Central sensitization in fibromyalgia and other musculoskeletal disorders

Arendt-Nielsen, Lars; Graven-Nielsen, Thomas

doi:10.1007/s11916-003-0034-0

Cited by 219Pain Mechanisms and TreatmentsFibromyalgia and Chronic Fatigue Syndrome ResearchPain Management and Treatment

Central sensitization in fibromyalgia and other musculoskeletal disorders

Arendt-Nielsen, Lars, Graven-Nielsen, Thomas·2003·Current Pain and Headache Reports

DOI 10.1007/s11916-003-0034-0

Open this paper in CoChat — free account

Abstract

Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by nociceptive stimuli (hyperalgesia), or increased referred pain areas with associated somatosensory changes. Some manifestations of sensitization, such as expanded referred muscle pain areas in patients with chronic musculoskeletal pain, can be explained from animal experiments showing extrasegmental spread of sensitization. An important part of the pain manifestations (eg, tenderness and referred pain) related to chronic musculoskeletal disorders may result from peripheral and central sensitization, which may play a role in the transition from acute to chronic pain.

Integrity signals

Registry

Crossref · 10.1007/s11916-003-0034-0

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pathophysiology of fibromyalgia syndrome seems to be related to sensitization of central nervous system processes, which underlie alterations in pain perception, deficient pain inhibition, temporal summation of pain, and other indicators of pain sensitization.
“Regarding the etiopathophysiology of FMS, while its etiology remains unknown, the pathophysiology of this chronic condition seems to be related to the sensitization of CNS processes, e.g., [5,22,23], which underlie the alterations in pain perception displayed by these patients, (e.g., allodynia and hyperalgesia) [24], deficient pain inhibition [25], temporal summation of pain [26] and other”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [24]

