Cognitive behavioral therapy (CBT) for subacute low back pain: a systematic review
Abstract
Purpose of review Chronic low back pain (CLBP) is a major source of physical and psychiatric morbidity and mortality, and the current overreliance on opioid analgesics has contributed to a burgeoning epidemic in the USA. Cognitive behavioral therapy (CBT) is an empirically supported treatment for CLBP, but little information exists regarding its potential efficacy for CLBP's precursor condition, subacute low back pain (sALBP), defined here as having a 7-12-week duration. Earlier intervention with CBT at the sALBP stage could produce larger clinical benefits. This systematic review was undertaken to characterize and highlight this knowledge gap.Recent findings Of 240 unique articles identified by comprehensive database searches, only six prospective, sALBP-focused, randomized controlled trials (RCTs) published within the past 20 years met criteria for inclusion in this review. These studies varied widely in their sample sizes, precise definition of sALBP, nature of CBT intervention, and outcome measures. Five of the six showed significant improvements associated with CBT, but the heterogeneity of the studies prevented quantitative comparisons. CBT has not been adequately studied as a potential early intervention treatment for sALBP patients. None of the six identified papers studied US civilians or leveraged innovations such as teletherapy-able to reach patients in remote or underserved areas-underscoring critical gaps in current back pain treatment. Given the severity of the US opioid epidemic, non-pharmacologic options such as CBT should be rigorously explored in the sALBP population.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Three reviews evaluated CBT following injury, and all reported CBT to improve distress-related outcomes, although overall quality of evidence was described as low.
“Three reviews evaluated CBT following injury,4143 and all reviews reported CBT to improve distress-related outcomes although, overall the quality of evidence was described as low.”
From Impact of healthcare interventions on distress following acute musculoskeletal/orthopaedic injury: A scoping review of systematic reviews (2024) · cites this paper as [43]
Cites
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392 · see citing works
The Economic Costs of Pain in the United States
Gaskin, D. J., & Richard, P. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.03.009 · Cited by 2,359 · see citing works
The epidemiology of low back pain
Hoy, D., Brooks, P., Blyth, F., & Buchbinder, R. (2010) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2010.10.002 · Cited by 2,037 · see citing works
A review of psychological risk factors in back and neck pain
Linton, S. J. (2000) · Spine · doi:10.1097/00007632-200005010-00017 · Cited by 1,776 · see citing works
Opioid Prescriptions for Chronic Pain and Overdose
Dunn, K. M., Saunders, K. W., Rutter, C. M., Banta‐Green, C. J., Merrill, J. O., Sullivan, M. D., Weisner, C. M., Silverberg, M. J., Campbell, C. I., Psaty, B. M., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00006 · Cited by 1,265 · see citing works
Corticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050 · see citing works
Fear-Avoidance Model of Chronic Pain: The Next Generation
Crombez, G., Eccleston, C., Van Damme, S., Vlaeyen, J. W. S., & Karoly, P. (2012) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182385392 · Cited by 960 · see citing works
Epidemiology of Low Back Pain in Adults
Manchikanti, L., Singh, V. P., Falco, F. J. E., Benyamin, R. M., & Hirsch, J. A. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12018 · Cited by 642 · see citing works
Lamb, S. E., Hansen, Z., Lall, R., Castelnuovo, E., Withers, E. J., Nichols, V., Potter, R., & Underwood, M. R. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62164-4 · Cited by 393 · see citing works
Kaye, A. D. (2017) · Pain Physician · doi:10.36076/ppj.2017.s109 · Cited by 320 · see citing works
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 314 · see citing works
The impact of opioids on the endocrine system
Katz, N., & Mazer, N. A. (2009) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181850df6 · Cited by 307 · see citing works
An analysis of the root causes for opioid-related overdose deaths in the United States
