Lactase non-persistence and lactose intolerance

Bayless, Theodore M.; Brown, Elizabeth; Paige, David M.

doi:10.1007/s11894-017-0558-9

Cited by 210Digestive system and related healthNutrition, Genetics, and DiseaseGastrointestinal motility and disorders

Lactase non-persistence and lactose intolerance

Bayless, Theodore M., Brown, Elizabeth, Paige, David M.·2017·Current Gastroenterology Reports

DOI 10.1007/s11894-017-0558-9

Open this paper in CoChat — free account

Abstract

Purpose of review To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Recent findings Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence. The dairy industry and Minnesota investigators have made efforts to minimize the influence of lactose intolerance on milk consumption. Some lactose intolerant individuals, without co-existent irritable bowel syndrome, are able to consume a glass of milk with a meal with no or minor symptoms. The high frequency of lactase persistence in offspring of Northern European countries and in some nomadic African tribes is due to mutations in the promoter of the lactase gene in association with survival advantage of milk drinking. Educational and commercial efforts to improve calcium and Vitamin D intake have focused on urging consumption of tolerable amounts of milk with a meal, use of lowered lactose-content foods including hard cheeses, yogurt, and lactose-hydrolyzed milk products.

Integrity signals

Registry

Crossref · 10.1007/s11894-017-0558-9

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Lactose intolerance results from reduced lactase activity and causes diarrhea, abdominal distension, and flatulence; symptoms relate to the amount consumed and usually occur above 12 g lactose.
“Lactose intolerance is due to decreased lactase activity, resulting in symptoms such as diarrhea, abdominal distension, and flatulence.The intensity of symptoms is related to the amount of lactose consumed, 57 and gastrointestinal symptoms typically occur when consuming amounts exceeding 12 g of lactose.58”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [57]

