Cited by 12Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesBlood Pressure and Hypertension Studies

Aldosterone Synthase Inhibition in Hypertension

Andersen, Karl·2013·Current Hypertension Reports

Abstract

Hypertension is an established risk factor for stroke, premature coronary artery disease and heart failure. Control of elevated blood pressure has been shown to result in significant reduction of cardiovascular risk. Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), not only causes salt and water reabsorbtion in the kidneys through its effect on the mineralocorticoid hormone receptor (MR), but also an MR-independent effect, not regulated by conventional MR blockade. Although many pharmacological agents target different levels of the RAAS cascade, these generally result in elevated renin concentration and plasma renin activity. This upstream feedback response subsequently results in elevated levels of angiotensin II, a potent vasoconstrictor and stimulus to aldosterone release. This aldosterone breakthrough counteracts the long-term blood pressure-lowering effect of these agents. Therefore the development of a new class of pharmacologic agents that directly inhibit the production of aldosterone may prove clinically useful in reducing aldosterone and thereby controlling elevated blood pressure.

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Registry

Crossref · 10.1007/s11906-013-0379-7

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  • Aldosterone synthase inhibitors attenuate cardiac and renal injury in models of experimental hypertension such as spontaneously hypertensive rats and uninephrectomized rats fed a high-salt diet.

    “Aldosterone synthase inhibitors have been shown to attenuate cardiac and renal injury in models of experimental hypertension, such as spontaneously hypertensive rats (SHRs) and uninephrectomized rats fed a high-salt diet77,78, but their efficacy in obesity-induced hypertension is unclear.”

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Authors
Andersen, K.
Affiliations
National University Hospital of Iceland (IS)
Corresponding author
Andersen, Karl
Venue
Current Hypertension Reports
Published
2013-08-06
Volume
15
Issue
5
Pages
484-488
ISSN
  • 1522-6417 (ISSN-L)
  • 1534-3111
OpenAlex
W2044305216
Cited by
12
References
49
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 4
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Locations
  • Current Hypertension Reports (publishedVersion)
  • PubMed (publishedVersion)
  • Hirsla (Landspítali University Hospital) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
aldosterone synthase inhibition, hypertension, renin-angiotensin-aldosterone system, mineralocorticoid receptor, renin-angiotensin system blockade, angiotensin II, blood pressure control, cardiovascular risk
MeSH terms
Aldosterone, Animals, Antihypertensive Agents, Enzyme Inhibitors, Humans, Hypertension, Renin-Angiotensin System, Cytochrome P-450 CYP11B2

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