Webster, L. R., Cochella, S., Dasgupta, N., Fakata, K. L., Fine, P. G., Fishman, S. M., Grey, T., Johnson, E. M., Lee, L. K., Passik, S. D., et al. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01134.x · Cited by 295 · see citing works
Relationship of Opioid Use and Dosage Levels to Fractures in Older Chronic Pain Patients
Saunders, K. W., Dunn, K. M., Merrill, J. O., Sullivan, M. D., Weisner, C. M., Braden, J. B., Psaty, B. M., & Korff, M. V. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1218-z · Cited by 271 · see citing works
Turner, J. A., Mancl, L., & Aaron, L. A. (2006) · Pain · doi:10.1016/j.pain.2005.11.017 · Cited by 270 · see citing works
Psychological treatment of chronic pain
Kerns, R. D., Sellinger, J., & Goodin, B. R. (2011) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-090310-120430 · Cited by 267 · see citing works
Brain white matter structural properties predict transition to chronic pain
Mansour, A. R., Baliki, M. N., Huang, L., Torbey, S., Herrmann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Pain · doi:10.1016/j.pain.2013.06.044 · Cited by 263 · see citing works
Richmond, H., Hall, A. M., Copsey, B., Hansen, Z., Williamson, E., Hoxey-Thomas, N., Cooper, Z., & Lamb, S. E. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134192 · Cited by 205 · see citing works
Kaye, A., Jones, M. R., Kaye, A., Ripoll, J. G., Galan, V., Beakley, B. D., Calixto, F., Bolden, J. L., Urman, R., & Manchikanti, L. (2017) · Pain Physician · doi:10.36076/ppj.2017.s111 · Cited by 199 · see citing works
Self-citationMeltzer, E. C., Rybin, D. V., Saitz, R., Samet, J. H., Schwartz, S. L., Butler, S. F., & Liebschutz, J. M. (2010) · Pain · doi:10.1016/j.pain.2010.11.006 · Cited by 158 · see citing works
Lazaridou, A., Kim, J., Cahalan, C. M., Loggia, M. L., Franceschelli, O., Berna, C., Schur, P. H., Napadow, V., & Edwards, R. R. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000422 · Cited by 136 · see citing works
Saunders, K. W., Korff, M. V., Campbell, C. I., Banta‐Green, C. J., Sullivan, M. D., Merrill, J. O., & Weisner, C. M. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.11.004 · Cited by 114 · see citing works
Storheim, K., Brox, J. I., Holm, I., Koller, A. K., & Bø, K. (2003) · Journal of Rehabilitation Medicine · doi:10.1080/16501970310010484 · Cited by 104 · see citing works
Non-pharmacological treatment of chronic widespread musculoskeletal pain
Hassett, A. L., & Williams, D. A. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2011.01.005 · Cited by 97 · see citing works
Reme, S. E., Sveinsdóttir, V. Ó., & Eriksen (2012) · Journal of Pain Research · doi:10.2147/jpr.s25330 · Cited by 91 · see citing works
Schiltenwolf, M., Buchner, M., Heindl, B., von Reumont, J., Müller, A. M., & Eich, W. (2005) · European Spine Journal · doi:10.1007/s00586-005-0008-5 · Cited by 85 · see citing works
Early identification and intervention in the prevention of musculoskeletal pain
Linton, S. J. (2002) · American Journal of Industrial Medicine · doi:10.1002/ajim.10052 · Cited by 84 · see citing works
Fleming, M., Davis, J., & Passik, S. (2008) · Pain medicine (Malden, Mass.) · doi:10.1111/j.1526-4637.2008.00491.x · Cited by 79 · see citing works
Cognitive–Behavioral Therapy for Chronic Low Back Pain in Older Persons: A Preliminary Study
Reid, M. C., Otis, J. D., Barry, L. C., & Kerns, R. D. (2003) · Pain Medicine · doi:10.1046/j.1526-4637.2003.03030.x · Cited by 60 · see citing works
Nonpharmacological Treatment of Pain in Rheumatic Diseases and Other Musculoskeletal Pain Conditions
Cunningham, N. R., & Kashikar‐Zuck, S. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-012-0306-y · Cited by 58 · see citing works
Werner, E. L., Storheim, K., Løchting, I., Wisløff, T., & Grotle, M. (2016) · SPINE · doi:10.1097/brs.0000000000001268 · Cited by 43 · see citing works
Preventing Progression to Chronicity in First Onset, Subacute Low Back Pain: An Exploratory Study
Slater, M. A., Weickgenant, A. L., Greenberg, M. A., Wahlgren, D. R., Williams, R. A., Carter, C., Patterson, T. L., Grant, I., Garfin, S. R., Webster, J. S., et al. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.10.032 · Cited by 40 · see citing works
Passik, S. D., & Lowery, A. E. (2011) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01130.x · Cited by 28 · see citing works
Lindell, O., Johansson, S.-E., & Strender, L.-E. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-172 · Cited by 28 · see citing works