Personal Communication
Bhunia, C. T. (1997) · IETE Journal of Education · doi:10.1080/09747338.1997.11415666 · Cited by 2,720 · see citing works
REGIONAL ILEITIS
Crohn, B. B. (1932) · JAMA · doi:10.1001/jama.1932.02740680019005 · Cited by 1,516 · see citing works
Identification of a variant associated with adult-type hypolactasia
Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., & Järvelä, I. E. (2002) · Nature Genetics · doi:10.1038/ng826 · Cited by 1,029 · see citing works
共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値
Whittaker, P. G., Morgan, M. R., Dean, P., Cameron, E., & Lind, T. (1980) · The Lancet · Cited by 724 · see citing works
Genetics of Lactase Persistence and Lactose Intolerance
Swallow, D. M. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143820 · Cited by 594 · see citing works
A Comparison of Symptoms after the Consumption of Milk or Lactose-Hydrolyzed Milk by People with Self-Reported Severe Lactose Intolerance
Suarez, F. L., Savaiano, D. A., & Levitt, M. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507063330101 · Cited by 512 · see citing works
Lactose digestion and the evolutionary genetics of lactase persistence
Ingram, C. J. E., Mulcare, C. A., Itan, Y., Thomas, M., & Swallow, D. M. (2008) · Human Genetics · doi:10.1007/s00439-008-0593-6 · Cited by 502 · see citing works
DO CD4-POSITIVE CYTOTOXIC T CELLS DAMAGE ISLET β CELLS IN TYPE 1 DIABETES?
Berardinis, P. D., James, R. F. L., Wise, P. H., Londei, M., Lake, S. P., & Feldmann, M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92785-7 · Cited by 468 · see citing works
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management
Deng, Y., Misselwitz, B., Dai, N., & Fox, M. R. (2015) · Nutrients · doi:10.3390/nu7095380 · Cited by 349 · see citing works
The geographic hypothesis and lactose malabsorption
Simoons, F. J. (1978) · Digestive Diseases and Sciences · doi:10.1007/bf01263095 · Cited by 308 · see citing works
Primary adult lactose intolerance and the milking habit: A problem in biologic and cultural interrelations
Simoons, F. J. (1970) · Digestive Diseases and Sciences · doi:10.1007/bf02235991 · Cited by 303 · see citing works
A racial difference in incidence of lactase deficiency. A survey of milk intolerance and lactase deficiency in healthy adult males
Bayless, T. M. (1966) · JAMA · doi:10.1001/jama.197.12.968 · Cited by 282 · see citing works
Self-citation
Systematic Review: Effective Management Strategies for Lactose Intolerance
Shaukat, A., Levitt, M. D., Taylor, B. C., MacDonald, R. H., Shamliyan, T., Kane, R. L., & Wilt, T. J. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-12-201006150-00241 · Cited by 266 · see citing works
LACTASE DEFICIENCY IN THE ADULT
Cuatrecasas, P., Lockwood, D., & Caldwell, J. (1965) · The Lancet · doi:10.1016/s0140-6736(65)90922-0 · Cited by 255 · see citing works
The Interrelationships between Lactose Intolerance and the Modern Dairy Industry: Global Perspectives in Evolutional and Historical Backgrounds
Silanikove, N., Leitner, G., & Merin, U. (2015) · Nutrients · doi:10.3390/nu7095340 · Cited by 238 · see citing works
ISOLATED INTESTINAL LACTASE DEFICIENCY IN THE ADULT
Auricchio, S., Landolt, M., Rubino, A., et al. (1963) · The Lancet · doi:10.1016/s0140-6736(63)92991-x · Cited by 188 · see citing works
Archaeology: The milk revolution
Curry, A. (2013) · Nature · doi:10.1038/500020a · Cited by 185 · see citing works
Adult-type hypolactasia and regulation of lactase expression
Troelsen, J. T. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.02.003 · Cited by 173 · see citing works
Lactose and Milk Intolerance: Clinical Implications
Bayless, T. M., Rothfeld, B., Massa, C., et al. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505292922205 · Cited by 161 · see citing works
Self-citation
INTESTINAL LACTASE DEFICIENCY AND LACTOSE INTOLERANCE IN ADULTS. PRELIMINARY REPORT.
Dahlqvist, A., Hammond, J. B., Crane, R. K., et al. (1963) · PubMed · Cited by 159 · see citing works
RECESSIVE INHERITANCE OF ADULT-TYPE LACTOSE MALABSORPTION
Sahi, T. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90862-3 · Cited by 158 · see citing works
Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome
Yang, J., Deng, Y., Chu, H., Cong, Y., Zhao, J., Pohl, D., Misselwitz, B., Fried, M., Dai, N., & Fox, M. R. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.034 · Cited by 158 · see citing works
Role of the Small Bowel and Colon in Lactose-Induced Diarrhea
Christopher, N. L., & Bayless, T. M. (1971) · Gastroenterology · doi:10.1016/s0016-5085(71)80083-5 · Cited by 143 · see citing works
Self-citation
National Institutes of Health Consensus Development Conference: Lactose Intolerance and Health
