Reduced brain habituation to somatosensory stimulation in patients with fibromyalgia
Abstract
OBJECTIVE: To examine brain activity elicited by repetitive nonpainful stimulation in patients with fibromyalgia (FM) and to determine possible psychophysiologic abnormalities in their ability to inhibit irrelevant sensory information. METHODS: Fifteen female patients with a diagnosis of FM (ages 30-64 years) and 15 healthy women (ages 39-61 years) participated in 2 sessions, during which electrical activity elicited in the brain by presentation of either tactile or auditory paired stimuli was recorded using an electroencephalogram. Each trial consisted of 2 identical stimuli (S1 and S2) delivered with a randomized interstimulus interval of 550 msec (+/-50 msec), which was separated by a fixed intertrain interval of 12 seconds. Event-related potentials (ERPs) elicited by 40 trials were averaged separately for each sensory modality. RESULTS: ERP amplitudes elicited by the somatosensory and auditory S2 stimuli were significantly reduced compared with those elicited by S1 stimuli in the healthy controls. Nevertheless, significant amplitude reductions from S1 stimuli to S2 stimuli were observed in FM patients for the auditory, but not the somatosensory, modality. CONCLUSION: Our findings suggest that in FM patients, there is abnormal information processing, which may be characterized by a lack of inhibitory control to repetitive nonpainful somatosensory information during stimulus coding and cognitive evaluation.
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“While significant gaps persist in understanding the causes and development of FM [10], it is proposed that a combination of biological, psychological, and social factors contributes to the amplification of pain and increased sensitivity of the central nervous system to peripheral stimuli [11].”
BackgroundHussein, M., Fathy, W., Abdelaleem, E. A., Nasser, M., Yehia, A., & Elanwar, R. (2022) · Pain Medicine · doi:10.1093/pm/pnac076 · Cited by 12 · see citing works
Tactile Detection in Fibromyalgia: A Systematic Review and a Meta-Analysis
Augière, T., Desjardins, A., Raynard, E. P., Brun, C., Pinard, A. M., Simoneau, M., & Mercier, C. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.740897 · Cited by 11 · see citing works
Jelinčić, V., Torta, D. M. E., Diest, I. V., & von Leupoldt, A. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108267 · Cited by 10 · see citing works
Bilgici, A. (2014) · The Annals of Clinical and Analytical Medicine · doi:10.4328/jcam.1181 · Cited by 10 · see citing works
Long-latency suppression of auditory and somatosensory change-related cortical responses
Takeuchi, N., Sugiyama, S., Inui, K., Kanemoto, K., & Nishihara, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199614 · Cited by 10 · see citing works
Decision Making and Fibromyalgia: A Systematic Review
Alfeo, F., Decarolis, D., Clemente, L., Delussi, M. D., de Tommaso, M., Curci, A., & Lanciano, T. (2022) · Brain Sciences · doi:10.3390/brainsci12111452 · Cited by 10 · see citing works
“FM patients showed general impairment in somatic information processing [111,112], which may have contributed to the difficulties exhibited in associated with FM.”
BackgroundTrigeminal nerve stimulation (TNS) for fibromyalgia: A case study
Shiozawa, P., da Silva, M. E., & Cordeiro, Q. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.01.014 · Cited by 8 · see citing works
Facial Emotion Recognition in Obesity and in Fibromyalgia: A Systematic Review
Vaioli, G., & Scarpina, F. (2021) · NeuroSci · doi:10.3390/neurosci2040025 · Cited by 8 · see citing works
Fibromyalgia as a Disorder Related to Distress and its Therapeutic Implications
Schweinhardt, P., Fitzcharles, M., Boomershine, C. S., Vierck, C. J., & Yunus, M. B. (2012) · Pain Research and Treatment · doi:10.1155/2012/950602 · Cited by 8 · see citing works
Jelinčić, V., D’Agostini, M., Ventura‐Bort, C., Cascio, L., Gorianskaia, E., Weymar, M., Torta, D. M. E., Diest, I. V., & von Leupoldt, A. (2025) · Psychophysiology · doi:10.1111/psyp.70048 · Cited by 7 · see citing works
“In addition, our previous research quantified N1 neural gating as the ratio of the S2 and S1 amplitudes, in accordance with most established research on the topic (Chan et al. 2012; Chan and Davenport 2008; Montoya et al. 2006).”
ERPs Studies of Short- and Long-Term Habituation in Humans: A Systematic Review
Pinto, J. A. P., Vogel, E. H., Aylwin, M. D. L. L., & Kreither, J. (2022) · Psykhe (Santiago) · doi:10.7764/psykhe.2021.36885 · Cited by 8 · see citing works
Cortical mechanisms of visual hypersensitivity in women at risk for chronic pelvic pain
Kmiecik, M. J., Tu, F. F., Silton, R. L., Dillane, K. E., Roth, G. E., Harte, S. E., & Hellman, K. M. (2021) · Pain · doi:10.1097/j.pain.0000000000002469 · Cited by 8 · see citing works
Neural indices of multimodal sensory and autonomic hyperexcitability in fibromyalgia
Marinković, K., Woodruff, D., White, D. R., Caudle, M. M., & Cronan, T. A. (2023) · Neurobiology of Pain · doi:10.1016/j.ynpai.2023.100140 · Cited by 7 · see citing works
“This aligns with deficient habituation of the auditory N100 in FM participants reported in one study (Choi et al., 2016), but another one failed to show this effect (Montoya et al., 2006).”
BackgroundThe Association of Sensory Responsiveness with Somatic Symptoms and Illness Anxiety
Rodic, D., Meyer, A. H., Lieb, R., & Meinlschmidt, G. (2015) · International Journal of Behavioral Medicine · doi:10.1007/s12529-015-9483-1 · Cited by 7 · see citing works
Carmassi, C., Cordone, A., Ciapparelli, A., Bertelloni, C. A., Barberi, F. M., Foghi, C., Pedrinelli, V., Dell’Oste, V., Bazzichi, L. M., & Dell’Osso, L. (2021) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/nivxh9 · Cited by 6 · see citing works
Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation
Montoro, C. I., Winterholler, C., Terrasa, J. L., & Montoya, P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.651253 · Cited by 6 · see citing works
Winterholler, C., Coura, M. H. F., & Montoya, P. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2025.1593746 · Cited by 6 · see citing works
Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli
Takeuchi, N., Kinukawa, T. A., Sugiyama, S., Inui, K., Kanemoto, K., & Nishihara, M. (2019) · Brain Topography · doi:10.1007/s10548-019-00721-z · Cited by 5 · see citing works
Samartin-Veiga, N., González-Villar, A. J., Triñanes, Y., Gómez‐Perretta, C., & Carrillo‐de‐la‐Peña, M. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-78377-0 · Cited by 5 · see citing works
Measuring habituation to stimuli: The Italian version of the Sensory Habituation Questionnaire
Tarantino, V., Passerello, N., Ben‐Sasson, A., Podoly, T. Y., Santostefano, A., Oliveri, M., Mandolesi, L., & Turriziani, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309030 · Cited by 4 · see citing works
Fisiopatología de la fibromialgia: alteraciones a nivel cerebral y muscular
Martín, J. M. E., & Barbosa, R. D. (2011) · Fisioterapia · doi:10.1016/j.ft.2011.05.004 · Cited by 4 · see citing works
Repeated exposure to aversive sensations differentially affects neural gating and bodily perception
Jelinčić, V., Torta, D. M. E., Bossche, L. V., Diest, I. V., & von Leupoldt, A. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104422 · Cited by 4 · see citing works
Acupuntura en el manejo complementario de la fibromialgia
Martínez, N. R., & Macías, M. Á. (2012) · Revista Colombiana de Reumatología · doi:10.1016/s0121-8123(12)70037-3 · Cited by 5 · see citing works
“© 2012, Asociación Colombiana de Reumatología 31 En esta entidad se presenta un procesamiento anormal de la información a nivel encefálico, caracterizado por la pérdida del control inhibitorio sobre la información somato-sensorial no dolorosa, durante la codificación de los estímulos y la evaluación cognitiva de los m…”
BackgroundHarrison, R., van Reekum, C. V., Adams, G., Gandhi, W., & Salomons, T. V. (2025) · Pain · doi:10.1097/j.pain.0000000000003636 · Cited by 3 · see citing works
Unusual Pain Disorders – What Can Be Learned from Them?
Sachau, J., Kersebaum, D., Baron, R., & Dickenson, A. H. (2021) · Journal of Pain Research · doi:10.2147/jpr.s287603 · Cited by 4 · see citing works
Otsuru, N., Ogawa, M., Yokota, H., Miyaguchi, S., Kojima, S., Saito, K., Inukai, Y., & Onishi, H. (2021) · European Journal of Pain · doi:10.1002/ejp.1863 · Cited by 3 · see citing works
“…Desmeules et al., 2003) but also for innocuous somatosensory stimuli, including warm or tactile ones (Geisser et al., 2003; Hollins et al., 2009; Montoya et al., 2006), and even for auditory stimuli, in fibromyalgia patients (Carrillo- De- La- Pena et al., 2006; Geisser et al., 2008; Hollins et…”
BackgroundManagement strategies for fibromyalgia
Littlejohn, G., & Marshakk, L. (2011) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s10691 · Cited by 3 · see citing works
“Level of evidence: RCT, meta-analysis, systematic review The diffuse noxious inhibitory control system helps to downregulate sensory input, including pain, via central descending antinociceptive pathways.(27,28) It is thought to be dysfunctional in fibromyalgia due to reduced levels of the key neurotransmitters, serot…”
Anti-nociceptive properties of cardiopulmonary baroreceptors in patients with chronic back pain
Iwakuma, Y., Liu, J., Clonch, D. A., Gangwish, M. E., Lam, C. M., & Holwerda, S. W. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2025.1593939 · Cited by 2 · see citing works
Jelinčić, V., Sone, M., Cerrahoğlu, B., Torta, D. M. E., Diest, I. V., & von Leupoldt, A. (2024) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2024.112463 · Cited by 2 · see citing works
Pregabalin and Fibromyalgia Syndrome: A Treatment Option
Lawson, K. (2009) · Clinical Medicine Therapeutics · doi:10.4137/cmt.s1094 · Cited by 2 · see citing works
A human experimental model of episodic pain
Petrini, L., Hennings, K., Li, X., Negro, F., & Arendt‐Nielsen, L. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.07.013 · Cited by 2 · see citing works
“In migraine patients an increase in SEP amplitude has been found and interpreted as a lack of habituation (de Tommaso et al., 2005;Montoya et al., 2006; Valeriani et al., 2003).”
BackgroundAssociation between pain, anxiety, and alpha2 frontal activity in women with fibromyalgia
de Melo, G. A., Madruga, M. L. L. H., Silva, C. J. D. A., & Alves, N. T. (2021) · Acta Scientiarum Health Sciences · doi:10.4025/actascihealthsci.v43i1.49846 · Cited by 2 · see citing works
“The 32 electrodes were placed on the scalp following the International 10-20 EEG System and the reference electrodes were placed on TP9 and TP10, left and right mastoids (Montoya et al., 2006; Fallon, Chiu, Li, Nurmikko, & Stancak, 2015), respectively.”
MethodWolfe, F., & Rasker, J. J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00052-9 · Cited by 2 · see citing works
Brown, C. A., Huneke, N. T. M., & Jones, A. K. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00141-x · Cited by 2 · see citing works
Cardiopulmonary baroreceptors modify pain intensity in patients with chronic back painPreprint
Iwakuma, Y., Clonch, D. A., Liu, J., Lam, C. M., & Holwerda, S. W. (2023) · Research Square · doi:10.21203/rs.3.rs-3154622/v1 · Cited by 2 · see citing works
Modulation of posterior insula selectively enhances nociceptive sensory gating in healthy humans
Legon, W., Isaac, G., Kapoor, A., & Strohman, A. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100220 · Cited by 1 · see citing works
“…task, these findings extend previous results with causal evidence that the PI directly regulates the flow of ascending nociceptive input and may underlie the sensory gating deficits observed in nociplastic and chronic overlapping pain condition (de Tommaso et al., 2011; Montoya et al., 2006).”
A System for Regulation of Anxiety-based Symptoms
Shenoy, P., & Kumar, T. (2023) · Global Conference on Information Technologies and Communications (GCITC) · doi:10.1109/gcitc60406.2023.10426204 · Cited by 1 · see citing works
“In addition, some studies show somatosensory feedback such as tactile and haptic sensations to be a powerful anxiety and stress reduction tool [24],[25].”
BackgroundIto, C. H., Campbell, F. Q., Montoya, P., Araújo, L., Sá, K. N., Meneses, F., Sá, K. N., Fonseca, A., Benevides, S. D., Zana, Y., et al. (2024) · Brain Imaging and Stimulation · doi:10.17267/2965-3738bis.2024.e5648 · Cited by 1 · see citing works
Targeting fibromyalgia pain: brain–spinal cord and peripheral contributions
Franklyn, K., Guymer, E. K., & Littlejohn, G. O. (2011) · International Journal of Clinical Rheumatology · doi:10.2217/ijr.11.41 · Cited by 1 · see citing works
Acupuncture as complementary treatment of fibromyalgya
Martínez, N. R., & Macías, M. Á. (2012) · Revista Colombiana de Reumatología · Cited by 1 · see citing works
Harrison, R. N., van Reekum, C. M., Adams, G. R., Gandhi, W., & Salomons, T. V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.06.555302 · Cited by 1 · see citing works
Isenstein, E. L., Lang, E. R., Freedman, E. G., & Foxe, J. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.05.697771 · Cited by 1 · see citing works
“For example, individuals with Tourette syndrome (Puts et al., 2015), fibromyalgia (Montoya et al., 2006), cerebral palsy (Kurz et al., 2017), and schizophrenia (Andrade et al., 2016) have been shown to have dysregulated adaptation to tactile stimuli.”
Middle and Long Latency Auditory Evoked Potentials and Their Usage in Fibromyalgia and Schizophrenia
Türker, H., Bilgici, A., & Alpaslan, H. (2012) · InTech eBooks · doi:10.5772/25440
“…the auditory but not the somatosensory modality and suggested also that there was abnormal information processing in FM patients characterized by a lack of inhibitory control to repetitive nonpainful somatosensory information during stimulus coding and cognitive evaluation (Montoya et al., 2006).”
Irritable Bowel Syndrome : Studies of central pathophysiological mechanisms and effects of treatment
Lowén, M. (2015) · Linköping University medical dissertations · doi:10.3384/diss.diva-122144
The Impact of Fibromyalgia and Sensory Processing on Participation of Daily Activities
Mendoza-Battle, F., Okun, R., & Sand, A. (2014) · doi:10.33015/dominican.edu/2014.ot.12
“, pressure, pain, hot, and cold) information during stimulus coding and cognitive evaluation (Collado et al., 2006).”
BackgroundDisability Management in Patients with Fibromyalgia Syndrome
Tait, R. C., & Figoora, V. (2009) · CRC Press eBooks · doi:10.3109/9781420086805-7
- Authors
- Montoya, P., Sitges, C., García‐Herrera, M., Rodríguez‐Cotes, A., Izquierdo, R., Truyols, M., & Collado, D.
- Affiliations
- Research Institute of Health Sciences (ES)
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2006-05-26
- Volume
- 54
- Issue
- 6
- Pages
- 1995-2003
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2017054516
- Cited by
- 113
- References
- 31
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 6
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- fibromyalgia, event-related potentials, sensory inhibition, tactile stimuli, auditory stimuli, sensory processing abnormalities, cognitive assessment
- MeSH terms
- Acoustic Stimulation, Adult, Brain, Electroencephalography, Female, Fibromyalgia, Habituation, Psychophysiologic, Humans, Middle Aged, Physical Stimulation, Touch
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