The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Ectopic fat and insulin resistance
Abstract
Ectopic fat is defined by the deposition of triglycerides within cells of non-adipose tissue that normally contain only small amounts of fat. Over the past decade, magnetic resonance spectroscopy has been used extensively for noninvasive quantification of intramyocellular, intrahepatocellular, and more recently myocardial and pancreatic lipids. In liver and muscle, triglyceride content usually correlates with whole-body and tissue-specific insulin sensitivity. However, fat mass and oxidative capacity influence this relationship, indicating that ectopic lipid content is not the only factor that explains insulin resistance. Ectopic lipids may rather serve as biomarkers of the balance between metabolic supply and demand in different states of insulin sensitivity. Consequently, ectopic lipid concentrations, particularly in the liver, decrease with lifestyle- or drug-induced improvement of insulin sensitivity.
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“Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [11]
In the citing paper
“an increased intramyocellar fat content and fatty acid metabolites have been shown to play a pivotal role in the development of insulin resistance in skeletal muscle [11–15].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [11]
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Cites
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
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Self-citationGoodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759
Goodpaster, B. H., Thaete, F. L., & Kelley, D. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.885 · Cited by 707
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo
Szczepaniak, L. S., Babcock, E. E., Schick, F., Dobbins, R. L., Garg, A., Burns, D. K., McGarry, J. D., & Stein, D. T. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e977 · Cited by 688
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Research works printed but not linked: 1
- Brehm A: Comparison of the effects of glimepiride vs. pioglitazone+nateglinide therapy on insulin sensitivity and ectopic fat storage in well-controlled type 2 diabetes. Diabetes 2005, 54(Suppl 1):A381.
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Microbiote intestinal et vitamines B dans l’obésité sévère : le cas de la biotine
Voland, L. (2022) · theses.fr (ABES) · doi:10.70675/3d6ab2f6z3844z4eccz9cbazdd1ace927949
Ulanowska, M., Gjela, M., Nielsen, M. H., Askeland, A., Vestergaard, P., Frøkjær, J. B., Højlund, K., Mellergaard, M., & Handberg, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-57976-3
Mao, N., Wang, R., Wang, Y., Jin, L., He, Y., & Wu, W. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1895734
Role of Inflammation in Diet-Induced Obesity: A Dissertation
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Metadata
- Authors
- Lettner, A., & Roden, M.
- Affiliations
- Hanusch Hospital (AT)
- Corresponding author
- Roden, Michael
- ORCID
- Roden, Michael
- Venue
- Current Diabetes Reports
- Published
- 2008-06
- Volume
- 8
- Issue
- 3
- Pages
- 185-191
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- OpenAlex
- W2151826036
- Cited by
- 106
- References
- 51
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 13 · 2013: 11 · 2012: 10
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- ectopic fat, insulin resistance, intramyocellular lipid, myocardial lipids, magnetic resonance spectroscopy, insulin sensitivity, oxidative capacity, fat mass, biomarkers, lifestyle intervention
- MeSH terms
- Animals, Choristoma, Humans, Insulin, Insulin Resistance, Obesity, Pancreas, Triglycerides
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