Role of Carotid Body in Intermittent Hypoxia-Related Hypertension
Open accessAbstract
Obstructive sleep apnea (OSA), a common breathing disorder, is recognized as an independent risk factor for systemic hypertension. Among the alterations induced by OSA, the chronic intermittent hypoxia (CIH) is considered the main factor for the hypertension. Exposure of rodents to CIH is the gold-standard method to study the mechanisms involved in the cardiovascular alterations induced by OSA. Although it is well known that CIH produces hypertension, the underlying mechanisms are not totally elucidated. It is likely that the CIH-induced systemic oxidative stress and inflammation may elicit endothelial dysfunction and increase the arterial blood pressure. In addition, OSA patients and animals exposed to CIH show sympathetic hyperactivity and potentiated cardiorespiratory responses to acute hypoxia, suggesting that CIH enhances the peripheral hypoxic chemoreflex. Recent experimental evidences support the proposal that CIH selectively enhances carotid body (CB) chemosensory reactivity to oxygen, which in turn increases sympathetic outflow leading to neurogenic hypertension. In this review, we will discuss the supporting evidence for a critical role of the CB in the generation and maintenance of the hypertension induced by CIH, also, the contribution of oxidative stress to enhance CB chemosensory drive and the activation of sympathetic-related centers in the brain.
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Studies in experimental animals suggest that chronic intermittent hypoxia produces sustained increases in sympathetic nerve activity and blood pressure.
“Studies in experimental animals suggest that chronic intermittent hypoxia produces sustained increases in SNA and BP186.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [186]
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- Authors
- Iturriaga, R., Oyarce, M. P., & Dias, A. C. R.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- Corresponding author
- Iturriaga, Rodrigo
- ORCID
- Iturriaga, Rodrigo
- Venue
- Current Hypertension Reports
- Published
- 2017-04-27
- Volume
- 19
- Issue
- 5
- Pages
- 38-38
- ISSN
- 1522-6417 (ISSN-L)
- 1534-3111
- OpenAlex
- W2607551768
- Cited by
- 46
- References
- 83
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Current Hypertension Reports (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico (1150040)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- carotid body, chronic intermittent hypoxia, obstructive sleep apnea, hypertension, oxidative stress, sympathetic hyperactivity, neurogenic hypertension, endothelial dysfunction, inflammation
- MeSH terms
- Animals, Hypoxia, Carotid Body, Humans, Hypertension, Inflammation, Oxidative Stress, Sleep Apnea, Obstructive
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