Myofascial pain and dysfunction : the trigger point manual
Travell, J. G., & Simons, D. G. (1982) · Medical Entomology and Zoology · Cited by 2,735 · see citing works
Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome
Staud, R., Vierck, C. J., Cannon, R. L., Mauderli, A. P., & Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(00)00432-2 · Cited by 774 · see citing works
Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input
Cook, A. J., Woolf, C. J., Wall, P. D., & McMahon, S. B. (1987) · Nature · doi:10.1038/325151a0 · Cited by 658 · see citing works
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin
Simone, D. A., Baumann, T., & LaMotte, R. H. (1989) · Pain · doi:10.1016/0304-3959(89)90079-1 · Cited by 507 · see citing works
Pressure-pain threshold in human temporal region. Evaluation of a new pressure algometer
Jensen, K., Andersen, H. Ø., Olesen, J., & Lindblom, U. (1986) · Pain · doi:10.1016/0304-3959(86)90235-6 · Cited by 424 · see citing works
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
Graven‐Nielsen, T., Kendall, S. A., Henriksson, K. G., Bengtsson, M., Sörensen, J., Johnson, A. F., Gerdle, B. U. C., & Arendt‐Nielsen, L. (2000) · Pain · doi:10.1016/s0304-3959(99)00308-5 · Cited by 417 · see citing works
Self-citation
ON DISTURBANCES OF SENSATION WITH ESPECIAL REFERENCE TO THE PAIN OF VISCERAL DISEASE
Head, H. H. (1893) · Brain · doi:10.1093/brain/16.1-2.1 · Cited by 400 · see citing works
Reliability of the pressure algometer as a measure of myofascial trigger point sensitivity
Reeves, J. L., Jaeger, B. A., & Graff‐Radford, S. B. (1986) · Pain · doi:10.1016/0304-3959(86)90117-x · Cited by 389 · see citing works
Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin
Carlton, S. M., Hargett, G. L., & Coggeshall, R. E. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11889-5 · Cited by 353 · see citing works
THE DERMATOMES IN MAN
Foerster, O. (1933) · Brain · doi:10.1093/brain/56.1.1 · Cited by 350 · see citing works
Muscle Pain: Understanding Its Nature, Diagnosis and Treatment
Mense, S., Simons, D. G., & Russell, I. J. (2000) · Medical Entomology and Zoology · Cited by 342 · see citing works
Clinical and Etiological Update of Myofascial Pain from Trigger Points
Simons, D. G. (1996) · Journal of Musculoskeletal Pain · doi:10.1300/j094v04n01_07 · Cited by 339 · see citing works
Muscle stiffness, strength loss, swelling and soreness following exercise-induced injury in humans
Howell, J. N., Chleboun, G., & Conatser, R. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019629 · Cited by 337 · see citing works
Central Hypersensitivity in Chronic Pain After Whiplash Injury
Curatolo, M., Petersen‐Felix, S., Arendt‐Nielsen, L., Giani, C., Zbinden, A. M., & Radanov, B. P. (2001) · Clinical Journal of Pain · doi:10.1097/00002508-200112000-00004 · Cited by 326 · see citing works
Self-citation
Proceedings of the 7th World Congress on Pain
Korevaar, W. C. (1995) · Clinical Journal of Pain · doi:10.1097/00002508-199509000-00017 · Cited by 320 · see citing works
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317 · see citing works
Self-citation
REFERRED PAIN FROM SKELETAL STRUCTURES
Inman, V. T., & SAUNDERS, J. B. D. M. (1944) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-194405000-00023 · Cited by 308 · see citing works
Generalised muscular hyperalgesia in chronic whiplash syndrome
Johansen, M. K., Graven‐Nielsen, T., Olesen, A. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00106-2 · Cited by 307 · see citing works
Self-citation
Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome
Gibson, S. J., Littlejohn, G. O., Gorman, M. M., Helme, R. D., & Granges, G. (1994) · Pain · doi:10.1016/0304-3959(94)90198-8 · Cited by 306 · cited 1× · see citing works
“Many clinical studies report increased sensitivity to painful stimuli of deep tissues within [5–12] and outside [6–8,11,13] muscle pain areas in patients compared with control”
Background
Peripheral group I metabotropic glutamate receptors modulate nociception in mice
Bhave, G. B., Karim, F., Carlton, S. M., & Gereau, R. W. (2001) · Nature Neuroscience · doi:10.1038/86075 · Cited by 295 · see citing works
EXPERIMENTS ON PAIN REFERRED FROM DEEP SOMATIC TISSUES
FEINSTEIN, B., Langton, J. N. K., Jameson, R. M., & Schiller, F. (1954) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195436050-00007 · Cited by 286 · see citing works
Hyperexcitability in fibromyalgia.
Sörensen, J., Graven‐Nielsen, T., Henriksson, K. G., Bengtsson, M., & Arendt‐Nielsen, L. (1998) · PubMed · Cited by 284 · see citing works
Self-citation
Multi-method assessment of experimental and clinical pain in patients with fibromyalgia
Lautenbacher, S., Rollman, G. B., & McCain, G. A. (1994) · Pain · doi:10.1016/0304-3959(94)90046-9 · Cited by 270 · see citing works
Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones
Hu, J. W., Sessle, B. J., Raboisson, P., Dallel, R., & Woda, A. (1992) · Pain · doi:10.1016/0304-3959(92)90131-t · Cited by 247 · see citing works
Appearance of new receptive fields in rat dorsal horn neurons following noxious stimulation of skeletal muscle: a model for referral of muscle pain?
Hoheisel, U., Mense, S., Simons, D. G., & Yu, X. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90064-r · Cited by 247 · see citing works
Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls
Kosek, E., Ekholm, J., & Hansson, P. T. (1996) · Pain · doi:10.1016/0304-3959(95)00112-3 · Cited by 245 · see citing works
Sex-Related Differences in Human Pain and Rat Afferent Discharge Evoked by Injection of Glutamate Into the Masseter Muscle
Cairns, B. E., Hu, J. W., Arendt‐Nielsen, L., Sessle, B. J., & Svensson, P. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.2.782 · Cited by 244 · see citing works
Self-citation
IS ALZHEIMER'S DISEASE DISTINCT FROM NORMAL AGEING?
Hofman, A. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92339-2 · Cited by 240 · see citing works
Pressure pain thresholds in normal muscles: reliability, measurement effects, and topographic differences
Ohrbach, R. K., & Gale, E. N. (1989) · Pain · doi:10.1016/0304-3959(89)90189-9 · Cited by 224 · see citing works
Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline
Graven‐Nielsen, T., Arendt‐Nielsen, L., Svensson, P. J., & Jensen, T. S. (1997) · Pain · doi:10.1016/s0304-3959(96)03243-5 · Cited by 212 · see citing works
Self-citation
Qualitatively altered nociception in chronic myofascial pain
Bendtsen, L., Jensen, R., & Olesen, J. (1996) · Pain · doi:10.1016/0304-3959(95)00239-1 · Cited by 202 · see citing works
Observations on Experimental Muscular Soreness
Asmussen, E. (1956) · Acta Rheumatologica Scandinavica · doi:10.3109/rhe1.1956.2.issue-1-4.12 · Cited by 202 · see citing works
Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis
Leffler, A., Kosek, E., Lerndal, T., Nordmark, B., & Hansson, P. T. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0313 · Cited by 195 · see citing works
Effect of chronic and experimental jaw muscle pain on pain-pressure thresholds and stimulus-response curves.
Svensson, P., Arendt‐Nielsen, L., Nielsen, H., & Larsen, J. K. (1995) · PubMed · Cited by 189 · see citing works
