CoChat
Sign Up
Cited by 11

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Relationship of Parasite Allergens to Allergic Diseases

Caraballo, Luis, Llinás-Caballero, Kevin·2023·Current Allergy and Asthma Reports
DOI 10.1007/s11882-023-01089-8PMC PMC10354133
Open this paper in CoChat — free account

Abstract

Purpose of Review: Helminth infections modify the natural history of allergic diseases, by either decreasing or increasing their symptoms. Several helminth components are involved in the increasing of the allergic response and symptoms, overcoming the concomitant immunosuppression of helminthiases. However, the role of individual IgE-binding molecules in this process remains to be defined. Recent Findings: We updated the list of helminth allergens and IgE-binding molecules, their effects on asthma presentation, and their impact on allergy diagnosis. Data from genetic and epigenetic studies of ascariasis are analyzed. A new species-specific A. lumbricoides allergen has been discovered, with potential use in molecular diagnosis. Summary: Most helminth IgE-binding components are not officially classified as allergens in the WHO/IUIS database, although there is evidence of their influence increasing allergic manifestations. Further immunological characterization of these components is needed to better understand their mechanisms of action and evaluate the ways in which they can influence the diagnosis of allergy.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s11882-023-01089-8

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1 Urbanization and allergies in the tropics: the influence of helminthiases and house dust mites. If we look at the current situation in the tropics, we can hypothesize that one of the reasons why urbanization leads to an increase in allergy is the reduction of severe forms of helminthiases due to the improvement of hygiene conditions associated with urbanization
Fig. 1 Urbanization and allergies in the tropics: the influence of helminthiases and house dust mites. If we look at the current situation in the tropics, we can hypothesize that one of the reasons why urbanization leads to an increase in allergy is the reduction of severe forms of helminthiases due to the improvement of hygiene conditions associated with urbanizationCC BY · PubMed Central
Fig. 2 An example of allergic sensitization in a child living in the tropics. Specific IgE against D. pteronyssinus (Dp), B. tropicalis (Bt), and Ascaris extracts were measured using ImmunoCAP™ 100. Specific IgE to A. lumbricoides GST (AsGST), tropomyosin (Asc l 3), and ABA-1 were measured by ELISA. Samples were collected at 7, 12, 26, and 36 months. Data on the child’s total IgE levels at these time points are also included. Figure obtained from data of the FRAAT cohort (reference 16)
Fig. 2 An example of allergic sensitization in a child living in the tropics. Specific IgE against D. pteronyssinus (Dp), B. tropicalis (Bt), and Ascaris extracts were measured using ImmunoCAP™ 100. Specific IgE to A. lumbricoides GST (AsGST), tropomyosin (Asc l 3), and ABA-1 were measured by ELISA. Samples were collected at 7, 12, 26, and 36 months. Data on the child’s total IgE levels at these time points are also included. Figure obtained from data of the FRAAT cohort (reference 16)CC BY · PubMed Central
Fig. 3 Blood eosinophil counts increase with the severity of A. lumbricoides infection. The number of eosinophils is expressed as absolute cell counts/μL. Low infection < 2500 eggs/g. Moderate/Severe = equal or > 2500 eggs/g. A total of 82 subjects were included
Fig. 3 Blood eosinophil counts increase with the severity of A. lumbricoides infection. The number of eosinophils is expressed as absolute cell counts/μL. Low infection < 2500 eggs/g. Moderate/Severe = equal or > 2500 eggs/g. A total of 82 subjects were includedCC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 108

  1. Caraballo L. The tropics, helminth infections and hygiene hypotheses. Expert Rev Clin Immunol. 2018;14(2):99–102. · DOI
  2. Caraballo L, Coronado S. Parasite allergens. Mol Immunol. 2018;100:113–9. · DOI
  3. •• Arrais M, Maricoto T, Nwaru BI, Cooper PJ, Gama JMR, Brito M, et al. Helminth infections and allergic diseases: systematic review and meta-analysis of the global literature. J Allergy Clin Immunol. 2022;149(6):2139–52. Important global analysis of the literature on the epidemiological evidence of helminth-allergy interactions. · DOI
  4. • Jogi NO, Kitaba N, Storaas T, Schlunssen V, Triebner K, Holloway JW, et al. Ascaris exposure and its association with lung function, asthma, and DNA methylation in Northern Europe. J Allergy Clin Immunol. 2022;149(6):1960–9. This work shows that helminthiases like ascariasis are still important in temperate regions. · DOI
