Cited by 106Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

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Ectopic fat and insulin resistance

Lettner, Angelika, Roden, Michael·2008·Current Diabetes Reports

DOI 10.1007/s11892-008-0032-z

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Abstract

Ectopic fat is defined by the deposition of triglycerides within cells of non-adipose tissue that normally contain only small amounts of fat. Over the past decade, magnetic resonance spectroscopy has been used extensively for noninvasive quantification of intramyocellular, intrahepatocellular, and more recently myocardial and pancreatic lipids. In liver and muscle, triglyceride content usually correlates with whole-body and tissue-specific insulin sensitivity. However, fat mass and oxidative capacity influence this relationship, indicating that ectopic lipid content is not the only factor that explains insulin resistance. Ectopic lipids may rather serve as biomarkers of the balance between metabolic supply and demand in different states of insulin sensitivity. Consequently, ectopic lipid concentrations, particularly in the liver, decrease with lifestyle- or drug-induced improvement of insulin sensitivity.

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Brehm A: Comparison of the effects of glimepiride vs. pioglitazone+nateglinide therapy on insulin sensitivity and ectopic fat storage in well-controlled type 2 diabetes. Diabetes 2005, 54(Suppl 1):A381.

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Authors: Lettner, A., & Roden, M.
Affiliations: Hanusch Hospital (AT)
Corresponding author: Roden, Michael
ORCID: Roden, Michael
Venue: Current Diabetes Reports
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 3
Pages: 185-191
ISSN: 1534-4827 (ISSN-L)
1539-0829
DOI: 10.1007/s11892-008-0032-z
OpenAlex: W2151826036
Cited by: 106
References: 51
Citations by year: 2026: 4 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 13 · 2013: 11 · 2012: 10
FWCI: 0.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Diabetes Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: ectopic fat, insulin resistance, intramyocellular lipid, myocardial lipids, magnetic resonance spectroscopy, insulin sensitivity, oxidative capacity, fat mass, biomarkers, lifestyle intervention
MeSH terms: Animals, Choristoma, Humans, Insulin, Insulin Resistance, Obesity, Pancreas, Triglycerides

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