Self-citation
Pain from excitation of identified muscle nociceptors in humans
Marchettini, P., Simone, D. A., Caputi, G., & Ochoa, J. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00851-7 · Cited by 170 · see citing works
Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain
Carli, G., Suman, A. L., Biasi, G., & Marcolongo, R. (2002) · Pain · doi:10.1016/s0304-3959(02)00297-x · Cited by 162 · see citing works
Identification of muscle afferents subserving sensation of deep pain in humans
Simone, D. A., Marchettini, P., Caputi, G., & Ochoa, J. L. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.883 · Cited by 159 · see citing works
Fibromyalgia--are there different mechanisms in the processing of pain? A double blind crossover comparison of analgesic drugs.
Sörensen, J., Bengtsson, Å., Ahlner, J., Henriksson, K. G., Ekselius, L., & Bengtsson, M. (1997) · PubMed · Cited by 159 · see citing works
Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders
Svensson, P. J., List, T., & Hector, G. (2001) · Pain · doi:10.1016/s0304-3959(01)00284-6 · Cited by 157 · see citing works
Observations relating to referred pain. Viscecromotor reflexes and other associated phenomena.
Lewis, T. (1939) · Medical Entomology and Zoology · Cited by 155 · see citing works
REFERRED PAIN AND ASSOCIATED PHENOMENA
Sinclair, D. C., Weddell, G., & Feindel, W. (1948) · Brain · doi:10.1093/brain/71.2.184 · Cited by 150 · see citing works
The consequences of eccentric contractions and their relationship to delayed onset muscle pain
Newham, D. J. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00635995 · Cited by 149 · see citing works
Evidence for the interaction of glutamate and NK1 receptors in the periphery
Carlton, S. M., Zhou, S., & Coggeshall, R. E. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01471-6 · Cited by 147 · see citing works
Referral of muscle pain
Mense, S. (1994) · APS Journal · doi:10.1016/s1058-9139(05)80227-x · Cited by 135 · see citing works
Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin
Babenko, V., Graven‐Nielsen, T., Svensson, P. J., Drewes, A. M., Jensen, T. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00026-3 · Cited by 130 · see citing works
Self-citation
PATTERNS OF REFERRED PAIN IN THE NORMAL SUBJECT
Hockaday, J. M., & Whitty, C. W. M. (1967) · Brain · doi:10.1093/brain/90.3.481 · Cited by 126 · see citing works
Experimentally induced muscle pain induces hypoalgesia in heterotopic deep tissues, but not in homotopic deep tissues
Graven‐Nielsen, T., Babenko, V., Svensson, P. J., & Arendt‐Nielsen, L. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01480-7 · Cited by 124 · see citing works
Self-citation
Referred pain from intraneural stimulation of muscle fascicles in the median nerve
Torebjörk, H. E., Ochoa, J. L., & Schady, W. (1984) · Pain · doi:10.1016/0304-3959(84)90882-0 · Cited by 123 · see citing works
Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles
Svensson, P. J., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (1998) · Pain · doi:10.1016/s0304-3959(97)00156-5 · Cited by 120 · see citing works
Self-citation
Stimulus–response functions in areas with experimentally induced referred muscle pain — a psychophysical study
Graven‐Nielsen, T., Arendt‐Nielsen, L., Svensson, P. J., & Jensen, T. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01077-3 · Cited by 115 · see citing works
Self-citation
Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain
Witting, N., Svensson, P. J., Gottrup, H., Arendt‐Nielsen, L., & Jensen, T. S. (2000) · Pain · doi:10.1016/s0304-3959(99)00231-6 · Cited by 114 · see citing works
Self-citation
Experimental deep tissue pain in wrist extensors—a model of lateral epicondylalgia
Slater, H., Arendt‐Nielsen, L., Wright, A., & Graven‐Nielsen, T. (2003) · European Journal of Pain · doi:10.1016/s1090-3801(02)00141-6 · Cited by 112 · see citing works
Self-citation
The reproducibility of muscle and joint tenderness detection methods and maximum mandibular movement measurement for the temporomandibular system.
Goulet, J., Clark, G. T., Flack, V. F., & Liu, C. (1998) · PubMed · Cited by 112 · see citing works
Muscle Pain: Understanding Its Nature, Diagnosis, and Treatment
Thompson, J. M. (2001) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)62122-8 · Cited by 98 · see citing works
Trigger Points in Patients with Lower Limb Osteoarthritis
Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Journal of Musculoskeletal Pain · doi:10.1300/j094v09n03_03 · Cited by 80 · see citing works
Self-citation
The influence of pain intensity on somatosensory perception in patients suffering from subacute/chronic lateral epicondylalgia
Leffler, A., Kosek, E., & Hansson, P. T. (2000) · European Journal of Pain · doi:10.1053/eujp.1999.0159 · Cited by 80 · see citing works
Study of Somatic Pain
Lewis, T. (1938) · BMJ · doi:10.1136/bmj.1.4023.321 · Cited by 78 · see citing works
Pressure-pain function in desensitized and hypersensitized muscle and skin assessed by cuff algometry
Polianskis, R., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2002) · Journal of Pain · doi:10.1054/jpai.2002.27140 · Cited by 76 · see citing works
Self-citation
Influence of pressure rates on the reliability of a pressure threshold meter.
List, T., Helkimo, M., & Karlsson, R. (1991) · PubMed · Cited by 72 · see citing works
Injection of hypertonic saline into musculus infraspinatus resulted in referred pain and sensory disturbances in the ipsilateral upper arm
Leffler, A., Kosek, E., & Hansson, P. T. (2000) · European Journal of Pain · doi:10.1053/eujp.1999.0160 · Cited by 70 · see citing works
The effect of compression and regional anaesthetic block on referred pain intensity in humans
Laursen, R. J., Graven‐Nielsen, T., Jensen, T. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(98)00214-0 · Cited by 67 · see citing works
Self-citation
Short-term reproducibility of pressure pain thresholds in masticatory muscles measured with a new algometer.
Isselée, H., Laat, A. D., Bogaerts, K., & Lysens, R. (1998) · PubMed · Cited by 66 · see citing works
Myofascial Pain Syndromes
Vecchiet, L., Giamberardino, M. A., & Saggini, R. (1991) · Clinical Journal of Pain · doi:10.1097/00002508-199108000-00004 · Cited by 62 · see citing works
Modifications of Cutaneous, Subcutaneous, and Muscular Sensory and Pain Thresholds After the Induction of an Experimental Algogenic Focus in the Skeletal Muscle
Vecchiet, L., Galletti, R., Giamberardino, M. A., Dragani, L., & Marini, F. (1988) · Clinical Journal of Pain · doi:10.1097/00002508-198803000-00011 · Cited by 58 · see citing works
Quantification of local and referred pain in humans induced by intramuscular electrical stimulation
Laursen, R. J., Graven‐Nielsen, T., Jensen, T. S., & Arendt‐Nielsen, L. (1997) · European Journal of Pain · doi:10.1016/s1090-3801(97)90068-9 · Cited by 57 · see citing works
Self-citation
Myofascial Pain Syndromes
Vecchiet, L., Giamberardino, M. A., & Saggini, R. (1991) · Clinical Journal of Pain · doi:10.1097/00002508-199103001-00004 · Cited by 54 · see citing works
Referred pain is dependent on sensory input from the periphery: A psychophysical study
Laursen, R. J., Graven‐Nielsen, T., Jensen, T. S., & Arendt‐Nielsen, L. (1997) · European Journal of Pain · doi:10.1016/s1090-3801(97)90035-5 · Cited by 53 · see citing works
Self-citation
Examiner expectancy effects in the measurement of pressure pain thresholds
Ohrbach, R. K., Crow, H. C., & Kamer, A. R. (1998) · Pain · doi:10.1016/s0304-3959(97)00174-7 · Cited by 53 · see citing works
Opioid-insensitive hypoalgesia to mechanical stimuli at sites ipsilateral and contralateral to experimental muscle pain in human volunteers
Graven‐Nielsen, T., Gibson, S. J., Laursen, R. J., Svensson, P. J., & Arendt‐Nielsen, L. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1169-7 · Cited by 42 · see citing works
Self-citation
Temporal summation of pain from skin, muscle and joint following nociceptive ultrasonic stimulation in humans
Wright, A., Graven‐Nielsen, T., Davies, I. A. I., & Arendt‐Nielsen, L. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1062-4 · Cited by 41 · see citing works
Self-citation
OBSERVATIONS ON PAIN PRODUCED BY INJECTION OF HYPERTONIC SALINE INTO MUSCLES AND OTHER SUPPORTIVE TISSUES
Steinbrocker, O., Isenberg, S. A., Silver, M., Neustadt, D. H., Kühn, P., & Schittone, M. T. (1953) · Journal of Clinical Investigation · doi:10.1172/jci102815 · Cited by 39 · see citing works
Muscle Pain Syndromes and Fibromyalgia: Pressure Algometry for Quantification of Diagnosis and Treatment Outcome
Fischer, A. A. (1998) · Cited by 32 · see citing works
SOME ASPECTS OF REFERRED PAIN
Whitty, C. W. M., & Willison, R. G. (1958) · The Lancet · doi:10.1016/s0140-6736(58)90058-8 · Cited by 28 · see citing works
Effect of tooth clenching and jaw opening on pain-pressure thresholds in the human jaw muscles.
McMillan, A. S., & Lawson, E. T. (1994) · PubMed · Cited by 27 · see citing works
Post‐exercise muscle soreness after eccentric exercise: psychophysical effects and implications on mean arterial pressure
Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2001.110503.x · Cited by 25 · see citing works
Self-citation
Distribution of cutaneous hyperalgesia
Klingon, G. H., & Jeffreys, W. H. (1958) · Neurology · doi:10.1212/wnl.8.4.272 · Cited by 16 · see citing works
Frequency-dependent conduction delay of motor-evoked potentials in multiple sclerosis
Nielsen, J. F. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199710)20:10 · Cited by 15 · see citing works
Pressure and Heat Pain Thresholds and Tolerances in Patients with Fibromyalgia
Nørregaard, J., Bendtsen, L., Lykkegaard, J. J., & Jensen, R. (1997) · Journal of Musculoskeletal Pain · doi:10.1300/j094v05n02_04 · Cited by 15 · see citing works
Pain influences somatosensory perception : An experimental and clinical study
Leffler, A. (2002) · Figshare · Cited by 7 · see citing works
Deep tissue pain in wrist extensors: a model of lateral epicondylalgia
Slater, H., Arendt‐Nielsen, L., Wright, A., & Graven‐Nielsen, T. (2001) · VBN Forskningsportal (Aalborg Universitet) · Cited by 2 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Sensitization in patients with painful knee osteoarthritis
Arendt‐Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven‐Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 992 · see citing works
Self-citation
Experimental and Clinical Applications of Quantitative Sensory Testing Applied to Skin, Muscles and Viscera
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548 · see citing works
Self-citation
Assessment of mechanisms in localized and widespread musculoskeletal pain
Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.107 · Cited by 547 · see citing works
Self-citation
Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome
Meeus, M., & Nijs, J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0433-9 · Cited by 541 · see citing works
The effects of sleep deprivation on pain inhibition and spontaneous pain in women
Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A. (2007) · Sleep · doi:10.1093/sleep/30.4.494 · Cited by 539 · see citing works
Nociplastic pain criteria or recognition of central sensitization? Pain phenotyping in the past, present and future
Nijs, J., Lahousse, A., Kapreli, E., Bilika, P., Saraçoğlu, İ., Malfliet, A., Coppieters, I., De Baets, L., Leysen, L., Roose, E., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153203 · Cited by 430 · see citing works
Myofascial Trigger Points and Sensitization: An Updated Pain Model for Tension-Type Headache
Fernández‐de‐las‐Peñas, C., Cuadrado, M. L., Arendt‐Nielsen, L., Simons, D. G., & Pareja, J. A. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01295.x · Cited by 282 · see citing works
Self-citation
Myofascial pain syndromes and their evaluation.
Bennett, R. (2007) · Baillière's Best Practice & Research : Clinical Rheumatology · doi:10.1016/j.berh.2007.02.014 · Cited by 272 · see citing works
Presurgical assessment of temporal summation of pain predicts the development of chronic postoperative pain 12 months after total knee replacement
Petersen, K. K., Arendt-Nielsen, L., Simonsen, O., Wilder-Smith, O., & Laursen, M. B. (2015) · Pain · doi:10.1016/j.pain.0000000000000022 · Cited by 269 · see citing works
Self-citation
Treatment of central sensitization in patients with chronic pain: time for change?
Nijs, J., Leysen, L., Vanlauwe, J., Logghe, T., Ickmans, K., Polli, A., Malfliet, A., Coppieters, I., & Huysmans, E. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1647166 · Cited by 225 · see citing works
Mechanisms of Disease: pain in fibromyalgia syndrome
Staud, R. M., & Rodriguez, M. E. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0091 · Cited by 211 · see citing works
Quantitative Sensory Testing Profiles in Chronic Back Pain Are Distinct From Those in Fibromyalgia
Blumenstiel, K., Gerhardt, A., Rolke, R., Bieber, C. S., Tesarz, J., Friederich, H., Eich, W., & Treede, R. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182177654 · Cited by 208 · see citing works
Relationship Between Fibromyalgia and Obesity in Pain, Function, Mood, and Sleep
Okifuji, A., Donaldson, G. W., Barck, L., & Fine, P. G. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.006 · Cited by 192 · see citing works
Health related quality of life and quantitative pain measurement in females with chronic non‐malignant pain
Laursen, B. S., Bajaj, P., Olesen, A. S., Delmar, C., & Arendt‐Nielsen, L. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.07.003 · Cited by 191 · see citing works
Self-citation
Generalized Hyperalgesia in Patients With Chronic Tension-Type Headache
Ashina, S., Bendtsen, L., Ashina, M., Magerl, W., & Jensen, R. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01150.x · Cited by 185 · see citing works
Patients with Chronic Pain After Abdominal Surgery Show Less Preoperative Endogenous Pain Inhibition and More Postoperative Hyperalgesia: A Pilot Study
Wilder‐Smith, O. H. G., Schreyer, T., Scheffer, G. J., & Arendt‐Nielsen, L. (2010) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360281003706069 · Cited by 177 · see citing works
Self-citation
Peripheral pain mechanisms in chronic widespread pain
Staud, R. M. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2010.01.010 · Cited by 160 · see citing works
Widespread sensitization in patients with chronic pain after revision total knee arthroplasty
Skou, S. T., Graven‐Nielsen, T., Rasmussen, S., Simonsen, O. H., Laursen, M. B., & Arendt‐Nielsen, L. (2013) · Pain · doi:10.1016/j.pain.2013.04.033 · Cited by 150 · see citing works
Self-citation
Pain Treatment for Patients With Osteoarthritis and Central Sensitization
Girbés, E. L., Nijs, J., Torres-Cueco, R., & Cubas, C. L. (2013) · Physical Therapy · doi:10.2522/ptj.20120253 · Cited by 149 · see citing works
The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?
Meeus, M., Nijs, J., Hermans, L., Goubert, D., & Calders, P. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.818657 · Cited by 152 · see citing works
Translational musculoskeletal pain research
Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2010.01.013 · Cited by 149 · see citing works
Self-citation
Topographical mapping and mechanical pain sensitivity of myofascial trigger points in the infraspinatus muscle
Ge, H., Fernández‐de‐las‐Peñas, C., Madeleine, P., & Arendt‐Nielsen, L. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.005 · Cited by 146 · see citing works
Self-citation
Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions
Okifuji, A., Bradshaw, D. H., & Olson, C. (2009) · Clinical Rheumatology · doi:10.1007/s10067-009-1094-2 · Cited by 146 · see citing works
Referred Pain from Muscle Trigger Points in the Masticatory and Neck-Shoulder Musculature in Women With Temporomandibular Disoders
Fernández‐de‐las‐Peñas, C., Galán-del-Río, F., Alonso‐Blanco, C., Jiménez‐García, R., Arendt‐Nielsen, L., & Svensson, P. J. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.03.005 · Cited by 138 · see citing works
Self-citation
Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness
Slater, H., Arendt‐Nielsen, L., Wright, A., & Graven‐Nielsen, T. (2005) · Pain · doi:10.1016/j.pain.2004.12.003 · Cited by 136 · see citing works
Self-citation
Muscle Pain: Sensory Implications and Interaction With Motor Control
Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31815b608f · Cited by 133 · see citing works
Self-citation
Neuropathic-like pain features and cross-sectional associations in rheumatoid arthritis
Koop, S. M. W., ten Klooster, P. M., Vonkeman, H. E., Steunebrink, L. M. M., & van de Laar, M. A. F. J. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0761-8 · Cited by 129 · see citing works
Cerebrospinal Fluid Glutamate Levels in Chronic Migraine
Peres, M. F. P., Zukerman, E., Soares, C. A. S., Alonso, E., Santos, B., & Faulhaber, M. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00750.x · Cited by 126 · see citing works
Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components
Morlion, B. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.534446 · Cited by 124 · see citing works
Prevalence of and Referred Pain From Myofascial Trigger Points in the Forearm Muscles in Patients With Lateral Epicondylalgia
Fernández‐Carnero, J., Fernández‐de‐las‐Peñas, C., De-la-Llave-Rincón, A. I., Ge, H., & Arendt‐Nielsen, L. (2007) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31803b3785 · Cited by 117 · see citing works
Self-citation
Sensitization, glutamate, and the link between migraine and fibromyalgia
Sarchielli, P., Filippo, M. D., Nardi, K., & Calabresi, P. (2007) · Current Pain and Headache Reports · doi:10.1007/s11916-007-0216-2 · Cited by 115 · see citing works
Reduced brain habituation to somatosensory stimulation in patients with fibromyalgia
Montoya, P., Sitges, C., García‐Herrera, M., Rodríguez‐Cotes, A., Izquierdo, R., Truyols, M., & Collado, D. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21910 · Cited by 113 · see citing works
Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique
Gerdle, B. U. C., Ghafouri, B., Ernberg, M. M., & Larsson, B. (2014) · Journal of Pain Research · doi:10.2147/jpr.s59144 · Cited by 111 · see citing works
Gender differences in pain: Do emotions play a role?
Rhudy, J. L., & Williams, A. E. (2005) · Gender Medicine · doi:10.1016/s1550-8579(05)80051-8 · Cited by 115 · see citing works
The Local and Referred Pain From Myofascial Trigger Points in the Temporalis Muscle Contributes to Pain Profile in Chronic Tension-type Headache
Fernández‐de‐las‐Peñas, C., Ge, H., Arendt‐Nielsen, L., Cuadrado, M. L., & Pareja, J. A. (2007) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318153496a · Cited by 104 · see citing works
Self-citation
Mortality in a cohort of Danish patients with fibromyalgia: Increased frequency of suicide
Dreyer, L., Kendall, S. A., Danneskiold‐Samsøe, B., Bartels, E. M., & Bliddal, H. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27623 · Cited by 104 · see citing works
Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans
Frey‐Law, L., Sluka, K. A., McMullen, T., Lee, J., Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2008) · Pain · doi:10.1016/j.pain.2008.08.014 · Cited by 98 · see citing works
Self-citation
Does a dose-response relation exist between spinal pain and temporomandibular disorders?
Wiesinger, B., Malker, H., Englund, E., & Wänman, A. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-28 · Cited by 96 · see citing works
The effect of emotional distress on persistent pelvic girdle pain after delivery: a longitudinal population study
Bjelland, E. K., Stuge, B., Engdahl, B., & Eberhard‐Gran, M. (2012) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12029 · Cited by 95 · see citing works
Neurophysiopathogenesis of Fibromyalgia Syndrome: A Unified Hypothesis
Russell, I. J., & Larson, A. A. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.06.005 · Cited by 94 · see citing works
Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: a randomized controlled trial
Senna, M. K., Sallam, R. A.-E. R., Ashour, H., & El-Arman, M. M. (2012) · Clinical Rheumatology · doi:10.1007/s10067-012-2053-x · Cited by 92 · see citing works
Neuropathic Features of Joint Pain: A Community‐Based Study
Soni, A., Batra, R. N., Gwilym, S. E., Spector, T. D., Hart, D. J., Arden, N., Cooper, C. C., Tracey, I., & Javaid, M. K. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37962 · Cited by 89 · see citing works
Induction and assessment of muscle pain, referred pain, and muscular hyperalgesia
Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2003) · Current Pain and Headache Reports · doi:10.1007/s11916-003-0060-y · Cited by 87 · see citing works
Self-citation
Fibromyalgia: Harmonizing Science with Clinical Practice Considerations
Perrot, S., Dickenson, A. H., & Bennett, R. M. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00190.x · Cited by 86 · see citing works
Is It All Central Sensitization? Role of Peripheral Tissue Nociception in Chronic Musculoskeletal Pain
Staud, R. M. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0134-x · Cited by 81 · see citing works
An increased response to experimental muscle pain is related to psychological status in women with chronic non-traumatic neck-shoulder pain
Sjörs, A., Larsson, B. K., Persson, A. L., & Gerdle, B. U. C. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-230 · Cited by 75 · see citing works
Headache impact in patients with orofacial pain
Mitrirattanakul, S., & Merrill, R. L. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0385 · Cited by 73 · see citing works
Fibromyalgia: Present to future
Bennett, R. M. (2005) · Current Rheumatology Reports · doi:10.1007/s11926-005-0022-y · Cited by 71 · see citing works
Effects of Gabapentin on Experimental Somatic Pain and Temporal Summation
Arendt‐Nielsen, L., Frøkjær, J. B., Staahl, C., Graven‐Nielsen, T., Huggins, J. P., Smart, T. S., & Drewes, A. M. (2007) · Regional Anesthesia & Pain Medicine · doi:10.1097/00115550-200709000-00004 · Cited by 69 · see citing works
Self-citation
Predictors of Osteoarthritis Pain: the Importance of Resilience
Bartley, E. J., Palit, S., & Staud, R. M. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0683-3 · Cited by 68 · see citing works
Reciprocal influence on the incidence of symptoms in trigeminally and spinally innervated areas
Marklund, S., Wiesinger, B., & Wänman, A. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2009.06.004 · Cited by 63 · see citing works
Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?
Nijs, J., Yılmaz, S. T., Elma, Ö., Tatta, J., Mullie, P., Vanderweeën, L., Clarys, P., Deliens, T., Coppieters, I., Weltens, N., et al. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1784142 · Cited by 62 · see citing works
Future perspectives: pathogenesis of chronic muscle pain
Staud, R. M. (2007) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.02.013 · Cited by 62 · see citing works
Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions
Nie, H., Madeleine, P., Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.06.015 · Cited by 59 · see citing works
Self-citation
Predictors of Physical Performance and Functional Ability in People 50+ With and Without Fibromyalgia
Jones, C. J., Rutledge, D. N., & Aquino, J. K. (2010) · Journal of Aging and Physical Activity · doi:10.1123/japa.18.3.353 · Cited by 55 · see citing works
Embodied pain in fibromyalgia: disturbed somatorepresentations and increased plasticity of the body schema
Martínez, E., Aira, Z., Buesa, I., Aizpurua, I., Rada, D., & Azkue, J. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194534 · Cited by 54 · see citing works
Pain relief in women with fibromyalgia: A cross-over study of superficial warmth stimulation and transcutaneous electrical nerve stimulation
Löfgren, M., & Norrbrink, C. (2009) · Journal of Rehabilitation Medicine · doi:10.2340/16501977-0371 · Cited by 54 · see citing works
Joint pain: more to it than just structural damage?
Arendt‐Nielsen, L. (2017) · Pain · doi:10.1097/j.pain.0000000000000812 · Cited by 54 · see citing works
Self-citation
High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression
Previtali, D., Capone, G., Marchettini, P., Candrian, C., Zaffagnini, S., & Filardo, G. (2022) · Cartilage · doi:10.1177/19476035221087698 · Cited by 53 · see citing works
Investigation of Central Pain Processing in Shoulder Pain: Converging Results From 2 Musculoskeletal Pain Models
Valencia, C., Kindler, L. L., Fillingim, R. B., & George, S. Z. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.10.006 · Cited by 53 · see citing works
Referred pain from myofascial trigger points in head and neck–shoulder muscles reproduces head pain features in children with chronic tension type headache
Fernández‐de‐las‐Peñas, C., Fernández-Mayoralas, D. M., Ortega‐Santiago, R., Ambite‐Quesada, S., Palacios‐Ceña, D., & Pareja, J. A. (2011) · The Journal of Headache and Pain · doi:10.1007/s10194-011-0316-6 · Cited by 52 · see citing works
Re-Examining Myofascial Pain Syndrome: Toward Biomarker Development and Mechanism-Based Diagnostic Criteria
Duarte, F. C. K., West, D. W. D., Linde, L. D., Hassan, S. I., & Kumbhare, D. A. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-01024-8 · Cited by 50 · see citing works
Bedside Testing for Chronic Pelvic Pain: Discriminating Visceral from Somatic Pain
Jarrell, J. F., Giamberardino, M. A., Robert, M., & Nasr‐Esfahani, M. (2011) · Pain Research and Treatment · doi:10.1155/2011/692102 · Cited by 49 · see citing works
Viscero‐somatic reflexes in referred pain areas evoked by capsaicin stimulation of the human gut
Arendt‐Nielsen, L., Schipper, K., Dimcevski, G. G., Sumikura, H., Krarup, A. L., Giamberardino, M. A., & Drewes, A. M. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.08.010 · Cited by 49 · see citing works
Self-citation
Transcranial direct current stimulation of 3 cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial
Samartin-Veiga, N., Pidal-Miranda, M., González-Villar, A. J., Bradley, C., Garcı́a-Larrea, L., O’Brien, A. T., & Carrillo‐de‐la‐Peña, M. T. (2021) · Pain · doi:10.1097/j.pain.0000000000002493 · Cited by 46 · see citing works
Standardizing procedures to study sensitization of human spinal nociceptive processes: Comparing parameters for temporal summation of the nociceptive flexion reflex (TS-NFR)
Terry, E. L., France, C. R., Bartley, E. J., DelVentura, J. L., Kerr, K. L., Vincent, A. L., & Rhudy, J. L. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.06.021 · Cited by 46 · see citing works
Pressure-induced referred pain is expanded by persistent soreness
Doménech‐García, V., Palsson, T. S., Herrero, P., & Graven‐Nielsen, T. (2016) · Pain · doi:10.1097/j.pain.0000000000000497 · Cited by 46 · see citing works
Self-citation
Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review
Galvez-Sánchez, C. M., Montoro, C. I., Moreno-Padilla, M., Reyes del Paso, G. A., & de la Coba, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122706 · Cited by 45 · see citing works
“, allodynia and hyperalgesia) [24], deficient pain inhibition [25], temporal summation of pain [26] and other indicators of pain sensitization [25–27].”
Background
Changes in Pain Sensitization After Bariatric Surgery
Stefanik, J. J., Felson, D. T., Apovian, C. M., Niu, J., Clancy, M. M., LaValley, M. P., & Neogi, T. (2018) · Arthritis Care & Research · doi:10.1002/acr.23513 · Cited by 45 · see citing works
Age Interactions on Pain Sensitization in Patients With Severe Knee Osteoarthritis and Controls
Petersen, K. K., Arendt‐Nielsen, L., Finocchietti, S., Hirata, R. P., Simonsen, O. H., Laursen, M. B., & Graven‐Nielsen, T. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000495 · Cited by 42 · see citing works
Self-citation
Brain morphometric changes in fibromyalgia and the impact of psychometric and clinical factors: a volumetric and diffusion-tensor imaging study
Mosch, B., Hagena, V., Herpertz, S., & Diers, M. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03064-0 · Cited by 40 · see citing works
Central motor control failure in fibromyalgia: a surface electromyography study
Casale, R., Sarzi‐Puttini, P., Atzeni, F., Gazzoni, M., Buskila, D., & Rainoldi, A. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-78 · Cited by 40 · see citing works
The transition of reported pain in different body regions – a one-year follow-up study