  5. • Cooper PJ, Figueiredo CA, Rodriguez A, Dos Santos LM, Ribeiro-Silva RC, Carneiro VL, et al. Understanding and controlling asthma in Latin America: a review of recent research informed by the SCAALA programme. Clinical and translational allergy. 2023;13(3):e12232. Interesting discussion about the effects or urbanization and other socioeconomic factors on allergic diseases in Latin America. · DOI
  6. Acevedo N, Zakzuk J, Caraballo L. House dust mite allergy under changing environments. Allergy Asthma Immunol Res. 2019;11(4):450–69. · DOI
  7. • Vacca F, Le Gros G. Tissue-specific immunity in helminth infections. Mucosal Immunol. 2022;15(6):1212–23. This is an update of the basic mechanisms of helminth immunity from experiments in animals, focused in tissue-specific aspects. · DOI
  8. Caraballo L, Zakzuk J, Acevedo N. Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin. Parasitology. 2021:1–13. · DOI
  9. Ahumada V, Garcia E, Dennis R, Rojas MX, Rondon MA, Perez A, et al. IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clin Exp Allergy. 2015;45(7):1189–200. · DOI · Paper page
  10. Caraballo L, Acevedo N, Zakzuk J. Ascariasis as a model to study the helminth/allergy relationships. Parasite Immunol. 2019;41(6):e12595. · DOI
  11. Hunninghake GM, Soto-Quiros ME, Avila L, Ly NP, Liang C, Sylvia JS, et al. Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol. 2007;119(3):654–61. · DOI · Paper page
  12. Buendia E, Zakzuk J, Mercado D, Alvarez A, Caraballo L. The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity. World Allergy Organ J. 2015;8(1):8. · DOI
  13. Lee TD, Xie CY. IgE regulation by nematodes: the body fluid of Ascaris contains a B-cell mitogen. J Allergy Clin Immunol. 1995;95(6):1246–54. · DOI
  14. Caraballo LAN, Buendia E. Human ascariasis increases the allergic response and allergic symptoms. Curr Trop Med Rep. 2015;2:224–32. · DOI
  15. Acevedo N, Sanchez J, Zakzuk J, Bornacelly A, Quiroz C, Alvarez A, et al. Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study. BMC Pulm Med. 2012;12:13. · DOI
  16. Acevedo N, Bornacelly A, Mercado D, Unneberg P, Mittermann I, Valenta R, et al. Genetic variants in CHIA and CHI3L1 are associated with the IgE response to the Ascaris resistance marker ABA-1 and the birch pollen allergen Bet v 1. PLoS ONE. 2016;11(12):e0167453. · DOI
  17. • Zakzuk J, Acevedo N, Harb H, Eick L, Renz H, Potaczek DP, et al. IgE levels to Ascaris and house dust mite allergens are associated with increased histone acetylation at key type-2 immune genes. Front Immunol. 2020;11:756. This study shows epigenetic mechanisms underlying the boosting of specific IgE against house dust mite allergens during human ascariasis. · DOI
  18. Acevedo N, Sanchez J, Erler A, Mercado D, Briza P, Kennedy M, et al. IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1. Allergy. 2009;64(11):1635–43. · DOI
  19. Acevedo NEA, Briza P, Puccio F, Ferreira F, Caraballo L. Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int Arch of Allergy Immunol. 2011;154:195–206. · DOI · Paper page
  20. Acevedo N, Mohr J, Zakzuk J, Samonig M, Briza P, Erler A, et al. Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. PLoS ONE. 2013;8(11):e78353. · DOI
  21. •• Ahumada V, Manotas M, Zakzuk J, Aglas L, Coronado S, Briza P, et al. Identification and physicochemical characterization of a new allergen from Ascaris lumbricoides. Int J Mol Sci. 2020;21(24). This article describes the last obtained A. lumbricoides allergen, including several technical procedures for supporting its allergenic activity. · DOI
  22. Ahumada V, Zakzuk J, Coronado S, Aglaz L, Araujo G, Briza P, et al. Identification of a new, no cross-reacting allergen from Ascaris lumbricoides [abstract]. World Allergy Organ J. 2020;13(8). · DOI
  23. Acevedo N, Erler A, Briza P, Puccio F, Ferreira F, Caraballo L. Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int Arch Allergy Immunol. 2011;154(3):195–206. · DOI · Paper page
  24. Mueller GA, Pedersen LC, Glesner J, Edwards LL, Zakzuk J, London RE, et al. Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: relevance for molecular diagnosis. J Allergy Clin Immunol. 2015;136(5):1369–77. · DOI
  25. • Zakzuk J, Lozano A, Caraballo L. Allergological importance of invertebrate glutathione transferases in tropical environments. Front Allergy. 2021;2:695262. A comprehensive review of GSTs from different organisms and their impact on allergic diseases. · DOI
  26. McSharry C, Xia Y, Holland CV, Kennedy MW. Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children. Infect Immun. 1999;67(2):484–9. · DOI
  27. Rasul TF, Bergholz DR, Faiz A. Latent Strongyloides stercoralis in an asymptomatic male with chronic peripheral eosinophilia. Cureus. 2021;13(12):e20140.