Suchy, F. J., Brannon, P. M., Carpenter, T. O., Fernandez, J. R., Gilsanz, V., Gould, J. B., Hall, K., Hui, S. L., Lupton, J., Mennella, J., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-12-201006150-00248 · Cited by 142 · see citing works
The Causal Element for the Lactase Persistence/ non‐persistence Polymorphism is Located in a 1 Mb Region of Linkage Disequilibrium in Europeans
Poulter, M., Hollox, E. J., Harvey, C. B., Mulcare, C. A., Peuhkuri, K., Kajander, K., Sarner, M., Korpela, R., & Swallow, D. M. (2003) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2003.00048.x · Cited by 133 · see citing works
Intestinal Lactase Deficiency and Lactose Intolerance in Adults
Dahlqvist, A., Hammond, J. B., Crane, R. K., et al. (1963) · Gastroenterology · doi:10.1016/s0016-5085(19)34844-9 · Cited by 133 · see citing works
The Scientific Basis of Guideline Recommendations on Sugar Intake
Erickson, J. M., Sadeghirad, B., Lytvyn, L., Slavin, J. L., & Johnston, B. C. (2016) · Annals of Internal Medicine · doi:10.7326/m16-2020 · Cited by 128 · see citing works
Intolerance of Small Amounts of Lactose by Individuals with Low Lactase Levels
Bedine, M. S., & Bayless, T. M. (1973) · Gastroenterology · doi:10.1016/s0016-5085(19)33008-2 · Cited by 125 · see citing works
Self-citation
Bloating and Distention in Irritable Bowel Syndrome: The Role of Gas Production and Visceral Sensation After Lactose Ingestion in a Population With Lactase Deficiency
Zhu, Y., Zheng, X., Cong, Y., Chu, H., Fried, M., Dai, N., & Fox, M. R. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.198 · Cited by 122 · see citing works
The effect of a lactose-restricted diet in patients with a positive lactose tolerance test, earlier diagnosed as irritable bowel syndrome: a 5-year follow-up study
Böhmer, C. J. M., & Tuynman, H. A. R. E. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200108000-00011 · Cited by 116 · see citing works
Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: a placebo effect?
Briet, F., Pochart, P., Marteau, P. R., Flourié, B., Arrigoni, E., & Rambaud, J. C. (1997) · Gut · doi:10.1136/gut.41.5.632 · Cited by 112 · see citing works
Lactose digestion; clinical and nutritional implications
Paige, D. M., & Bayless, T. M. (1981) · Johns Hopkins University Press eBooks · Cited by 110 · see citing works
Self-citation
Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease
Opstelten, J. L., Leenders, M. B., Dik, V. K., Chan, S. S. M., van Schaik, F. D. M., Khaw, K., Luben, R., Hallmans, G., Karling, P., Lindgren, S. C., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000798 · Cited by 99 · see citing works
Milk and Lactose Intolerance in Healthy Orientals
Huang, S.-S., & Bayless, T. M. (1968) · Science · doi:10.1126/science.160.3823.83-a · Cited by 98 · see citing works
Self-citation
Lactose Intolerance in Healthy Children
Huang, S.-S., & Bayless, T. M. (1967) · New England Journal of Medicine · doi:10.1056/nejm196706082762303 · Cited by 96 · see citing works
Self-citation
Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging
Labrie, V., Buske, O. J., Oh, E. S., Jeremian, R., Ptak, C., Gasiūnas, G., Maleckas, A., Petereit, R., Žvirblienė, A., Adamonis, K., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3227 · Cited by 93 · see citing works
Adaptation to Lactose in Lactase Non Persistent People: Effects on Intolerance and the Relationship between Dairy Food Consumption and Evalution of Diseases
Szilagyi, A. (2015) · Nutrients · doi:10.3390/nu7085309 · Cited by 83 · see citing works
Lactose hydrolyzed milk
Paige, D., Bayless, T. M., Huang, S., et al. (1975) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.8.818 · Cited by 83 · see citing works
Self-citation
Prevalence of gastro-esophageal reflux disease and its risk factors in a community-based population in southern India
Wang, H., Leena, K. B., Plymoth, A., et al. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0452-1 · Cited by 78 · see citing works
Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases
Szilagyi, A., Galiatsatos, P., & Xue, X. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0183-8 · Cited by 78 · see citing works
Molecular genetics of human lactase deficiencies
Järvelä, I. E., Torniainen, S., & Kolho, K. (2009) · Annals of Medicine · doi:10.1080/07853890903121033 · Cited by 77 · see citing works
LACTOSE MALDIGESTION IN AUSTRALIAN ABORIGINAL CHILDREN
Elliott, R. B., Maxwell, G. M., & Vawser, N. D. (1967) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1967.tb21011.x · Cited by 70 · see citing works
Clinical Implications of Lactose Malabsorption Versus Lactose Intolerance
Levitt, M. D., Wilt, T. J., & Shaukat, A. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182889f0f · Cited by 67 · see citing works
Lactase persistence versus decline in human adults: Multifactorial events are involved in down-regulation after weaning
