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Cited by 209

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders

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Gonzales, Michael L., LaSalle, Janine M.·2010·Current Psychiatry Reports
DOI 10.1007/s11920-010-0097-7
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Abstract

Methyl CpG binding protein-2 (MeCP2) is an essential epigenetic regulator in human brain development. Rett syndrome, the primary disorder caused by mutations in the X-linked MECP2 gene, is characterized by a period of cognitive decline and development of hand stereotypies and seizures following an apparently normal early infancy. In addition, MECP2 mutations and duplications are observed in a spectrum of neurodevelopmental disorders, including severe neonatal encephalopathy, X-linked mental retardation, and autism, implicating MeCP2 as an essential regulator of postnatal brain development. In this review, we compare the mutation types and inheritance patterns of the human disorders associated with MECP2. In addition, we summarize the current understanding of MeCP2 as a central epigenetic regulator of activity-dependent synaptic maturation. As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies.

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Research works printed but not linked: 41

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Metadata

Authors
Gonzales, M. L., & LaSalle, J. M.
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2010-03-24
Volume
12
Issue
2
Pages
127-134
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-010-0097-7
OpenAlex
W2044763721
Cited by
209
References
10
FWCI
13.08
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders. https://app.cochat.ai/papers/10.1007/s11920-010-0097-7
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Gonzales, M. L., & LaSalle, J. M. (2010). The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders. Current Psychiatry Reports. https://doi.org/10.1007/s11920-010-0097-7

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