Cited by 310HIV-related health complications and treatmentsHIV/AIDS Research and InterventionsHIV Research and Treatment

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HIV and aging: time for a new paradigm.

Justice, Amy C.·2010·Current HIV/AIDS Reports

DOI 10.1007/s11904-010-0041-9

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Abstract

The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectrum of disease experienced by those aging with HIV remains strongly influenced by HIV, its treatment, and the behaviors, conditions, and demographics associated with HIV infection. Our focus must shift from a narrow interest in CD4 counts, HIV-RNA, and AIDS-defining illnesses to determining the optimal management of HIV infection as a complex chronic disease in which the causes of morbidity and mortality are multiple and overlapping. We need a new paradigm of care with which to maximize functional status, minimize frailty, and prolong life expectancy. A composite index that summarizes a patient's risk of morbidity and mortality could facilitate this work and help chart its progress.

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Authors: Justice, A. C.
Affiliations: Yale University (US)
Corresponding author: Justice, Amy C.
ORCID: Justice, Amy C.
Venue: Current HIV/AIDS Reports
Publisher: Springer Science and Business Media LLC
Published: 2010-04-13
Volume: 7
Issue: 2
Pages: 69-76
ISSN: 1548-3568 (ISSN-L)
1548-3576
DOI: 10.1007/s11904-010-0041-9
OpenAlex: W2158666805
Cited by: 309
References: 52
Citations by year: 2026: 6 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 18 · 2019: 25 · 2018: 23 · 2017: 19 · 2016: 24 · 2015: 21 · 2014: 38 · 2013: 37 · 2012: 35
FWCI: 28.63
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current HIV/AIDS Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: aging with HIV, non-AIDS comorbidities, highly active antiretroviral therapy, viral suppression, chronic disease management, frailty, functional status, mortality risk, morbidity risk, composite risk index
MeSH terms: Acquired Immunodeficiency Syndrome, Aging, Clinical Trials as Topic, Humans, Middle Aged, Health Behavior, HIV Infections, Comorbidity, Anti-HIV Agents

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HIV and aging: time for a new paradigm.

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