The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
HIV and aging: time for a new paradigm.
Abstract
The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectrum of disease experienced by those aging with HIV remains strongly influenced by HIV, its treatment, and the behaviors, conditions, and demographics associated with HIV infection. Our focus must shift from a narrow interest in CD4 counts, HIV-RNA, and AIDS-defining illnesses to determining the optimal management of HIV infection as a complex chronic disease in which the causes of morbidity and mortality are multiple and overlapping. We need a new paradigm of care with which to maximize functional status, minimize frailty, and prolong life expectancy. A composite index that summarizes a patient's risk of morbidity and mortality could facilitate this work and help chart its progress.
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“The cumulative burden of these complications reduces a person’s ability to compensate and respond to many events, which collectively results in onset of frailty and other geriatric syndromes (15, 17, 48).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
In the citing paper
“However, eGFR can be readily obtained from standard blood chemistry panels and is an important component in multi-variate models of mortality and hospitalization in HIV-infected persons (15, 17, 48, 55).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
In the citing paper
“A number of studies have noted the importance of anemia and RBC size/shape (typically measured by mean cell volume (MCV) and red blood cell distribution width (RDW), respectively) as important indicators of mortality and hospitalization risk in multivariate analyses (17).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [17]
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Metadata
- Authors
- Justice, A. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Justice, Amy C.
- ORCID
- Justice, Amy C.
- Venue
- Current HIV/AIDS Reports
- Published
- 2010-04-13
- Volume
- 7
- Issue
- 2
- Pages
- 69-76
- ISSN
- 1548-3568 (ISSN-L)
- 1548-3576
- OpenAlex
- W2158666805
- Cited by
- 309
- References
- 52
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 18 · 2019: 25 · 2018: 23 · 2017: 19 · 2016: 24 · 2015: 21 · 2014: 38 · 2013: 37 · 2012: 35
- FWCI
- 28.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current HIV/AIDS Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- aging with HIV, non-AIDS comorbidities, highly active antiretroviral therapy, viral suppression, chronic disease management, frailty, functional status, mortality risk, morbidity risk, composite risk index
- MeSH terms
- Acquired Immunodeficiency Syndrome, Aging, Clinical Trials as Topic, Humans, Middle Aged, Health Behavior, HIV Infections, Comorbidity, Anti-HIV Agents
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