The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Insomnia Disorder and Brain’s Default-Mode Network
Abstract
Purpose of review Insomnia disorder (ID) is a prevalent sleep disorder that significantly compromises the physical and mental health of individuals. This article reviews novel approaches in the study of brain networks and impaired function in ID through the application of modern neuroimaging techniques such as functional magnetic resonance imaging (fMRI). Recent findings The default-mode network (DMN) is presumed to be correlated with self-referential information processing, and it appears to be altered or unbalanced in insomnia. A growing body of evidence suggests the lack of deactivation of brain regions comprising the DMN when insomnia patients are at rest. Moreover, core areas of the DMN demonstrate greater activation in insomnia patients when compared to healthy controls in self-referential related tasks. Despite the few studies on the topic, underpinning the correlation between abnormal DMN activity and ID deserves further attention in the future. Implications for therapeutics are briefly outlined.
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“Notably, this elevation relates positively to the degree of objective sleep disturbance, consistent with a disorder of 24-hour hyperarousal rather than simply sleep loss [25].”
From Pre-Sleep Anxiety: Mechanisms and Therapeutic Approaches in Clinical Practice. (2026) · cites this paper as [25]
Citations
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Jeong, H. S., Kim, Y., Joo, Y., Suh, C., Shim, Y., Lee, H., Choi, Y., Jin, Y., Yoon, S. J., & Lyoo, I. K. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120792
Klonteig, S., Scarth, M., & Bjørnebekk, A. (2024) · Figshare · doi:10.6084/m9.figshare.25045436
Shao, Z., Du, Z., Song, Q., Liu, S., Cai, S., Liu, D., & Yuan, K. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.03.025
Zhai, S.-Y., Yang, S., Zhang, Z.-Y., & Zhou, H. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.04.002
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“Moreover, a growing body of evidence suggested that patients with sleep disturbances showed greater activation in core regions of DMN during self-reference-related tasks compared with controls [14].”
Wei, S., Zhang, L., Chen, X., Han, Y., Lv, D., Yao, P., Chen, L., Yuan, Y., Zhao, J., Ou, Y., et al. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150482
You, Y., Meng, L., Li, S., Li, Z., Changyong, Z., & Cao, Y. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1886224
“Notably, previous neuroimaging studies have suggested that sleep deprivation and insomnia are associated with altered precuneus activity and disrupted DMN connectivity, particularly involving self-referential processing and internal mentation (40, 41).”
Zhuang, X., Zhang, X., yin, Y., Ti, S. U., Xu, T., & Feng, T. (2026) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2026.113479
Ma, L., Mei, B., Zhang, M., Li, W., Wang, X., Tian, J., Zhang, H., Lang, Y., Lv, Q., Wei, Y., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1892235
“More than that, poor sleep quality has been shown to negatively impact human brain networks (15).”
Poststroke sleep phenotypes and executive dysfunction: toward a sleep-network-executive framework
Xu, J., Zhang, Y., Lin, D., Yan, X., Xie, N., Si, S., & ShuMing, Y. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1978796
Metadata
- Authors
- Marques, D. R., Gomes, A. A., Caetano, G., & Castelo-Branco, M.
- Affiliations
- University of Aveiro (PT)
- University of Coimbra (PT)
- University of Lisbon (PT)
- Corresponding author
- Marques, Daniel Ruivo
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2018-06-09
- Volume
- 18
- Issue
- 8
- Pages
- 45-45
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2807404538
- Cited by
- 112
- References
- 29
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 18 · 2023: 19 · 2022: 14 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- insomnia, default mode network, self-referential processing, functional MRI, sleep disorders, brain network dysfunction
- MeSH terms
- Adult, Brain, Brain Mapping, Cognition, Female, Humans, Sleep Initiation and Maintenance Disorders, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways
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