatty Acid Research and HealthLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Effect of conjugated linoleic acid on body composition in mice

Park, Yeonhwa, Albright, Karen J., Liu, Wei, Storkson, Jayne M., Cook, Mark E., Pariza, Michael W.·1997·Lipids
DOI 10.1007/s11745-997-0109-x
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Abstract

The effects of conjugated linoleic acid (CLA) on body composition were investigated. ICR mice were fed a control diet containing 5.5% corn oil or a CLA-supplemented diet (5.0% corn oil plus 0.5% CLA). Mice fed CLA-supplemented diet exhibited 57% and 60% lower body fat and 5% and 14% increased lean body mass relative to controls (P < 0.05). Total carnitine palmitoyltransferase activity was increased by dietary CLA supplementation in both fat pad and skeletal muscle; the differences were significant for fat pad of fed mice and skeletal muscle of fasted mice. In cultured 3T3-L1 adipocytes CLA treatment (1 x 10(-4)M) significantly reduced heparin-releasable lipoprotein lipase activity (-66%) and the intracellular concentrations of triacylglyceride (-8%) and glycerol (-15%), but significantly increased free glycerol in the culture medium (+22%) compared to control (P < 0.05). The effects of CLA on body composition appear to be due in part to reduced fat deposition and increased lipolysis in adipocytes, possibly coupled with enhanced fatty acid oxidation in both muscle cells and adipocytes.

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Crossref · 10.1007/s11745-997-0109-x

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  • Despite compelling evidence that CLA supplementation can influence body composition in rodent models, human data are more modest.

    “Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [134]

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Authors
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Pariza, Michael W.
ORCID
Venue
Lipids
Publisher
Wiley
Published
1997-08
Volume
32
Issue
8
Pages
853-858
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
DOI
10.1007/s11745-997-0109-x
OpenAlex
W2024468043
Cited by
1,163
References
39
Citations by year
2026: 5 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 14 · 2021: 13 · 2020: 24 · 2019: 12 · 2018: 15 · 2017: 21 · 2016: 34 · 2015: 26 · 2014: 33 · 2013: 47 · 2012: 39
FWCI
45.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wisconsin Alumni Research Foundation
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
conjugated linoleic acid, body composition, fat mass, lean body mass, carnitine palmitoyltransferase, lipoprotein lipase, adipocytes, lipolysis, fatty acid oxidation, skeletal muscle, fat pad, 3T3-L1 adipocytes, triglycerides, glycerol, dietary supplementation
MeSH terms
Adipose Tissue, Animals, Body Composition, Body Weight, Carnitine O-Palmitoyltransferase, Corn Oil, Diet, Dietary Fats, Female, Glycerol, Linoleic Acids, Lipolysis, Lipoprotein Lipase, Liver, Male, Mice, Inbred ICR, Muscles, 3T3 Cells, Adipocytes, Mice

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