Rossi, M., Maiuri, L., Fusco, M., et al. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70031-3 · Cited by 65 · see citing works
Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age
Enattah, N. S. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i25.3508 · Cited by 65 · see citing works
Fecal Hydrogen Production and Consumption Measurements (Response to Daily Lactose Ingestion by Lactose Maldigesters)
Hertzler, S. R., Savaiano, D. A., & Levitt, M. D. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018822103911 · Cited by 62 · see citing works
Impact of Lactose Containing Foods and the Genetics of Lactase on Diseases: An Analytical Review of Population Data
Shrier, I., Szilagyi, A., & Correa, J. A. (2008) · Nutrition and Cancer · doi:10.1080/01635580701745301 · Cited by 61 · see citing works
Dairy Intake, Dietary Adequacy, and Lactose Intolerance
Heaney, R. P. (2013) · Advances in Nutrition · doi:10.3945/an.112.003368 · Cited by 61 · see citing works
Lactose intolerance and health disparities among African Americans and Hispanic Americans: an updated consensus statement.
Bailey, R., Fileti, C. P., Keith, J., Tropez-Sims, S., Price, W., & Allison-Ottey, S. (2013) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30113-9 · Cited by 60 · see citing works
Perception of lactose intolerance impairs health-related quality of life
Casellas, F., Aparici, A., Pérez, M. J., & Rodríguez, P. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.80 · Cited by 58 · see citing works
RECURRENT ABDOMINAL PAIN DUE TO MILK AND LACTOSE INTOLERANCE IN SCHOOL-AGED CHILDREN
Bayless, T. M., & Huang, S.-S. (1971) · PEDIATRICS · doi:10.1542/peds.47.6.1029 · Cited by 50 · see citing works
Self-citation
Lactose malabsorption and milk rejection in Negro children.
Dm, P., Tm, B., Gd, F., et al. (1971) · PubMed · Cited by 50 · see citing works
The Prevalence of Self-reported Lactose Intolerance and the Consumption of Dairy Foods Among African American Adults Are Less Than Expected
Keith, J. N., Nicholls, J., Reed, A., et al. (2011) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30241-8 · Cited by 45 · see citing works
Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene
Diekmann, L., Pfeiffer, K., & Naim, H. Y. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0261-y · Cited by 42 · see citing works
Nutrition and Health Disparities: The Role of Dairy in Improving Minority Health Outcomes
Brown-Riggs, C. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13010028 · Cited by 42 · see citing works
Lactase persistence versus lactose intolerance: Is there an intermediate phenotype?
Dzialanski, Z., Barany, M., Engfeldt, P., et al. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.11.001 · Cited by 37 · see citing works
The Onset of Lactase Persistence in Europe
Gerbault, P. (2013) · Human Heredity · doi:10.1159/000360136 · Cited by 29 · see citing works
Lactase non-persistence as a determinant of milk avoidance and calcium intake in children and adolescents
Almon, R., Sjöstróm, M., & Nilsson, T. (2013) · Journal of Nutritional Science · doi:10.1017/jns.2013.11 · Cited by 29 · see citing works
A study of lactose absorption capacity in twins
M�tneki, J., Czeizel, A. E., Flatz, S. D., et al. (1984) · Human Genetics · doi:10.1007/bf00291356 · Cited by 28 · see citing works
Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south–central Italy patients
Santonocito, C., Scapaticci, M., Guarino, D., Annicchiarico, E. B., Lisci, R., Penitente, R., Gasbarrini, A., Zuppi, C., & Capoluongo, E. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.09.026 · Cited by 28 · see citing works
Intolerance of Eight Ounces of Milk in Healthy Lactose-Intolerant Teen-Agers
Mitchell, K. J., Bayless, T. M., Paige, D. M., et al. (1975) · PEDIATRICS · doi:10.1542/peds.56.5.718 · Cited by 27 · see citing works
Self-citation
Milk programs: helpful or harmful to Negro children?
Paige, D., Bayless, T. M., & Graham, G. G. (1972) · American Journal of Public Health · doi:10.2105/ajph.62.11.1486 · Cited by 27 · see citing works
Self-citation
Lactose malabsorption in preschool black children
Paige, D., Bayless, T. M., Mellitis, E., et al. (1977) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/30.7.1018 · Cited by 27 · see citing works
Self-citation
Adult Lactose Digestion Status and Effects on Disease
Szilagyi, A. (2015) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2015/904686 · Cited by 27 · see citing works
Diversity of lactase persistence in African milk drinkers
Jones, B. L., Oljira, T., Liebert, A., Zmarz, P., Montalva, N., Tarekeyn, A., Ekong, R., Thomas, M., Bekele, E., Bradman, N. N., et al. (2015) · Human Genetics · doi:10.1007/s00439-015-1573-2 · Cited by 23 · see citing works
Effect of C/T −13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia
Kuchay, R. A. H., Thapa, B. R., Mahmood, A., & Mahmood, S. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.06.032 · Cited by 22 · see citing works
Functional Significance of Single Nucleotide Polymorphisms in the Lactase Gene in Diverse US Patients and Evidence for a Novel Lactase Persistence Allele at −13909 in Those of European Ancestry
Baffour‐Awuah, N. Y., Fleet, S. E., Montgomery, R. K., Baker, S. S., Butler, J. L., Campbell, C., Tischfield, S., Mitchell, P. D., Allende‐Richter, S., Moon, J. E., et al. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000595 · Cited by 22 · see citing works
Frequency of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups
Raz, M., Sharon, Y., Yerushalmi, B., & Birk, R. Z. (2013) · Gene · doi:10.1016/j.gene.2013.01.049 · Cited by 20 · see citing works
Pregnancy and lactose intolerance
Paige, D. M., Bayless, T. M., & Graham, G. G. (1973) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/26.3.238 · Cited by 15 · see citing works
Self-citation
Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians
Baadkar, S. V., Mukherjee, M. S., & Lele, S. S. (2014) · Annals of Human Biology · doi:10.3109/03014460.2014.902992 · Cited by 14 · see citing works
Age Dependency of the Lactase Persistence and Lactase Restriction Phenotypes Among Children in Sri Lanka and Britain
Thomas, S., Walker‐Smith, J. A., Senewiratne, B., et al. (1990) · Journal of Tropical Pediatrics · doi:10.1093/tropej/36.2.80 · Cited by 11 · see citing works
A study of the molecular variants associated with lactase persistence in different Ecuadorian ethnic groups
Paz‐y‐Miño, C., Burgos, G., López‐Cortés, A., Herrera, C., Gaviria, A., Tejera, E., & Cabrera‐Andrade, A. (2016) · American Journal of Human Biology · doi:10.1002/ajhb.22865 · Cited by 11 · see citing works
The management of lactose intolerance among primary care physicians and its correlation with management by gastroenterologists: The SEPD-SEMG national survey
Argüelles‐Arias, F., Ledo, P. R., Tenías, J. M., et al. (2015) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2015.3771/2015 · Cited by 10 · see citing works
Lactose digestion in pregnant African-Americans
Paige, D. M., Witter, F. R., Bronner, Y. L., et al. (2003) · Public Health Nutrition · doi:10.1079/phn2003489 · Cited by 9 · see citing works
Self-citation
Lactose maldigestion--age-specific prevalence in black and Indian children.
Wittenberg, D. F., & Moosa, A. (1990) · PubMed · Cited by 8 · see citing works
Lactose Intolerance
Paige, D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-375083-9.00169-0 · Cited by 4 · see citing works
Self-citation
Another New Branchiate Oligochæte
Beddard, F. E. (1894) · Nature · doi:10.1038/050020a0 · Cited by 1 · see citing works
JNMA Introduces New Medical-Legal Column
Hoover, E. L. (2010) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30473-9 · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management
Misselwitz, B., Butter, M., Verbeke, K., & Fox, M. R. (2019) · Gut · doi:10.1136/gutjnl-2019-318404 · Cited by 390 · see citing works
Nutritional management of lactose intolerance: the importance of diet and food labelling
Facioni, M. S., Raspini, B., Pivari, F., Dogliotti, E., & Cena, H. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02429-2 · Cited by 164 · see citing works
Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164 · see citing works
Refractory hypothyroidism: unraveling the complexities of diagnosis and management
Quiroz-Aldave, J. E., Concepción-Zavaleta, M. J., Durand-Vásquez, M. D. C., Concepción-Urteaga, L. A., Gamarra-Osorio, E. R., Suárez-Rojas, J., Rafael-Robles, L. D. P., Paz-Ibarra, J., & Román-González, A. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.09.003 · Cited by 14 · see citing works

Authors: Bayless, T. M., Brown, E., & Paige, D. M.
Affiliations: Johns Hopkins University (US)
Corresponding author: Bayless, Theodore M.
ORCID: Brown, Elizabeth
Paige, David M.
Venue: Current Gastroenterology Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-04-18
Volume: 19
Issue: 5
Pages: 23-23
ISSN: 1522-8037 (ISSN-L)
1534-312X
DOI: 10.1007/s11894-017-0558-9
OpenAlex: W2607218014
Cited by: 210
References: 78
Citations by year: 2026: 15 · 2025: 22 · 2024: 21 · 2023: 20 · 2022: 25 · 2021: 40 · 2020: 24 · 2019: 21 · 2018: 20 · 2017: 2
FWCI: 2.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Current Gastroenterology Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: lactase non-persistence, lactose intolerance, lactase persistence, milk consumption, dairy products, calcium intake, vitamin D intake, irritable bowel syndrome, northern European populations
MeSH terms: Animals, Dairy Products, Humans, Lactose Intolerance, Milk, Down-Regulation, Irritable Bowel Syndrome, Lactase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lactase non-persistence and lactose intolerance

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks