The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
HIV and aging: time for a new paradigm.
Abstract
The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectrum of disease experienced by those aging with HIV remains strongly influenced by HIV, its treatment, and the behaviors, conditions, and demographics associated with HIV infection. Our focus must shift from a narrow interest in CD4 counts, HIV-RNA, and AIDS-defining illnesses to determining the optimal management of HIV infection as a complex chronic disease in which the causes of morbidity and mortality are multiple and overlapping. We need a new paradigm of care with which to maximize functional status, minimize frailty, and prolong life expectancy. A composite index that summarizes a patient's risk of morbidity and mortality could facilitate this work and help chart its progress.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The cumulative burden of these complications reduces a person’s ability to compensate and respond to many events, which collectively results in onset of frailty and other geriatric syndromes (15, 17, 48).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
In the citing paper
“However, eGFR can be readily obtained from standard blood chemistry panels and is an important component in multi-variate models of mortality and hospitalization in HIV-infected persons (15, 17, 48, 55).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
In the citing paper
“A number of studies have noted the importance of anemia and RBC size/shape (typically measured by mean cell volume (MCV) and red blood cell distribution width (RDW), respectively) as important indicators of mortality and hospitalization risk in multivariate analyses (17).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
Citations
Cites
Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents
(1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-12_part_2-199806151-00003 · Cited by 5,197
Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581
Antiretroviral Treatment of Adult HIV Infection
Thompson, M., Aberg, J. A., Hoy, J., Telenti, A., Benson, C., Cahn, P. E., Eron, J. J., Günthard, H. F., Hammer, S. M., Reiss, P., et al. (2012) · JAMA · doi:10.1001/jama.2012.7961 · Cited by 2,493
CD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605
Mortality in the Highly Active Antiretroviral Therapy Era
Palella, F. J., Baker, R. K., Moorman, A. C., Chmiel, J. S., Wood, K. C., Brooks, J. T., & Holmberg, S. D. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000233310.90484.16 · Cited by 1,362
Antiretroviral Treatment of Adult HIV Infection
Hammer, S. M., Eron, J. J., Reiss, P., Schooley, R. T., Thompson, M., Walmsley, S. L., Cahn, P. E., Fischl, M. A., Gatell, J. M., Hirsch, M., et al. (2008) · JAMA · doi:10.1001/jama.300.5.555 · Cited by 1,117
Effect of Early versus Deferred Antiretroviral Therapy for HIV on Survival
Kitahata, M. M., Gange, S. J., Abraham, A. G., Merriman, B., Saag, M. S., Justice, A. C., Hogg, R. S., Deeks, S. G., Eron, J. J., Brooks, J. T., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807252 · Cited by 1,105
Self-citationDepartment of Health and Human Services
C.Miller, D., & J.Salkind, N. (2002) · Sage eBooks · doi:10.4135/9781412984386.n104 · Cited by 1,033
Cited by
Sorted by citations
Items 301–310 of 310
Kokorelias, K. M., Posa, S., Valentine, D., Dove, E., Sheppard, C. L., Arbess, G., Eaton, A. D., & Sirisegaram, L. (2026) · Health Expectations · doi:10.1111/hex.70610
Chen, T., Chen, X., Wang, S., Wang, L., Wang, T., Xie, Y., Wang, Y., Wang, M., Lin, H., & He, N. (2026) · AIDS · doi:10.1097/qad.0000000000004490
Eye Health and Vision Function in Adults Aging with Well-Controlled HIV
Abraham, A. G., Guo, X., Lawa, S., Mihailović, A., Plankey, M. W., Brown, T. T., Margolick, J. B., Ramulu, P. Y., & Banerjee, S. (2026) · Viruses · doi:10.3390/v18040431
Hong, S. Y., Woodley, D., Pao, M., Goetz, H., Alvarez, A., White, M., Hirsch, B. E., Burns, E., & McGowan, J. P. (2026) · Viruses · doi:10.3390/v18050572
Odeigah, L. O., Ologe, M. O., Oshikoya, K. A., & Fadare, J. O. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1851353
Gómez-Mercado, C. A., Giraldo, P. A., Giraldo, N. A., Hincapié, A. M., Madrigal-Cadavid, J., & Acevedo, J. I. E. (2026) · Biomédica · doi:10.7705/biomedica.7947
Troya, J., Busca, C., Matarranz, M., Galindo, M. J., Fernández-Regueras, M., Sánchez-López, M. B., García-Rosado, D., Torralba, M., de Santiago, A. D., Fanjul, F. J., et al. (2026) · AIDS · doi:10.1097/qad.0000000000004607
Metadata
- Authors
- Justice, A. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Justice, Amy C.
- ORCID
- Justice, Amy C.
- Venue
- Current HIV/AIDS Reports
- Published
- 2010-04-13
- Volume
- 7
- Issue
- 2
- Pages
- 69-76
- ISSN
- 1548-3568 (ISSN-L)
- 1548-3576
- OpenAlex
- W2158666805
- Cited by
- 309
- References
- 52
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 18 · 2019: 25 · 2018: 23 · 2017: 19 · 2016: 24 · 2015: 21 · 2014: 38 · 2013: 37 · 2012: 35
- FWCI
- 28.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current HIV/AIDS Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- aging with HIV, non-AIDS comorbidities, highly active antiretroviral therapy, viral suppression, chronic disease management, frailty, functional status, mortality risk, morbidity risk, composite risk index
- MeSH terms
- Acquired Immunodeficiency Syndrome, Aging, Clinical Trials as Topic, Humans, Middle Aged, Health Behavior, HIV Infections, Comorbidity, Anti-HIV Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