Learning mechanisms in pain chronification—teachings from placebo research
Ingvar, M. (2015) · Pain · doi:10.1097/j.pain.0000000000000093 · Cited by 18 · see citing works
Limiting the Potential Harms of High-Dose Opioid Therapy
Sullivan, M. D. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.101 · Cited by 17 · see citing works
Opioids for chronic musculoskeletal pain: Putting patient safety first
Korff, M. V. (2013) · Pain · doi:10.1016/j.pain.2013.09.017 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Knezevic, N. N., Candido, K. D., Vlaeyen, J. W. S., Van Zundert, J., & Cohen, S. P. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00733-9 · Cited by 1,345 · see citing works
Prevalence of chronic pain among adults in the United States
Yong, R. J., Mullins, P. M., & Bhattacharyya, N. (2022) · Pain · doi:10.1097/j.pain.0000000000002291 · Cited by 839 · see citing works
Philippe, T. J., Sikder, N., Jackson, A., Koblanski, M. E., Liow, E., Pilarinos, A., & Vasarhelyi, K. (2022) · JMIR Mental Health · doi:10.2196/35159 · Cited by 436 · see citing works
Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress
Shi, Y., & Wu, W. (2023) · BMC Medicine · doi:10.1186/s12916-023-03076-2 · Cited by 260 · see citing works
de Oliveira, M. F. D., Johnson, D. S., Demchak, T. J., Tomazoni, S. S., & Leal‐Junior, E. C. P. (2021) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.21.07236-1 · Cited by 116 · see citing works
Ziadni, M. S., Gonzalez-Castro, L., Anderson, S., Krishnamurthy, P., & Darnall, B. D. (2021) · Journal of Medical Internet Research · doi:10.2196/29672 · Cited by 59 · see citing works
Online teletherapy for chronic pain: A systematic review
Mariano, T. Y., Wan, L., Edwards, R. R., & Jamison, R. N. (2021) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x19871746 · Cited by 52 · see citing works
Mariano, T. Y., Burgess, F. W., Bowker, M., Kirschner, J., Wout‐Frank, M. V. ‘., Jones, R. N., Halladay, C. W., Stein, M. D., & Greenberg, B. D. (2018) · Pain Medicine · doi:10.1093/pm/pny188 · Cited by 49 · see citing works
Fullen, B. M., Morlion, B. J., Linton, S. J., Roomes, D., van Griensven, J., Abraham, L., Beck, C., Wilhelm, S., Constantinescu, C., & Perrot, S. (2022) · Pain Practice · doi:10.1111/papr.13103 · Cited by 30 · see citing works
Apeldoorn, A. T., Swart, N. M., Conijn, D., Meerhoff, G. A., & Ostelo, R. (2024) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.24.08352-7 · Cited by 33 · see citing works
Ziadni, M. S., Anderson, S. R., Gonzalez-Castro, L., & Darnall, B. D. (2021) · Trials · doi:10.1186/s13063-021-05303-8 · Cited by 17 · see citing works
Tornero, C. (2022) · NeuroTarget · doi:10.47924/neurotarget2022197 · Cited by 14 · see citing works
Babatunde, F. O., MacDermid, J., Grewal, R., Macedo, L., & Szekeres, M. (2020) · JMIR Human Factors · doi:10.2196/17088 · Cited by 12 · see citing works
“…improvements in pain, daily function, quality of life, and overall mental health compared with active treatments alone for several musculoskeletal (MSK) problems [27,28] including knee pain [29], low back pain, [30,31] fibromyalgia, [32] preoperative spine [33] and post total joint surgery [34].”
Bernaers, L., Cnockaert, E., Braeckman, L., Mairiaux, P., & Willems, T. M. (2022) · Clinical Rehabilitation · doi:10.1177/02692155221146447 · Cited by 13 · see citing works
Physical therapy for acute and sub-acute low back pain: A systematic review and expert consensus
Wang, X., Wang, Y., Witchalls, J. B., Han, J., Zhang, Z., Page, P., Zhu, Y., Stecco, C., Lin, J., El‐Ansary, D., et al. (2024) · Clinical Rehabilitation · doi:10.1177/02692155241229398 · Cited by 12 · see citing works
Bagheri, R., Hedayati, R., Ehsani, F., Hemati-Boruojeni, N., Abri, A., & Taghizadeh Delkhosh, C. (2020) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2019.03.015 · Cited by 10 · see citing works
Ehsani, F., Yousefi, M. S. H., Jafarzadeh, A., Zoghi, M., & Jaberzadeh, S. J. (2023) · Brain Sciences · doi:10.3390/brainsci13101381 · Cited by 9 · see citing works
Sim, A., McNeilage, A. G., Gholamrezaei, A., Rebbeck, T., & Ashton-James, C. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085778 · Cited by 8 · see citing works
“Several reviews included data on the duration and frequency of the exercise interventions and reported a large range from 15 min sessions to 3-hour sessions and a frequency that ranged from one session per week to seven sessions per week.”
BackgroundPsychological interventions in preventing chronicity of sub-acute back pain: a systematic review
Orenius, T., Silén, E., Nuortimo, A., & Ristolainen, L. (2022) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2021-0063 · Cited by 8 · see citing works
Virtual Reality for Subacute Pain After Orthopedic Traumatic Musculoskeletal Injuries
Mace, R. A., Brewer, J. R., Cohen, J. E., Ly, T. V., Weaver, M. J., & Borsook, D. (2024) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001231 · Cited by 7 · see citing works
Carrière, J. S., Coutu, M., Darnall, B. D., Léonard, G., Royer, M.-P., Li, M., Bordeleau, M., & Durand, M. (2025) · Journal of Pain Research · doi:10.2147/jpr.s527830 · Cited by 4 · see citing works
Rujipong, P., Kantaruksa, K., Chaloumsuk, N., & Yothayai, C. (2021) · The Open Nursing Journal · doi:10.2174/1874434602115010085 · Cited by 3 · see citing works
Migliorini, F., Schäfer, L., Simeone, F., Memminger, M. K., Eschweiler, J., & Vaishya, R. (2026) · European journal of medical research · doi:10.1186/s40001-026-04084-7 · Cited by 3 · see citing works
Other Psychiatric Disorders, Psychosocial Factors, Sleep, and Pain
Bair, M. J., & Owen‐Smith, A. A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197675250.003.0006 · Cited by 3 · see citing works
Perioperative Psychological Interventions
Fehon, D. C., & Swanson, A. C. (2018) · Springer eBooks · doi:10.1007/978-3-319-99774-2_7 · Cited by 2 · see citing works
Delasas, G. E., Delgado, N. M., Mojica, I. K., Ragasa, S., Dones, V. C., & Manlapaz, D. (2025) · JBI Evidence Synthesis · doi:10.11124/jbies-23-00480 · Cited by 4 · see citing works
Pawełczyk, A. M., Lusa, W., & Radek, M. (2023) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2023.0042 · Cited by 2 · see citing works
„Graded balance“ in der Schmerztherapie
Hasenbring, M. I., & Titze, C. (2025) · Der Schmerz · doi:10.1007/s00482-025-00893-7 · Cited by 1 · see citing works
Pawełczyk, A. M., Błaszczyk, M., Pawełczyk, T., & Radek, M. (2020) · Aktualności Neurologiczne · doi:10.15557/an.2020.0014
Miki, T., Kondo, Y., Kurakata, H., Takebayashi, T., & Samukawa, M. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-055144 · Cited by 1 · see citing works
Ferreira, L. A. S., Barbosa, D., Kerppers, I. I., Xavier, G., & Ferreira, M. B. (2018) · Revista FisiSenectus · doi:10.22298/rfs.2017.v5.n2.4304
Substance Use Disorders: Second Wave Approaches
Ecker, A. H., Hogan, J., Dawson, D. B., & Cucciare, M. A. (2022) · Springer eBooks · doi:10.1007/978-3-031-11677-3_24
Can emotional distress induce acute low back pain? A systematic review
Collins, S., McDevitt‐Petrovic, O., & Henderson, E. M. (2023) · Physiotherapy Practice and Research · doi:10.3233/ppr-230737
Prevalencia del dolor crónico entre adultos en los Estados Unidos
Yong, R. J., Mullins, P. M., & Bhattacharyya, N. (2023) · NeuroTarget · doi:10.47924/neurotarget2023457
Ziadni, M. S., Dildine, T. C., Edwards, K. A., Herrick, A., You, D. S., & Darnall, B. D. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106220
- Authors
- Mariano, T. Y., Urman, R. D., Hutchison, C. A., Jamison, R. N., & Edwards, R. R.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Mariano, Timothy Y.
- Venue
- Current Pain and Headache Reports
- Published
- 2018-02-23
- Volume
- 22
- Issue
- 3
- Pages
- 15-15
- ISSN
- 1531-3433 (ISSN-L)
- 1534-3081
- OpenAlex
- W2789820066
- Cited by
- 35
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Pain and Headache Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- cognitive behavioral therapy, subacute low back pain, chronic low back pain, early intervention, opioid epidemic, non-pharmacological treatment, external beam radiotherapy, randomized controlled trials
- MeSH terms
- Humans, Cognitive Behavioral Therapy, Low Back Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review