  28. Araujo ES, de Jesus Pereira CA, de Moura Pereira AT, Moreira JM, de Rezende MC, Rodrigues JL, et al. The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice. Parasitol Res. 2016;115(8):3107–17. · DOI
  29. de las Marinas MD, Martorell A, Felix R, Cerdá JC, García A, Navalpotro D. Strongyloidiasis: an emerging infectious disease that simulates allergic diseases. J Investig Allergol Clin Immunol. 2012;22(4):286–7.
  30. • Hazan G, Orscheln RC, Kertz L, Rivera-Spoljaric K. A child with chronic cough and eosinophilia secondary to Strongyloides stercoralis infection. Pediatr Pulmonol. 2022;57(10):2562–4. This is an example of what is still happening during helminth infections. · DOI
  31. Salam R, Sharaan A, Jackson SM, Solis RA, Zuberi J. Strongyloides hyperinfection syndrome: a curious case of asthma worsened by systemic corticosteroids. Am J Case Rep. 2020;21: e925221. · DOI
  32. Tamarozzi F, Martello E, Giorli G, Fittipaldo A, Staffolani S, Montresor A, et al. Morbidity associated with chronic Strongyloides stercoralis infection: a systematic review and meta-analysis. Am J Trop Med Hyg. 2019;100(6):1305–11. · DOI
  33. Neva FA, Gam AA, Maxwell C, Pelletier LL. Skin test antigens for immediate hypersensitivity prepared from infective larvae of Strongyloides stercoralis. Am J Trop Med Hyg. 2001;65(5):567–72. · DOI
  34. Ravi V, Ramachandran S, Thompson RW, Andersen JF, Neva FA. Characterization of a recombinant immunodiagnostic antigen (NIE) from Strongyloides stercoralis L3-stage larvae. Mol Biochem Parasitol. 2002;125(1–2):73–81. · DOI
  35. Ravi V, Nutman TB, Andersen JF, Neva FA, King TP. Strongyloides stercoralis recombinant NIE antigen shares epitope with recombinant Ves v 5 and Pol a 5 allergens of insects. Am J Trop Med Hyg. 2005;72(5):549–53. · DOI
  36. Varatharajalu R, Parandaman V, Ndao M, Andersen JF, Neva FA. Strongyloides stercoralis excretory/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera. Microbiol Immunol. 2011;55(2):115–22. · DOI
  37. Ahmad H, Arifin N, Nolan TJ, Lok JB, Anuar NS, Noordin R. Strongyloides-specific IgE phage cDNA clones and development of a novel ELISA for strongyloidiasis. Diagnostics (Basel). 2021;11(6). · DOI
  38. Medeiros M Jr, Figueiredo JP, Almeida MC, Matos MA, Araujo MI, Cruz AA, et al. Schistosoma mansoni infection is associated with a reduced course of asthma. J Allergy Clin Immunol. 2003;111(5):947–51. · DOI · Paper page
  39. van den Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, et al. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet. 2000;356(9243):1723–7. · DOI
  40. Smits HH, Hammad H, van Nimwegen M, Soullie T, Willart MA, Lievers E, et al. Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection. J Allergy Clin Immunol. 2007;120(4):932–40. · DOI
  41. Webb EL, Nampijja M, Kaweesa J, Kizindo R, Namutebi M, Nakazibwe E, et al. Helminths are positively associated with atopy and wheeze in Ugandan fishing communities: results from a cross-sectional survey. Allergy. 2016;71(8):1156–69. · DOI
  42. Nkurunungi G, Kabagenyi J, Nampijja M, Sanya RE, Walusimbi B, Nassuuna J, et al. Schistosoma mansoni-specific immune responses and allergy in Uganda. Parasite Immunol. 2018;40(1). · DOI
  43. Yombo DJK, Mentink-Kane MM, Wilson MS, Wynn TA, Madala SK. Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation. J Biol Chem. 2019;294(41):15082–94. · DOI
  44. Dunne DW, Webster M, Smith P, Langley JG, Richardson BA, Fulford AJ, et al. The isolation of a 22 kDa band after SDS-PAGE of Schistosoma mansoni adult worms and its use to demonstrate that IgE responses against the antigen(s) it contains are associated with human resistance to reinfection. Parasite Immunol. 1997;19(2):79–89. · DOI
  45. Fitzsimmons CM, Stewart TJ, Hoffmann KF, Grogan JL, Yazdanbakhsh M, Dunne DW. Human IgE response to the Schistosoma haematobium 22.6 kDa antigen. Parasite Immunol. 2004;26(8–9):371–6. · DOI
  46. Santiago ML, Hafalla JC, Kurtis JD, Aligui GL, Wiest PM, Olveda RM, et al. Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the human IgE response: similarity of IgE-binding epitopes to allergen peptides. Int Arch Allergy Immunol. 1998;117(2):94–104. · DOI
  47. Fitzsimmons CM, Jones FM, Stearn A, Chalmers IW, Hoffmann KF, Wawrzyniak J, et al. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Negl Trop Dis. 2012;6(4):e1593. · DOI
  48. Wan D, Ludolf F, Alanine DG, Stretton O, Ali Ali E, Al-Barwary N, et al. Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins. PLoS Negl Trop Dis. 2014;8(9):e3124. · DOI
  49. Farnell EJ, Tyagi N, Ryan S, Chalmers IW, Pinot de Moira A, Jones FM, et al. Known allergen structures predict Schistosoma mansoni IgE-binding antigens in human infection. Front Immunol. 2015;6:26. · DOI · Paper page
  50. Farias LP, Rodrigues D, Cunna V, Rofatto HK, Faquim-Mauro EL, Leite LC. Schistosoma mansoni venom allergen like proteins present differential allergic responses in a murine model of airway inflammation. PLoS Negl Trop Dis. 2012;6(2):e1510. · DOI
  51. Meyer NH, Mayerhofer H, Tripsianes K, Blindow S, Barths D, Mewes A, et al. A crystallin fold in the interleukin-4-inducing principle of Schistosoma mansoni eggs (IPSE/alpha-1) mediates IgE binding for antigen-independent basophil activation. J Biol Chem. 2015;290(36):22111–26. · DOI
  52. Schramm G, Hamilton JV, Balog CI, Wuhrer M, Gronow A, Beckmann S, et al. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs. Mol Biochem Parasitol. 2009;166(1):4–14. · DOI
  53. Braga Emidio N, Antonia do Nascimento Gusmao M, Castro Borges W, Ryuichi Nakaie C, Gomes Vasconcelos E, Faria Pinto P. Identification of a linear IgE inducing epitope on the SmATPDase1 surface. Acta Biochim Biophys Sin (Shanghai). 2017;49(6):564–6. · DOI
  54. Furmonaviciene R, Sewell HF, Shakib F. Comparative molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources. Clin Exp Allergy. 2000;30(9):1307–13. · DOI
  55. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorak J, Delcroix M, et al. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010;11:56. · DOI
  56. Gasan TA, Kuipers ME, Roberts GH, Padalino G, Forde-Thomas JE, Wilson S, et al. Schistosoma mansoni larval extracellular vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae. PLoS Negl Trop Dis. 2021;15(11):e0009981. · DOI
  57. Mendonca LR, Veiga RV, Dattoli VC, Figueiredo CA, Fiaccone R, Santos J, et al. Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. PLoS Negl Trop Dis. 2012;6(11):e1886. · DOI
  58. Aghaei S, Riahi SM, Rostami A, Mohammadzadeh I, Javanian M, Tohidi E, et al. Toxocara spp. infection and risk of childhood asthma: a systematic review and meta-analysis. Acta Trop. 2018;182:298–304. · DOI · Paper page
  59. Rubinsky-Elefant G, Hoshino-Shimizu S, Jacob CM, Sanchez MC, Ferreira AW. Potential immunological markers for diagnosis and therapeutic assessment of toxocariasis. Rev Inst Med Trop Sao Paulo. 2011;53(2):61–5. · DOI
  60. Chapman PR, Giacomin P, Loukas A, McCarthy JS. Experimental human hookworm infection: a narrative historical review. PLoS Negl Trop Dis. 2021;15(12):e0009908. · DOI
  61. Wordemann M, Diaz RJ, Heredia LM, Collado Madurga AM, Ruiz Espinosa A, Prado RC, et al. Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children. Trop Med Int Health. 2008;13(2):180–6. · DOI
  62. Sangsupawanich P, Mahakittikun V, Chongsuvivatwong V, Mo-suwan L, Choprapawon C. Effect of helminthic infections together with mite allergen exposure on the risk of wheeze in preschool children. Asian Pac J Allergy Immunol. 2010;28(1):29–34.
  63. Falcone FH, Telford G, Hooi D, Brown AP, Seabra R, Feary J, et al. Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients. J Allergy Clin Immunol. 2009;124(6):1343–50 e7. · DOI
  64. Phillips C, Coward WR, Pritchard DI, Hewitt CR. Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites. J Leukoc Biol. 2003;73(1):165–71. · DOI
  65. Balfour E, Zalka A, Lazova R. Cutaneous larva migrans with parts of the larva in the epidermis. Cutis. 2002;69(5):368–70.
  66. Griffiths GD, Hornby RJ, Scott L, Pritchard DI, Brown AP, Hooi DSW, et al. Development of a model of hookworm infection exhibiting salient characteristics of human infection. Am J Trop Med Hyg. 2008;78(6):936–45. · DOI
  67. de Hurtado I, Layrisse M. Epidemiologic role of skin hypersensitivity in hookworm disease. Am J Trop Med Hyg. 1968;17(1):72–8. · DOI
  68. Loukas A, Croese J, Opdebeeck J, Prociv P. Detection of antibodies to secretions of Ancylostoma caninum in human eosinophilic enteritis. Trans R Soc Trop Med Hyg. 1992;86(6):650–3. · DOI
  69. Pritchard DI, Brown A, Kasper G, McElroy P, Loukas A, Hewitt C, et al. A hookworm allergen which strongly resembles calreticulin. Parasite Immunol. 1999;21(9):439–50. · DOI
  70. Pritchard DI, Quinnell RJ, Brown A, Bockarie MJ, Caddick R, Hooi DSW. Basophil competence during hookworm (Necator americanus) infection. Am J Trop Med Hyg. 2007;77(5):860–5. · DOI
  71. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, et al. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005;19(12):1743–5. · DOI
  72. Asojo OA. Structure of a two-CAP-domain protein from the human hookworm parasite Necator americanus. Acta Crystallogr D Biol Crystallogr. 2011;67(Pt 5):455–62. · DOI
  73. Kelleher A, Darwiche R, Rezende WC, Farias LP, Leite LC, Schneiter R, et al. Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs. Acta Crystallogr D Biol Crystallogr. 2014;70(Pt 8):2186–96. · DOI
  74. Diemert DJ, Pinto AG, Freire J, Jariwala A, Santiago H, Hamilton RG, et al. Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths. J Allergy Clin Immunol. 2012;130(1):169–76 e6. · DOI
  75. Winter JA, Davies OR, Brown AP, Garnett MC, Stolnik S, Pritchard DI. The assessment of hookworm calreticulin as a potential vaccine for necatoriasis. Parasite Immunol. 2005;27(4):139–46. · DOI
  76. Ghosh K, Hotez PJ. Antibody-dependent reductions in mouse hookworm burden after vaccination with Ancylostoma caninum secreted protein 1. J Infect Dis. 1999;180(5):1674–81. · DOI
  77. Loukas A, Opdebeeck J, Croese J, Prociv P. Immunologic incrimination of Ancylostoma caninum as a human enteric pathogen. Am J Trop Med Hyg. 1994;50(1):69–77. · DOI
  78. Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA. Specific allergic sensitisation to filarial antigens in tropical eosinophilia syndrome. Lancet. 1979;1(8127):1158–61. · DOI
  79. Cadman ET, Thysse KA, Bearder S, Cheung AY, Johnston AC, Lee JJ, et al. Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae. PLoS Pathog. 2014;10(3):e1003988. · DOI
  80. Mehlotra RK, Hall LR, Haxhiu MA, Pearlman E. Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness. Infect Immun. 2001;69(3):1463–8. · DOI
  81. Mitre E, Nutman TB. IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections. J Allergy Clin Immunol. 2006;117(4):939–45. · DOI
  82. Garraud O, Nkenfou C, Bradley JE, Perler FB, Nutman TB. Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies. J Immunol. 1995;155(3):1316–25. · DOI
  83. Klion AD, Donelson JE. OvGalBP, a filarial antigen with homology to vertebrate galactoside-binding proteins. Mol Biochem Parasitol. 1994;65(2):305–15. · DOI
  84. Grove DI, Cabrera BD, Valeza FS, Guinto RS, Ash LR, Warren KS. Sensitivity and specificity of skin reactivity to Brugia malayi and Dirofilaria immitis antigens in Bancroftian and Malayan filariasis in the Philippines. Am J Trop Med Hyg. 1977;26(2):220–9. · DOI
  85. • Hadadianpour A, Daniel J, Zhang J, Spiller BW, Makaraviciute A, DeWitt AM, et al. Human IgE mAbs identify major antigens of parasitic worm infection. J Allergy Clin Immunol. 2022;150(6):1525–33. This study describes several IgE-binding ESPs using MoAbs showing that TTR are the main inducers of IgE response against filaria and have allergenic activity inducing anaphylaxis in mice. · DOI
  86. Lobos E, Zahn R, Weiss N, Nutman TB. A major allergen of lymphatic filarial nematodes is a parasite homolog of the γ-glutamyl transpeptidase. Mol Med. 1996;2(6):712–24. · DOI
  87. Gounni AS, Spanel-Borowski K, Palacios M, Heusser C, Moncada S, Lobos E. Pulmonary inflammation induced by a recombinant Brugia malayi γ-glutamyl transpeptidase homolog: involvement of humoral autoimmune responses. Mol Med. 2001;7(5):344–54. · DOI
  88. Lobos E, Nutman TB, Hothersall JS, Moncada S. Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with Bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity. Infect Immun. 2003;71(2):747–53. · DOI
  89. Santiago Hda C, Ribeiro-Gomes FL, Bennuru S, Nutman TB. Helminth infection alters IgE responses to allergens structurally related to parasite proteins. J Immunol. 2015;194(1):93–100. · DOI · Paper page
  90. Bielory BP, Mainardi T, Rottem M. Evolutionary immune response to conserved domains in parasites and aeroallergens. Allergy Asthma Proc. 2013;34(1):93–102. · DOI
  91. Santiago HC, Bennuru S, Boyd A, Eberhard M, Nutman TB. Structural and immunologic cross-reactivity among filarial and mite tropomyosin: implications for the hygiene hypothesis. J Allergy Clin Immunol. 2011;127(2):479–86. · DOI
  92. Santiago HC, LeeVan E, Bennuru S, Ribeiro-Gomes F, Mueller E, Wilson M, et al. Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization. J Allergy Clin Immunol. 2012;130(1):248–56 e9. · DOI
  93. Darwiche R, Lugo F, Drurey C, Varossieau K, Smant G, Wilbers RHP, et al. Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis. Int J Parasitol. 2018;48(5):371–8. · DOI
  94. Anand SB, Gnanasekar M, Thangadurai M, Prabhu PR, Kaliraj P, Ramaswamy K. Immune response studies with Wuchereria bancrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis. Parasitol Res. 2007;101(4):981–8. · DOI
  95. Cooper PJ, Chico ME, Rodrigues LC, Ordonez M, Strachan D, Griffin GE, et al. Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol. 2003;111(5):995–1000. · DOI
  96. Cooper PJ, Chis Ster I, Chico ME, Vaca M, Oviedo Y, Maldonado A, et al. Impact of early life geohelminths on wheeze, asthma and atopy in Ecuadorian children at 8 years. Allergy. 2021;76(9):2765–75. · DOI
  97. Zakzuk J, Casadiego S, Mercado A, Alvis-Guzman N, Caraballo L. Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. Acta Trop. 2018;187:1–4. · DOI
  98. Acevedo N, Caraballo L. IgE cross-reactivity between Ascaris lumbricoides and mite allergens: possible influences on allergic sensitization and asthma. Parasite Immunol. 2011;33(6):309–21. · DOI
  99. Ghahremani GG, Hahn ME. Resurgence of intestinal ascariasis among adults: radiological diagnosis and clinical implications. Abdom Radiol (NY). 2022;47(3):915–22. · DOI
  100. •• Murangi T, Prakash P, Moreira BP, Basera W, Botha M, Cunningham S, et al. Ascaris lumbricoides and ticks associated with sensitization to galactose alpha1,3-galactose and elicitation of the alpha-gal syndrome. J Allergy Clin Immunol. 2022;149(2):698–707 e3. In this important work, the existence of alpha-gal in A. lumbricoides and other sources is demonstrated by several approaches. · DOI · Paper page
  101. Arkestal K, Sibanda E, Thors C, Troye-Blomberg M, Mduluza T, Valenta R, et al. Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-alpha 1,3-galactose. J Allergy Clin Immunol. 2011;127(4):1024–8. · DOI
  102. Zakzuk J, Acevedo N, Cifuentes L, Bornacelly A, Sanchez J, Ahumada V, et al. Early life IgE responses in children living in the tropics: a prospective analysis. Pediatr Allergy Immunol. 2013;24(8):788–97. · DOI
  103. Price DB, Rigazio A, Campbell JD, Bleecker ER, Corrigan CJ, Thomas M, et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med. 2015;3(11):849–58. · DOI
  104. Yanola J, Nachaiwieng W, Duangmano S, Prasannarong M, Somboon P, Pornprasert S. Current prevalence of intestinal parasitic infections and their impact on hematological and nutritional status among Karen hill tribe children in Omkoi District, Chiang Mai Province. Thailand Acta Trop. 2018;180:1–6. · DOI
  105. Peñaranda Garcia D. Effects of Ascaris lumbricoides in eosinophils, regulatory B cells and asthma severity in asthmatic patients from a helminth endemic populatio [Master's Thesis]. Cartagena, Colombia: Institute for Immunological Research, University of Cartagena; 2019.
  106. Escamilla-Gil JM, Fernandez-Nieto M, Acevedo N. Understanding the cellular sources of the fractional exhaled nitric oxide (FeNO) and its role as a biomarker of type 2 inflammation in asthma. Biomed Res Int. 2022;2022:5753524. · DOI
  107. Porsbjerg C, Melen E, Lehtimaki L, Shaw D. Asthma Lancet. 2023;401(10379):858–73. · DOI
  108. De Vivero MM, Escamilla JM, Espinoza H, Regino R, Florez de Arco L, Caraballo L, et al. Type 2 inflammation biomarkers in adult asthmatic patients from a tropical environment and IgE sensitized to the helminth Ascaris [abstract]. Allergy. 2021;76(S110):424–582. · DOI

Cited by

Sorted by citations

See all 11

Metadata

Authors
Caraballo, L., & Llinás-Caballero, K.
Venue
Current Allergy and Asthma Reports
Publisher
Springer Science and Business Media LLC
Published
2023-06-03
Volume
23
Issue
7
Pages
363-373
ISSN
  • 1529-7322
  • 1534-6315
DOI
10.1007/s11882-023-01089-8
PMC
PMC10354133
Cited by
11
References
1
Language
en
Licence
Funders
  • Colombian Ministry of Science (Minciencias) and Sistema General de Regalías (BPIN20200000100405)
  • University of Cartagena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Relationship of Parasite Allergens to Allergic Diseases. https://app.cochat.ai/papers/10.1007/s11882-023-01089-8
The paper
Caraballo, L., & Llinás-Caballero, K. (2023). The Relationship of Parasite Allergens to Allergic Diseases. Current Allergy and Asthma Reports. https://doi.org/10.1007/s11882-023-01089-8