Gummesson, C., Isacsson, S., Isacsson, A., Andersson, H. I., Ektor-Andersen, J., Östergren, P., Hanson, B. S., & the Malmö Shoulder-Neck Study group (2006) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-7-17 · Cited by 40 · see citing works
Is neuropathic pain underdiagnosed in musculoskeletal pain conditions? The Danish PainDETECTive study
Jespersen, A., Amris, K., Bliddal, H., Andersen, S., Lavik, B., Janssen, H., & Poulsen, P. B. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.502748 · Cited by 39 · see citing works
Sensory processing and central pain modulation in patients with chronic shoulder pain: A case‐control study
Kuppens, K., Hans, G., Roussel, N., Struyf, F., Fransen, E., Cras, P., van Wilgen, C. P., & Nijs, J. (2018) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12982 · Cited by 37 · see citing works
Fibromyalgia: Present to future
Bennett, R. M. (2004) · Current Pain and Headache Reports · doi:10.1007/s11916-996-0011-5 · Cited by 39 · see citing works
Clinical approach to patients with neuropathic pain.
Stillman, M. J. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.8.726 · Cited by 39 · see citing works
Experimental hypoglycemia is a human model of stress-induced hyperalgesia
Gibbons, C. H., Adler, G. K., Bonyhay, I., & Freeman, R. (2012) · Pain · doi:10.1016/j.pain.2012.06.030 · Cited by 38 · see citing works
Chronic Pain and Surgery: A Review of New Insights from Sensory Testing
Wilder‐Smith, O. H. G. (2011) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2010.505256 · Cited by 36 · see citing works
Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome
Soon, B., Vicenzino, B., Schmid, A. B., & Coppieters, M. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183252 · Cited by 37 · see citing works
In the Shoulder or in the Brain? Behavioral, Psychosocial and Cognitive Characteristics of Unilateral Chronic Shoulder Pain with Symptoms of Central Sensitization
Bilika, P., Nijs, J., Fandridis, E. M., Dimitriadis, Z., Στριμπάκος, Ν., & Kapreli, E. (2022) · Healthcare · doi:10.3390/healthcare10091658 · Cited by 37 · see citing works
Consultation prevalence among children, adolescents and young adults with pain conditions: A description of age‐ and gender differences
Bondesson, E., Olofsson, T., Caverius, U., Schelin, M. E. C., & Jöud, A. (2019) · European Journal of Pain · doi:10.1002/ejp.1518 · Cited by 35 · see citing works
Phenotypes of Women with and Without Endometriosis and Relationship with Functional Pain Disability
Evans, S., Mikocka‐Walus, A. A., OLIVE, L. S., Seidman, L. C., Druitt, M. L., & Payne, L. A. (2020) · Pain Medicine · doi:10.1093/pm/pnaa362 · Cited by 37 · see citing works
Fibromyalgia syndrome: a relevant recent construction of an ancient condition?
Perrot, S. (2008) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283005479 · Cited by 33 · see citing works
Analgesic effects of 5‐HT3receptor antagonists
Riering, K., Rewerts, C., & Zieglgänsberger, W. (2004) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740410006970 · Cited by 33 · see citing works
Early Factors Associated with the Development of Chronic Pain in Trauma Patients
Daoust, R., Paquet, J., Moore, L., Émond, M., Gosselin, S., Lavigne, G. J., Choinière, M., Boulanger, A., Mac‐Thiong, J., & Chauny, J. (2018) · Pain Research and Management · doi:10.1155/2018/7203218 · Cited by 32 · see citing works
Application of the grading system for “nociplastic pain” in chronic primary and chronic secondary pain conditions: a field study
Schmidt, H., Drusko, A., Renz, M. P., Schlömp, L., Tost, H., Schuh‐Hofer, S., Tesarz, J., Meyer‐Lindenberg, A., & Treede, R. (2024) · Pain · doi:10.1097/j.pain.0000000000003355 · Cited by 37 · see citing works
Algometry for the assessment of central sensitisation to pain in fibromyalgia patients: a systematic review
de la Coba, P., Montoro, C. I., del Paso, G. A. R., & Galvez-Sánchez, C. M. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2075560 · Cited by 31 · see citing works
Relationship Between Pain and Neuropathic Symptoms in Chronic Musculoskeletal Pain
Giske, L. E., Bautz‐Holter, E., Sandvik, L., & Røe, C. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00622.x · Cited by 31 · see citing works
A diagnosis of rheumatoid arthritis, endometriosis or IBD is associated with later onset of fibromyalgia and chronic widespread pain
Pardo, F. L., Bondesson, E., Schelin, M. E. C., & Jöud, A. (2019) · European Journal of Pain · doi:10.1002/ejp.1432 · Cited by 33 · see citing works
Managing chronic whiplash associated pain with a combination of low‐dose opioid (remifentanil) and NMDA‐antagonist (ketamine)
Lemming, D., Sörensen, J., Graven‐Nielsen, T., Lauber, R., Arendt‐Nielsen, L., & Gerdle, B. U. C. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2006.11.002 · Cited by 31 · see citing works
Self-citation
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain
In, A., Strohman, A., Payne, B., & Legon, W. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.07.020 · Cited by 30 · see citing works
The Osteoarthritis Knee Model: Psychophysical Characteristics and Putative Outcomes
Harden, R. N., Wallach, G., Gagnon, C. M., Zereshki, A., Mukai, A., Saraçoğlu, M., Kuroda, M. M., Graciosa, J. R., & Bruehl, S. P. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.11.009 · Cited by 30 · see citing works
Psychological predictors of change in the number of musculoskeletal pain sites among Norwegian employees: a prospective study
Christensen, J. O., Johansen, S., & Knardahl, S. (2017) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-017-1503-7 · Cited by 29 · see citing works
Neuropathic Pain in Elderly Patients with Chronic Low Back Painand Effects of Pregabalin: A Preliminary Study
Sakai, Y., Ito, K., Hida, T., Ito, S., & Harada, A. (2015) · Asian Spine Journal · doi:10.4184/asj.2015.9.2.254 · Cited by 28 · see citing works
Provoked Vestibulodynia and the Health Care Implications of Comorbid Pain Conditions
Lester, R. A., Brotto, L. A., & Sadownik, L. A. (2015) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)30049-4 · Cited by 28 · see citing works
People with musculoskeletal shoulder pain demonstrate no signs of altered pain processing.
Haik, M. N., Evans, K., Smith, A., Henriquez, L., & Bisset, L. (2019) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2018.11.008 · Cited by 26 · see citing works
Development and Preliminary Psychometric Testing of the Centrality of Pain Scale
Nicolaidis, C., Chianello, T., & Gerrity, M. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01072.x · Cited by 27 · see citing works
A Prospective Crossover Comparison Study of the Single-Needle and Multiple-Needle Techniques for Facet-Joint Medial Branch Block
STOJANOVIC, M., DEY, D., Hord, E. D., Zhou, Y. M., & Cohen, S. P. (2005) · Regional Anesthesia & Pain Medicine · doi:10.1016/j.rapm.2005.05.007 · Cited by 27 · see citing works
High Rate of Pain Sensitization in Musculoskeletal Shoulder Diseases
Previtali, D., Bordoni, V., Filardo, G., Marchettini, P., Guerra, E., & Candrian, C. (2021) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000914 · Cited by 26 · see citing works

Messung von Muskelschmerz und Hyperalgesie
Arendt‐Nielsen, L., Mense, S., & Graven‐Nielsen, T. (2003) · Der Schmerz · doi:10.1007/s00482-003-0260-8 · Cited by 18 · see citing works
Self-citation
Peripheral and central sensitization in musculoskeletal pain disorders: An experimental approach
Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2002) · Current Rheumatology Reports · doi:10.1007/s11926-002-0040-y · Cited by 186 · see citing works
Self-citation
Muscle Pain: Sensory Implications and Interaction With Motor Control
Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31815b608f · Cited by 133 · see citing works
Self-citation
Deep Tissue Hyperalgesia
Arendt‐Nielsen, L., & Graven‐Nielsen, T. (2002) · Journal of Musculoskeletal Pain · doi:10.1300/j094v10n01_09 · Cited by 13 · see citing works
Self-citation
Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition
Arendt‐Nielsen, L., & Henriksson, K. G. (2007) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2007.03.007 · Cited by 190 · see citing works
Self-citation

Authors: Arendt-Nielsen, L., & Graven-Nielsen, T.
Venue: Current Pain and Headache Reports
Publisher: Springer Science and Business Media LLC
Published: 2003-10
Volume: 7
Issue: 5
Pages: 355-361
ISSN: 1531-3433 (ISSN-L)
1534-3081
DOI: 10.1007/s11916-003-0034-0
OpenAlex: W2161320464
Cited by: 219
References: 80
Citations by year: 2026: 5 · 2025: 6 · 2024: 16 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 10
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Pain and Headache Reports (publishedVersion)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders: Danmarks Grundforskningsfond
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: central sensitization, fibromyalgia, chronic musculoskeletal pain, muscle hyperalgesia, referred pain, allodynia, transition from acute to chronic pain
MeSH terms: Fibromyalgia, Humans, Musculoskeletal Diseases, Nerve Endings, Neuropeptides, Nociceptors, Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Central sensitization in fibromyalgia and other musculoskeletal disorders

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks